SitesBLAST
Comparing WP_012334439.1 NCBI__GCF_000019365.1:WP_012334439.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
8b7sA Crystal structure of the chloramphenicol-inactivating oxidoreductase from novosphingobium sp (see paper)
36% identity, 96% coverage: 2:540/561 of query aligns to 2:458/458 of 8b7sA
- binding flavin-adenine dinucleotide: G11 (= G11), G13 (= G13), S14 (= S14), A15 (= A15), E35 (= E35), A36 (= A36), W47 (= W64), P65 (≠ G82), G67 (= G84), V180 (≠ T224), A214 (≠ S259), G215 (= G260), A218 (= A263), T270 (= T336), Y391 (= Y473), A424 (= A506), I435 (≠ L517), N436 (= N518)
5nccA Structure of fatty acid photodecarboxylase in complex with fad and palmitic acid (see paper)
33% identity, 96% coverage: 3:541/561 of query aligns to 22:578/578 of 5nccA
- active site: R347 (≠ P325), L420 (≠ V387), I421 (≠ G388), S507 (≠ A472), A509 (≠ H474), G552 (= G515), Q553 (≠ N516)
- binding flavin-adenine dinucleotide: G30 (= G11), G32 (= G13), T33 (≠ S14), A34 (= A15), L53 (= L34), E54 (= E35), A55 (= A36), F74 (≠ L57), W80 (= W64), A98 (≠ G82), G100 (= G84), G105 (= G89), S106 (= S90), N110 (= N94), A111 (≠ G95), T112 (≠ M96), L113 (≠ C97), V238 (≠ T224), A278 (≠ S259), H282 (≠ A263), L286 (≠ I267), N508 (≠ Y473), Q553 (≠ N516), T554 (≠ L517), G555 (≠ N518), V558 (≠ T521)
6yrvAAA structure of fap after illumination at 100k (see paper)
33% identity, 97% coverage: 3:544/561 of query aligns to 6:572/573 of 6yrvAAA
- binding carbon dioxide: R375 (≠ H364), N499 (≠ Y473)
- binding flavin-adenine dinucleotide: G14 (= G11), G16 (= G13), T17 (≠ S14), A18 (= A15), L37 (= L34), E38 (= E35), A39 (= A36), F58 (≠ L57), W64 (= W64), A82 (≠ G82), G89 (= G89), S90 (= S90), N94 (= N94), A95 (≠ G95), T96 (≠ M96), L97 (≠ C97), M191 (≠ V193), V222 (≠ T224), C264 (= C258), A265 (≠ S259), G266 (= G260), H269 (≠ A263), N499 (≠ Y473), A534 (= A506), Q544 (≠ N516), T545 (≠ L517), G546 (≠ N518)
- binding heptadecane: V377 (≠ L366), G379 (vs. gap), M380 (≠ L368), G386 (= G374), T389 (≠ H376), Y390 (≠ A377), F393 (≠ S380), T408 (vs. gap), Q410 (vs. gap)
A0A248QE08 Fatty acid photodecarboxylase, chloroplastic; CvFAP; EC 4.1.1.106 from Chlorella variabilis (Green alga) (see paper)
32% identity, 96% coverage: 3:538/561 of query aligns to 82:642/654 of A0A248QE08
- TA 93:94 (≠ SA 14:15) binding FAD
- E114 (= E35) binding FAD
- L162 (≠ G86) binding FAD
- S166 (= S90) binding FAD
- NATL 170:173 (≠ NGMC 94:97) binding FAD
- V298 (≠ T224) binding FAD
- C432 (≠ F344) binding hexadecanoate
- R451 (≠ H364) binding hexadecanoate
- Y466 (≠ A377) binding hexadecanoate
- Q486 (vs. gap) binding hexadecanoate
- G622 (≠ N518) binding FAD
3ljpA Crystal structure of choline oxidase v464a mutant (see paper)
34% identity, 95% coverage: 3:533/561 of query aligns to 12:527/530 of 3ljpA
- active site: I333 (≠ A346), P377 (≠ V387), N378 (≠ G388), A464 (= A472), H466 (= H474), V509 (≠ G515), N510 (= N516)
- binding dihydroflavine-adenine dinucleotide: G22 (= G13), S23 (= S14), E44 (= E35), A45 (= A36), W71 (= W64), R89 (= R83), A90 (≠ G84), G95 (= G89), C96 (≠ S90), H99 (≠ I93), N100 (= N94), S101 (≠ G95), I103 (≠ C97), A232 (≠ T224), T269 (≠ S259), D273 (≠ A263), Y465 (= Y473), H466 (= H474), D499 (= D505), A500 (= A506), N510 (= N516), P511 (≠ L517), N512 (= N518), V515 (≠ T521)
4mjwA Crystal structure of choline oxidase in complex with the reaction product glycine betaine (see paper)
34% identity, 95% coverage: 3:533/561 of query aligns to 12:527/532 of 4mjwA
- active site: I333 (≠ A346), P377 (≠ V387), N378 (≠ G388), V464 (≠ A472), H466 (= H474), V509 (≠ G515), N510 (= N516)
- binding flavin-adenine dinucleotide: G20 (= G11), G22 (= G13), S23 (= S14), E44 (= E35), A45 (= A36), W71 (= W64), R89 (= R83), A90 (≠ G84), G95 (= G89), C96 (≠ S90), H99 (≠ I93), N100 (= N94), S101 (≠ G95), I103 (≠ C97), R231 (≠ L223), A232 (≠ T224), T269 (≠ S259), G270 (= G260), D273 (≠ A263), Y465 (= Y473), H466 (= H474), A500 (= A506), N510 (= N516), P511 (≠ L517), N512 (= N518), V515 (≠ T521)
2jbvA Crystal structure of choline oxidase reveals insights into the catalytic mechanism (see paper)
34% identity, 95% coverage: 3:533/561 of query aligns to 12:527/527 of 2jbvA
- active site: I333 (≠ A346), P377 (≠ V387), N378 (≠ G388), V464 (≠ A472), H466 (= H474), V509 (≠ G515), N510 (= N516)
- binding [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl (2R,3S,4S)-5-[(4aS,10aR)-7,8-dimethyl-2,4-dioxo-1,3,4,4a,5,10a-hexahydrobenzo[g]pteridin-10(2H)-yl]-2,3,4-trihydroxypentyl dihydrogen diphosphate: G22 (= G13), S23 (= S14), E44 (= E35), A45 (= A36), W71 (= W64), A90 (≠ G84), G95 (= G89), C96 (≠ S90), H99 (≠ I93), N100 (= N94), S101 (≠ G95), I103 (≠ C97), R231 (≠ L223), A232 (≠ T224), T269 (≠ S259), G270 (= G260), D273 (≠ A263), V464 (≠ A472), Y465 (= Y473), H466 (= H474), D499 (= D505), A500 (= A506), N510 (= N516), P511 (≠ L517), N512 (= N518), V515 (≠ T521)
4ha6A Crystal structure of pyridoxine 4-oxidase - pyridoxamine complex (see paper)
34% identity, 93% coverage: 6:529/561 of query aligns to 3:501/508 of 4ha6A
- active site: F360 (vs. gap), G361 (= G388), H444 (≠ A472), H446 (= H474), G487 (= G515), P488 (≠ N516)
- binding flavin-adenine dinucleotide: G8 (= G11), G10 (= G13), S11 (= S14), A12 (= A15), E32 (= E35), A33 (= A36), W58 (= W64), R77 (= R83), G78 (= G84), G83 (= G89), S84 (= S90), L87 (≠ I93), H88 (≠ N94), A89 (≠ G95), M90 (= M96), G91 (≠ C97), V218 (≠ T224), A251 (≠ S259), G252 (= G260), E255 (≠ A263), H445 (≠ Y473), A478 (= A506), P488 (≠ N516), I489 (≠ L517), H490 (≠ N518)
- binding 4-(aminomethyl)-5-(hydroxymethyl)-2-methylpyridin-3-ol: A89 (≠ G95), S314 (≠ F344), H444 (≠ A472), H446 (= H474)
3t37A Crystal structure of pyridoxine 4-oxidase from mesorbium loti
34% identity, 93% coverage: 6:529/561 of query aligns to 3:501/509 of 3t37A
- active site: F360 (vs. gap), G361 (= G388), H444 (≠ A472), H446 (= H474), G487 (= G515), P488 (≠ N516)
- binding flavin-adenine dinucleotide: G8 (= G11), G10 (= G13), S11 (= S14), A12 (= A15), E32 (= E35), A33 (= A36), W58 (= W64), R77 (= R83), G78 (= G84), R79 (≠ K85), G83 (= G89), S84 (= S90), H88 (≠ N94), A89 (≠ G95), G91 (≠ C97), R217 (≠ L223), V218 (≠ T224), A251 (≠ S259), E255 (≠ A263), H445 (≠ Y473), A478 (= A506), P488 (≠ N516), I489 (≠ L517), H490 (≠ N518)
E4QP00 5-(hydroxymethyl)furfural oxidase; 5-hydroxymethylfurfural oxidase; HMFO; Thiol oxidase; EC 1.1.3.47; EC 1.8.3.- from Methylovorus sp. (strain MP688) (see paper)
33% identity, 94% coverage: 5:532/561 of query aligns to 6:527/531 of E4QP00
- V101 (≠ I93) mutation to H: Abolishes activity.
- M103 (≠ G95) mutation to A: 16-fold reduction in catalytic efficiency on vanillyl alcohol.
- V367 (≠ S382) mutation to K: 1.6-fold reduction in catalytic efficiency on vanillyl alcohol. Shows significantly improved activity on the aldehyde 5-formyl-2-furancarboxylate, which results in a better 5-hydroxymethylfurfural to 2,5-furandicarboxylate conversion.; mutation to R: 1.4-fold reduction in catalytic efficiency on vanillyl alcohol. Shows significantly improved activity on the aldehyde 5-formyl-2-furancarboxylate, which results in a better 5-hydroxymethylfurfural to 2,5-furandicarboxylate conversion. Displays a catalytic efficiency toward 5-formyl-2-furancarboxylate that is over 1000-fold higher than that for wild-type; when associated with F-466.
- W369 (≠ Q384) mutation to A: 7.5-fold reduction in catalytic efficiency on vanillyl alcohol.
- V465 (≠ A472) mutation to A: 18-fold reduction in catalytic efficiency on vanillyl alcohol.
- W466 (≠ Y473) mutation to A: 39-fold reduction in catalytic efficiency on vanillyl alcohol. In contrast to wild-type, is active on secondary alcohols, such as (S)-1-phenylethanol, and is strictly enantionselective as this mutant has no activity on (R)-1-phenylethanol. Shows increased activity on the aldehyde 5-formyl-2-furancarboxylate.; mutation to F: 3.4-fold reduction in catalytic efficiency on vanillyl alcohol. In contrast to wild-type, is active on secondary alcohols, such as (S)-1-phenylethanol, and is strictly enantionselective as this mutant has no activity on (R)-1-phenylethanol. Shows increased activity on the aldehyde 5-formyl-2-furancarboxylate. Displays a catalytic efficiency toward 5-formyl-2-furancarboxylate that is over 1000-fold higher than that for wild-type; when associated with R-367.
- H467 (= H474) mutation to A: Abolishes activity.
- N511 (= N516) mutation to A: 53-fold reduction in catalytic efficiency on vanillyl alcohol.
4udqA Crystal structure of 5-hydroxymethylfurfural oxidase (hmfo) in the reduced state
33% identity, 94% coverage: 5:532/561 of query aligns to 2:523/525 of 4udqA
- active site: L331 (≠ I327), F364 (= F383), W365 (≠ Q384), V461 (≠ A472), H463 (= H474), A506 (≠ G515), N507 (= N516)
- binding flavin-adenine dinucleotide: G8 (= G11), G10 (= G13), T11 (≠ S14), A12 (= A15), E32 (= E35), A33 (= A36), W64 (= W64), G88 (= G84), G93 (= G89), G94 (≠ S90), N98 (= N94), M99 (≠ G95), V101 (≠ C97), V229 (≠ T224), T261 (≠ C258), A262 (≠ S259), W462 (≠ Y473), H463 (= H474), A497 (= A506), N507 (= N516), T508 (≠ L517), N509 (= N518), T512 (= T521)
8bxlB Patulin synthase from penicillium expansum (see paper)
31% identity, 95% coverage: 3:534/561 of query aligns to 12:588/590 of 8bxlB
- binding flavin-adenine dinucleotide: G20 (= G11), G22 (= G13), T23 (≠ S14), A24 (= A15), E44 (= E35), A45 (= A36), W80 (= W64), G100 (= G84), G105 (= G89), S106 (= S90), R109 (≠ I93), N110 (= N94), Y111 (≠ G95), A113 (≠ C97), L253 (= L223), A254 (≠ T224), A288 (≠ S259), Q292 (≠ A263), F525 (≠ Y473), D559 (= D505), A560 (= A506), H570 (≠ N516), P571 (≠ L517), Q572 (≠ N518), L575 (≠ T521)
4h7uA Crystal structure of pyranose dehydrogenase from agaricus meleagris, wildtype (see paper)
29% identity, 93% coverage: 4:526/561 of query aligns to 15:566/577 of 4h7uA
- active site: A343 (= A326), V426 (≠ G388), Y510 (≠ A472), H512 (= H474), A555 (≠ G515), H556 (≠ N516)
- binding [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl (2R,3S,4S)-2,3,4-trihydroxy-5-[(4aR)-4a-hydroxy-7,8-dimethyl-2,4-dioxo-3,4,4a,5-tetrahydrobenzo[g]pteridin-10(2H)-yl]pentyl dihydrogen diphosphate (non-preferred name): G22 (= G11), G24 (= G13), T25 (≠ S14), A26 (= A15), E46 (= E35), A47 (= A36), W74 (= W64), G99 (= G89), C100 (≠ S90), H103 (≠ I93), N104 (= N94), G105 (= G95), V107 (≠ C97), L242 (= L223), V243 (≠ T224), G282 (≠ S259), G283 (= G260), A286 (= A263), H512 (= H474), A546 (= A506), H556 (≠ N516), T557 (≠ L517), Q558 (≠ N518), V561 (≠ T521)
Q3L245 Pyranose dehydrogenase 1; PDH 1; Pyranose:quinone oxidoreductase 1; EC 1.1.99.29 from Leucoagaricus meleagris (Western flat-topped agaric) (Agaricus meleagris) (see 2 papers)
29% identity, 93% coverage: 4:526/561 of query aligns to 40:591/602 of Q3L245
- N100 (≠ A65) modified: carbohydrate, N-linked (GlcNAc...) asparagine
- H128 (≠ I93) modified: Tele-8alpha-FAD histidine
- N344 (= N296) modified: carbohydrate, N-linked (GlcNAc...) asparagine
- H537 (= H474) active site, Proton acceptor
- H581 (≠ N516) active site
Sites not aligning to the query:
4yntA Crystal structure of aspergillus flavus fad glucose dehydrogenase (see paper)
29% identity, 95% coverage: 2:533/561 of query aligns to 2:564/570 of 4yntA
- active site: V342 (≠ R330), F413 (≠ S382), W414 (≠ F383), N502 (≠ A472), H504 (= H474), G546 (= G515), H547 (≠ N516)
- binding dihydroflavine-adenine dinucleotide: G13 (= G13), T14 (≠ S14), S15 (≠ A15), E35 (= E35), A36 (= A36), F56 (≠ Y55), W62 (= W64), R80 (≠ G82), G82 (= G84), G87 (= G89), T88 (≠ S90), N92 (= N94), G93 (= G95), M94 (= M96), A95 (≠ C97), A234 (≠ T224), A274 (≠ S259), R278 (≠ A263), F503 (≠ Y473), A537 (= A506), H547 (≠ N516), L548 (= L517), V549 (≠ N518), L552 (≠ T521)
4ynuA Crystal structure of aspergillus flavus fadgdh in complex with d- glucono-1,5-lactone (see paper)
29% identity, 95% coverage: 2:533/561 of query aligns to 1:563/569 of 4ynuA
- active site: V341 (≠ R330), F412 (≠ S382), W413 (≠ F383), N501 (≠ A472), H503 (= H474), G545 (= G515), H546 (≠ N516)
- binding flavin-adenine dinucleotide: G12 (= G13), T13 (≠ S14), S14 (≠ A15), E34 (= E35), A35 (= A36), Y51 (≠ A51), F55 (≠ Y55), W61 (= W64), R79 (≠ G82), G81 (= G84), G86 (= G89), T87 (≠ S90), N91 (= N94), G92 (= G95), T232 (≠ L223), A233 (≠ T224), A273 (≠ S259), G274 (= G260), R277 (≠ A263), F502 (≠ Y473), A536 (= A506), H546 (≠ N516), L547 (= L517), V548 (≠ N518), L551 (≠ T521)
- binding D-glucono-1,5-lactone: Y51 (≠ A51), E411 (≠ H381), A496 (= A467), N497 (≠ H468), R499 (≠ E470), R499 (≠ E470), N501 (≠ A472), H503 (= H474), H546 (≠ N516)
7vzsA Fad-dpendent glucose dehydrogenase complexed with an inhibitor at ph7.56
29% identity, 95% coverage: 2:533/561 of query aligns to 1:563/566 of 7vzsA
- binding D-glucal: Y6 (≠ F7), L22 (= L23), N25 (≠ D26), Y51 (≠ A51), I349 (= I338), Q356 (≠ E345), E411 (≠ H381), E444 (≠ D419), W445 (≠ Q420), K448 (≠ R423), R499 (≠ E470), N501 (≠ A472), H546 (≠ N516), K563 (≠ R533)
- binding flavin-adenine dinucleotide: G10 (= G11), G12 (= G13), T13 (≠ S14), S14 (≠ A15), E34 (= E35), A35 (= A36), Y51 (≠ A51), F55 (≠ Y55), W61 (= W64), R79 (≠ G82), G81 (= G84), G86 (= G89), T87 (≠ S90), N91 (= N94), G92 (= G95), M93 (= M96), A94 (≠ C97), T232 (≠ L223), A233 (≠ T224), A273 (≠ S259), G274 (= G260), R277 (≠ A263), F502 (≠ Y473), A536 (= A506), H546 (≠ N516), L547 (= L517), V548 (≠ N518), L551 (≠ T521)
Sites not aligning to the query:
5oc1A Crystal structure of aryl-alcohol oxidase from pleurotus eryngii in complex with p-anisic acid (see paper)
27% identity, 94% coverage: 4:533/561 of query aligns to 1:562/565 of 5oc1A
- active site: V339 (≠ P317), N413 (≠ G388), A414 (≠ S389), I499 (≠ A472), H501 (= H474), A544 (≠ G515), H545 (≠ N516)
- binding 4-methoxybenzoic acid: Y91 (≠ G95), I356 (vs. gap), I390 (≠ A357), F396 (≠ Y363), T412 (≠ V387), I499 (≠ A472), H501 (= H474), H545 (≠ N516)
- binding flavin-adenine dinucleotide: G8 (= G11), G10 (= G13), N11 (≠ S14), A12 (= A15), E32 (= E35), A33 (= A36), W60 (= W64), P78 (≠ G82), G80 (= G84), G85 (= G89), S86 (= S90), H90 (≠ N94), Y91 (≠ G95), V93 (≠ C97), V230 (≠ T224), S270 (≠ C258), A271 (≠ S259), G272 (= G260), F500 (≠ Y473), H545 (≠ N516), T546 (≠ L517), Q547 (≠ N518), I550 (≠ T521)
3fimB Crystal structure of aryl-alcohol-oxidase from pleurotus eryingii (see paper)
27% identity, 94% coverage: 4:533/561 of query aligns to 1:562/565 of 3fimB
- active site: V339 (≠ P317), N413 (≠ G388), A414 (≠ S389), I499 (≠ A472), H501 (= H474), A544 (≠ G515), H545 (≠ N516)
- binding flavin-adenine dinucleotide: G8 (= G11), N11 (≠ S14), A12 (= A15), E32 (= E35), A33 (= A36), W60 (= W64), P78 (≠ G82), G80 (= G84), G85 (= G89), S86 (= S90), H90 (≠ N94), Y91 (≠ G95), V93 (≠ C97), V230 (≠ T224), S270 (≠ C258), A271 (≠ S259), F500 (≠ Y473), H501 (= H474), H545 (≠ N516), T546 (≠ L517), Q547 (≠ N518), I550 (≠ T521)
3q9tA Crystal structure analysis of formate oxidase (see paper)
26% identity, 95% coverage: 5:535/561 of query aligns to 7:572/577 of 3q9tA
- active site: A335 (= A326), D422 (≠ G388), A508 (= A472), H510 (= H474), C552 (≠ G515), R553 (≠ N516)
- binding [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl(2R,3S,4S)-5-(8-formyl-7-methyl-2,4-dioxo-3,4-dihydrobenzo[g]pteridin-10(2H)-yl)-2,3,4-trihydroxypentyl dihydrogendiphosphate: G15 (= G13), T16 (≠ S14), E37 (= E35), A38 (= A36), W65 (= W64), T85 (≠ G82), R86 (= R83), G87 (= G84), G92 (= G89), S93 (= S90), N97 (= N94), Y98 (≠ G95), F99 (≠ M96), T100 (≠ C97), S229 (≠ T224), S265 (≠ C258), Q266 (≠ S259), E270 (≠ A263), F509 (≠ Y473), D542 (= D505), A543 (= A506), R553 (≠ N516), I554 (≠ L517), Q555 (≠ N518), V558 (≠ T521)
Query Sequence
>WP_012334439.1 NCBI__GCF_000019365.1:WP_012334439.1
MTQEYDFIIVGAGSAGNVLAARLTEDADVSVLLLEAGGPDYRFDFRTQMPAALAYPLQGR
RYNWAYLTDPEPHMNNRRMECGRGKGLGGSSLINGMCYIRGNPLDYDGWARLPSLADWSY
GDCLPYFRRAETRDLGPDTYHGGDGPLYVTAAKPGGNVLFEAMIEAGVQAGYPRTADLNG
YQQEGFGPMDRSVTAKGRRSSTARGYLDQARERPNLTIVTHALTDRILFNGKRASGVVYL
RGNKEPSFARARREVLVCSGAIASPQILQRSGVGPANLLRNLDVPLVLDLPGVGENLQDH
LEMYVQYECRQPVSLAPALKPWNQPAIGARWLFAGTGIGASNQFEAGGFIRSDSEFAWPN
LQYHFLPLAISYNGSHAVKSHSFQAHVGSMRSPSRGRIRLTSRDPHAHPSILFNYMSADQ
DWREFRVAIRITREIMAQPALDPYRGREISPGAALRSDAELDAFVRAHAETAYHPSCSCK
MGEDAMAVVDGRGRVHGLEGLRVVDASIMPQIVTGNLNAPTIMIAEKIADDIRGRTPLPR
SQAAYFVAGDTPPRRRPVRAS
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory