Comparing WP_012284030.1 NCBI__GCF_000019165.1:WP_012284030.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
O23346 Imidazoleglycerol-phosphate dehydratase 2, chloroplastic; IGPD 2; Protein HISTIDINE BIOSYNTHESIS 5B; EC 4.2.1.19 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
54% identity, 96% coverage: 8:195/195 of query aligns to 82:269/272 of O23346
Sites not aligning to the query:
5el9A A. Thaliana igpd2 in complex with the triazole-phosphonate inhibitor, (s)-c348, to 1.1a resolution (see paper)
54% identity, 96% coverage: 8:195/195 of query aligns to 9:196/199 of 5el9A
P34047 Imidazoleglycerol-phosphate dehydratase 1, chloroplastic; IGPD 1; Protein HISTIDINE BIOSYNTHESIS 5A; EC 4.2.1.19 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
53% identity, 96% coverage: 8:195/195 of query aligns to 80:267/270 of P34047
5ekwA A. Thaliana igpd2 in complex with the racemate of the triazole- phosphonate inhibitor, c348 (see paper)
53% identity, 95% coverage: 8:193/195 of query aligns to 9:194/194 of 5ekwA
4qnkA The structure of wt a. Thaliana igpd2 in complex with mn2+ and phosphate (see paper)
54% identity, 90% coverage: 8:182/195 of query aligns to 9:183/185 of 4qnkA
4mu1A The structure of wt a. Thaliana igpd2 in complex with mn2+, imidazole, and sulfate at 1.5 a resolution (see paper)
54% identity, 90% coverage: 8:182/195 of query aligns to 9:183/185 of 4mu1A
4mu0A The structure of wt a. Thaliana igpd2 in complex with mn2+ and 1,2,4- triazole at 1.3 a resolution (see paper)
54% identity, 90% coverage: 8:182/195 of query aligns to 9:183/185 of 4mu0A
4mu3A The form a structure of an e21q catalytic mutant of a. Thaliana igpd2 in complex with mn2+ and a mixture of its substrate, 2r3s-igp, and an inhibitor, 2s3s-igp, to 1.12 a resolution (see paper)
54% identity, 90% coverage: 8:182/195 of query aligns to 9:183/186 of 4mu3A
2f1dA X-ray structure of imidazoleglycerol-phosphate dehydratase (see paper)
54% identity, 90% coverage: 8:182/195 of query aligns to 8:182/183 of 2f1dA
8qavA Medicago truncatula hisn5 (igpd) in complex with mn and ig2 (see paper)
55% identity, 89% coverage: 8:181/195 of query aligns to 8:181/184 of 8qavA
8qawA Medicago truncatula hisn5 (igpd) in complex with mn, imd, edo, fmt, gol and trs (see paper)
55% identity, 89% coverage: 8:181/195 of query aligns to 9:182/185 of 8qawA
6fwhL Acanthamoeba igpd in complex with r-c348 to 1.7a resolution (see paper)
51% identity, 99% coverage: 2:195/195 of query aligns to 2:194/195 of 6fwhL
6fwhA Acanthamoeba igpd in complex with r-c348 to 1.7a resolution (see paper)
51% identity, 99% coverage: 2:195/195 of query aligns to 3:195/196 of 6fwhA
Q9S5G5 Histidine biosynthesis bifunctional protein HisB; EC 3.1.3.15; EC 4.2.1.19 from Escherichia coli O157:H7 (see paper)
52% identity, 99% coverage: 2:195/195 of query aligns to 167:355/355 of Q9S5G5
Sites not aligning to the query:
P9WML9 Imidazoleglycerol-phosphate dehydratase; IGPD; EC 4.2.1.19 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
47% identity, 94% coverage: 12:195/195 of query aligns to 21:210/210 of P9WML9
2ae8B Crystal structure of imidazoleglycerol-phosphate dehydratase from staphylococcus aureus subsp. Aureus n315
49% identity, 87% coverage: 6:174/195 of query aligns to 4:165/172 of 2ae8B
P40374 Imidazoleglycerol-phosphate dehydratase; IGPD; EC 4.2.1.19 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
41% identity, 100% coverage: 1:195/195 of query aligns to 1:216/216 of P40374
1rhyB Crystal structure of imidazole glycerol phosphate dehydratase (see paper)
45% identity, 91% coverage: 2:179/195 of query aligns to 3:178/180 of 1rhyB
5xdsA Crystal structure of mycobacterium tuberculosis hisb bound with an inhibitor (see paper)
46% identity, 88% coverage: 12:182/195 of query aligns to 12:189/191 of 5xdsA
4lomA Crystal structure of mycobacterium tuberculosis hisb in complex with its substrate
46% identity, 88% coverage: 12:182/195 of query aligns to 12:189/191 of 4lomA
>WP_012284030.1 NCBI__GCF_000019165.1:WP_012284030.1
MRGASYVRNTAETRISIDLFLDGKGVYDGTTGIGFLDHMFTLLARHGQLDLTIGCQGDLE
VDTHHTVEDLGICLGNALAQALGDKKGICRYGHAYVPMDETLVRVCLDLSGRPFLVYKVK
IPVERVGQLETEMVEEFFRALSNRAGMNLHIHLLEGGNGHHIIEAIFKAFGRALRQAVAI
DPDNAGRVLSTKGVL
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Lawrence Berkeley National Laboratory