SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing WP_012170857.1 NCBI__GCF_000010525.1:WP_012170857.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 12 hits to proteins with known functional sites (download)

P45131 Homoserine O-acetyltransferase; HAT; Homoserine O-trans-acetylase; Homoserine transacetylase; HTA; EC 2.3.1.31 from Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) (see 2 papers)
34% identity, 85% coverage: 62:408/409 of query aligns to 19:356/358 of P45131

query
sites
P45131

G

G

A

G

P

K

L

L

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D

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N

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A

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Y

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A

L306 (≠ V358) mutation to R: Can no longer use acetyl-CoA as acyl donor, but can use succinyl-CoA.

Sites not aligning to the query:

1 modified: Initiator methionine, Removed

D2Z028 L-serine/homoserine O-acetyltransferase; Homoserine O-trans-acetylase; EC 2.3.1.30; EC 2.3.1.31 from Streptomyces lavendulae (see paper)
32% identity, 86% coverage: 57:408/409 of query aligns to 18:371/374 of D2Z028

query
sites
D2Z028

Y

F

T

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T

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R

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D

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N

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-

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A

G52 (≠ F91) mutation to A: Has much lower activity for the acetylation of L-serine but keeps the activity against L-homoserine. Utilizes L-homoserine as a substrate for acetylation but barely utilizes L-serine; when associated with G-55.
P55 (≠ G94) mutation to G: Can acetylate both L-serine and L-homoserine. Utilizes L-homoserine as a substrate for acetylation but barely utilizes L-serine; when associated with A-52.

Q10341 Serine O-succinyltransferase; SST; EC 2.3.1.- from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
32% identity, 69% coverage: 49:329/409 of query aligns to 82:352/504 of Q10341

query
sites
Q10341

K

K

K

K

S

F

F

Y

T

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K

K

A

A

Sites not aligning to the query:

426 G→D: In cys2-1: Leads to auxotrophy for cysteine.

Q6FEQ3 Homoserine O-succinyltransferase; HST; Homoserine transsuccinylase; HTS; EC 2.3.1.46 from Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1) (see paper)
30% identity, 88% coverage: 48:407/409 of query aligns to 14:372/387 of Q6FEQ3

query
sites
Q6FEQ3

E

Q

K

K

K

F

S

Q

F

F

T

E

L

E

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P

A

L

Y

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A

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S

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D

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R

P

D

Q

L

Q

K

D

S

P

G

A

K

A

F

A

M

M

Y

G

G

N

F

-

D

-

V

R

E

F

F

L

Q

V

V

E

E

S

S

T

Y

I

L

D

R

K

Y

I

Q

S

G

A

E

A

Q

R

F

A

S

E

R

L

N

S

F

D

D

A

A

N

N

H

T

L

Y

L

L

Y

I

L

M

V

T

K

K

A

A

N

L

Q

D

L

Y

F

F

V

D

A

P

G

S

G

R

D

E

-

Y

-

E

-

Q

-

S

-

L

-

T

A

K

A

A

V

M

S

A

R

Q

I

T

K

Q

A

C

P

R

V

F

L

L

L

V

I

V

S

S

T

F

D

T

E

T

D

D

L

W

V
x
R

F

F

P

A

P

P

P

E

V

R

I

S

A

Q

K

E

T

I

A

V

E

D

R

A

V

L

R

I

A

T

G

N

G

H

A

K

K

P

V

V

E

T

Q

Y

V

L

K

D

I

V

G

D

G

A

G

E

R

Q

G

G

H

H

L

D

N

S

G

F

V

L

V

F

N

P

I

I

S

P

E

L

A

Y

G

V

D

K

A

T

I

L

R

R

T

A

F

F

L

L

R323 (≠ V358) mutation to L: Can no longer use succinyl-CoA as acyl donor, but can use acetyl-CoA.

5w8oB Homoserine transacetylase metx from mycobacterium hassiacum (see paper)
32% identity, 77% coverage: 56:369/409 of query aligns to 8:310/346 of 5w8oB

query
sites
5w8oB

A

A

Y

L

T

T

T

L

Q

E

G

S

G

G

A

A

P

V

L

I

K

D

D

N

V

V

K

Q

I

I

G

A

W

V

E

E

A

R

Y

W

G

G

T

E

L

L

N

S

A

P

D

S

K

R

S

D

N

N

V

V

I

V

L

V

V

V

T

L

H

H

F

A

F

L

S

T

G

G

S

D

S

S

H

H

A

V

A

A

G

G

K

P

Y

-

K

-

A

-

D

-

D

-

K

-

V

-

A

P

G

G

Y

W

W

W

D
|
D

A

G

I

V

I
x
V

G

G

P

P

G

G

K

A

P

A

L

I

D

D

T

T

D

R

K

R

Y

W

Y

C

I

A

I

I

S

A

S

T

D

N

T

V

L

L

V

G

N

G

L

C

N

R

A

G

Y

-

D

-

P

-

N

-

V

-

I

-

T

S

T

T

G

G

P

P

A

G

S

S

L

L

Q

H

P

P

G

-

T

D

D

G

K

K

P

A

Y

W

G

G

M

S

S

R

F

F

P

P

V

A

V

V

G

T

I

V

R

R

D

D

F

Q

V

V

N

R

V

A

Q

D

K

L

A

A

L

A

L

L

E

N

S

A

L

M

G

G

I

I

T

H

R

Q

L

V

H

A

A

A

V

V

A

V

G

G

A

G

S

S

M

M

G

G

A

G

L

A

Q

R

A

A

Y

L

E

E

W

W

A

V

S

I

S

G

Y

H

P

P

E

E

M

T

V

V

-

R

G

A

R

G

I

L

I

I

P

L

V

A

I

V

G

G

A

A

S

R

E

A

T

T

S

A

G

D

W

Q

L

-

I

I

A

G

L

T

L

Q

D

S

A

T

W

Q

G

V

A

A

P

A

I

I

R

K

V

A

D

D

A

P

N

N

W

W

N

Q

N

N

G

G

D

D

Y

Y

Y

Y

G

G

R

T

-

G

T

L

P

K

P

P

K

D

A

V

G

G

L

L

T

Q

Q

I

A

A

L

R

K

R

M

F

V

A

T

H

L

L

W

T

A

Y

G

R

Y

G

W

E

T

V

W

E

V

L

D

D

D

T

T

R

F

F

G

G

R

N

K

A

W

-

A

-

E

-

P

P

Q

Q

Q

D

D

D

P

E

A

N

A

P

A

L

M

L

G

G

N

G

R

R

F

Y

L

A

V

V

E

E

S

S

T

Y

I

L

D

E

K

Y

I

Q

S

G

A

R

A

K

R

L

A

V

E

D

L

R

S

F

D

D

A

A

N

G

H

T

L

Y

L

V

Y

T

L

L

V

T

K

D

A

S

N

L

Q

S

L

S

F

H

-

D

-

V

-

G

-

R

-

G

V

R

A

G

G

G

G

V

D

E

A

A

A

A

V

L

S

R

R

S

I

C

K

E

A

V

P

P

V

V

L

V

L

V

I

G

S

G

T

F

D

T

E

S

D

D

L

R

V

L

F

Y

P

P

P

L

P

R

V

L

I

Q

A

E

K

E

T

L

A

A

E

E

binding calcium ion: D58 (= D113), V61 (≠ I116)

6iohA Crystal structure of homoserine o-acetyltransferase in complex with homoserine from mycobacterium smegmatis atcc 19420 (see paper)
31% identity, 82% coverage: 34:369/409 of query aligns to 1:327/375 of 6iohA

query
sites
6iohA

S

A

V

T

L

V

P

P

T

L

P

P

A

A

S

E

A

G

L

E

D

I

A

G

I

L

V

V

E

H

K

I

K

G

S

A

F

L

T

T

L

L

P

-

A

-

Y

-

T

-

T

-

Q

E

G

N

G

G

A

T

P

V

L

L

K

P

D

D

V

V

K

T

I

I

G

A

W

V

E

Q

A

R

Y

W

G

G

T

E

L

L

N

A

A

P

D

D

K

R

S

G

N

N

V

V

I

V

L

M

V

V

T

L

H

H

F

A

F

L

S
x
T

G

G

S

D

S

S

H

H

A

V

A

T

G

G

K

P

Y

A

K

G

A

D

D

G

D

H

K

P

V

T

A

A

G

G

Y

W

W

W

D

D

A

G

I

V

I

A

G

G

P

P

G

G

K

A

P

P

L

I

D

D

T

T

D

D

K

H

Y

W

Y

C

I

A

I

I

S

A

S

T

D

N

T

V

L

L

V

G

N

G

L

C

N

R

A

G

Y

-

D

-

P

-

N

-

V

-

I

-

T

S

T

T

G

G

P

P

A

G

S

S

L

L

Q

A

P

P

G

-

T

D

D

G

K

K

P

P

Y

W

G

G

M

S

S

R

F

F

P

P

V

Q

V

I

G

T

I

I

R

R

D

D

F

Q

V

V

N

A

V

A

Q

D

K

R

A

A

L

A

L

L

E

A

S

A

L

L

G

G

I

I

T

T

R

E

L

V

H

A

A

A

V

V

A

V

G

G

A

G

S
|
S

M

M

G

G

A

G

L

A

Q

R

A

A

Y

L

E

E

W

W

A

L

S

V

S

T

Y

H

P

P

E

D

M

D

V

V

-

R

G

A

R

G

I

L

I

V

P

L

V

A

I

V

G

G

A

A

S

R

E

A

T

T

S

A

G

D

W

Q

L

-

I

I

A

G

L

T

L

Q

D

S

A

T

W

Q

G

V

A

A

P

A

I

I

R

K

V

A

D

D

A

P

N

D

W

W

N

Q

N

G

G

G

D

D

Y

Y

Y

H

G

G

R

T

-

G

T

R

P

A

P

P

K

T

A

E

G

G

L

M

T

E

Q

I

A

A

L
x
R

K

R

M

F

V

A

T

H

L

L

W

T

A
x
Y

G

R

Y

G

W

E

T

E

W

E

V

L

D

D

D

D

T

R

F

F

G

A

R

N

K

T

W

-

A

-

E

-

P

P

Q

Q

Q

D

D

D

P

E

A

D

A

P

A

L

M

T

G

G

N

G

R

R

F

Y

L

A

V

V

E

Q

S

S

T

Y

I

L

D

E

K

Y

I

Q

S

G

A

G

A

K

R

L

A

A

E

R

L

R

S

F

D

D

A

P

N

G

H

-

L

-

L

T

Y

Y

L

V

V

V

K

L

A

S

N

D

Q

A

L

L

F

S

V

S

-

H

-

D

-

V

-

G

-

R

-

G

-

R

A

G

G

G

G

V

D

E

A

A

A

A

V

L

S

R

R

S

I

C

K

P

A

V

P

P

V

V

L

V

L

V

I

G

S

G

T

I

D

T

E

S

D

D

L

R

V

L

F

Y

P

P

P

I

P

R

V

L

I

Q

A

Q

K

E

T

L

A

A

E

E

binding l-homoserine: T55 (≠ S93), S151 (= S196), R221 (≠ L265), Y228 (≠ A272)

Sites not aligning to the query:

binding l-homoserine: 344, 345

6ioiA Crystal structure of homoserine o-acetyltransferase in complex with coa from mycobacterium smegmatis atcc 19420 (see paper)
31% identity, 82% coverage: 34:369/409 of query aligns to 1:327/366 of 6ioiA

query
sites
6ioiA

S

A

V

T

L

V

P

P

T

L

P

P

A

A

S

E

A

G

L

E

D

I

A

G

I

L

V

V

E

H

K

I

K

G

S

A

F

L

T

T

L

L

P

-

A

-

Y

-

T

-

T

-

Q

E

G

N

G

G

A

T

P

V

L

L

K

P

D

D

V

V

K

T

I

I

G

A

W

V

E

Q

A

R

Y

W

G

G

T

E

L

L

N

A

A

P

D

D

K

R

S

G

N

N

V

V

I

V

L

M

V

V

T

L

H

H

F

A

F

L

S
x
T

G

G

S

D

S

S

H

H

A

V

A

T

G

G

K

P

Y

A

K

G

A

D

D

G

D

H

K

P

V

T

A

A

G

G

Y

W

W

W

D

D

A

G

I

V

I

A

G

G

P

P

G

G

K

A

P

P

L

I

D

D

T

T

D

D

K

H

Y

W

Y

C

I

A

I

I

S

A

S

T

D

N

T

V

L

L

V

G

N

G

L

C

N

R

A

G

Y

-

D

-

P

-

N

-

V

-

I

-

T

S

T

T

G

G

P

P

A

G

S

S

L

L

Q

A

P

P

G

-

T

D

D

G

K

K

P

P

Y

W

G

G

M

S

S

R

F

F

P

P

V

Q

V

I

G

T

I

I

R

R

D

D

F

Q

V

V

N

A

V

A

Q

D

K

R

A

A

L

A

L

L

E

A

S

A

L

L

G

G

I

I

T

T

R

E

L

V

H

A

A

A

V

V

A

V

G

G

A

G

S

S

M

M

G

G

A

G

L

A

Q

R

A

A

Y

L

E

E

W

W

A

L

S

V

S

T

Y

H

P

P

E

D

M

D

V

V

-

R

G

A

R

G

I

L

I

V

P

L

V

A

I

V

G

G

A

A

S

R

E

A

T

T

S

A

G

D

W

Q

L

-

I

I

A

G

L

T

L

Q

D

S

A

T

W

Q

G

V

A

A

P

A

I

I

R

K

V

A

D

D

A

P

N

D

W

W

N

Q

N

G

G

G

D

D

Y

Y

Y

H

G

G

R

T

-

G

T

R

P

A

P

P

K

T

A

E

G

G

L

M

T

E

Q

I

A

A

L
x
R

K

R

M

F

V

A

T

H

L

L

W

T

A
x
Y

G

R

Y

G

W

E

T

E

W

E

V

L

D

D

D

D

T

R

F

F

G

A

R

N

K

T

W

-

A

-

E

-

P

P

Q
|
Q

Q

D

D

D

P

E

A

D

A

P

A

L

M

T

G

G

N

G

R

R

F

Y

L

A

V

V

E

Q

S
|
S

T
x
Y

I

L

D

E

K
x
Y

I

Q

S

G

A

G

A
x
K

R

L

A

A

E

R

L

R

S

F

D

D

A

P

N

G

H

-

L

-

L

T

Y

Y

L

V

V

V

K

L

A

S

N

D

Q

A

L

L

F

S

V

S

-

H

-

D

-

V

-

G

-

R

-

G

-

R

A

G

G

G

G

V

D

E

A

A

A

A

V

L

S

R

R

S

I

C

K

P

A

V

P

P

V

V

L

V

L

V

I

G

S

G

T

I

D

T

E

S

D

D

L

R

V

L

F

Y

P

P

P

I

P

R

V

L

I

Q

A

Q

K

E

T

L

A

A

E

E

binding coenzyme a: T55 (≠ S93), R221 (≠ L265), Y228 (≠ A272), Q243 (= Q290), S258 (= S305), Y259 (≠ T306), Y262 (≠ K309), K266 (≠ A313)

Sites not aligning to the query:

binding coenzyme a: 345, 348

2vatA Crystal structure of deacetylcephalosporin c acetyltransferase in complex with coenzyme a (see paper)
27% identity, 86% coverage: 57:409/409 of query aligns to 18:347/347 of 2vatA

query
sites
2vatA

Y

F

T

T

T

L

Q

E

G

S

G

G

A

V

P

I

L

L

K

R

D

D

V

V

K

P

I

V

G

A

W

Y

E

K

A

S

Y

W

G

G

T

R

L

M

N

N

A

V

D

S

K

R

S

D

N

N

V

C

I

V

L

I

V

V

T

C

H

H

F

T

F

L

S

T

G

S

S

S

S

A

H

H

A

-

A

-

G

-

K

-

Y

-

K

-

A

-

D

-

D

-

K

-

V

V

A

T

G

S

Y

W

W

W

D

P

A

T

I

L

I

F

G

G

P

Q

G

G

K

R

P

A

L

F

D

D

T

T

D

S

K

R

Y

Y

Y

F

I

I

I

I

S

C

S

-

D

-

T

-

L

-

V

-

N

-

L

L

N

N

A

Y

Y

L

D

G

P

S

N

P

V

F

I

G

T

S

T

A

G

G

P

P

A

C

S

S

L

P

Q

D

P

P

G

D

T

A

D

E

K

R

P

P

Y

Y

G

G

M

A

S

K

F

F

P

P

V

R

V

T

G

T

I

I

R

R

D

D

F

D

V

V

N

R

V

I

Q

H

K

R

A

Q

L

V

L

L

E

D

S

R

L

L

G

G

I

V

T

R

R

Q

L

I

H

A

A

A

V

V

A

V

G

G

A

A

S

S

M

M

G

G

A

G

L

M

Q

H

A

T

Y

L

E

E

W

W

A

A

S

F

S

F

Y

G

P

P

E

E

M

Y

V

V

G

R

R

K

I

I

I

V

P

P

V

I

I

A

G

T

A

S

S

C

E

R

T

Q

S

S

G

G

W

W

L

C

I

A

A

A

L

W

L

F

D

E

A

T

W

Q

G

R

A

Q

P

C

I

I

R

Y

V

D

D

D

A

P

N

K

W

Y

N

L

N

D

G

G

D

E

Y

Y

Y

D

G

V

R

D

T

D

P

Q

P

P

K

V

A

R

G

G

L

L

T

E

Q

T

A

A

L
x
R

K

K

M

I

V

A

T

N

L

L

W

-

A

-

G

-

Y

-

W

-

T

-

W

-

V

-

D

-

D

-

T

T

F
x
Y

G
x
K

R

S

K

K

W

-

A

-

E

-

P

-

Q

-

Q

-

D

-

P

-

A

-

A

P

A

A

M

M

G

D

N

E

R
|
R

F

F

L

H

V

M

E

A

S

P

T

G

I

V

D

Q

K

P

I

I

S

E

A

A

A

V

R

S

A
x
S

E
x
Y

L

L

S

R

-
x
Y

-
x
Q

-

A

-

Q

-
x
K

-

F

-

A

-

A

-

S

-

F

D

D

A

A

N

N

-

C

H

Y

L

I

L

A

Y

M

L

T

V

L

K

K

A

F

N

D

Q

T

L

H

F

D

V

I

A

S

G

R

G

G

D

R

A

A

-

G

-

S

-

I

-

P

-

E

A

A

V

L

S

A

R

M

I

I

K

T

A

Q

P

P

V

A

L

L

L

I

I

I

S

C

T

A

D

R

E

S

D

D

L

G

V

L

F

Y

P

-

P

-

P

-

V

-

I

-

A

-

K

S

T

F

A

D

E

E

R

H

V

V

R

E

A

M

G

G

G

R

A

S

-

I

-

P

K

N

V

S

E

R

Q

L

V

C

K

V

I

V

G

D

G

T

G

N

R

E

G

G

H
|
H

L
x
D

N

F

G

F

V

V

V
x
M

N

E

I

A

S

D

E

K

A

V

G

N

D

D

A

A

I

V

R

R

T

G

F

F

L

L

A

D

K

Q

binding coenzyme a: R210 (≠ L265), Y217 (≠ F282), K218 (≠ G283), R226 (= R300), S241 (≠ A315), Y242 (≠ E316), Y245 (vs. gap), Q246 (vs. gap), K249 (vs. gap), H327 (= H389), D328 (≠ L390), M332 (≠ V394)

2vavB Crystal structure of deacetylcephalosporin c acetyltransferase (dac- soak) (see paper)
27% identity, 86% coverage: 57:407/409 of query aligns to 19:347/350 of 2vavB

query
sites
2vavB

Y

F

T

T

T

L

Q

E

G

S

G

G

A

V

P

I

L

L

K

R

D

D

V

V

K

P

I

V

G

A

W

Y

E

K

A

S

Y

W

G

G

T

R

L

M

N

N

A

V

D

S

K

R

S

D

N

N

V

C

I

V

L

I

V

V

T

C

H

H

F
x
T

F
x
L

S
x
T

G

S

S

S

S

A

H

H

A

-

A

-

G

-

K

-

Y

-

K

-

A

-

D

-

D

-

K

-

V

V

A

T

G

S

Y

W

W

W

D

P

A

T

I

L

I

F

G

G

P

Q

G

G

K

R

P

A

L

F

D

D

T

T

D

S

K

R

Y

Y

Y

F

I

I

I

I

S

C

S

-

D

-

T

-

L

-

V

-

N

-

L

L

N

N

A

Y

Y

L

D

G

P

S

N

P

V

F

I

G

T

S

T

A

G

G

P

P

A

C

S

S

L

P

Q

D

P

P

G

D

T

A

D

Q

K

R

P

P

Y

Y

G

G

M

A

S

K

F

F

P

P

V

R

V

T

G

T

I

I

R

R

D

D

F

D

V

V

N

R

V

I

Q

H

K

R

A

Q

L

V

L

L

E

D

S

R

L

L

G

G

I

V

T

R

R

Q

L

I

H

A

A

A

V

V

A

V

G

G

A

A

S
|
S

M

M

G

G

A

G

L

M

Q

H

A

T

Y

L

E

E

W

W

A

A

S

F

S

F

Y

G

P

P

E

E

M

Y

V

V

G

R

R

K

I

I

I

V

P

P

V

I

I

A

G

T

A

S

S

C

E

R

T

Q

S

S

G

G

W

W

L

C

I

A

A

A

L

W

L

F

D

E

A

T

W

Q

G

R

A

Q

P

C

I

I

R

Y

V

D

D

D

A

P

N

K

W

Y

N

L

N

D

G

G

D

E

Y

Y

Y

D

G

V

R

D

T

D

P

Q

P

P

K

V

A

R

G

G

L

L

T

E

Q

T

A

A

L
x
R

K

K

M

I

V

A

T

N

L

L

W

T

A
x
Y

G
x
K

Y

S

W

K

T

P

W

A

V

M

D

D

D

E

T
x
R

F

F

G

H

R

M

K

-

W

-

A

-

E

-

P

-

Q

-

Q

-

D

-

P

-

A

A

A

P

A

G

M

V

G

G

N

Q

R

P

F

I

L

E

V

A

E

V

S

S

T

S

I

Y

D

L

K

R

I

Y

S

Q

A

A

A

Q

R

K

A

F

E

A

L

A

S

S

-

F

D

D

A

A

N

N

-

C

H

Y

L

I

L

A

Y

M

L

T

V

L

K

K

A

F

N

D

Q

T

L

H

F

D

V

I

A

S

G

R

G

G

D

R

A

A

-

G

-

S

-

I

-

P

-

E

A

A

V

L

S

A

R

M

I

I

K

T

A

Q

P

P

V

A

L

L

L

I

I

I

S

C

T

A

D

R

E

S

D

D

L

G

V

L

F

Y

P

-

P

-

P

-

V

-

I

-

A

-

K

S

T

F

A

D

E

E

R

H

V

V

R

E

A

M

G

G

G

R

A

S

-

I

-

P

K

N

V

S

E

R

Q

L

V

C

K

V

I

V

G

D

G

T

G

N

R

E

G

G

H

H

L
x
D

N

F

G

F

V

V

V

M

N

E

I

A

S

D

E

K

A

V

G

N

D

D

A

A

I

V

R

R

T

G

F

F

L

L

binding 4-(3-acetoxymethyl-2-carboxy-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-en-7-ylcarbamoyl)-1-carboxy-butyl-ammonium: T53 (≠ F91), L54 (≠ F92), T55 (≠ S93), S142 (= S196), R211 (≠ L265), Y218 (≠ A272), K219 (≠ G273), R227 (≠ T281), D330 (≠ L390)

7rytB Crystal structure of mycobacterium tuberculosis acetylated homoserine transacetylase with coenzyme a (see paper)
30% identity, 90% coverage: 39:407/409 of query aligns to 5:361/368 of 7rytB

query
sites
7rytB

P

P

A

A

S

E

A

G

L

E

D

I

A

G

I

L

V

I

E

D

K

V

K

G

S

S

F

L

T

Q

L

L

P

-

A

-

Y

-

T

-

T

-

Q

E

G

S

G

G

A

A

P

V

L

I

K

D

D

D

V

V

K

C

I

I

G

A

W

V

E

Q

A

R

Y

W

G

G

T

K

L

L

N

S

A

P

D

A

K

R

S

D

N

N

V

V

I

V

L

V

V

V

T

L

H

H

F
x
A

F

L

S

T

G

G

S

D

S

S

H

H

A

I

A

T

G

G

K

P

Y

A

K

G

A

P

D

G

D

H

K

P

V

T

A

P

G

G

Y

W

W

W

D

D

A

G

I

V

I

A

G

G

P

P

G

G

K

A

P

P

L

I

D

D

T

T

D

T

K

R

Y

W

Y

C

I

A

I

V

S

A

S

T

D

N

T

V

L

L

V

G

N

G

L

C

N

R

A

G

Y

-

D

-

P

-

N

-

V

-

I

-

T

S

T

T

G

G

P

P

A

S

S

S

L

L

Q

A

P

R

G

-

T

D

D

G

K

K

P

P

Y

W

G

G

M

S

S

R

F

F

P

P

V

L

V

I

G

S

I

I

R

R

D

D

F

Q

V

V

N

Q

V

A

Q

D

K

V

A

A

L

A

L

L

E

A

S

A

L

L

G

G

I

I

T

T

R

E

L

V

H

A

A

A

V

V

A

V

G

G

A

G

S
|
S

M

M

G

G

A

G

L

A

Q

R

A

A

Y

L

E

E

W

W

A

V

S

V

S

G

Y

Y

P

P

E

D

M

R

V

V

-

R

G

A

R

G

I

L

I

L

P

L

V

A

I

V

G

G

A

A

S

R

E

A

T

T

S

A

G

D

W

Q

L

-

I

I

A

G

L

T

L

Q

D

T

A

T

W

Q

G

I

A

A

P

A

I

I

R

K

V

A

D

D

A

P

N

D

W

W

N

Q

N

S

G

G

D

D

Y

Y

Y

H

-

E

-

T

G

G

R

R

T

A

P

-

P

P

K

D

A

A

G

G

L

L

T

R

Q

L

A

A

L
x
R

K

R

M

F

V

A

T

H

L

L

W

T

A
x
Y

G
x
R

Y

G

W

E

T

I

W

E

V

L

D

D

D

T

T
x
R

F

F

G

A

R

N

K

H

W

-

A

N

E

Q

P

G

Q

N

Q

E

D

D

P

P

A

T

A

A

A

-

M

-

G

G

N

G

R

R

F

Y

L

A

V

V

E

Q

S
|
S

T
x
Y

I

L

D

E

K
x
H

I

Q

S

G

A

D

A
x
K

R

L

A

L

E

S

L

R

S

F

D

D

A

A

N

G

H

S

L

Y

L

V

Y

I

L

L

V

T

K

E

A

A

-

L

N

N

Q

S

L

H

F

D

V

V

A

G

G

R

G

G

-

R

-

G

-

G

-

V

D

S

A

A

A

A

V

L

S

R

R

A

I

C

K

P

A

V

P

P

V

V

L

V

L

V

I

G

S

G

T

I

D

T

E

S

D

D

L

R

V

L

F

Y

P

P

P

L

P

R

V

L

I

Q

A

Q

K

E

T

L

A

A

E

D

R

L

V

L

-

P

-

G

R

C

A

A

G

G

G

L

A

R

K

V

V

V

E

E

Q

S

V

V

K

Y

I

-

G

-

G

-

G

-

R

-

G

G

H

H

L
x
D

N

G

G

F

V

L

V

V

N

E

I

T

S

E

E

A

A

V

G

G

D

E

A

L

I

I

R

R

T

Q

F

T

L

L

binding coenzyme a: A52 (≠ F91), S150 (= S196), R220 (≠ L265), Y227 (≠ A272), R228 (≠ G273), R236 (≠ T281), S257 (= S305), Y258 (≠ T306), H261 (≠ K309), K265 (≠ A313), D344 (≠ L390)

6puxA Homoserine transacetylase metx from mycobacterium tuberculosis (see paper)
30% identity, 90% coverage: 39:407/409 of query aligns to 6:362/366 of 6puxA

query
sites
6puxA

P

P

A

A

S

E

A

G

L

E

D

I

A

G

I

L

V

I

E

D

K

V

K

G

S

S

F

L

T

Q

L

L

P

-

A

-

Y

-

T

-

T

-

Q

E

G

S

G

G

A

A

P

V

L

I

K

D

D

D

V

V

K

C

I

I

G

A

W

V

E

Q

A

R

Y

W

G

G

T

K

L

L

N

S

A

P

D

A

K

R

S

D

N

N

V

V

I

V

L

V

V

V

T

L

H

H

F

A

F

L

S

T

G

G

S

D

S

S

H

H

A

I

A

T

G

G

K

P

Y

A

K

G

A

P

D

G

D

H

K

P

V

T

A

P

G

G

Y

W

W

W

D

D

A

G

I

V

I

A

G

G

P

P

G

G

K

A

P

P

L

I

D

D

T

T

D

T

K

R

Y

W

Y

C

I

A

I

V

S

A

S

T

D

N

T

V

L

L

V

G

N

G

L

C

N

R

A

G

Y

-

D

-

P

-

N

-

V

-

I

-

T

S

T

T

G

G

P

P

A

S

S

S

L

L

Q

A

P

R

G

-

T

D

D

G

K

K

P

P

Y

W

G

G

M

S

S

R

F

F

P

P

V

L

V

I

G
x
S

I
|
I

R

R

D

D

F

Q

V

V

N

Q

V

A

Q

D

K

V

A

A

L

A

L

L

E

A

S

A

L

L

G

G

I

I

T

T

R

E

L

V

H

A

A

A

V

V

A

V

G

G

A

G

S

S

M

M

G

G

A

G

L

A

Q

R

A

A

Y

L

E

E

W

W

A

V

S

V

S

G

Y

Y

P

P

E

D

M

R

V

V

-

R

G

A

R

G

I

L

I

L

P

L

V

A

I

V

G

G

A

A

S

R

E

A

T

T

S

A

G

D

W

Q

L

-

I

I

A

G

L

T

L

Q

D

T

A

T

W

Q

G

I

A

A

P

A

I

I

R

K

V

A

D

D

A

P

N

D

W

W

N

Q

N

S

G

G

D

D

Y

Y

Y

H

-

E

-

T

G

G

R

R

T

A

P

-

P

P

K

D

A

A

G

G

L

L

T

R

Q

L

A

A

L

R

K

R

M

F

V

A

T

H

L

L

W

T

A

Y

G

R

Y

G

W

E

T

I

W

E

V

L

D

D

D

T

T

R

F

F

G

A

R

N

K

H

W

-

A

N

E

Q

P

G

Q

N

Q

E

D

D

P

P

A

T

A

A

A

-

M

-

G

G

N

G

R

R

F

Y

L

A

V

V

E

Q

S

S

T

Y

I

L

D

E

K

H

I

Q

S

G

A

D

A

K

R

L

A

L

E

S

L

R

S

F

D

D

A

A

N

G

H

S

L

Y

L

V

Y

I

L

L

V

T

K

E

A
|
A

-

L

N

N

Q
x
S

L
x
H

F

D

V

V

A

G

G

R

G

G

-

R

-

G

-

G

-

V

D

S

A

A

A

A

V

L

S

R

R

A

I

C

K

P

A

V

P

P

V

V

L

V

L

V

I

G

S

G

T

I

D

T

E

S

D

D

L

R

V

L

F

Y

P

P

P

L

P

R

V

L

I

Q

A

Q

K

E

T

L

A

A

E
x
D

R

L

V
x
L

-

P

-

G

R

C

A

A

G

G

G

L

A

R

K

V

V

V

E

E

Q

S

V

V

K

Y

I

-

G

-

G

-

G

-

R

-

G

G

H

H

L

D

N

G

G

F

V

L

V

V

N

E

I

T

S

E

E

A

A

V

G

G

D

E

A

L

I

I

R

R

T

Q

F

T

L

L

binding magnesium ion: S124 (≠ G169), I125 (= I170), A282 (= A329), S285 (≠ Q331), H286 (≠ L332), D327 (≠ E369), L329 (≠ V371)

8f2lA Crystal structure of mycobacterium tuberculosis homoserine transacetylase in complex with l-homoserine (see paper)
30% identity, 90% coverage: 39:407/409 of query aligns to 5:361/367 of 8f2lA

query
sites
8f2lA

P

P

A

A

S

E

A

G

L

E

D

I

A

G

I

L

V

I

E

D

K

V

K

G

S

S

F

L

T

Q

L

L

P

-

A

-

Y

-

T

-

T

-

Q

E

G

S

G

G

A

A

P

V

L

I

K

D

D

D

V

V

K

C

I

I

G

A

W

V

E

Q

A

R

Y

W

G

G

T

K

L

L

N

S

A

P

D

A

K

R

S

D

N

N

V

V

I

V

L

V

V

V

T

L

H

H

F
x
A

F
x
L

S
x
T

G

G

S

D

S

S

H

H

A

I

A

T

G

G

K

P

Y

A

K

G

A

P

D

G

D

H

K

P

V

T

A

P

G

G

Y

W

W

W

D

D

A

G

I

V

I

A

G

G

P

P

G

G

K

A

P

P

L

I

D

D

T

T

D

T

K

R

Y

W

Y

C

I

A

I

V

S

A

S

T

D

N

T

V

L

L

V

G

N

G

L

C

N

R

A

G

Y

-

D

-

P

-

N

-

V

-

I

-

T

S

T

T

G

G

P

P

A

S

S

S

L

L

Q

A

P

R

G

-

T

D

D

G

K

K

P

P

Y

W

G

G

M

S

S

R

F

F

P

P

V

L

V

I

G

S

I

I

R

R

D

D

F

Q

V

V

N

Q

V

A

Q

D

K

V

A

A

L

A

L

L

E

A

S

A

L

L

G

G

I

I

T

T

R

E

L

V

H

A

A

A

V

V

A

V

G

G

A

G

S

S

M

M

G

G

A

G

L

A

Q

R

A

A

Y

L

E

E

W

W

A

V

S

V

S

G

Y

Y

P

P

E

D

M

R

V

V

-

R

G

A

R

G

I

L

I

L

P

L

V

A

I

V

G

G

A

A

S

R

E

A

T

T

S

A

G

D

W

Q

L

-

I

I

A

G

L

T

L

Q

D

T

A

T

W

Q

G

I

A

A

P

A

I

I

R

K

V

A

D

D

A

P

N

D

W

W

N

Q

N

S

G

G

D

D

Y

Y

Y

H

-

E

-

T

G

G

R

R

T

A

P

-

P

P

K

D

A

A

G

G

L

L

T

R

Q

L

A

A

L
x
R

K

R

M

F

V

A

T

H

L

L

W

T

A
x
Y

G

R

Y

G

W

E

T

I

W

E

V

L

D

D

D

T

T

R

F

F

G

A

R

N

K

H

W

-

A

N

E

Q

P

G

Q

N

Q

E

D

D

P

P

A

T

A

A

A

-

M

-

G

G

N

G

R

R

F

Y

L

A

V

V

E

Q

S

S

T

Y

I

L

D

E

K

H

I

Q

S

G

A

D

A

K

R

L

A

L

E

S

L

R

S

F

D

D

A

A

N

G

H

S

L

Y

L

V

Y

I

L

L

V

T

K

E

A

A

-

L

N

N

Q

S

L

H

F

D

V

V

A

G

G

R

G

G

-

R

-

G

-

G

-

V

D

S

A

A

A

A

V

L

S

R

R

A

I

C

K

P

A

V

P

P

V

V

L

V

L

V

I

G

S

G

T

I

D

T

E

S

D

D

L

R

V

L

F

Y

P

P

P

L

P

R

V

L

I

Q

A

Q

K

E

T

L

A

A

E

D

R

L

V

L

-

P

-

G

R

C

A

A

G

G

G

L

A

R

K

V

V

V

E

E

Q

S

V

V

K

Y

I

-

G

-

G

-

G

-

R

-

G

G

H

H

L

D

N

G

G

F

V

L

V

V

N

E

I

T

S

E

E

A

A

V

G

G

D

E

A

L

I

I

R

R

T

Q

F

T

L

L

binding l-homoserine: A52 (≠ F91), L53 (≠ F92), T54 (≠ S93), R220 (≠ L265), Y227 (≠ A272)

Query Sequence

>WP_012170857.1 NCBI__GCF_000010525.1:WP_012170857.1
MRPITQTLERLCLKSNHVRAMAWAFALALAVAGSVLPTPASALDAIVEKKSFTLPAYTTQ
GGAPLKDVKIGWEAYGTLNADKSNVILVTHFFSGSSHAAGKYKADDKVAGYWDAIIGPGK
PLDTDKYYIISSDTLVNLNAYDPNVITTGPASLQPGTDKPYGMSFPVVGIRDFVNVQKAL
LESLGITRLHAVAGASMGALQAYEWASSYPEMVGRIIPVIGASETSGWLIALLDAWGAPI
RVDANWNNGDYYGRTPPKAGLTQALKMVTLWAGYWTWVDDTFGRKWAEPQQDPAAAMGNR
FLVESTIDKISAARAELSDANHLLYLVKANQLFVAGGDAAVSRIKAPVLLISTDEDLVFP
PPVIAKTAERVRAGGAKVEQVKIGGGRGHLNGVVNISEAGDAIRTFLAK

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory