SitesBLAST
Comparing WP_012336155.1 NCBI__GCF_000019365.1:WP_012336155.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
4rjiC Acetolactate synthase from bacillus subtilis bound to thdp - crystal form i (see paper)
29% identity, 94% coverage: 11:537/561 of query aligns to 5:532/555 of 4rjiC
- binding magnesium ion: D438 (= D442), D465 (≠ N469), T467 (≠ S471)
- binding thiamine diphosphate: P24 (= P30), E48 (= E54), P74 (= P80), S387 (≠ N392), H388 (≠ Y393), Q411 (≠ A415), G437 (= G441), D438 (= D442), G439 (= G443), G440 (≠ D444), T467 (≠ S471), Y468 (= Y472), D469 (≠ G473), M470 (≠ T474), V471 (≠ I475)
Sites not aligning to the query:
4rjkG Acetolactate synthase from bacillus subtilis bound to lthdp - crystal form ii (see paper)
29% identity, 94% coverage: 11:537/561 of query aligns to 4:531/553 of 4rjkG
- binding magnesium ion: D437 (= D442), D464 (≠ N469), T466 (≠ S471)
- binding 3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-(1-carboxy-1-hydroxyethyl)-5-(2-{[hydroxy(phosphonooxy)phosphoryl]oxy}ethyl)-4-methyl-1,3-thiazol-3-ium: E47 (= E54), Q110 (= Q117)
- binding thiamine diphosphate: I384 (≠ A390), G385 (= G391), S386 (≠ N392), H387 (≠ Y393), Q410 (≠ A415), L412 (≠ M417), G436 (= G441), D437 (= D442), G438 (= G443), G439 (≠ D444), T466 (≠ S471), Y467 (= Y472), D468 (≠ G473), M469 (≠ T474), V470 (≠ I475)
Sites not aligning to the query:
4rjkF Acetolactate synthase from bacillus subtilis bound to lthdp - crystal form ii (see paper)
29% identity, 94% coverage: 11:537/561 of query aligns to 4:531/552 of 4rjkF
- binding magnesium ion: D437 (= D442), D464 (≠ N469), T466 (≠ S471)
- binding pyruvic acid: A25 (≠ E32), K26 (≠ S33)
- binding thiamine diphosphate: P23 (= P30), E47 (= E54), P73 (= P80), G385 (= G391), S386 (≠ N392), H387 (≠ Y393), Q410 (≠ A415), L412 (≠ M417), G436 (= G441), D437 (= D442), G438 (= G443), G439 (≠ D444), T466 (≠ S471), Y467 (= Y472), D468 (≠ G473), M469 (≠ T474), V470 (≠ I475)
Sites not aligning to the query:
5d6rB Acetolactate synthase from klebsiella pneumoniae in complex with mechanism-based inhibitor
29% identity, 94% coverage: 11:537/561 of query aligns to 8:533/548 of 5d6rB
- active site: I26 (≠ V29), G28 (= G31), A29 (≠ E32), K30 (≠ S33), I31 (≠ F34), E51 (= E54), T74 (= T77), H113 (≠ F116), Q114 (= Q117), S115 (≠ E118), Q163 (≠ K166), L254 (= L257), E281 (≠ P284), M386 (≠ A390), Q412 (≠ A415), M414 (= M417), D439 (= D442), D466 (≠ N469), G468 (≠ S471), Y469 (= Y472), M471 (≠ T474), V472 (≠ I475), Q475 (≠ H478)
- binding 3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-[(Z)-2-fluoro-1-hydroxy-2-phosphonoethenyl]-5-(2-{[(S)-hydroxy(phosphonooxy)phosphoryl]oxy}ethyl)-4-methyl-1,3-thiazol-3-ium: M386 (≠ A390), G387 (= G391), S388 (≠ N392), Q412 (≠ A415), M414 (= M417), D439 (= D442), G440 (= G443), G468 (≠ S471), Y469 (= Y472), N470 (≠ G473), M471 (≠ T474)
- binding magnesium ion: R63 (≠ K66), Q212 (≠ S216), D439 (= D442), D466 (≠ N469), G468 (≠ S471)
Sites not aligning to the query:
1ozfA The crystal structure of klebsiella pneumoniae acetolactate synthase with enzyme-bound cofactors (see paper)
29% identity, 94% coverage: 11:537/561 of query aligns to 8:532/545 of 1ozfA
- active site: I26 (≠ V29), G28 (= G31), A29 (≠ E32), K30 (≠ S33), I31 (≠ F34), E51 (= E54), T74 (= T77), H113 (≠ F116), Q114 (= Q117), S115 (≠ E118), Q163 (≠ K166), L253 (= L257), E280 (≠ P284), M385 (≠ A390), Q411 (≠ A415), M413 (= M417), D438 (= D442), D465 (≠ N469), G467 (≠ S471), Y468 (= Y472), M470 (≠ T474), V471 (≠ I475), Q474 (≠ H478)
- binding magnesium ion: D438 (= D442), D465 (≠ N469), G467 (≠ S471)
- binding phosphate ion: G249 (= G253), R250 (≠ D254), Q257 (≠ P261), R343 (≠ A355), R394 (= R399), L396 (vs. gap), Y397 (= Y401)
- binding thiamine diphosphate: G386 (= G391), S387 (≠ N392), F388 (≠ Y393), Q411 (≠ A415), M413 (= M417), G437 (= G441), D438 (= D442), G439 (= G443), D465 (≠ N469), G467 (≠ S471), Y468 (= Y472), N469 (≠ G473), M470 (≠ T474), V471 (≠ I475)
Sites not aligning to the query:
1ozgA The crystal structure of klebsiella pneumoniae acetolactate synthase with enzyme-bound cofactor and with an unusual intermediate (see paper)
29% identity, 94% coverage: 11:537/561 of query aligns to 9:536/549 of 1ozgA
- active site: I27 (≠ V29), G29 (= G31), A30 (≠ E32), K31 (≠ S33), I32 (≠ F34), E52 (= E54), T75 (= T77), H114 (≠ F116), Q115 (= Q117), S116 (≠ E118), Q164 (≠ K166), L257 (= L257), E284 (≠ P284), M389 (≠ A390), Q415 (≠ A415), M417 (= M417), D442 (= D442), D469 (≠ N469), G471 (≠ S471), Y472 (= Y472), M474 (≠ T474), V475 (≠ I475), Q478 (≠ H478)
- binding 2-hydroxyethyl dihydrothiachrome diphosphate: M389 (≠ A390), G390 (= G391), S391 (≠ N392), F392 (≠ Y393), Q415 (≠ A415), M417 (= M417), G441 (= G441), D442 (= D442), G443 (= G443), D469 (≠ N469), G471 (≠ S471), Y472 (= Y472), N473 (≠ G473), M474 (≠ T474), V475 (≠ I475)
- binding magnesium ion: D442 (= D442), D469 (≠ N469), G471 (≠ S471)
- binding phosphate ion: G253 (= G253), R254 (≠ D254), Q261 (≠ P261), R347 (≠ A355), R398 (= R399), Y401 (= Y401)
Sites not aligning to the query:
5dx6B Acetolactate synthase from klebsiella pneumoniae soaked with beta- fluoropyruvate
29% identity, 96% coverage: 1:537/561 of query aligns to 7:539/557 of 5dx6B
- active site: I38 (≠ V29), G40 (= G31), A41 (≠ E32), K42 (≠ S33), I43 (≠ F34), E63 (= E54), T86 (= T77), H125 (≠ F116), Q126 (= Q117), S127 (≠ E118), Q175 (≠ K166), L268 (= L257), E295 (≠ P284), M392 (≠ A390), Q418 (≠ A415), M420 (= M417), D445 (= D442), D472 (≠ N469), G474 (≠ S471), Y475 (= Y472), M477 (≠ T474), V478 (≠ I475), Q481 (≠ H478)
- binding 3-fluoro-2-oxopropanoic acid: G264 (= G253), R265 (≠ D254), Q272 (≠ P261), A400 (≠ H398), R401 (= R399), Y404 (= Y401)
- binding magnesium ion: S135 (≠ G126), T138 (≠ A129), D445 (= D442), D472 (≠ N469), G474 (≠ S471)
- binding thiamine diphosphate: G393 (= G391), S394 (≠ N392), F395 (≠ Y393), Q418 (≠ A415), M420 (= M417), G444 (= G441), D445 (= D442), G446 (= G443), D472 (≠ N469), G474 (≠ S471), Y475 (= Y472), N476 (≠ G473), M477 (≠ T474), V478 (≠ I475)
Sites not aligning to the query:
5wkcA Saccharomyces cerevisiae acetohydroxyacid synthase in complex with the herbicide penoxsulam (see paper)
27% identity, 96% coverage: 1:537/561 of query aligns to 1:549/591 of 5wkcA
- active site: Y29 (≠ V29), G31 (= G31), G32 (≠ E32), A33 (≠ S33), I34 (≠ F34), E55 (= E54), T78 (= T77), F117 (= F116), Q118 (= Q117), E119 (= E118), K167 (= K166), R222 (≠ A222), M258 (≠ L257), V285 (≠ P284), V401 (≠ A390), L426 (vs. gap), G427 (≠ A415), M429 (= M417), D454 (= D442), N481 (= N469), E483 (≠ S471), Q484 (≠ Y472), M486 (≠ T474), V487 (≠ I475), W490 (≠ H478), L512 (≠ Y500), G517 (= G505), L518 (≠ G506)
- binding 2-[3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-2-[(1~{S})-1-(dioxidanyl)-1-oxidanyl-ethyl]-4-methyl-1,3-thiazol-5-yl]ethyl phosphono hydrogen phosphate: V401 (≠ A390), G402 (= G391), Q403 (≠ N392), H404 (≠ Y393), G427 (≠ A415), M429 (= M417), G453 (= G441), D454 (= D442), A455 (≠ G443), S456 (≠ D444), M459 (= M447), N481 (= N469), E483 (≠ S471), Q484 (≠ Y472), G485 (= G473), M486 (≠ T474), V487 (≠ I475)
- binding ethaneperoxoic acid: G32 (≠ E32), Q118 (= Q117)
- binding flavin-adenine dinucleotide: R157 (= R156), G211 (= G211), A212 (≠ G212), G213 (≠ S213), N216 (≠ S216), T238 (≠ S237), L239 (≠ Y238), Q240 (≠ R239), L256 (= L255), M258 (≠ L257), G278 (= G277), A279 (≠ G278), R280 (= R279), R284 (≠ I283), V285 (≠ P284), E311 (≠ H304), V312 (≠ A305), N316 (≠ E309), D330 (≠ S323), A331 (≠ P324), M406 (≠ A395), G424 (≠ T413)
- binding magnesium ion: D454 (= D442), N481 (= N469), E483 (≠ S471)
- binding 2-(2,2-difluoroethoxy)-N-(5,8-dimethoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)-6-(trifluoromethyl)benzenesulfonamide: G32 (≠ E32), A33 (≠ S33), V107 (≠ I106), F117 (= F116), K167 (= K166), M258 (≠ L257), R284 (≠ I283), M486 (≠ T474), W490 (≠ H478)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: P30 (= P30), E55 (= E54)
Sites not aligning to the query:
1t9dA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, metsulfuron methyl (see paper)
27% identity, 96% coverage: 1:537/561 of query aligns to 1:554/596 of 1t9dA
- active site: Y29 (≠ V29), G31 (= G31), G32 (≠ E32), A33 (≠ S33), I34 (≠ F34), E55 (= E54), T78 (= T77), F117 (= F116), Q118 (= Q117), E119 (= E118), K167 (= K166), R227 (≠ A222), M263 (≠ L257), V290 (≠ P284), V406 (≠ A390), L431 (vs. gap), G432 (≠ A415), M434 (= M417), D459 (= D442), N486 (= N469), E488 (≠ S471), Q489 (≠ Y472), M491 (≠ T474), V492 (≠ I475), W495 (≠ H478), L517 (≠ Y500), G522 (= G505), L523 (≠ G506)
- binding methyl 2-[({[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: G32 (≠ E32), A33 (≠ S33), V107 (≠ I106), P108 (≠ E107), F117 (= F116), K167 (= K166), M263 (≠ L257), D288 (≠ E282), R289 (≠ I283), W495 (≠ H478)
- binding flavin-adenine dinucleotide: R157 (= R156), G216 (= G211), A217 (≠ G212), G218 (≠ S213), N221 (≠ S216), T243 (≠ S237), L244 (≠ Y238), Q245 (≠ R239), M260 (≠ D254), L261 (= L255), H264 (≠ A258), G283 (= G277), A284 (≠ G278), R285 (= R279), D287 (≠ G281), R289 (≠ I283), V290 (≠ P284), E316 (≠ H304), V317 (≠ A305), N321 (≠ E309), G334 (≠ A322), D335 (≠ S323), A336 (≠ P324), Q410 (≠ A394), M411 (≠ A395), G429 (≠ T413), G430 (≠ S414)
- binding magnesium ion: D459 (= D442), N486 (= N469), E488 (≠ S471)
- binding 2,5-dimethyl-pyrimidin-4-ylamine: E55 (= E54), P81 (= P80), Q118 (= Q117), G432 (≠ A415), M434 (= M417), M464 (= M447)
Sites not aligning to the query:
1t9bA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, chlorsulfuron (see paper)
27% identity, 96% coverage: 1:537/561 of query aligns to 1:541/583 of 1t9bA
- active site: Y29 (≠ V29), G31 (= G31), G32 (≠ E32), A33 (≠ S33), I34 (≠ F34), E55 (= E54), T78 (= T77), F117 (= F116), Q118 (= Q117), E119 (= E118), K167 (= K166), R214 (≠ A222), M250 (≠ L257), V277 (≠ P284), V393 (≠ A390), L418 (vs. gap), G419 (≠ A415), M421 (= M417), D446 (= D442), N473 (= N469), E475 (≠ S471), Q476 (≠ Y472), M478 (≠ T474), V479 (≠ I475), W482 (≠ H478), L504 (≠ Y500), G509 (= G505), L510 (≠ G506)
- binding 1-(2-chlorophenylsulfonyl)-3-(4-methoxy-6-methyl-l,3,5-triazin-2-yl)urea: V107 (≠ I106), P108 (≠ E107), F117 (= F116), D275 (≠ E282), R276 (≠ I283), M478 (≠ T474), W482 (≠ H478)
- binding flavin-adenine dinucleotide: R157 (= R156), G203 (= G211), A204 (≠ G212), G205 (≠ S213), N208 (≠ S216), T230 (≠ S237), L231 (≠ Y238), Q232 (≠ R239), M247 (≠ D254), L248 (= L255), M250 (≠ L257), H251 (≠ A258), G270 (= G277), A271 (≠ G278), R272 (= R279), D274 (≠ G281), R276 (≠ I283), V277 (≠ P284), E303 (≠ H304), V304 (≠ A305), N308 (≠ E309), D322 (≠ S323), A323 (≠ P324), Q397 (≠ A394), M398 (≠ A395), G416 (≠ T413), G417 (≠ S414)
- binding magnesium ion: D446 (= D442), N473 (= N469), E475 (≠ S471)
Sites not aligning to the query:
1t9aA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, tribenuron methyl (see paper)
27% identity, 96% coverage: 1:537/561 of query aligns to 2:555/597 of 1t9aA
- active site: Y30 (≠ V29), G32 (= G31), G33 (≠ E32), A34 (≠ S33), I35 (≠ F34), E56 (= E54), T79 (= T77), F118 (= F116), Q119 (= Q117), E120 (= E118), K168 (= K166), R228 (≠ A222), M264 (≠ L257), V291 (≠ P284), V407 (≠ A390), L432 (vs. gap), G433 (≠ A415), M435 (= M417), D460 (= D442), N487 (= N469), E489 (≠ S471), Q490 (≠ Y472), M492 (≠ T474), V493 (≠ I475), W496 (≠ H478), L518 (≠ Y500), G523 (= G505), L524 (≠ G506)
- binding methyl 2-[4-methoxy-6-methyl-1,3,5-trazin-2-yl(methyl)carbamoylsulfamoyl]benzoate: G33 (≠ E32), V108 (≠ I106), P109 (≠ E107), F118 (= F116), K168 (= K166), M264 (≠ L257), D289 (≠ E282), R290 (≠ I283), M492 (≠ T474), V493 (≠ I475), W496 (≠ H478)
- binding flavin-adenine dinucleotide: R158 (= R156), G217 (= G211), A218 (≠ G212), G219 (≠ S213), N222 (≠ S216), T244 (≠ S237), L245 (≠ Y238), Q246 (≠ R239), L262 (= L255), M264 (≠ L257), H265 (≠ A258), G284 (= G277), A285 (≠ G278), R286 (= R279), D288 (≠ G281), R290 (≠ I283), V291 (≠ P284), E317 (≠ H304), V318 (≠ A305), N322 (≠ E309), G335 (≠ A322), D336 (≠ S323), A337 (≠ P324), Q411 (≠ A394), M412 (≠ A395), G430 (≠ T413), G431 (≠ S414)
- binding magnesium ion: D460 (= D442), N487 (= N469), E489 (≠ S471)
- binding propyl trihydrogen diphosphate: V407 (≠ A390), G408 (= G391), Q409 (≠ N392), H410 (≠ Y393), M435 (= M417), G459 (= G441), D460 (= D442), A461 (≠ G443), S462 (≠ D444), N487 (= N469), E489 (≠ S471), Q490 (≠ Y472), G491 (= G473), M492 (≠ T474)
- binding 5-{[ethyl(methyl)amino]methyl}-2-methyl-5,6-dihydropyrimidin-4-amine: G433 (≠ A415), M435 (= M417), M465 (= M447)
Sites not aligning to the query:
7egvA Acetolactate synthase from trichoderma harzianum with inhibitor harzianic acid (see paper)
28% identity, 97% coverage: 2:544/561 of query aligns to 1:553/590 of 7egvA
- active site: Y28 (≠ V29), G30 (= G31), G31 (≠ E32), A32 (≠ S33), I33 (≠ F34), E54 (= E54), T77 (= T77), F116 (= F116), Q117 (= Q117), K166 (= K166), E220 (≠ A221), M256 (≠ L257), V283 (≠ P284), V400 (≠ A390), L425 (vs. gap), G426 (≠ A415), M428 (= M417), Q483 (≠ Y472), M485 (≠ T474), V486 (≠ I475), W489 (≠ H478), L511 (≠ Y500), G516 (= G505), I517 (≠ G506)
- binding flavin-adenine dinucleotide: R156 (= R156), G209 (= G211), Q210 (vs. gap), G211 (= G212), T236 (≠ S237), L237 (≠ Y238), H238 (≠ R239), G276 (= G277), S277 (≠ G278), R278 (= R279), D280 (≠ G281), R282 (≠ I283), V283 (≠ P284), E309 (≠ H304), I310 (≠ A305), D328 (≠ S323), V329 (vs. gap), M405 (≠ A395), G423 (≠ T413), G424 (≠ S414)
- binding (2S)-3-methyl-2-[[(2S,4R)-1-methyl-4-[(2E,4E)-octa-2,4-dienoyl]-3,5-bis(oxidanylidene)pyrrolidin-2-yl]methyl]-2-oxidanyl-butanoic acid: F493 (≠ E482), Y494 (≠ F483)
- binding magnesium ion: D453 (= D442), N480 (= N469), E482 (≠ S471)
- binding 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-2-oxo-2,3-dihydro-1,3-thiazol-5-yl}ethyl trihydrogendiphosphate: P29 (= P30), E54 (= E54), Q117 (= Q117), V400 (≠ A390), G401 (= G391), Q402 (≠ N392), H403 (≠ Y393), G426 (≠ A415), M428 (= M417), D453 (= D442), A454 (≠ G443), S455 (≠ D444), E482 (≠ S471), Q483 (≠ Y472), G484 (= G473), M485 (≠ T474), V486 (≠ I475)
1t9bB Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, chlorsulfuron (see paper)
27% identity, 96% coverage: 1:537/561 of query aligns to 1:553/595 of 1t9bB
- active site: Y29 (≠ V29), G31 (= G31), G32 (≠ E32), A33 (≠ S33), I34 (≠ F34), E55 (= E54), T78 (= T77), F117 (= F116), Q118 (= Q117), E119 (= E118), K167 (= K166), R226 (≠ A222), M262 (≠ L257), V289 (≠ P284), V405 (≠ A390), L430 (vs. gap), G431 (≠ A415), M433 (= M417), D458 (= D442), N485 (= N469), E487 (≠ S471), Q488 (≠ Y472), M490 (≠ T474), V491 (≠ I475), W494 (≠ H478), L516 (≠ Y500), G521 (= G505), L522 (≠ G506)
- binding 1-(2-chlorophenylsulfonyl)-3-(4-methoxy-6-methyl-l,3,5-triazin-2-yl)urea: V107 (≠ I106), P108 (≠ E107), D287 (≠ E282), R288 (≠ I283), M490 (≠ T474), W494 (≠ H478)
- binding flavin-adenine dinucleotide: R157 (= R156), G215 (= G211), A216 (≠ G212), G217 (≠ S213), N220 (≠ S216), T242 (≠ S237), L243 (≠ Y238), Q244 (≠ R239), M259 (≠ D254), L260 (= L255), M262 (≠ L257), H263 (≠ A258), G282 (= G277), A283 (≠ G278), R284 (= R279), D286 (≠ G281), R288 (≠ I283), V289 (≠ P284), E315 (≠ H304), V316 (≠ A305), N320 (≠ E309), G333 (≠ A322), D334 (≠ S323), A335 (≠ P324), Q409 (≠ A394), M410 (≠ A395), G428 (≠ T413), G429 (≠ S414)
- binding magnesium ion: D458 (= D442), N485 (= N469), E487 (≠ S471)
Sites not aligning to the query:
1t9cA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, sulfometuron methyl (see paper)
27% identity, 96% coverage: 1:537/561 of query aligns to 1:554/596 of 1t9cA
- active site: Y29 (≠ V29), G31 (= G31), G32 (≠ E32), A33 (≠ S33), I34 (≠ F34), E55 (= E54), T78 (= T77), F117 (= F116), Q118 (= Q117), E119 (= E118), K167 (= K166), R227 (≠ A222), M263 (≠ L257), V290 (≠ P284), V406 (≠ A390), L431 (vs. gap), G432 (≠ A415), M434 (= M417), D459 (= D442), N486 (= N469), E488 (≠ S471), Q489 (≠ Y472), M491 (≠ T474), V492 (≠ I475), W495 (≠ H478), L517 (≠ Y500), G522 (= G505), L523 (≠ G506)
- binding methyl 2-[({[(4,6-dimethylpyrimidin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: G32 (≠ E32), V107 (≠ I106), P108 (≠ E107), F117 (= F116), K167 (= K166), D288 (≠ E282), R289 (≠ I283), W495 (≠ H478)
- binding flavin-adenine dinucleotide: R157 (= R156), G216 (= G211), A217 (≠ G212), G218 (≠ S213), N221 (≠ S216), T243 (≠ S237), L244 (≠ Y238), Q245 (≠ R239), L261 (= L255), M263 (≠ L257), H264 (≠ A258), G283 (= G277), A284 (≠ G278), R285 (= R279), D287 (≠ G281), R289 (≠ I283), V290 (≠ P284), E316 (≠ H304), V317 (≠ A305), N321 (≠ E309), G334 (≠ A322), D335 (≠ S323), A336 (≠ P324), M411 (≠ A395), G429 (≠ T413), G430 (≠ S414)
- binding magnesium ion: D459 (= D442), N486 (= N469), E488 (≠ S471)
Sites not aligning to the query:
1n0hA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, chlorimuron ethyl (see paper)
27% identity, 96% coverage: 1:537/561 of query aligns to 3:557/599 of 1n0hA
- active site: Y31 (≠ V29), G33 (= G31), G34 (≠ E32), A35 (≠ S33), I36 (≠ F34), E57 (= E54), T80 (= T77), F119 (= F116), Q120 (= Q117), E121 (= E118), K169 (= K166), R230 (≠ A222), M266 (≠ L257), V293 (≠ P284), V409 (≠ A390), L434 (vs. gap), G435 (≠ A415), M437 (= M417), D462 (= D442), N489 (= N469), E491 (≠ S471), Q492 (≠ Y472), M494 (≠ T474), V495 (≠ I475), W498 (≠ H478), L520 (≠ Y500), G525 (= G505), L526 (≠ G506)
- binding 4-{[(4'-amino-2'-methylpyrimidin-5'-yl)methyl]amino}pent-3-enyl diphosphate: V409 (≠ A390), G410 (= G391), Q411 (≠ N392), H412 (≠ Y393), G435 (≠ A415), M437 (= M417), G461 (= G441), D462 (= D442), A463 (≠ G443), S464 (≠ D444), M467 (= M447), N489 (= N469), E491 (≠ S471), Q492 (≠ Y472), G493 (= G473), V495 (≠ I475)
- binding 2-[[[[(4-chloro-6-methoxy-2-pyrimidinyl)amino]carbonyl]amino]sulfonyl]benzoic acid ethyl ester: G34 (≠ E32), A35 (≠ S33), V109 (≠ I106), P110 (≠ E107), F119 (= F116), K169 (= K166), M266 (≠ L257), D291 (≠ E282), R292 (≠ I283), V495 (≠ I475), W498 (≠ H478)
- binding flavin-adenine dinucleotide: R159 (= R156), G219 (= G211), A220 (≠ G212), G221 (≠ S213), N224 (≠ S216), T246 (≠ S237), L247 (≠ Y238), Q248 (≠ R239), L264 (= L255), G265 (= G256), M266 (≠ L257), H267 (≠ A258), G286 (= G277), A287 (≠ G278), R288 (= R279), D290 (≠ G281), R292 (≠ I283), V293 (≠ P284), E319 (≠ H304), V320 (≠ A305), N324 (≠ E309), G337 (≠ A322), D338 (≠ S323), A339 (≠ P324), M414 (≠ A395), G432 (≠ T413), G433 (≠ S414)
- binding magnesium ion: D462 (= D442), N489 (= N469), E491 (≠ S471)
- binding thiamine diphosphate: Y31 (≠ V29), E57 (= E54), P83 (= P80)
Sites not aligning to the query:
1t9dB Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, metsulfuron methyl (see paper)
27% identity, 96% coverage: 2:537/561 of query aligns to 1:540/582 of 1t9dB
- active site: Y28 (≠ V29), G30 (= G31), G31 (≠ E32), A32 (≠ S33), I33 (≠ F34), E54 (= E54), T77 (= T77), F116 (= F116), Q117 (= Q117), E118 (= E118), K166 (= K166), R213 (≠ A222), M249 (≠ L257), V276 (≠ P284), V392 (≠ A390), L417 (vs. gap), G418 (≠ A415), M420 (= M417), D445 (= D442), N472 (= N469), E474 (≠ S471), Q475 (≠ Y472), M477 (≠ T474), V478 (≠ I475), W481 (≠ H478), L503 (≠ Y500), G508 (= G505), L509 (≠ G506)
- binding methyl 2-[({[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: G31 (≠ E32), A32 (≠ S33), V106 (≠ I106), P107 (≠ E107), F116 (= F116), K166 (= K166), M249 (≠ L257), D274 (≠ E282), R275 (≠ I283), W481 (≠ H478)
- binding flavin-adenine dinucleotide: R156 (= R156), G202 (= G211), A203 (≠ G212), G204 (≠ S213), N207 (≠ S216), T229 (≠ S237), L230 (≠ Y238), Q231 (≠ R239), L247 (= L255), M249 (≠ L257), H250 (≠ A258), G269 (= G277), A270 (≠ G278), R271 (= R279), D273 (≠ G281), R275 (≠ I283), V276 (≠ P284), E302 (≠ H304), V303 (≠ A305), N307 (≠ E309), G320 (≠ A322), D321 (≠ S323), A322 (≠ P324), Q396 (≠ A394), M397 (≠ A395), G415 (≠ T413), G416 (≠ S414)
- binding magnesium ion: D445 (= D442), N472 (= N469), E474 (≠ S471)
- binding 2,5-dimethyl-pyrimidin-4-ylamine: E54 (= E54), P80 (= P80), G418 (≠ A415), M420 (= M417), M450 (= M447)
Sites not aligning to the query:
6u9dB Saccharomyces cerevisiae acetohydroxyacid synthase (see paper)
26% identity, 96% coverage: 1:537/561 of query aligns to 5:565/607 of 6u9dB
- active site: Y33 (≠ V29), G35 (= G31), G36 (≠ E32), A37 (≠ S33), I38 (≠ F34), E59 (= E54), T82 (= T77), F121 (= F116), Q122 (= Q117), E123 (= E118), K171 (= K166), M274 (≠ L257), V301 (≠ P284), V417 (≠ A390), G443 (≠ A415), M445 (= M417), D470 (= D442), N497 (= N469), E499 (≠ S471), Q500 (≠ Y472), M502 (≠ T474), V503 (≠ I475), W506 (≠ H478)
- binding methyl 2-[(4,6-dimethoxypyrimidin-2-yl)carbamoylsulfamoylmethyl]benzoate: G36 (≠ E32), V111 (≠ I106), P112 (≠ E107), F121 (= F116), K171 (= K166), D299 (≠ E282), R300 (≠ I283), M502 (≠ T474), W506 (≠ H478)
- binding flavin-adenine dinucleotide: R161 (= R156), A228 (≠ G212), G229 (≠ S213), N232 (≠ S216), T254 (≠ S237), L255 (≠ Y238), Q256 (≠ R239), L272 (= L255), M274 (≠ L257), G294 (= G277), R296 (= R279), D298 (≠ G281), R300 (≠ I283), V301 (≠ P284), E327 (≠ H304), V328 (≠ A305), N332 (≠ E309), D346 (≠ S323), A347 (≠ P324), M422 (≠ A395), G440 (≠ T413), G441 (≠ S414)
- binding magnesium ion: D470 (= D442), N497 (= N469)
- binding thiamine diphosphate: E59 (= E54), P85 (= P80), V417 (≠ A390), G418 (= G391), Q419 (≠ N392), H420 (≠ Y393), G443 (≠ A415), M445 (= M417), A471 (≠ G443), S472 (≠ D444), N497 (= N469), E499 (≠ S471), Q500 (≠ Y472), G501 (= G473), M502 (≠ T474), V503 (≠ I475)
P07342 Acetolactate synthase catalytic subunit, mitochondrial; Acetohydroxy-acid synthase catalytic subunit; AHAS; ALS; EC 2.2.1.6 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
26% identity, 96% coverage: 1:537/561 of query aligns to 85:645/687 of P07342
- R241 (= R156) binding FAD
- 355:376 (vs. 258:279, 23% identical) binding FAD
- 407:426 (vs. 304:323, 20% identical) binding FAD
5dx6A Acetolactate synthase from klebsiella pneumoniae soaked with beta- fluoropyruvate
29% identity, 94% coverage: 11:537/561 of query aligns to 9:528/541 of 5dx6A
- active site: I27 (≠ V29), G29 (= G31), A30 (≠ E32), K31 (≠ S33), I32 (≠ F34), E52 (= E54), T75 (= T77), Q159 (≠ K166), L249 (= L257), E276 (≠ P284), M381 (≠ A390), Q407 (≠ A415), M409 (= M417), D434 (= D442), D461 (≠ N469), G463 (≠ S471), Y464 (= Y472), M466 (≠ T474), V467 (≠ I475), Q470 (≠ H478)
- binding 3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-[(1R)-2-fluoro-1-hydroxyethyl]-5-(2-{[(S)-hydroxy(phosphonooxy)phosphoryl]oxy}ethyl)-4-methyl-1,3-thiazol-3-ium: M381 (≠ A390), G382 (= G391), S383 (≠ N392), F384 (≠ Y393), Q407 (≠ A415), M409 (= M417), G433 (= G441), D434 (= D442), G435 (= G443), D461 (≠ N469), G463 (≠ S471), Y464 (= Y472), N465 (≠ G473)
- binding magnesium ion: S119 (≠ G126), T122 (≠ A129), D434 (= D442), D461 (≠ N469), G463 (≠ S471)
Sites not aligning to the query:
5wdgA Acetolactate synthase from klebsiella pneumoniae in complex with a reaction intermediate
29% identity, 94% coverage: 11:537/561 of query aligns to 9:525/538 of 5wdgA
- active site: I27 (≠ V29), G29 (= G31), A30 (≠ E32), K31 (≠ S33), I32 (≠ F34), E52 (= E54), T75 (= T77), Q157 (≠ K166), L246 (= L257), E273 (≠ P284), M378 (≠ A390), Q404 (≠ A415), M406 (= M417), D431 (= D442), D458 (≠ N469), G460 (≠ S471), Y461 (= Y472), M463 (≠ T474), V464 (≠ I475), Q467 (≠ H478)
- binding (2S,3S)-2,3-dihydroxy-3-[(7S,8R,9aS)-8-(2-{[(R)-hydroxy(phosphonooxy)phosphoryl]oxy}ethyl)-2,7-dimethyl-5,7,8,10-tetrahydro-9aH-pyrimido[4,5-d][1,3]thiazolo[3,2-a]pyrimidin-9a-yl]-2-methylbutanoic acid: M378 (≠ A390), S380 (≠ N392), F381 (≠ Y393), Q404 (≠ A415), M406 (= M417), G430 (= G441), D431 (= D442), G432 (= G443), G433 (≠ D444), D458 (≠ N469), G460 (≠ S471), Y461 (= Y472), N462 (≠ G473), M463 (≠ T474), V464 (≠ I475)
- binding magnesium ion: R64 (≠ K66), S117 (≠ G126), T120 (≠ A129), Q204 (≠ S216), D431 (= D442), D458 (≠ N469), G460 (≠ S471)
- binding pyruvic acid: G94 (≠ S96), R147 (= R156)
Sites not aligning to the query:
- active site: 527
- binding (2S,3S)-2,3-dihydroxy-3-[(7S,8R,9aS)-8-(2-{[(R)-hydroxy(phosphonooxy)phosphoryl]oxy}ethyl)-2,7-dimethyl-5,7,8,10-tetrahydro-9aH-pyrimido[4,5-d][1,3]thiazolo[3,2-a]pyrimidin-9a-yl]-2-methylbutanoic acid: 527
Query Sequence
>WP_012336155.1 NCBI__GCF_000019365.1:WP_012336155.1
MDEARPGRTAARVLVDQLVANGVRHVFTVPGESFLPVLDALRDSGIAVTTCRQEGAAAMM
AEAHGKATGMPGICFVTRGPGATNASAGLHVAQQDSTPMILFVGQIERRFREREAFQELD
YRAVFGPMAKWATEIDDPDRVPEFVARAFATATAGRPGPVVVALPKDMLSEATAAPLAPP
FRPVEAAPGEEDVARLADLVASAERPLLLLGGSRWSEGACAAIARFAEAFDLPVATSYRR
SPLFDALHPNYAGDLGLAPNPKLVARARAADLLVLLGGRLGEIPSQGYSLLDVPGPRTRL
VHIHAGPEELGRVYQPFLAINASPARTAAALARLPAPARIPWREETRAAHAEFLAWGERA
TPQPGGVNLGEVIIHLREVLPRDAVLCNGAGNYAAWIHRFYRFRGLASHIAPTSASMGYG
VPAAVAMKRLWPQRTVVSINGDGDFLMNGQEFATAVQYRLPLVVIVADNASYGTIRMHQE
REFPDRVVATDLVNPDFAAYARAFGGLGWTVERTEDFPAAFREASACGRPAIIHLKIATD
AITPGQTLTQIRDRAVAGRAA
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory