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Comparing WP_012282818.1 NCBI__GCF_000019165.1:WP_012282818.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
7q4vB Electron bifurcating hydrogenase - hydabc from a. Woodii (see paper)
60% identity, 90% coverage: 68:658/659 of query aligns to 4:598/599 of 7q4vB
- binding fe2/s2 (inorganic) cluster: C11 (= C75), C16 (= C80), C48 (= C112), F49 (≠ H113), L51 (≠ F115), C52 (= C116)
- binding flavin mononucleotide: G166 (= G228), G168 (= G230), N196 (= N256), D198 (= D258), F284 (= F344), G287 (= G347), E288 (= E348), E289 (= E349), N324 (= N384)
- binding iron/sulfur cluster: C457 (= C517), G458 (= G518), K459 (= K519), C460 (= C520), C463 (= C523), C503 (= C563), G506 (= G566), F544 (≠ Y604), C551 (= C611), K552 (≠ R612), G553 (= G613), C554 (= C614), G555 (≠ T615), I556 (≠ L616), C557 (= C617), C561 (= C621), P562 (= P622), Y574 (= Y634), C581 (= C641), K583 (= K643), C584 (= C644), G585 (= G645), A586 (= A646), C587 (= C647), C591 (= C651), F593 (= F653), S595 (≠ A655)
- binding zinc ion: C440 (= C500), H527 (= H587), C533 (= C593)
8a6tB Cryo-em structure of the electron bifurcating fe-fe hydrogenase hydabc complex from thermoanaerobacter kivui in the reduced state (see paper)
57% identity, 89% coverage: 74:658/659 of query aligns to 30:629/630 of 8a6tB
- binding fe2/s2 (inorganic) cluster: C31 (= C75), G33 (= G77), C36 (= C80), C82 (= C112), F85 (= F115), C86 (= C116)
- binding flavin mononucleotide: G201 (= G230), N227 (= N256), E230 (= E259), N355 (= N384), G535 (= G564), L536 (= L565)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: S320 (≠ E349), R337 (= R366), R340 (≠ Y369), T341 (≠ P370), N342 (≠ A371), S433 (= S462)
- binding iron/sulfur cluster: S487 (= S516), C488 (= C517), G489 (= G518), C491 (= C520), C494 (= C523), C534 (= C563), L536 (= L565), G537 (= G566), Y575 (= Y604), I577 (= I606), C582 (= C611), I583 (≠ R612), C585 (= C614), C588 (= C617), C592 (= C621), A596 (≠ C625), I597 (= I626), I607 (= I636), C612 (= C641), C618 (= C647), C622 (= C651), K624 (≠ F653), A626 (= A655), I627 (≠ V656)
- binding zinc ion: C471 (= C500), H558 (= H587), C564 (= C593)
8oh5B Cryo-em structure of the electron bifurcating transhydrogenase stnabc complex from sporomusa ovata (state 2) (see paper)
59% identity, 87% coverage: 81:656/659 of query aligns to 12:581/584 of 8oh5B
- binding fe2/s2 (inorganic) cluster: C41 (= C112), C45 (= C116)
- binding flavin mononucleotide: R154 (= R229), K164 (= K239), N181 (= N256), F269 (= F344), E273 (= E348), E274 (= E349), I307 (= I382), N308 (= N383), N309 (= N384), G489 (= G564), L490 (= L565)
- binding nicotinamide-adenine-dinucleotide: G155 (= G230), G156 (= G231), F159 (= F234), F163 (≠ Q238), E273 (= E348), E274 (= E349), K291 (≠ R366), F294 (≠ Y369), G413 (= G488)
- binding iron/sulfur cluster: P288 (= P363), C442 (= C517), G443 (= G518), C445 (= C520), C448 (= C523), C488 (= C563), L490 (= L565), G491 (= G566), I531 (= I606), C536 (= C611), T540 (= T615), C542 (= C617), C546 (= C621), P547 (= P622), V548 (= V623), H559 (≠ Y634), C566 (= C641), T567 (≠ I642), K568 (= K643), C569 (= C644), C572 (= C647)
- binding zinc ion: C425 (= C500), H512 (= H587), C518 (= C593), C523 (= C598)
Sites not aligning to the query:
7q4vF Electron bifurcating hydrogenase - hydabc from a. Woodii (see paper)
64% identity, 71% coverage: 193:658/659 of query aligns to 1:469/470 of 7q4vF
- binding flavin mononucleotide: G37 (= G228), G39 (= G230), N67 (= N256), G158 (= G347), E159 (= E348), E160 (= E349), G375 (= G564)
- binding nicotinamide-adenine-dinucleotide: G40 (= G231), F43 (= F234), K48 (= K239), R177 (= R366), F180 (≠ Y369), M297 (= M486)
- binding iron/sulfur cluster: S327 (= S516), C328 (= C517), G329 (= G518), K330 (= K519), C331 (= C520), C334 (= C523), L373 (= L562), C374 (= C563), F415 (≠ Y604), I417 (= I606), C422 (= C611), G424 (= G613), C425 (= C614), G426 (≠ T615), I427 (≠ L616), C428 (= C617), C432 (= C621), P433 (= P622), I437 (= I626), Y445 (= Y634), C452 (= C641), K454 (= K643), C455 (= C644), G456 (= G645), A457 (= A646), C458 (= C647), C462 (= C651), P463 (≠ K652), I467 (≠ V656)
- binding zinc ion: C311 (= C500), H398 (= H587), C404 (= C593), C409 (= C598)
8a5eB Cryo-em structure of the electron bifurcating fe-fe hydrogenase hydabc complex from acetobacterium woodii in the reduced state (see paper)
66% identity, 67% coverage: 217:658/659 of query aligns to 3:446/447 of 8a5eB
- binding flavin mononucleotide: G14 (= G228), G16 (= G230), N44 (= N256), G135 (= G347), E137 (= E349), N171 (= N383), N172 (= N384), G352 (= G564)
- binding 1,4-dihydronicotinamide adenine dinucleotide: G16 (= G230), G17 (= G231), F20 (= F234), K25 (= K239), F28 (= F242), D49 (= D261), R154 (= R366), F157 (≠ Y369), S250 (= S462)
- binding iron/sulfur cluster: P151 (= P363), C305 (= C517), G306 (= G518), K307 (= K519), C308 (= C520), C311 (= C523), C351 (= C563), G354 (= G566), F392 (≠ Y604), C399 (= C611), G401 (= G613), C402 (= C614), G403 (≠ T615), C405 (= C617), C409 (= C621), P410 (= P622), I414 (= I626), C429 (= C641), K431 (= K643), C432 (= C644), G433 (= G645), C435 (= C647), C439 (= C651), P440 (≠ K652), I444 (≠ V656)
- binding zinc ion: C288 (= C500), H375 (= H587), C381 (= C593), C386 (= C598)
7p8nB Tmhydabc- t. Maritima hydrogenase with bridge closed (see paper)
52% identity, 89% coverage: 72:656/659 of query aligns to 28:612/613 of 7p8nB
- binding fe2/s2 (inorganic) cluster: C31 (= C75), G33 (= G77), T34 (= T78), C36 (= C80), C67 (= C112), C68 (≠ H113), G69 (= G114), R70 (≠ F115), C71 (= C116)
- binding flavin mononucleotide: G185 (= G228), R186 (= R229), G187 (= G230), N213 (= N256), D215 (= D258), E216 (= E259), G217 (= G260), F301 (= F344), G304 (= G347), E305 (= E348), E306 (= E349), N340 (= N383), N341 (= N384), G521 (= G564), L522 (= L565)
- binding iron/sulfur cluster: P320 (= P363), S473 (= S516), C474 (= C517), G475 (= G518), K476 (= K519), C477 (= C520), C480 (= C523), L519 (= L562), C520 (= C563), L522 (= L565), G523 (= G566), Y560 (= Y604), C567 (= C611), C570 (= C614), G571 (≠ T615), C573 (= C617), C577 (= C621), Y590 (= Y634), I592 (= I636), C597 (= C641), K599 (= K643), C600 (= C644), G601 (= G645), C603 (= C647), C607 (= C651)
- binding zinc ion: C457 (= C500), H544 (= H587), C549 (= C593), C554 (= C598)
7t30B Structure of electron bifurcating ni-fe hydrogenase complex hydabcsl in fmn/NAD(h) bound state (see paper)
68% identity, 64% coverage: 176:598/659 of query aligns to 1:424/425 of 7t30B
- binding fe2/s2 (inorganic) cluster: C326 (= C500), C364 (≠ T538), H413 (= H587), C419 (= C593), A421 (= A595), C424 (= C598)
- binding flavin mononucleotide: G54 (= G228), G56 (= G230), K65 (= K239), N82 (= N256), D84 (= D258), E85 (= E259), G173 (= G347), E175 (= E349), N210 (= N384), G390 (= G564), L391 (= L565)
- binding nicotinamide-adenine-dinucleotide: G56 (= G230), G57 (= G231), A58 (= A232), F60 (= F234), K65 (= K239), F68 (= F242), E85 (= E259), E175 (= E349), R192 (= R366), F195 (≠ Y369), I312 (≠ M486), M313 (≠ V487), S315 (= S489)
- binding iron/sulfur cluster: S342 (= S516), C343 (= C517), G344 (= G518), C346 (= C520), C349 (= C523), S387 (= S561), C389 (= C563), L391 (= L565), G392 (= G566)
7t2rB Structure of electron bifurcating ni-fe hydrogenase complex hydabcsl in fmn-free apo state (see paper)
68% identity, 64% coverage: 176:598/659 of query aligns to 1:424/425 of 7t2rB
- binding fe2/s2 (inorganic) cluster: C326 (= C500), D329 (= D503), C364 (≠ T538), H413 (= H587), C419 (= C593), A421 (= A595), C424 (= C598)
- binding iron/sulfur cluster: P189 (= P363), C343 (= C517), G344 (= G518), C346 (= C520), C349 (= C523), C389 (= C563), G392 (= G566)
6vw7D Formate dehydrogenase fdsabg subcomplex fdsbg from c. Necator - nadh bound (see paper)
47% identity, 73% coverage: 102:584/659 of query aligns to 35:510/514 of 6vw7D
- binding flavin mononucleotide: G154 (= G228), G156 (= G230), K165 (= K239), N182 (= N256), E185 (= E259), G273 (= G347), E274 (= E348), E275 (= E349), N309 (= N383), N310 (= N384), S313 (≠ T387), A490 (≠ G564), M491 (≠ L565)
- binding 1,4-dihydronicotinamide adenine dinucleotide: A158 (= A232), F160 (= F234), K165 (= K239), T168 (≠ F242), E275 (= E349), L295 (≠ Y369)
- binding iron/sulfur cluster: V271 (= V345), V289 (≠ P363), S442 (= S516), C443 (= C517), G444 (= G518), K445 (= K519), C446 (= C520), C449 (= C523), L488 (= L562), C489 (= C563), M491 (≠ L565), G492 (= G566)
4hea1 Crystal structure of the entire respiratory complex i from thermus thermophilus (see paper)
47% identity, 63% coverage: 177:592/659 of query aligns to 11:428/437 of 4hea1
- binding flavin mononucleotide: G63 (= G228), K74 (= K239), N91 (= N256), D93 (= D258), Y179 (≠ F344), G182 (= G347), E183 (= E348), N218 (= N383), N219 (= N384), L401 (= L565)
- binding iron/sulfur cluster: I180 (≠ V345), P198 (= P363), S351 (= S516), C352 (= C517), G353 (= G518), K354 (= K519), C355 (= C520), C358 (= C523), F398 (≠ L562), C399 (= C563), L401 (= L565)
2ybb1 Fitted model for bovine mitochondrial supercomplex i1iii2iv1 by single particle cryo-em (emd-1876) (see paper)
47% identity, 63% coverage: 177:592/659 of query aligns to 11:428/437 of 2ybb1
- binding flavin mononucleotide: G63 (= G228), G65 (= G230), N91 (= N256), D93 (= D258), G182 (= G347), E183 (= E348), E184 (= E349), N218 (= N383), N219 (= N384), T222 (= T387), P400 (≠ G564)
- binding 1,4-dihydronicotinamide adenine dinucleotide: G65 (= G230), G66 (= G231), F69 (= F234), K74 (= K239), F77 (= F242), E96 (≠ D261), Y179 (≠ F344), E184 (= E349), K201 (≠ R366), F204 (≠ Y369), T324 (≠ S489)
- binding iron/sulfur cluster: S351 (= S516), C352 (= C517), K354 (= K519), C355 (= C520), C358 (= C523), F398 (≠ L562), C399 (= C563), L401 (= L565), A402 (≠ G566)
Q56222 NADH-quinone oxidoreductase subunit 1; NADH dehydrogenase I chain 1; NDH-1 subunit 1; EC 7.1.1.- from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8) (see paper)
47% identity, 63% coverage: 177:592/659 of query aligns to 12:429/438 of Q56222
- K75 (= K239) binding FMN
- NADES 92:96 (≠ NADEG 256:260) binding FMN
- YICGEE 180:185 (≠ FVCGEE 344:349) binding FMN
- INN 218:220 (= INN 382:384) binding FMN
- C353 (= C517) binding [4Fe-4S] cluster
- C356 (= C520) binding [4Fe-4S] cluster
- C359 (= C523) binding [4Fe-4S] cluster
- C400 (= C563) binding [4Fe-4S] cluster
6tg9B Cryo-em structure of nadh reduced form of NAD+-dependent formate dehydrogenase from rhodobacter capsulatus (see paper)
43% identity, 75% coverage: 88:584/659 of query aligns to 19:492/493 of 6tg9B
- binding flavin mononucleotide: G146 (= G228), R147 (= R229), G148 (= G230), N174 (= N256), D176 (= D258), E177 (= E259), Y254 (≠ F344), G257 (= G347), E258 (= E348), N293 (= N383), N294 (= N384), S297 (≠ T387)
- binding 1,4-dihydronicotinamide adenine dinucleotide: F152 (= F234), K157 (= K239), E258 (= E348), E259 (= E349), L279 (≠ Y369), K466 (= K558), L470 (= L562)
- binding iron/sulfur cluster: S426 (= S516), C427 (= C517), G428 (= G518), T429 (≠ K519), C430 (= C520), C433 (= C523), L470 (= L562), C471 (= C563), G474 (= G566)
8qh7B Crystal structure of respiratory complex i subunits nuoef from aquifex aeolicus bound to reduced 3-acetylpyridine adenine dinucleotide (without reducing agent) (see paper)
44% identity, 64% coverage: 168:587/659 of query aligns to 1:415/417 of 8qh7B
- binding acetyl pyridine adenine dinucleotide, reduced: G65 (= G230), G66 (= G231), A67 (= A232), F69 (= F234), K74 (= K239), E93 (= E259), E95 (≠ D261), Y178 (≠ F344), E183 (= E349), Y203 (= Y369)
- binding 1-deoxy-1-(7,8-dimethyl-2,4-dioxo-3,4-dihydro-2h-benzo[g]pteridin-1-id-10(5h)-yl)-5-o-phosphonato-d-ribitol: G63 (= G228), G65 (= G230), K74 (= K239), N90 (= N256), D92 (= D258), E93 (= E259), G181 (= G347), E182 (= E348), V216 (≠ I382), N217 (= N383), N218 (= N384), T221 (= T387)
- binding iron/sulfur cluster: P197 (= P363), T344 (≠ S516), C345 (= C517), G346 (= G518), Q347 (≠ K519), C348 (= C520), C351 (= C523), S389 (= S561), I390 (≠ L562), C391 (= C563), L393 (= L565), G394 (= G566)
8qg1B Crystal structure of oxidized respiratory complex i subunits nuoef from aquifex aeolicus bound to adp-ribose (see paper)
44% identity, 64% coverage: 168:587/659 of query aligns to 1:415/417 of 8qg1B
- binding adenosine-5-diphosphoribose: G66 (= G231), A67 (= A232), F69 (= F234), K74 (= K239), E183 (= E349), Y203 (= Y369)
- binding flavin mononucleotide: G63 (= G228), G65 (= G230), K74 (= K239), N90 (= N256), D92 (= D258), E93 (= E259), Y178 (≠ F344), G181 (= G347), E182 (= E348), V216 (≠ I382), N217 (= N383), N218 (= N384), T221 (= T387)
- binding iron/sulfur cluster: P197 (= P363), T344 (≠ S516), C345 (= C517), G346 (= G518), Q347 (≠ K519), C348 (= C520), C351 (= C523), I390 (≠ L562), C391 (= C563), L393 (= L565), G394 (= G566)
6q9cB Crystal structure of aquifex aeolicus nadh-quinone oxidoreductase subunits nuoe and nuof bound to nadh under anaerobic conditions (see paper)
44% identity, 64% coverage: 168:587/659 of query aligns to 2:416/418 of 6q9cB
- binding flavin mononucleotide: G64 (= G228), G66 (= G230), K75 (= K239), N91 (= N256), D93 (= D258), E94 (= E259), G182 (= G347), E183 (= E348), E184 (= E349), V217 (≠ I382), N218 (= N383), N219 (= N384), T222 (= T387), G393 (= G564)
- binding 1,4-dihydronicotinamide adenine dinucleotide: G66 (= G230), G67 (= G231), A68 (= A232), F70 (= F234), K75 (= K239), E94 (= E259), E96 (≠ D261), Y179 (≠ F344), E184 (= E349), Y204 (= Y369)
- binding iron/sulfur cluster: P198 (= P363), T345 (≠ S516), C346 (= C517), G347 (= G518), Q348 (≠ K519), C349 (= C520), C352 (= C523), I391 (≠ L562), C392 (= C563), L394 (= L565), G395 (= G566)
8qgwB Crystal structure of oxidized respiratory complex i subunits nuoef from aquifex aeolicus bound to oxidized 3-acetylpyridine adenine dinucleotide (see paper)
44% identity, 64% coverage: 168:587/659 of query aligns to 1:415/418 of 8qgwB
- binding 3-acetylpyridine adenine dinucleotide: G66 (= G231), A67 (= A232), F69 (= F234), K74 (= K239), E183 (= E349), Y203 (= Y369)
- binding flavin mononucleotide: G63 (= G228), G65 (= G230), K74 (= K239), N90 (= N256), E93 (= E259), Y178 (≠ F344), G181 (= G347), E182 (= E348), E183 (= E349), V216 (≠ I382), N217 (= N383), N218 (= N384), T221 (= T387)
- binding iron/sulfur cluster: P197 (= P363), T344 (≠ S516), C345 (= C517), G346 (= G518), Q347 (≠ K519), C348 (= C520), C351 (= C523), I390 (≠ L562), C391 (= C563), L393 (= L565), G394 (= G566)
6saqB Wild-type nuoef from aquifex aeolicus bound to nadh-oh (see paper)
44% identity, 64% coverage: 168:587/659 of query aligns to 2:416/419 of 6saqB
- binding flavin mononucleotide: G64 (= G228), G66 (= G230), K75 (= K239), N91 (= N256), D93 (= D258), E94 (= E259), Y179 (≠ F344), G182 (= G347), E183 (= E348), N218 (= N383), N219 (= N384), T222 (= T387)
- binding [[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{S},4~{R},5~{R})-5-[[(1~{E},3~{Z})-5-azanyl-4-oxidanyl-5-oxidanylidene-penta-1,3-dienyl]-methanoyl-amino]-3,4-bis(oxidanyl)oxolan-2-yl]methyl hydrogen phosphate: G66 (= G230), G67 (= G231), A68 (= A232), F70 (= F234), K75 (= K239), E94 (= E259), E96 (≠ D261), T99 (≠ A264), E184 (= E349), Y204 (= Y369), T318 (≠ S489)
- binding iron/sulfur cluster: P198 (= P363), T345 (≠ S516), C346 (= C517), G347 (= G518), Q348 (≠ K519), C349 (= C520), C352 (= C523), I391 (≠ L562), C392 (= C563), G395 (= G566)
6hl3B Wild-type nuoef from aquifex aeolicus - oxidized form bound to NAD+ (see paper)
44% identity, 64% coverage: 168:587/659 of query aligns to 1:415/416 of 6hl3B
- binding flavin mononucleotide: G63 (= G228), G65 (= G230), K74 (= K239), N90 (= N256), D92 (= D258), E93 (= E259), G181 (= G347), E182 (= E348), E183 (= E349), V216 (≠ I382), N217 (= N383), N218 (= N384), T221 (= T387)
- binding nicotinamide-adenine-dinucleotide: G65 (= G230), G66 (= G231), A67 (= A232), F69 (= F234), K74 (= K239), E95 (≠ D261), Y178 (≠ F344), E183 (= E349), K200 (≠ R366), Y203 (= Y369)
- binding iron/sulfur cluster: I179 (≠ V345), P197 (= P363), T344 (≠ S516), C345 (= C517), G346 (= G518), Q347 (≠ K519), C348 (= C520), C351 (= C523), S389 (= S561), I390 (≠ L562), C391 (= C563), L393 (= L565), G394 (= G566)
6hl2B Wild-type nuoef from aquifex aeolicus - oxidized form (see paper)
44% identity, 64% coverage: 168:587/659 of query aligns to 1:415/416 of 6hl2B
- binding flavin mononucleotide: G63 (= G228), G65 (= G230), K74 (= K239), N90 (= N256), E93 (= E259), G181 (= G347), E182 (= E348), E183 (= E349), V216 (≠ I382), N217 (= N383), N218 (= N384), T221 (= T387)
- binding iron/sulfur cluster: P197 (= P363), T344 (≠ S516), C345 (= C517), G346 (= G518), Q347 (≠ K519), C348 (= C520), C351 (= C523), S389 (= S561), I390 (≠ L562), C391 (= C563), G394 (= G566)
Query Sequence
>WP_012282818.1 NCBI__GCF_000019165.1:WP_012282818.1
MKSLMDPCCQRCAHRPETPCREYLRCRTEGPLCHDDEQCRKARLERIEAVEGATPAQRPM
QNLIHESRRWRLLLCAGTGCIASGGAPVVAALREVVEERGMSNQVAIVLTGCHGFCEQGP
IVVVEPGNTFYRRVSAADVRDIVDTHLIGGQKVDRLLYRLPGGEAVASYPEIPFYARQHR
IVLANCGHINPEDLGEYLARQGYRGFLKALAMERAAVIAEVKRSGLRGRGGAGFLTGQKW
EFTADAPGEEKYIVCNADEGDPGAFMDRSVLEGDPHAVLEGMLVAGYAIGAREGYIYVRA
EYPLAIRRLRTAIAQAEACGLLGENILASGFSFRVYVKAGAGAFVCGEETALLTSIEGNR
GMPRVRPPYPAVKGLWSKPTNINNVETLANIPHILRRGADWYAAMGVGRSKGSKVFALTG
KVNNTGLVEVPMGLSLREIIFAIGGGIQGGKAFKAVQIGGPSGGCLPESLLDTPVDYESL
LEAGAMVGSGGLVVMDESTCMVDIARYFLNFTQQESCGKCAPCREGTKRMLEIVTRITEG
EGRLEDLEALEKLAAVIKDTSLCGLGQSAPNPVLTTLRYFRDEYEAHIHDQRCPAGRCAA
LLTYRIDADKCRGCTLCARRCPVGCITGKPREAYAIDETRCIKCGACLECCKFGAVIRR
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory