Comparing WP_012168732.1 NCBI__GCF_000010525.1:WP_012168732.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
8uw6B Acetylornithine deacetylase from escherichia coli, di-zinc form. (see paper)
33% identity, 99% coverage: 4:380/382 of query aligns to 7:378/381 of 8uw6B
Sites not aligning to the query:
7uoiA Crystallographic structure of dape from enterococcus faecium (see paper)
27% identity, 98% coverage: 6:381/382 of query aligns to 13:383/383 of 7uoiA
P44514 Succinyl-diaminopimelate desuccinylase; SDAP desuccinylase; N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase; EC 3.5.1.18 from Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) (see 3 papers)
27% identity, 89% coverage: 40:380/382 of query aligns to 39:374/377 of P44514
5vo3A Crystal structure of dape in complex with the products (succinic acid and diaminopimelic acid) (see paper)
26% identity, 99% coverage: 4:380/382 of query aligns to 10:378/380 of 5vo3A
7t1qA Crystal structure of the succinyl-diaminopimelate desuccinylase (dape) from acinetobacter baumannii in complex with succinic acid
28% identity, 87% coverage: 51:382/382 of query aligns to 50:376/377 of 7t1qA
7lgpB Dape enzyme from shigella flexneri
29% identity, 99% coverage: 4:382/382 of query aligns to 8:377/377 of 7lgpB
4pqaA Crystal structure of succinyl-diaminopimelate desuccinylase from neisseria meningitidis mc58 in complex with the inhibitor captopril (see paper)
31% identity, 67% coverage: 2:257/382 of query aligns to 4:258/375 of 4pqaA
Sites not aligning to the query:
4o23A Crystal structure of mono-zinc form of succinyl diaminopimelate desuccinylase from neisseria meningitidis mc58 (see paper)
31% identity, 67% coverage: 2:257/382 of query aligns to 4:258/376 of 4o23A
P37111 Aminoacylase-1; ACY-1; N-acyl-L-amino-acid amidohydrolase; EC 3.5.1.14 from Sus scrofa (Pig) (see paper)
25% identity, 92% coverage: 3:352/382 of query aligns to 12:347/407 of P37111
Sites not aligning to the query:
4h2kA Crystal structure of the catalytic domain of succinyl-diaminopimelate desuccinylase from haemophilus influenzae (see paper)
33% identity, 50% coverage: 4:194/382 of query aligns to 8:204/258 of 4h2kA
Sites not aligning to the query:
Q03154 Aminoacylase-1; ACY-1; N-acyl-L-amino-acid amidohydrolase; EC 3.5.1.14 from Homo sapiens (Human) (see 6 papers)
25% identity, 67% coverage: 3:257/382 of query aligns to 12:276/408 of Q03154
Sites not aligning to the query:
Q8P8J5 N-acetyl-L-citrulline deacetylase; ACDase; Acetylcitrulline deacetylase; EC 3.5.1.- from Xanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25) (see paper)
27% identity, 99% coverage: 2:378/382 of query aligns to 7:363/366 of Q8P8J5
3pfoA Crystal structure of a putative acetylornithine deacetylase (rpa2325) from rhodopseudomonas palustris cga009 at 1.90 a resolution
27% identity, 54% coverage: 64:268/382 of query aligns to 99:304/426 of 3pfoA
Sites not aligning to the query:
2f7vA Structure of acetylcitrulline deacetylase complexed with one co (see paper)
26% identity, 99% coverage: 2:378/382 of query aligns to 8:358/360 of 2f7vA
4op4B Crystal structure of the catalytic domain of dape protein from v.Cholerea in the zn bound form (see paper)
38% identity, 30% coverage: 51:164/382 of query aligns to 50:166/265 of 4op4B
Sites not aligning to the query:
1lfwA Crystal structure of pepv (see paper)
32% identity, 40% coverage: 2:152/382 of query aligns to 28:172/468 of 1lfwA
Sites not aligning to the query:
P45494 Beta-Ala-Xaa dipeptidase; Beta-Ala-His dipeptidase; Peptidase V; EC 3.4.13.- from Lactobacillus delbrueckii subsp. lactis (see paper)
32% identity, 40% coverage: 2:152/382 of query aligns to 28:172/470 of P45494
Sites not aligning to the query:
7ljhA Structure of poly(aspartic acid) hydrolase pahz2 with zn+2 bound (see paper)
24% identity, 85% coverage: 46:370/382 of query aligns to 66:384/400 of 7ljhA
Q96KN2 Beta-Ala-His dipeptidase; CNDP dipeptidase 1; Carnosine dipeptidase 1; Glutamate carboxypeptidase-like protein 2; Serum carnosinase; EC 3.4.13.20 from Homo sapiens (Human) (see 4 papers)
35% identity, 27% coverage: 45:146/382 of query aligns to 103:212/507 of Q96KN2
Sites not aligning to the query:
3dljA Crystal structure of human carnosine dipeptidase 1
38% identity, 22% coverage: 64:146/382 of query aligns to 96:181/471 of 3dljA
Sites not aligning to the query:
>WP_012168732.1 NCBI__GCF_000010525.1:WP_012168732.1
MSTLDLLDRLIAFPTVSRDPNRELIAFVQAFLGQHGIASEIIATPDGRKANLFATIGPTD
RPGIMLSGHTDVVPVEGQAWTADPFRLRVADGRAYGRGAADMKGFLAAALALAARAAARP
LETPLHLALSHDEEVGCVGVRSLIERLSTASVRPRLCIIGEPTSLRVATGHKGKLAARAT
CCGVEGHSALAPKALNAIHLACDFVGLLRTHQDRIAESGARDADYDIPYTTLHAGVIAGG
TALNIVPNRCTVDFEIRNIAQDDASEVLTRLLDDAARLVAERRAAFPAADIAVEVVNDYP
GLATPKEAEVVAFVQALVDDASTFKVAFGTEGGLFDARLSIPTVICGPGSMDQGHKPDEF
IALDQLEACDRMMDRLLHRLAA
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory