SitesBLAST

P19921 Carbon monoxide dehydrogenase small chain; CO dehydrogenase subunit S; CO-DH S; EC 1.2.5.3 from Afipia carboxidovorans (strain ATCC 49405 / DSM 1227 / KCTC 32145 / OM5) (Oligotropha carboxidovorans) (see 2 papers)
46% identity, 39% coverage: 14:172/405 of query aligns to 2:159/166 of P19921

query
sites
P19921

A

A

S

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I

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N

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Q

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C

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C

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N

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G

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G

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-

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C

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A

A

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A

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G

N

N

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C

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C

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T

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G

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Y

A

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N

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I

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K

A

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A

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-

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N

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C42 (= C54) binding [2Fe-2S] cluster
C47 (= C59) binding [2Fe-2S] cluster
C50 (= C62) binding [2Fe-2S] cluster
C62 (= C74) binding [2Fe-2S] cluster
C102 (= C113) binding [2Fe-2S] cluster
C105 (= C116) binding [2Fe-2S] cluster
C137 (= C148) binding [2Fe-2S] cluster
C139 (= C150) binding [2Fe-2S] cluster

1n5wD Crystal structure of the cu,mo-co dehydrogenase (codh); oxidized form (see paper)
46% identity, 38% coverage: 18:172/405 of query aligns to 4:157/158 of 1n5wD

query
sites
1n5wD

I

I

T

E

L

L

T

T

L

I

N

N

G

G

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S

P

V

V

A

E

A

A

T

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A

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E

E

A

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T

N

L

L

L

A

I

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F

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D

E

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L

Q

N

N

L

L

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T

G

G

T

A

H

H

I

I

G

G

C
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C

E

D

H

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x
S

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x
H

C
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C

G
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G

A

A

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C

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T

I

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D

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C

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G

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I

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E

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M

-

A

D

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D

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A

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N

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E

M

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H

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L

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Q

C
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C

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G

F

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C

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P

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G

M

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A

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E

A

A

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I

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A

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G

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N

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C

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G

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Y

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binding flavin-adenine dinucleotide: S43 (≠ G57), H44 (≠ V58)
binding fe2/s2 (inorganic) cluster: C40 (= C54), S43 (≠ G57), C45 (= C59), G46 (= G60), C48 (= C62), C60 (= C74), C100 (= C113), G101 (= G114), C103 (= C116), C135 (= C148), C137 (= C150)
binding pterin cytosine dinucleotide: Q99 (= Q112), C137 (= C150)

1n5wA Crystal structure of the cu,mo-co dehydrogenase (codh); oxidized form (see paper)
46% identity, 38% coverage: 18:172/405 of query aligns to 4:157/161 of 1n5wA

query
sites
1n5wA

I

I

T

E

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L

T

T

L

I

N

N

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G

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H

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V

A

E

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A

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E

A

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T

N

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L

L

A

I

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E

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Q

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N

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G

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A

H

H

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I

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G

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C

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x
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x
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C

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G

A

A

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C

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T

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D

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G

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C

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A

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N

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I

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C

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T

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P

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G

M

M

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A

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L

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A

A

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A

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G

G

N

N

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G

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Y

A

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binding flavin-adenine dinucleotide: S43 (≠ G57), H44 (≠ V58)
binding fe2/s2 (inorganic) cluster: I38 (= I52), G39 (= G53), C40 (= C54), S43 (≠ G57), C45 (= C59), G46 (= G60), C48 (= C62), C60 (= C74), C100 (= C113), G101 (= G114), C103 (= C116), C135 (= C148), C137 (= C150)

4zohC Crystal structure of glyceraldehyde oxidoreductase (see paper)
44% identity, 36% coverage: 18:162/405 of query aligns to 12:155/161 of 4zohC

query
sites
4zohC

I

I

T

T

L

L

T

K

L

I

N

N

G

G

R

E

S

K

V

Y

A

E

A

T

T

E

A

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E

E

A

P

R

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N

L

L

L

A

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D

H

L

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V

L

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R

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E

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-

L

L

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L

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G

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H

H

I

I

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G

C
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C

E

D

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x
S

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N

C
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C

G
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G

A

A

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C

T

T

I

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L

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D

N

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G

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A

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A

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D

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G

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A

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T

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E

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D

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A

A

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F

N

W

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E

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N

H

H

A

A

L

L

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Q

C
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C

G
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G

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Y

C
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C

T

T

P

P

G

G

M

M

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I

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M

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E

A

A

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Y

D

W

L

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N

A

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E

E

A

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I

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R

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G

G

L

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A

S

G

G

N

N

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L

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G

Y

Y

A

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G

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I

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K

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A

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A

binding fe2/s2 (inorganic) cluster: C47 (= C54), S50 (≠ G57), C52 (= C59), G53 (= G60), C55 (= C62), C67 (= C74), C106 (= C113), G107 (= G114), C109 (= C116), C141 (= C148), C143 (= C150)
binding pterin cytosine dinucleotide: Q105 (= Q112), C143 (= C150)

1sb3C Structure of 4-hydroxybenzoyl-coa reductase from thauera aromatica (see paper)
44% identity, 37% coverage: 17:167/405 of query aligns to 4:154/161 of 1sb3C

query
sites
1sb3C

M

I

I

L

T

R

L

L

T

T

L

L

N

N

G

G

R

R

S

A

V

R

A

E

A

D

T

L

A

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E

P

A

D

R

N

T

M

N

L

L

L

A

L

D

D

L

Y

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L

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R

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E

T

T

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N

G

L

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G

G

T

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H

K

I
x
Q

G

G

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C

E

D

H

G

G
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G

V

E

C
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C

G
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G

A

A

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C

T

T

I

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L

L

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V

D

D

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D

E

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P

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A

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A

A

A

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A

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C

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Q

A

G

G

A

K

D

K

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E

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S

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L

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A

D

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D

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A

G

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T

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L

L

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A

A

F

F

N

H

R

E

E

K

H

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A

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T

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Q

C
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C

G
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G

F

F

C
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C

T

T

P

P

G

G

M

M

L

I

V

M

S

A

A

S

R

E

D

A

L

L

V

L

L

R

R

K

L

N

P

P

E

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A

P

D

S

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R

A

D

R

E

I

I

R

K

L

A

G

A

L

L

A

A

G

G

N

N

L

L

C
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C

R

R

C
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C

T

T

G

G

Y

Y

A

V

G

K

I

I

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I

K

K

A

S

V

V

A

E

S

T

V

A

I

A

A

A

R

R

binding fe2/s2 (inorganic) cluster: Q39 (≠ I52), C41 (= C54), G44 (= G57), C46 (= C59), G47 (= G60), C49 (= C62), C61 (= C74), C100 (= C113), G101 (= G114), C103 (= C116), C135 (= C148), C137 (= C150)
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): Q99 (= Q112), C137 (= C150)

7dqxC Crystal structure of xanthine dehydrogenase family protein
42% identity, 37% coverage: 18:167/405 of query aligns to 6:156/160 of 7dqxC

query
sites
7dqxC

I

L

T

T

L

V

T

E

L

V

N

N

G

G

R

V

S

T

V

H

A

A

A

T

T

D

A

V

E

E

A

P

R

R

T

R

N

L

L

L

A

A

D

D

L

F

V

L

R

R

D

D

T

D

L

L

N

H

L

L

T

R

G

G

T

T

H

R

I

V

G

G

C
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C

E

E

H

H

G
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G

V
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V

C
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C

G

G

A

S

C
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C

T

T

I

V

L

I

V

L

D

D

G

G

E

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P

P

A

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R
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R

A

S

C
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C

I

T

S

V

F

L

A

A

A

V

A

Q

C

A

Q

N

G

N

A

S

D

R

V

I

V

E

T

T

I

V

E

E

G

S

L

L

D

Q

D

K

D

D

A

G

V

Q

T

L

A

H

E

P

L

L

R

Q

A

R

A

S

F

F

N

S

R

K

E

C

H

H

A

A

L

L

Q
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Q

C
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C

G

G

F

F

C
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C

T

T

P

S

G

G

M

F

L

L

V

M

S

T

A

L

R

K

-

P

-

L

-

Y

-

D

-

E

D

D

L

V

V

T

L

L

R

D

L

A

P

T

E

S

A

A

D

R

E

E

A

A

R

-

I

-

R

-

L

-

G

-

L

I

A

S

G

G

N

N

L

L

C
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C

R

R

C
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C

T

T

G

G

Y

Y

A

Q

G

Q

I

I

V

V

K

E

A

A

V

T

A

V

S

D

V

A

I

F

A

H

A

C

R

R

binding fe2/s2 (inorganic) cluster: C42 (= C54), G45 (= G57), V46 (= V58), C47 (= C59), C50 (= C62), R60 (= R72), C62 (= C74), Q100 (= Q112), C101 (= C113), C104 (= C116), C137 (= C148), C139 (= C150)
binding pterin cytosine dinucleotide: Q100 (= Q112), C139 (= C150)

P77165 Aldehyde oxidoreductase iron-sulfur-binding subunit PaoA; EC 1.2.99.6 from Escherichia coli (strain K12) (see paper)
37% identity, 35% coverage: 18:160/405 of query aligns to 63:220/229 of P77165

query
sites
P77165

I

L

T

T

L

L

T

K

L

V

N

N

G

G

R

K

S

T

V

E

A

Q

A

L

T

E

A

V

E

D

A

T

R

R

T

T

N

T

L

L

A

L

D

D

L

T

V

L

R

R

D

E

T

N

L

L

N

H

L

L

T

I

G

G

T

T

H

K

I

K

G

G

C
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C

E

D

H

H

G

G

V

Q

C
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C

G
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G

A

A

C
|
C

T

T

I

V

L

L

V

V

D

N

G

G

E

R

P

R

A

L

R

N

A

A

C
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C

I

L

S

T

F

L

A

A

A

V

A

M

C

H

Q

Q

G

G

A

A

D

E

V

I

V

T

T

T

I

I

E

E

G

G

L

L

D

G

D

S

D

P

A

D

V

N

T

L

A

H

E

P

L

M

R

Q

A

A

F

F

N

I

R

K

E

H

H

D

A

G

L

F

Q

Q

C
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C

G

G

F

Y

C
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C

T

T

P

S

G

G

M

Q

L

I

V

C

S

S

A

S

R

V

D

A

L

V

V

L

L

K

R

E

L

I

-

Q

-

D

-

G

-

I

-

P

-

S

-

H

-

V

-

T

-

V

-

D

-

L

-

V

-

S

-

A

P

P

E

E

A

T

D

T

E

A

A

D

R

E

I

I

R

R

L

E

G

R

L

M

A

S

G

G

N

N

L

I

C
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C

R

R

C
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C

T

G

G

A

Y

Y

A

A

G

N

I

I

V

L

K

A

A

A

V

I

C99 (= C54) binding [2Fe-2S] cluster
C104 (= C59) binding [2Fe-2S] cluster
G105 (= G60) binding [2Fe-2S] cluster
C107 (= C62) binding [2Fe-2S] cluster
C119 (= C74) binding [2Fe-2S] cluster
C158 (= C113) binding [2Fe-2S] cluster
C161 (= C116) binding [2Fe-2S] cluster
C208 (= C148) binding [2Fe-2S] cluster
C210 (= C150) binding [2Fe-2S] cluster

3hrdD Crystal structure of nicotinate dehydrogenase (see paper)
38% identity, 35% coverage: 18:160/405 of query aligns to 6:148/160 of 3hrdD

query
sites
3hrdD

I

I

T

N

L

L

T

N

L

L

N

N

G

G

R

E

S

A

V

R

A

S

A

I

T

V

A

T

E

E

A

P

R

N

T

K

N

R

L

L

A

L

D

D

L

L

V

L

R

R

D

E

T

D

L

F

N

G

L

L

T

T

G

S

T

V

H

K

I
x
E

G

G

C
|
C

E
x
S

H
x
E

G
|
G

V
x
E

C
|
C

G
|
G

A

A

C
|
C

T

T

I

V

L

I

V

F

D

N

G

G

E

D

P

P

A

V

R

T

A

T

C
|
C

I

C

S

M

F

L

A

A

A

G

A

Q

C

A

Q

D

G

E

A

S

D

T

V

I

T

T

I

L

E

E

G

G

L

V

D

A

D

E

D

D

A

G

V

K

T

P

A

S

E

L

L

L

R

Q

A

Q

A

C

F

F

N

L

R

E

E

A

H

G

A

A

L

V

Q
|
Q

C
|
C

G
|
G

F

Y

C
|
C

T

T

P

P

G

G

M

M

L

I

V

L

S

T

A

A

R

K

D

A

L

L

V

L

L

D

R

K

L

N

P

P

E

D

A

P

D

T

E

D

A

E

R

E

I

I

R

T

L

V

G

A

L

M

A

S

G

G

N

N

L

L

C
|
C

R

R

C
|
C

T

T

G

G

Y

Y

A

I

G

K

I

I

V

H

K

A

A

A

V

V

binding flavin-adenine dinucleotide: E44 (≠ H56), G45 (= G57), E46 (≠ V58)
binding fe2/s2 (inorganic) cluster: E40 (≠ I52), C42 (= C54), S43 (≠ E55), G45 (= G57), C47 (= C59), G48 (= G60), C50 (= C62), C62 (= C74), Q100 (= Q112), C101 (= C113), G102 (= G114), C104 (= C116), C136 (= C148), C138 (= C150)
binding pterin cytosine dinucleotide: Q100 (= Q112), C138 (= C150)

5g5gA Escherichia coli periplasmic aldehyde oxidase (see paper)
37% identity, 35% coverage: 18:160/405 of query aligns to 12:169/175 of 5g5gA

query
sites
5g5gA

I

L

T

T

L

L

T

K

L

V

N

N

G

G

R

K

S

T

V

E

A

Q

A

L

T

E

A

V

E

D

A

T

R

R

T

T

N

T

L

L

A

L

D

D

L

T

V

L

R

R

D

E

T

N

L

L

N

H

L

L

T

I

G

G

T

T

H

K

I

K

G
|
G

C
|
C

E
x
D

H

H

G
|
G

V

Q

C
|
C

G
|
G

A

A

C
|
C

T

T

I

V

L

L

V

V

D

N

G

G

E

R

P

R

A

L

R

N

A

A

C
|
C

I

L

S

T

F

L

A

A

A

V

A

M

C

H

Q

Q

G

G

A

A

D

E

V

I

V

T

T

T

I

I

E

E

G

G

L

L

D

G

D

S

D

P

A

D

V

N

T

L

A

H

E

P

L

M

R

Q

A

A

F

F

N

I

R

K

E

H

H

D

A

G

L

F

Q

Q

C
|
C

G
|
G

F

Y

C
|
C

T

T

P

S

G

G

M

Q

L

I

V

C

S

S

A

S

R

V

D

A

L

V

V

L

L

K

R

E

L

I

-

Q

-

D

-

G

-

I

-

P

-

S

-

H

-

V

-

T

-

V

-

D

-

L

-

V

-

S

-

A

P

P

E

E

A

T

D

T

E

A

A

D

R

E

I

I

R

R

L

E

G

R

L

M

A

S

G

G

N

N

L

I

C
|
C

R

R

C
|
C

T

G

G

A

Y

Y

A

A

G

N

I

I

V

L

K

A

A

A

V

I

binding fe2/s2 (inorganic) cluster: G47 (= G53), C48 (= C54), D49 (≠ E55), G51 (= G57), C53 (= C59), G54 (= G60), C56 (= C62), C68 (= C74), C107 (= C113), G108 (= G114), C110 (= C116), C157 (= C148), C159 (= C150)

Q0QLF3 Nicotinate dehydrogenase small FeS subunit; NDH; Nicotinic acid hydroxylase small FeS subunit; NAH; EC 1.17.1.5 from Eubacterium barkeri (Clostridium barkeri) (see paper)
38% identity, 35% coverage: 18:160/405 of query aligns to 6:148/157 of Q0QLF3

query
sites
Q0QLF3

I

I

T

N

L

L

T

N

L

L

N

N

G

G

R

E

S

A

V

R

A

S

A

I

T

V

A

T

E

E

A

P

R

N

T

K

N

R

L

L

A

L

D

D

L

L

V

L

R

R

D

E

T

D

L

F

N

G

L

L

T

T

G

S

T

V

H

K

I

E

G

G

C
|
C

E

S

H

E

G

G

V

E

C
|
C

G

G

A

A

C
|
C

T

T

I

V

L

I

V

F

D

N

G

G

E

D

P

P

A

V

R

T

A

T

C
|
C

I

C

S

M

F

L

A

A

A

G

A

Q

C

A

Q

D

G

E

A

S

D

T

V

I

T

T

I

L

E

E

G

G

L

V

D

A

D

E

D

D

A

G

V

K

T

P

A

S

E

L

L

L

R

Q

A

Q

A

C

F

F

N

L

R

E

E

A

H

G

A

A

L

V

Q

Q

C
|
C

G

G

F

Y

C
|
C

T

T

P

P

G

G

M

M

L

I

V

L

S

T

A

A

R

K

D

A

L

L

V

L

L

D

R

K

L

N

P

P

E

D

A

P

D

T

E

D

A

E

R

E

I

I

R

T

L

V

G

A

L

M

A

S

G

G

N

N

L

L

C
|
C

R

R

C
|
C

T

T

G

G

Y

Y

A

I

G

K

I

I

V

H

K

A

A

A

V

V

C42 (= C54) binding [2Fe-2S] cluster
C47 (= C59) binding [2Fe-2S] cluster
C50 (= C62) binding [2Fe-2S] cluster
C62 (= C74) binding [2Fe-2S] cluster
C101 (= C113) binding [2Fe-2S] cluster
C104 (= C116) binding [2Fe-2S] cluster
C136 (= C148) binding [2Fe-2S] cluster
C138 (= C150) binding [2Fe-2S] cluster

5y6qA Crystal structure of an aldehyde oxidase from methylobacillus sp. Ky4400 (see paper)
39% identity, 37% coverage: 18:165/405 of query aligns to 5:153/157 of 5y6qA

query
sites
5y6qA

I

L

T

T

L

M

T

Q

L

V

N

N

G

G

R

Q

S

P

V

Y

A

P

A

M

T

E

A

I

E

D

A

P

R

R

T

V

N

T

L

L

A

L

D

D

L

A

V

L

R

R

D

E

T

H

L

L

N

N

L

L

T

T

G

G

T

T

H

K

I

K

G
|
G

C
|
C

E
x
D

H

Q

G
|
G

V

Q

C
|
C

G
|
G

A

A

C
|
C

T

T

I

V

L

L

V

V

D

N

G

G

E

Q

P

R

A

V

R

L

A

S

C
|
C

I

L

S

T

F

L

A

A

A

Q

C

A

Q

D

G

G

A

A

D

E

V

V

V

T

T

S

I

I

E

E

G

G

L

L

D

-

D

Q

A

S

V

A

T

S

A

G

E

E

L

L

-

H

-

P

-

V

R

Q

A

R

A

C

F

F

N

V

R

E

E

N

H

D

A

A

L

F

Q
|
Q

C
|
C

G
|
G

F

Y

C
|
C

T

T

P

P

G

G

M

Q

L

I

V

M

S

S

A

A

R

V

D

A

L

C

V

I

L

K

R

E

L

G

P

H

E

A

A

G

D

S

E

D

A

D

R

E

I

I

R

R

L

E

G

Y

L

M

A

S

G

G

N

N

L

L

C
|
C

R

R

C
|
C

T

G

G

A

Y

Y

A

P

G

H

I

I

V

I

K

D

A

A

V

I

A

K

S

Q

V

A

I

A

A

A

binding fe2/s2 (inorganic) cluster: G40 (= G53), C41 (= C54), D42 (≠ E55), G44 (= G57), C46 (= C59), G47 (= G60), C49 (= C62), C61 (= C74), C101 (= C113), G102 (= G114), C104 (= C116), C136 (= C148), C138 (= C150)
binding pterin cytosine dinucleotide: Q100 (= Q112), C138 (= C150)

8gy3B Cryo-em structure of membrane-bound aldehyde dehydrogenase from gluconobacter oxydans
40% identity, 38% coverage: 20:171/405 of query aligns to 5:154/154 of 8gy3B

query
sites
8gy3B

L

F

T

E

L

L

N

N

G

G

R

Q

S

P

V

V

A

T

A

V

T

D

A

A

E

P

A

A

R

D

T

T

N

P

L

L

A

L

D

W

L

V

V

I

R

R

D

D

T

D

L

L

N

N

L

L

T

T

G

G

T

T

H

K

I

F

G
|
G

C
|
C

E
x
G

H

I

G
|
G

V

E

C
|
C

G
|
G

A

A

C
|
C

T

T

I

V

L

H

V

V

D

G

G

G

E

R

P

A

A

T

R

R

A

S

C
|
C

I

I

S

T

F

P

A

L

A

S

A

A

C

V

Q

E

G

G

A

A

D

S

V

I

V

T

T

T

I

I

E

E

G

G

L

L

D

-

D

D

D

P

A

A

V

G

T

N

A

H

E

V

L

V

R

Q

A

V

A

A

F

W

N

R

R

D

E

Q

H

Q

A

V

L

P

Q
|
Q

C
|
C

G

G

F

Y

C
|
C

T
x
Q

P

S

G

G

M

Q

L

I

V

M

S

Q

A

A

R

A

D

S

L

L

V

L

L

K

R

D

L

Y

P

P

E

N

A

P

D

T

E

D

A

D

R

Q

I

I

R

D

L

G

G

V

L

M

A

G

G

G

N

S

L

L

C
|
C

R

R

C
|
C

T

M

G

T

Y

Y

A

I

G

R

I

I

V

R

K

K

A

A

V

I

A

K

S

E

V

A

I

-

A

A

A

S

R

R

R

Q

A

Q

Q

E

G

G

binding fe2/s2 (inorganic) cluster: G38 (= G53), C39 (= C54), G40 (≠ E55), G42 (= G57), C44 (= C59), G45 (= G60), C47 (= C62), C59 (= C74), C97 (= C113), C100 (= C116), Q101 (≠ T117), C132 (= C148), C134 (= C150)
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): Q96 (= Q112), C134 (= C150)

4usaA Aldehyde oxidoreductase from desulfovibrio gigas (mop), soaked with trans-cinnamaldehyde (see paper)
37% identity, 37% coverage: 20:170/405 of query aligns to 6:162/907 of 4usaA

query
sites
4usaA

L

I

T

T

L

V

N

N

G

G

R

I

S

E

V

Q

A

N

A

L

T

F

A

V

E

D

A

A

R

E

T

A

N

L

L

L

A

S

D

D

L

V

V

L

R

R

D

Q

T

Q

L

L

N

G

L

L

T

T

G

G

T

V

H

K

I
x
V

G

G

C
|
C

E
|
E

H

Q

G
|
G

V

Q

C
|
C

G
|
G

A

A

C
|
C

T

S

I

V

L

I

V

L

D

D

G

G

E

K

P

V

A

V

R
|
R

A

A

C
|
C

I

V

S

T

-

K

F

M

A

K

A

R

A

V

C

A

Q

D

G

G

A

A

D

Q

V

I

V

T

T

T

I

I

E

E

G

G

L

V

D

G

D

Q

D

P

A

E

V

N

T

L

A

H

E

P

L

L

R

Q

A

K

A

A

F

W

N

V

R

L

E

H

H

G

A

G

L

A

Q
|
Q

C
|
C

G
|
G

F

F

C
|
C

T

S

P

P

G

G

M

F

L

I

V

V

S

S

A

A

R

K

D

G

L

L

V

L

L

D

R

T

L

N

-

A

-

D

P

P

E

S

A

R

D

E

E

D

A

V

R

R

I

D

R

W

L

F

G

Q

L

K

A

H

G

R

N

N

L

A

C
|
C

R

R

C
|
C

T

T

G

G

Y

Y

A

K

G

P

I

L

V

V

K

D

A

A

V

V

-

M

-

D

-

A

A

A

S

A

V

V

I

I

A

N

A

G

R

K

A

P

Q

E

binding fe2/s2 (inorganic) cluster: V38 (≠ I52), C40 (= C54), E41 (= E55), G43 (= G57), C45 (= C59), G46 (= G60), C48 (= C62), R58 (= R72), C60 (= C74), C100 (= C113), G101 (= G114), C103 (= C116), C137 (= C148), C139 (= C150)
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): Q99 (= Q112), C139 (= C150)

Sites not aligning to the query:

active site: 390, 425, 501, 505, 533, 869, 870
binding bicarbonate ion: 460, 531, 532, 535, 539
binding hydrocinnamic acid: 255, 425, 494, 497, 535, 626
binding magnesium ion: 899, 903
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): 420, 421, 422, 533, 650, 653, 654, 655, 656, 695, 696, 697, 700, 701, 799, 800, 804, 807, 865, 866, 867, 868, 869

4us9A Aldehyde oxidoreductase from desulfovibrio gigas (mop), soaked with 3- phenylpropionaldehyde (see paper)
37% identity, 37% coverage: 20:170/405 of query aligns to 6:162/907 of 4us9A

query
sites
4us9A

L

I

T

T

L

V

N

N

G

G

R

I

S

E

V

Q

A

N

A

L

T

F

A

V

E

D

A

A

R

E

T

A

N

L

L

L

A

S

D

D

L

V

V

L

R

R

D

Q

T

Q

L

L

N

G

L

L

T

T

G

G

T

V

H

K

I
x
V

G

G

C
|
C

E
|
E

H

Q

G
|
G

V

Q

C
|
C

G
|
G

A

A

C
|
C

T

S

I

V

L

I

V

L

D

D

G

G

E

K

P

V

A

V

R
|
R

A

A

C
|
C

I

V

S

T

-

K

F

M

A

K

A

R

A

V

C

A

Q

D

G

G

A

A

D

Q

V

I

V

T

T

T

I

I

E

E

G

G

L

V

D

G

D

Q

D

P

A

E

V

N

T

L

A

H

E

P

L

L

R

Q

A

K

A

A

F

W

N

V

R

L

E

H

H

G

A

G

L

A

Q
|
Q

C
|
C

G
|
G

F

F

C
|
C

T

S

P

P

G

G

M

F

L

I

V

V

S

S

A

A

R

K

D

G

L

L

V

L

L

D

R

T

L

N

-

A

-

D

P

P

E

S

A

R

D

E

E

D

A

V

R

R

I

D

R

W

L

F

G

Q

L

K

A

H

G

R

N

N

L

A

C
|
C

R

R

C
|
C

T

T

G

G

Y

Y

A

K

G

P

I

L

V

V

K

D

A

A

V

V

-

M

-

D

-

A

A

A

S

A

V

V

I

I

A

N

A

G

R

K

A

P

Q

E

binding fe2/s2 (inorganic) cluster: V38 (≠ I52), C40 (= C54), E41 (= E55), G43 (= G57), C45 (= C59), G46 (= G60), C48 (= C62), R58 (= R72), C60 (= C74), C100 (= C113), G101 (= G114), C103 (= C116), C137 (= C148), C139 (= C150)
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): Q99 (= Q112), C139 (= C150)

Sites not aligning to the query:

active site: 390, 425, 501, 505, 533, 869, 870
binding 3-phenylpropanal: 255, 257, 258, 752
binding bicarbonate ion: 460, 498, 531, 532, 535, 539, 890, 892
binding magnesium ion: 899, 903
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): 420, 421, 422, 533, 650, 653, 654, 655, 656, 695, 696, 697, 700, 701, 799, 800, 804, 807, 865, 866, 867, 868, 869

4us8A Aldehyde oxidoreductase from desulfovibrio gigas (mop), soaked with benzaldehyde (see paper)
37% identity, 37% coverage: 20:170/405 of query aligns to 6:162/907 of 4us8A

query
sites
4us8A

L

I

T

T

L

V

N

N

G

G

R

I

S

E

V

Q

A

N

A

L

T

F

A

V

E

D

A

A

R

E

T

A

N

L

L

L

A

S

D

D

L

V

V

L

R

R

D

Q

T

Q

L

L

N

G

L

L

T

T

G

G

T

V

H

K

I
x
V

G

G

C
|
C

E
|
E

H

Q

G
|
G

V

Q

C
|
C

G
|
G

A

A

C
|
C

T

S

I

V

L

I

V

L

D

D

G

G

E

K

P

V

A

V

R
|
R

A

A

C
|
C

I

V

S

T

-

K

F

M

A

K

A

R

A

V

C

A

Q

D

G

G

A

A

D

Q

V

I

V

T

T

T

I

I

E

E

G

G

L

V

D

G

D

Q

D

P

A

E

V

N

T

L

A

H

E

P

L

L

R

Q

A

K

A

A

F

W

N

V

R

L

E

H

H

G

A

G

L

A

Q
|
Q

C
|
C

G
|
G

F

F

C
|
C

T

S

P

P

G

G

M

F

L

I

V

V

S

S

A

A

R

K

D

G

L

L

V

L

L

D

R

T

L

N

-

A

-

D

P

P

E

S

A

R

D

E

E

D

A

V

R

R

I

D

R

W

L

F

G

Q

L

K

A

H

G

R

N

N

L

A

C
|
C

R

R

C
|
C

T

T

G

G

Y

Y

A

K

G

P

I

L

V

V

K

D

A

A

V

V

-

M

-

D

-

A

A

A

S

A

V

V

I

I

A

N

A

G

R

K

A

P

Q

E

binding fe2/s2 (inorganic) cluster: V38 (≠ I52), C40 (= C54), E41 (= E55), G43 (= G57), C45 (= C59), G46 (= G60), C48 (= C62), R58 (= R72), C60 (= C74), C100 (= C113), G101 (= G114), C103 (= C116), C137 (= C148), C139 (= C150)
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): Q99 (= Q112), C139 (= C150)

Sites not aligning to the query:

active site: 390, 425, 501, 505, 533, 869, 870
binding bicarbonate ion: 460, 498, 531, 532, 535, 539
binding benzaldehyde: 255, 255, 394, 425, 425, 425, 425, 497, 497, 501, 531, 535, 535, 626, 626, 626, 694, 696, 697
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): 420, 421, 422, 533, 653, 654, 655, 656, 695, 696, 697, 700, 701, 799, 800, 804, 807, 865, 866, 867, 868, 869

4c7yA Aldehyde oxidoreductase from desulfovibrio gigas (mop), soaked with sodium dithionite and sodium sulfide (see paper)
37% identity, 37% coverage: 20:170/405 of query aligns to 6:162/907 of 4c7yA

query
sites
4c7yA

L

I

T

T

L

V

N

N

G

G

R

I

S

E

V

Q

A

N

A

L

T

F

A

V

E

D

A

A

R

E

T

A

N

L

L

L

A

S

D

D

L

V

V

L

R

R

D

Q

T

Q

L

L

N

G

L

L

T

T

G

G

T

V

H

K

I

V

G

G

C
|
C

E
|
E

H

Q

G
|
G

V

Q

C
|
C

G
|
G

A

A

C
|
C

T

S

I

V

L

I

V

L

D

D

G

G

E

K

P

V

A

V

R
|
R

A

A

C
|
C

I

V

S

T

-

K

F

M

A

K

A

R

A

V

C

A

Q

D

G

G

A

A

D

Q

V

I

V

T

T

T

I

I

E

E

G

G

L

V

D

G

D

Q

D

P

A

E

V

N

T

L

A

H

E

P

L

L

R

Q

A

K

A

A

F

W

N

V

R

L

E

H

H

G

A

G

L

A

Q
|
Q

C
|
C

G
|
G

F

F

C
|
C

T

S

P

P

G

G

M

F

L

I

V

V

S

S

A

A

R

K

D

G

L

L

V

L

L

D

R

T

L

N

-

A

-

D

P

P

E

S

A

R

D

E

E

D

A

V

R

R

I

D

R

W

L

F

G

Q

L

K

A

H

G

R

N

N

L

A

C
|
C

R

R

C
|
C

T

T

G

G

Y

Y

A

K

G

P

I

L

V

V

K

D

A

A

V

V

-

M

-

D

-

A

A

A

S

A

V

V

I

I

A

N

A

G

R

K

A

P

Q

E

binding fe2/s2 (inorganic) cluster: C40 (= C54), E41 (= E55), G43 (= G57), C45 (= C59), G46 (= G60), C48 (= C62), R58 (= R72), C60 (= C74), C100 (= C113), G101 (= G114), C103 (= C116), C137 (= C148), C139 (= C150)
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): Q99 (= Q112), C139 (= C150)

Sites not aligning to the query:

active site: 390, 425, 501, 505, 533, 869, 870
binding bicarbonate ion: 460, 498, 531, 535, 539
binding magnesium ion: 899, 903
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): 420, 421, 422, 533, 650, 653, 654, 655, 656, 695, 696, 700, 701, 799, 800, 804, 807, 865, 866, 867, 868, 869
binding hydrogen peroxide: 696, 697, 869

3fc4A Ethylene glycol inhibited form of aldehyde oxidoreductase from desulfovibrio gigas (see paper)
37% identity, 37% coverage: 20:170/405 of query aligns to 6:162/907 of 3fc4A

query
sites
3fc4A

L

I

T

T

L

V

N

N

G

G

R

I

S

E

V

Q

A

N

A

L

T

F

A

V

E

D

A

A

R

E

T

A

N

L

L

L

A

S

D

D

L

V

V

L

R

R

D

Q

T

Q

L

L

N

G

L

L

T

T

G

G

T

V

H

K

I
x
V

G

G

C
|
C

E
|
E

H

Q

G
|
G

V

Q

C
|
C

G
|
G

A

A

C
|
C

T

S

I

V

L

I

V

L

D

D

G

G

E

K

P

V

A

V

R
|
R

A

A

C
|
C

I

V

S

T

-

K

F

M

A

K

A

R

A

V

C

A

Q

D

G

G

A

A

D

Q

V

I

V

T

T

T

I

I

E

E

G

G

L

V

D

G

D

Q

D

P

A

E

V

N

T

L

A

H

E

P

L

L

R

Q

A

K

A

A

F

W

N

V

R

L

E

H

H

G

A

G

L

A

Q
|
Q

C
|
C

G
|
G

F

F

C
|
C

T

S

P

P

G

G

M

F

L

I

V

V

S

S

A

A

R

K

D

G

L

L

V

L

L

D

R

T

L

N

-

A

-

D

P

P

E

S

A

R

D

E

E

D

A

V

R

R

I

D

R

W

L

F

G

Q

L

K

A

H

G

R

N

N

L

A

C
|
C

R

R

C
|
C

T

T

G

G

Y

Y

A

K

G

P

I

L

V

V

K

D

A

A

V

V

-

M

-

D

-

A

A

A

S

A

V

V

I

I

A

N

A

G

R

K

A

P

Q

E

binding fe2/s2 (inorganic) cluster: V38 (≠ I52), C40 (= C54), E41 (= E55), G43 (= G57), C45 (= C59), G46 (= G60), C48 (= C62), R58 (= R72), C60 (= C74), C100 (= C113), G101 (= G114), C103 (= C116), C137 (= C148), C139 (= C150)
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): Q99 (= Q112), C139 (= C150)

Sites not aligning to the query:

active site: 390, 425, 501, 505, 533, 869, 870
binding 1,2-ethanediol: 535, 622, 696, 697, 869
binding magnesium ion: 899, 903
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): 419, 420, 421, 422, 533, 650, 653, 654, 655, 656, 695, 696, 700, 701, 799, 800, 804, 807, 865, 866, 867, 868, 869

Query Sequence

>WP_012112667.1 NCBI__GCF_000017645.1:WP_012112667.1
MNALPRPEGTALGASPMITLTLNGRSVAATAEARTNLADLVRDTLNLTGTHIGCEHGVCG
ACTILVDGEPARACISFAAACQGADVVTIEGLDDDAVTAELRAAFNREHALQCGFCTPGM
LVSARDLVLRLPEADEARIRLGLAGNLCRCTGYAGIVKAVASVIAARRAQGIGPLTAERR
LGPVGARAGGATAIAVPLANVAALAAPAAEPLALGETFIPANSFDQGFEVPFPPADVFAF
FGRIEDVAACLPGAVIDAMPSADLVEGGMRVKLGPIGTTFRGTARIRRDEATSSGTIHGA
GGDGRSRTEGEIRYRVLPGTTPGSACVALSVGYTLKGPLAQFGRPGLVREVAGRLIADFA
ANLEARLSGAPAPAATGPGLNPLKLLTALISQKLGALWHRIRPAS

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory