SitesBLAST
Comparing WP_012113784.1 NCBI__GCF_000017645.1:WP_012113784.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 6 hits to proteins with known functional sites (download)
7w2jC Cryo-em structure of membrane-bound fructose dehydrogenase from gluconobacter japonicus
40% identity, 55% coverage: 45:416/680 of query aligns to 1:387/418 of 7w2jC
- binding heme c: C13 (= C57), C16 (= C60), H17 (= H61), T42 (≠ P85), I44 (= I87), Y55 (≠ W98), L75 (= L118), Y76 (= Y119), A78 (= A121), M79 (= M122), R122 (= R164), H161 (= H202), C162 (= C203), C165 (= C206), H166 (= H207), A191 (= A232), P192 (= P233), R223 (≠ S264), P227 (= P268), M228 (= M269), V289 (≠ N325), C290 (= C326), C293 (= C329), H294 (= H330), Y305 (≠ T340), Y306 (≠ V341), P307 (= P342), L309 (= L344), N312 (= N347), T313 (≠ P348), T314 (≠ A349), D322 (≠ N357), I327 (≠ V362), V331 (≠ L366), R333 (vs. gap), I340 (≠ G373), M342 (= M375), P343 (= P376), F345 (= F378)
8jejC Cryo-em structure of na-dithionite reduced membrane-bound fructose dehydrogenase from gluconobacter japonicus
38% identity, 55% coverage: 45:416/680 of query aligns to 1:401/413 of 8jejC
- binding heme c: C13 (= C57), C16 (= C60), H17 (= H61), T42 (≠ P85), I44 (= I87), F60 (= F103), L64 (≠ V107), L75 (= L118), Y76 (= Y119), M79 (= M122), P80 (= P123), Y84 (= Y127), R122 (= R164), C162 (= C203), C165 (= C206), H166 (= H207), I186 (≠ V227), W189 (≠ F230), A191 (= A232), P192 (= P233), I194 (= I235), W205 (= W245), Y213 (≠ F253), R223 (≠ S264), M228 (= M269), V303 (≠ N325), C304 (= C326), C307 (= C329), H308 (= H330), Y320 (≠ V341), P321 (= P342), L323 (= L344), T327 (≠ P348), T328 (≠ A349), D336 (≠ N357), I341 (≠ V362), V345 (≠ L366), R347 (vs. gap), I354 (≠ G373), M356 (= M375), F359 (= F378), I376 (≠ L390)
- binding ubiquinone-10: M36 (≠ F79), P77 (= P120), S124 (≠ G166), W128 (= W170), C165 (= C206), L173 (≠ G214)
Sites not aligning to the query:
Q47945 Alcohol dehydrogenase (quinone), cytochrome c subunit; ADH; Alcohol dehydrogenase (quinone), subunit II; Cytochrome c-553; Cytochrome c553; Ethanol:Q2 reductase; G3-ADH subunit II; Quinohemoprotein-cytochrome c complex; Ubiquinol oxidase; EC 1.1.5.5 from Gluconobacter oxydans (strain 621H) (Gluconobacter suboxydans) (see paper)
37% identity, 61% coverage: 1:417/680 of query aligns to 1:436/478 of Q47945
- 1:36 (vs. 1:39, 23% identical) signal peptide
- Q37 (≠ K40) modified: Pyrrolidone carboxylic acid
8gy2B Cryo-em structure of membrane-bound alcohol dehydrogenase from gluconobacter oxydans
38% identity, 55% coverage: 41:417/680 of query aligns to 2:398/433 of 8gy2B
- binding heme c: C18 (= C57), C21 (= C60), H22 (= H61), T46 (≠ P85), I48 (= I87), Y59 (≠ W98), L68 (≠ V107), R73 (= R112), V79 (≠ L118), Y80 (= Y119), M83 (= M122), F88 (≠ Y127), R126 (= R164), H165 (= H202), C166 (= C203), C169 (= C206), H170 (= H207), I201 (≠ W231), A202 (= A232), P203 (= P233), L205 (≠ I235), W216 (= W245), F224 (= F253), A234 (≠ S264), V235 (= V265), F236 (= F266), F236 (= F266), M239 (= M269), N301 (= N325), C302 (= C326), C305 (= C329), H306 (= H330), M316 (≠ T340), F317 (≠ V341), P318 (= P342), L320 (= L344), P324 (= P348), G342 (= G365), S352 (≠ T371), V354 (≠ G373), M356 (= M375), F359 (= F378), M375 (≠ V394)
- binding ubiquinone-10: C21 (= C60), L34 (= L73), P39 (= P78), P81 (= P120), L129 (≠ M167), W132 (= W170), E168 (≠ D205), R173 (= R210), I197 (≠ V227), D241 (≠ E271)
Sites not aligning to the query:
8gy3A Cryo-em structure of membrane-bound aldehyde dehydrogenase from gluconobacter oxydans
37% identity, 60% coverage: 11:421/680 of query aligns to 8:434/440 of 8gy3A
- binding heme c: Y52 (≠ D56), C53 (= C57), C56 (= C60), H57 (= H61), S84 (≠ P85), I86 (= I87), W97 (= W98), F102 (= F103), L117 (= L118), F121 (≠ M122), F126 (≠ Y127), R163 (= R164), C203 (= C203), C206 (= C206), H207 (= H207), A232 (= A232), P233 (= P233), L235 (≠ I235), W245 (= W245), Y253 (≠ F253), L254 (= L254), G263 (≠ T263), S264 (= S264), M269 (= M269), Y292 (≠ L292), C337 (= C326), C340 (= C329), H341 (= H330), P353 (= P342), L355 (= L344), N358 (= N347), N359 (≠ P348), V372 (≠ A361), I377 (≠ L366), G382 (= G369), Q383 (≠ G370), I386 (≠ G373), M388 (= M375), F391 (= F378)
- binding ubiquinone-10: E55 (≠ P59), T76 (= T77), F78 (= F79), Y118 (= Y119), P119 (= P120), I160 (≠ F161), G166 (= G166), Q167 (≠ M167), F169 (≠ A169), W170 (= W170), H202 (= H202), R210 (= R210), L213 (≠ M213)
8hddB Complex structure of catalytic, small, and a partial electron transfer subunits from burkholderia cepacia fad glucose dehydrogenase (see paper)
42% identity, 14% coverage: 321:415/680 of query aligns to 25:121/121 of 8hddB
- binding protoporphyrin ix containing fe: C30 (= C326), C33 (= C329), H34 (= H330), Y46 (≠ V341), P47 (= P342), T54 (≠ A349), V66 (≠ A361), I67 (≠ V362), R73 (vs. gap), I80 (≠ G373), M82 (= M375), P83 (= P376)
Query Sequence
>WP_012113784.1 NCBI__GCF_000017645.1:WP_012113784.1
MVRASGFSRRIAALAAATFLSAGAPAVAQIATYPVADAAKDADLVARGEYLAKAADCMPC
HTGDKAKPFAGGLGLNTPFGMIYSPNITSDRSTGIGLWTYEQFVNAVRNGIRKDGAYLYP
AMPFDAYTEISDDDMKALWAFVRRIPPIPNTPPANGLEFPFNVRLGMLAWRELFFQNARF
VPNAAKSAEWNRGAYLVNALGHCSDCHTPRNIMGATKGKAHFLGADVDGFWAPDIATDAL
MKDGWTVDTLSVFLKTGSAPAKTSVFGPMAEVVHDSLGFLTDADRAAIVTYLFDSPRPAD
VPAPQAASPLPAAVYTRASALYVDNCAVCHMDKGAGRGDTVPALAGNPAVVAVEPYNIIM
AVLGGLPTGGTYGAMPSFAGRLDDRQIADLANYVRTSWGNTAAPNVTASMVASWRATTHV
PDYGTQAADAFTCPDVGGAPGSDGPDPKAVAALSAMMAGGQHSIPMMVDAYKAASGSAGS
GTVVDALTAAYCPVVAKSDAPTWQKYAELRRFTLQTALEVSRRTITGPVDSQPIAWALPV
GPGLVLKEPKSLVGKLACPADDGKAVPADLSAAATKLLGAPKPPMAGDAISTLATTLYQQ
NPKAPPADVANALIAAYCRVVVAEPNTTVADQNELLNGFAGQAVQALQLLPPRKVVVEVP
TKPAAPAPAPAAAPVPAKKK
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory