Comparing WP_012171581.1 NCBI__GCF_000010525.1:WP_012171581.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
Q96KP4 Cytosolic non-specific dipeptidase; CNDP dipeptidase 2; Glutamate carboxypeptidase-like protein 1; Peptidase A; Threonyl dipeptidase; EC 3.4.13.18 from Homo sapiens (Human)
29% identity, 98% coverage: 1:449/459 of query aligns to 1:461/475 of Q96KP4
4mmoA The crystal structure of a m20 family metallo-carboxypeptidase sso-cp2 from sulfolobus solfataricus
33% identity, 95% coverage: 15:449/459 of query aligns to 1:425/437 of 4mmoA
2zogA Crystal structure of mouse carnosinase cn2 complexed with zn and bestatin (see paper)
28% identity, 98% coverage: 1:449/459 of query aligns to 5:465/478 of 2zogA
2zofA Crystal structure of mouse carnosinase cn2 complexed with mn and bestatin (see paper)
28% identity, 98% coverage: 1:449/459 of query aligns to 5:465/478 of 2zofA
Q9D1A2 Cytosolic non-specific dipeptidase; CNDP dipeptidase 2; Glutamate carboxypeptidase-like protein 1; Threonyl dipeptidase; EC 3.4.13.18 from Mus musculus (Mouse) (see 2 papers)
28% identity, 98% coverage: 1:449/459 of query aligns to 1:461/475 of Q9D1A2
4g1pA Structural and mechanistic basis of substrate recognition by novel di- peptidase dug1p from saccharomyces cerevisiae
27% identity, 98% coverage: 7:455/459 of query aligns to 8:471/479 of 4g1pA
Q96KN2 Beta-Ala-His dipeptidase; CNDP dipeptidase 1; Carnosine dipeptidase 1; Glutamate carboxypeptidase-like protein 2; Serum carnosinase; EC 3.4.13.20 from Homo sapiens (Human) (see 4 papers)
27% identity, 98% coverage: 2:449/459 of query aligns to 33:494/507 of Q96KN2
Sites not aligning to the query:
3dljA Crystal structure of human carnosine dipeptidase 1
27% identity, 98% coverage: 2:449/459 of query aligns to 4:459/471 of 3dljA
2pokA Crystal structure of a m20 family metallo peptidase from streptococcus pneumoniae
28% identity, 67% coverage: 36:344/459 of query aligns to 38:345/458 of 2pokA
Sites not aligning to the query:
3pfeA Crystal structure of a m20a metallo peptidase (dape, lpg0809) from legionella pneumophila subsp. Pneumophila str. Philadelphia 1 at 1.50 a resolution
27% identity, 96% coverage: 19:459/459 of query aligns to 21:469/471 of 3pfeA
4pqaA Crystal structure of succinyl-diaminopimelate desuccinylase from neisseria meningitidis mc58 in complex with the inhibitor captopril (see paper)
29% identity, 47% coverage: 18:235/459 of query aligns to 5:209/375 of 4pqaA
Sites not aligning to the query:
4o23A Crystal structure of mono-zinc form of succinyl diaminopimelate desuccinylase from neisseria meningitidis mc58 (see paper)
29% identity, 47% coverage: 18:235/459 of query aligns to 5:209/376 of 4o23A
3pfoA Crystal structure of a putative acetylornithine deacetylase (rpa2325) from rhodopseudomonas palustris cga009 at 1.90 a resolution
29% identity, 47% coverage: 65:278/459 of query aligns to 81:268/426 of 3pfoA
Sites not aligning to the query:
1q7lA Zn-binding domain of the t347g mutant of human aminoacylase-i (see paper)
29% identity, 38% coverage: 18:192/459 of query aligns to 6:174/192 of 1q7lA
Q03154 Aminoacylase-1; ACY-1; N-acyl-L-amino-acid amidohydrolase; EC 3.5.1.14 from Homo sapiens (Human) (see 6 papers)
32% identity, 32% coverage: 18:162/459 of query aligns to 12:150/408 of Q03154
Sites not aligning to the query:
7lgpB Dape enzyme from shigella flexneri
27% identity, 40% coverage: 77:260/459 of query aligns to 58:238/377 of 7lgpB
P37111 Aminoacylase-1; ACY-1; N-acyl-L-amino-acid amidohydrolase; EC 3.5.1.14 from Sus scrofa (Pig) (see paper)
31% identity, 32% coverage: 14:162/459 of query aligns to 8:150/407 of P37111
Sites not aligning to the query:
4op4B Crystal structure of the catalytic domain of dape protein from v.Cholerea in the zn bound form (see paper)
39% identity, 12% coverage: 83:138/459 of query aligns to 63:113/265 of 4op4B
Sites not aligning to the query:
7t1qA Crystal structure of the succinyl-diaminopimelate desuccinylase (dape) from acinetobacter baumannii in complex with succinic acid
26% identity, 39% coverage: 68:244/459 of query aligns to 42:222/377 of 7t1qA
Sites not aligning to the query:
5vo3A Crystal structure of dape in complex with the products (succinic acid and diaminopimelic acid) (see paper)
27% identity, 48% coverage: 18:238/459 of query aligns to 11:216/380 of 5vo3A
Sites not aligning to the query:
>WP_012171581.1 NCBI__GCF_000010525.1:WP_012171581.1
MAGVDEVLNAVDAGLDASLARLSDFLRIPSISTDPAYAAACRQAADFAAEALTGLGLAAT
VRETAGHPVVIGRTDTGAARRVLFYGHYDVQPVDPLDLWDSPPFEPRIATGTDGKTRIYA
RGACDDKGQVSTFLEALRALKTVQGKLPVDVTVLLEGEEECGSPSLPAFLAANAEELKAD
VALVCDTGMWDPQTPAITTSLRGILHTEFTITGADRDLHSGLFGGAARNPIHVLARILAA
VHDDTGHITIPGFYDDVAEMPQAVRDAWNALGLTPEAFLGPVGLSVAAGESDRSLIEQIQ
SRPTFEVNGIYGGYQGQGSKTIIPSTATAKVTMRLVANQDPAKIAAAFKDFVQARLPADC
KVTFGKSEGSRAVLVPPDSPDLAKARTALQAEWGTTPVAIGSGGSIPIVGQFKNVLGMDT
LLIGFGLDDDRVHSPNEKYDLTCFHKGTRSWVRVLSALA
Or try a new SitesBLAST search
SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory