SitesBLAST
Comparing WP_012282103.1 NCBI__GCF_000019165.1:WP_012282103.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
3qguA L,l-diaminopimelate aminotransferase from chlamydomonas reinhardtii (see paper)
46% identity, 98% coverage: 5:406/409 of query aligns to 8:402/406 of 3qguA
Sites not aligning to the query:
Q9ZQI7 Aminotransferase ALD1, chloroplastic; AGD2-like defense response protein 1; EC 2.6.1.- from Arabidopsis thaliana (Mouse-ear cress) (see paper)
41% identity, 98% coverage: 5:406/409 of query aligns to 41:436/456 of Q9ZQI7
- Y108 (= Y72) binding pyridoxal 5'-phosphate
- AQ 142:143 (≠ SK 108:109) binding pyridoxal 5'-phosphate
- N223 (= N187) binding pyridoxal 5'-phosphate
- D251 (= D215) binding pyridoxal 5'-phosphate
- Y254 (= Y218) binding pyridoxal 5'-phosphate
- S281 (= S246) binding pyridoxal 5'-phosphate
- S283 (= S248) binding pyridoxal 5'-phosphate
- R292 (= R257) binding pyridoxal 5'-phosphate
- N323 (= N292) binding pyridoxal 5'-phosphate
4fl0B Crystal structure of ald1 from arabidopsis thaliana (see paper)
41% identity, 98% coverage: 5:406/409 of query aligns to 8:403/409 of 4fl0B
- binding pyridoxal-5'-phosphate: G108 (= G107), A109 (≠ S108), Q110 (≠ K109), F133 (≠ Y132), N190 (= N187), D218 (= D215), Y221 (= Y218), S248 (= S246), S250 (= S248), K251 (= K249), R259 (= R257)
Q93ZN9 LL-diaminopimelate aminotransferase, chloroplastic; AtDAP-AT; DAP-AT; DAP-aminotransferase; LL-DAP-aminotransferase; Protein ABERRANT GROWTH AND DEATH 2; EC 2.6.1.83 from Arabidopsis thaliana (Mouse-ear cress) (see 3 papers)
45% identity, 98% coverage: 5:406/409 of query aligns to 62:457/461 of Q93ZN9
- Y72 (= Y15) binding substrate
- G99 (= G42) binding substrate
- Y129 (= Y72) binding pyridoxal 5'-phosphate
- AK 163:164 (≠ SK 108:109) binding pyridoxal 5'-phosphate
- K164 (= K109) binding substrate
- Y187 (= Y132) binding pyridoxal 5'-phosphate; binding substrate
- N244 (= N187) binding pyridoxal 5'-phosphate; binding substrate
- Y275 (= Y218) binding pyridoxal 5'-phosphate
- SFS 302:304 (= SFS 246:248) binding pyridoxal 5'-phosphate
- K305 (= K249) modified: N6-(pyridoxal phosphate)lysine; mutation to N: Loss of LL-DAP-aminotransferase activity.; mutation to Q: Loss of LL-DAP-aminotransferase activity.
- R313 (= R257) binding pyridoxal 5'-phosphate
- N344 (= N292) binding pyridoxal 5'-phosphate; binding substrate
- P398 (= P346) mutation to S: In agd2-1; reduced activity and increased resistance to pathogen.
- R439 (= R388) binding substrate
3ei5A Crystal structure of ll-diaminopimelate aminotransferase from arabidopsis thaliana complexed with plp-glu: an external aldimine mimic (see paper)
45% identity, 98% coverage: 5:406/409 of query aligns to 9:404/408 of 3ei5A
- binding N-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)-L-glutamic acid: Y19 (= Y15), F21 (= F17), I45 (= I41), G46 (= G42), Y76 (= Y72), G109 (= G107), A110 (≠ S108), K111 (= K109), Y134 (= Y132), N191 (= N187), D219 (= D215), Y222 (= Y218), S249 (= S246), S251 (= S248), R260 (= R257), N291 (= N292), R386 (= R388)
2z1zA Crystal structure of ll-diaminopimelate aminotransferase from arabidopsis thaliana complexed with l-malate ion (see paper)
45% identity, 98% coverage: 5:406/409 of query aligns to 9:404/408 of 2z1zA
- binding pyridoxal-5'-phosphate: Y76 (= Y72), G109 (= G107), A110 (≠ S108), K111 (= K109), Y134 (= Y132), N191 (= N187), D219 (= D215), Y222 (= Y218), S249 (= S246), S251 (= S248), K252 (= K249), R260 (= R257), N291 (= N292)
3ei6A Crystal structure of ll-diaminopimelate aminotransferase from arabidopsis thaliana complexed with plp-dap: an external aldimine mimic (see paper)
45% identity, 98% coverage: 5:406/409 of query aligns to 9:404/410 of 3ei6A
- binding (2S,6S)-2-amino-6-[({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)amino]heptanedioic acid: Y19 (= Y15), F21 (= F17), G46 (= G42), Y76 (= Y72), G109 (= G107), A110 (≠ S108), K111 (= K109), Y134 (= Y132), N191 (= N187), D219 (= D215), Y222 (= Y218), S249 (= S246), S251 (= S248), K252 (= K249), R260 (= R257), N291 (= N292), R386 (= R388)
3ei9A Crystal structure of k270n variant of ll-diaminopimelate aminotransferase from arabidopsis thaliana complexed with l-glu: external aldimine form (see paper)
45% identity, 98% coverage: 5:406/409 of query aligns to 9:404/412 of 3ei9A
- binding (E)-N-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene)-L-glutamic acid: Y19 (= Y15), F21 (= F17), I45 (= I41), G46 (= G42), Y76 (= Y72), G109 (= G107), A110 (≠ S108), K111 (= K109), Y134 (= Y132), N191 (= N187), D219 (= D215), Y222 (= Y218), S249 (= S246), S251 (= S248), R260 (= R257), N291 (= N292), R386 (= R388)
3ei8A Crystal structure of k270n variant of ll-diaminopimelate aminotransferase from arabidopsis thaliana complexed with ll-dap: external aldimine form (see paper)
45% identity, 98% coverage: 5:406/409 of query aligns to 9:404/411 of 3ei8A
- binding (2S,6S)-2-amino-6-{[(1E)-{3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene]amino}heptanedioic acid: Y76 (= Y72), N291 (= N292)
- binding pyridoxal-5'-phosphate: G109 (= G107), A110 (≠ S108), K111 (= K109), Y134 (= Y132), N191 (= N187), D219 (= D215), Y222 (= Y218), S249 (= S246), S251 (= S248), R260 (= R257)
O84395 LL-diaminopimelate aminotransferase; DAP-AT; DAP-aminotransferase; LL-DAP-aminotransferase; EC 2.6.1.83 from Chlamydia trachomatis serovar D (strain ATCC VR-885 / DSM 19411 / UW-3/Cx) (see paper)
39% identity, 98% coverage: 5:406/409 of query aligns to 4:387/394 of O84395
- AK 104:105 (≠ SK 108:109) binding pyridoxal 5'-phosphate
- N174 (= N187) binding pyridoxal 5'-phosphate
- Y205 (= Y218) binding pyridoxal 5'-phosphate
- SFS 233:235 (= SFS 246:248) binding pyridoxal 5'-phosphate
- K236 (= K249) modified: N6-(pyridoxal phosphate)lysine
6l1oB Product bound bacf structure from bacillus subtillis (see paper)
29% identity, 95% coverage: 17:406/409 of query aligns to 17:385/392 of 6l1oB
- binding 4'-deoxy-4'-aminopyridoxal-5'-phosphate: G103 (≠ S108), K104 (= K109), Y128 (= Y132), N174 (≠ C183), D206 (= D215), Y209 (= Y218), S236 (= S246), S238 (= S248), K239 (= K249), R247 (= R257)
- binding tyrosine: F17 (= F17), Q39 (≠ I41), G40 (= G42), K104 (= K109), Y128 (= Y132), E130 (≠ V134), Y325 (= Y347), R367 (= R388)
6l1lB Apo-bacf structure from bacillus subtillis (see paper)
29% identity, 95% coverage: 17:406/409 of query aligns to 17:385/393 of 6l1lB
6l1nA Substrate bound bacf structure from bacillus subtillis (see paper)
29% identity, 95% coverage: 17:406/409 of query aligns to 17:384/393 of 6l1nA
- binding glycine: Y127 (= Y132), N177 (= N187), Y324 (= Y347), R366 (= R388)
- binding pyridoxal-5'-phosphate: G102 (≠ S108), Y127 (= Y132), N173 (≠ C183), N177 (= N187), D205 (= D215), Y208 (= Y218), S235 (= S246), S237 (= S248), R246 (= R257)
Sites not aligning to the query:
2x5dD Crystal structure of a probable aminotransferase from pseudomonas aeruginosa (see paper)
26% identity, 91% coverage: 35:407/409 of query aligns to 18:373/380 of 2x5dD
- active site: Y113 (= Y132), D191 (= D215), A193 (= A217), K225 (= K249)
- binding pyridoxal-5'-phosphate: G87 (= G107), S88 (= S108), K89 (= K109), Y113 (= Y132), D191 (= D215), A193 (= A217), Y194 (= Y218), T222 (≠ S246), S224 (= S248), K225 (= K249), R233 (= R257)
1gdeA Crystal structure of pyrococcus protein a-1 e-form (see paper)
27% identity, 91% coverage: 35:405/409 of query aligns to 26:381/388 of 1gdeA
- active site: K232 (= K249)
- binding glutamic acid: F120 (≠ Y132), N170 (= N187), R361 (= R388)
- binding pyridoxal-5'-phosphate: G94 (= G107), A95 (≠ S108), N96 (vs. gap), F120 (≠ Y132), N166 (≠ C183), D198 (= D215), Y201 (= Y218), S231 (= S248), K232 (= K249), R240 (= R257)
1gd9A Crystall structure of pyrococcus protein-a1 (see paper)
27% identity, 91% coverage: 35:405/409 of query aligns to 26:381/388 of 1gd9A
- active site: K232 (= K249)
- binding pyridoxal-5'-phosphate: G94 (= G107), A95 (≠ S108), N96 (vs. gap), F120 (≠ Y132), N170 (= N187), D198 (= D215), V200 (≠ A217), Y201 (= Y218), S231 (= S248), K232 (= K249), R240 (= R257)
P14909 Aspartate aminotransferase; AspAT; Transaminase A; EC 2.6.1.1 from Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (Sulfolobus solfataricus) (see 3 papers)
29% identity, 62% coverage: 14:268/409 of query aligns to 19:261/402 of P14909
- K203 (= K209) modified: N6-methyllysine; partial
Sites not aligning to the query:
- 1 modified: Initiator methionine, Removed
- 385 modified: N6-methyllysine; partial
2o1bA Structure of aminotransferase from staphylococcus aureus
25% identity, 87% coverage: 36:390/409 of query aligns to 21:353/376 of 2o1bA
- active site: Y115 (= Y132), D192 (= D215), A194 (= A217), K225 (= K249)
- binding pyridoxal-5'-phosphate: T90 (≠ S108), K91 (= K109), Y115 (= Y132), N164 (= N187), D192 (= D215), A194 (= A217), Y195 (= Y218), S222 (= S246), S224 (= S248), K225 (= K249), R233 (= R257)
Q58097 (5-formylfuran-3-yl)methyl phosphate transaminase; 4-HFC-P:alanine aminotransferase; EC 2.6.1.108 from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
22% identity, 79% coverage: 82:406/409 of query aligns to 75:365/370 of Q58097
- K222 (= K249) modified: N6-(pyridoxal phosphate)lysine
1v2fA Crystal structure of t.Th hb8 glutamine aminotransferase complex with 3-phenylpropionate (see paper)
25% identity, 90% coverage: 37:405/409 of query aligns to 28:364/368 of 1v2fA
- active site: F112 (≠ Y132), A181 (= A205), A183 (≠ E207), K222 (= K249)
- binding hydrocinnamic acid: Q32 (≠ I41), G33 (= G42), Y57 (= Y72), F112 (≠ Y132), F253 (= F291), R347 (= R388)
- binding pyridoxal-5'-phosphate: G86 (≠ D106), A87 (≠ G107), T88 (≠ S108), F112 (≠ Y132), N163 (= N187), D191 (= D215), V193 (≠ A217), Y194 (= Y218), S219 (= S246), K222 (= K249), R230 (= R257)
Sites not aligning to the query:
Query Sequence
>WP_012282103.1 NCBI__GCF_000019165.1:WP_012282103.1
MALVNENYLKLPGSYLFSEIARRVNQFKKANPEADIIRLGIGDVTRPLVPAVVEAMKKAV
DEMGRAETFRGYGPEQGYDFLIGQIIENDYKPRGIDLGMDEVFVSDGSKCDTANFQEILG
IGNIVAVTDPVYPVYVDSNVMAGRSGAFNEKGQFDDIVYLPCTEANGMKPELPKTRVDMI
YLCFPNNPTGMTLTKEELKQWVDYARENKSIILYDAAYEAFIQEAHIPRSIYEIEGAREV
AVEFRSFSKTAGFTGTRCAFTVVPKEVMAYDREGRAYSLNGLWLRRQTTKFNGVSYPVQA
AAAAIYTEAGKKQVKETIEYYMENARIIREGLVEAGYKVFGGVNAPYIWLKTPDNMSSWD
FFDKLISVANVVGTPGAGFGASGEGYFRLTAFGTRENTVKALERIRTRM
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SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory