Comparing WP_012336174.1 NCBI__GCF_000019365.1:WP_012336174.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 19 hits to proteins with known functional sites (download)
8uw6B Acetylornithine deacetylase from escherichia coli, di-zinc form. (see paper)
33% identity, 90% coverage: 17:368/389 of query aligns to 19:359/381 of 8uw6B
Sites not aligning to the query:
7uoiA Crystallographic structure of dape from enterococcus faecium (see paper)
27% identity, 77% coverage: 73:373/389 of query aligns to 72:367/383 of 7uoiA
Q8P8J5 N-acetyl-L-citrulline deacetylase; ACDase; Acetylcitrulline deacetylase; EC 3.5.1.- from Xanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25) (see paper)
29% identity, 94% coverage: 9:374/389 of query aligns to 7:352/366 of Q8P8J5
2f7vA Structure of acetylcitrulline deacetylase complexed with one co (see paper)
27% identity, 94% coverage: 9:374/389 of query aligns to 8:347/360 of 2f7vA
P44514 Succinyl-diaminopimelate desuccinylase; SDAP desuccinylase; N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase; EC 3.5.1.18 from Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) (see 3 papers)
27% identity, 66% coverage: 34:290/389 of query aligns to 28:281/377 of P44514
Sites not aligning to the query:
5vo3A Crystal structure of dape in complex with the products (succinic acid and diaminopimelic acid) (see paper)
27% identity, 66% coverage: 34:290/389 of query aligns to 32:285/380 of 5vo3A
Sites not aligning to the query:
7t1qA Crystal structure of the succinyl-diaminopimelate desuccinylase (dape) from acinetobacter baumannii in complex with succinic acid
28% identity, 77% coverage: 44:343/389 of query aligns to 36:330/377 of 7t1qA
Sites not aligning to the query:
7lgpB Dape enzyme from shigella flexneri
30% identity, 50% coverage: 71:264/389 of query aligns to 63:259/377 of 7lgpB
4o23A Crystal structure of mono-zinc form of succinyl diaminopimelate desuccinylase from neisseria meningitidis mc58 (see paper)
31% identity, 50% coverage: 71:264/389 of query aligns to 62:258/376 of 4o23A
4pqaA Crystal structure of succinyl-diaminopimelate desuccinylase from neisseria meningitidis mc58 in complex with the inhibitor captopril (see paper)
31% identity, 50% coverage: 71:264/389 of query aligns to 62:258/375 of 4pqaA
Sites not aligning to the query:
3pfoA Crystal structure of a putative acetylornithine deacetylase (rpa2325) from rhodopseudomonas palustris cga009 at 1.90 a resolution
26% identity, 64% coverage: 11:260/389 of query aligns to 22:289/426 of 3pfoA
Sites not aligning to the query:
1lfwA Crystal structure of pepv (see paper)
33% identity, 35% coverage: 11:147/389 of query aligns to 17:160/468 of 1lfwA
Sites not aligning to the query:
P45494 Beta-Ala-Xaa dipeptidase; Beta-Ala-His dipeptidase; Peptidase V; EC 3.4.13.- from Lactobacillus delbrueckii subsp. lactis (see paper)
33% identity, 35% coverage: 11:147/389 of query aligns to 17:160/470 of P45494
Sites not aligning to the query:
P37111 Aminoacylase-1; ACY-1; N-acyl-L-amino-acid amidohydrolase; EC 3.5.1.14 from Sus scrofa (Pig) (see paper)
24% identity, 89% coverage: 32:376/389 of query aligns to 35:386/407 of P37111
Sites not aligning to the query:
4h2kA Crystal structure of the catalytic domain of succinyl-diaminopimelate desuccinylase from haemophilus influenzae (see paper)
32% identity, 35% coverage: 34:170/389 of query aligns to 30:167/258 of 4h2kA
Sites not aligning to the query:
4op4B Crystal structure of the catalytic domain of dape protein from v.Cholerea in the zn bound form (see paper)
38% identity, 28% coverage: 72:180/389 of query aligns to 63:176/265 of 4op4B
Sites not aligning to the query:
5xoyA Crystal structure of lysk from thermus thermophilus in complex with lysine (see paper)
26% identity, 96% coverage: 15:388/389 of query aligns to 20:338/341 of 5xoyA
P54968 IAA-amino acid hydrolase ILR1; EC 3.5.1.- from Arabidopsis thaliana (Mouse-ear cress) (see paper)
26% identity, 45% coverage: 160:335/389 of query aligns to 211:365/442 of P54968
Sites not aligning to the query:
3rzaA Crystal structure of a tripeptidase (sav1512) from staphylococcus aureus subsp. Aureus mu50 at 2.10 a resolution
21% identity, 62% coverage: 132:373/389 of query aligns to 133:356/373 of 3rzaA
Sites not aligning to the query:
>WP_012336174.1 NCBI__GCF_000019365.1:WP_012336174.1
MTHAGPTLTPLALLERLVAFDTSSEKSNLPLIAFVEEYLAGLGVPFVRVPNRAGDKAALF
ATIGPMRDGGVVLSGHTDVVSPAGQDWTSDPFRLRLAEGRLHGRGAVDMKGFCALCLGLV
PEMLAADLARPIHLLLSYDEETTCLGVVDAIARFGIDLPRPGAVIVGEPTGLEVADAHKS
VATFVTTVLGHEAHSSKPALGANAVMAAAELVAELNRIADELIARGDPSGRFDPPYSTVH
VGVIGGGTVRNILPGRCTFEWEFRGLPDLDLDEVPRRFAAAAETVARERLNRFGPYGRIE
TVRDASVPGLSPDPGSAAERLGLRLAGRNRTISVPYATEAGRFQREGLPTIVCGPGSIDQ
AHQPDEYITVAAFEAGEAFLRGLIRDCAA
Or try a new SitesBLAST search
SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory