SitesBLAST
Comparing WP_012384256.1 NCBI__GCF_000019845.1:WP_012384256.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
3triA Structure of a pyrroline-5-carboxylate reductase (proc) from coxiella burnetii (see paper)
35% identity, 95% coverage: 13:275/276 of query aligns to 4:268/272 of 3triA
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G9 (= G18), G11 (= G20), N12 (≠ K21), M13 (= M22), N35 (≠ E44), R36 (≠ P45), S37 (≠ H46), K40 (vs. gap), N56 (≠ A66), A69 (= A75), V70 (≠ I76), K71 (= K77), Q74 (≠ M80), M77 (≠ E83), L96 (≠ I101), A97 (≠ L102), V98 (≠ A103), M119 (= M124), P120 (= P125)
2ag8A NADP complex of pyrroline-5-carboxylate reductase from neisseria meningitidis (see paper)
32% identity, 95% coverage: 13:274/276 of query aligns to 2:258/263 of 2ag8A
- binding nadp nicotinamide-adenine-dinucleotide phosphate: L6 (≠ A17), G7 (= G18), G9 (= G20), N10 (≠ K21), M11 (= M22), A30 (≠ G41), N31 (≠ V42), R32 (≠ I43), G33 (≠ E44), K36 (≠ P47), A64 (= A75), V65 (≠ I76), K66 (= K77), A73 (= A84), V87 (≠ I101), A88 (≠ L102), A89 (= A103), M110 (= M124), P111 (= P125)
5bshA Crystal structure of medicago truncatula (delta)1-pyrroline-5- carboxylate reductase (mtp5cr) in complex with l-proline (see paper)
32% identity, 95% coverage: 13:275/276 of query aligns to 10:272/272 of 5bshA
5bsgA Crystal structure of medicago truncatula (delta)1-pyrroline-5- carboxylate reductase (mtp5cr) in complex with NADP+ (see paper)
32% identity, 95% coverage: 13:275/276 of query aligns to 10:272/272 of 5bsgA
- binding chloride ion: S236 (= S238), T241 (= T243)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G15 (= G18), G17 (= G20), K18 (= K21), M19 (= M22), H43 (= H46), S44 (≠ P47), N45 (≠ S48), N63 (vs. gap), S76 (≠ A75), V77 (≠ I76), K78 (= K77), L81 (≠ M80), V85 (≠ A84), V102 (≠ I101), A103 (≠ L102), A104 (= A103), P125 (= P125)
5bsfA Crystal structure of medicago truncatula (delta)1-pyrroline-5- carboxylate reductase (mtp5cr) in complex with NAD+ (see paper)
32% identity, 95% coverage: 13:275/276 of query aligns to 10:272/272 of 5bsfA
- binding chloride ion: S236 (= S238), T241 (= T243)
- binding nicotinamide-adenine-dinucleotide: G15 (= G18), G17 (= G20), K18 (= K21), M19 (= M22), H43 (= H46), N63 (vs. gap), S76 (≠ A75), V77 (≠ I76), K78 (= K77), L81 (≠ M80), V85 (≠ A84), V102 (≠ I101), A104 (= A103), P125 (= P125)
5bseA Crystal structure of medicago truncatula (delta)1-pyrroline-5- carboxylate reductase (mtp5cr) (see paper)
32% identity, 95% coverage: 13:275/276 of query aligns to 10:272/272 of 5bseA
8td7A Structure of pycr1 complexed with 2s-hydroxy-3-methylbutyric acid (see paper)
33% identity, 95% coverage: 13:274/276 of query aligns to 9:275/282 of 8td7A
8tcwA Structure of pycr1 complexed with 2-methyl-3-(2-oxoimidazolidin-1-yl) benzoic acid (see paper)
33% identity, 95% coverage: 13:274/276 of query aligns to 9:275/282 of 8tcwA
8tdcA Structure of pycr1 complexed with nadh and 1,3-dithiane-2-carboxylic acid (see paper)
33% identity, 95% coverage: 13:274/276 of query aligns to 3:269/276 of 8tdcA
- binding 1,3-dithiane-2-carboxylic acid: V232 (= V236), S234 (= S238), G237 (= G241), A238 (≠ T242), T239 (= T243)
- binding 1,4-dihydronicotinamide adenine dinucleotide: G8 (= G18), A9 (= A19), G10 (= G20), Q11 (≠ K21), L12 (≠ M22), S35 (≠ H46), P36 (= P47), N57 (≠ A66), A70 (= A75), V71 (≠ I76), K72 (= K77), I79 (≠ A84), C96 (≠ I101), A97 (≠ L102), A98 (= A103), M122 (= M124), T123 (≠ P125), T125 (≠ L127)
8td8A Structure of pycr1 complexed with nadh and 2s-hydroxy-3,3- dimethylbutyric acid (see paper)
33% identity, 95% coverage: 13:274/276 of query aligns to 3:269/276 of 8td8A
- binding (2S)-2-hydroxy-3,3-dimethylbutanoic acid: V232 (= V236), S234 (= S238), T239 (= T243)
- binding 1,4-dihydronicotinamide adenine dinucleotide: G8 (= G18), A9 (= A19), G10 (= G20), Q11 (≠ K21), L12 (≠ M22), P36 (= P47), N57 (≠ A66), A70 (= A75), V71 (≠ I76), K72 (= K77), C96 (≠ I101), A97 (≠ L102), A98 (= A103), M122 (= M124), T123 (≠ P125), T125 (≠ L127)
8td2A Structure of pycr1 complexed with nadh and cyclobutane-1,1- dicarboxylic acid (see paper)
33% identity, 95% coverage: 13:274/276 of query aligns to 3:269/276 of 8td2A
- binding 1,4-dihydronicotinamide adenine dinucleotide: G8 (= G18), G10 (= G20), Q11 (≠ K21), L12 (≠ M22), P36 (= P47), L40 (= L51), N57 (≠ A66), A70 (= A75), V71 (≠ I76), P73 (= P78), I79 (≠ A84), C96 (≠ I101), A97 (≠ L102), A98 (= A103), M122 (= M124), T123 (≠ P125), T125 (≠ L127)
- binding cyclobutane-1,1-dicarboxylic acid: V232 (= V236), S234 (= S238), A238 (≠ T242), T239 (= T243)
5uatC Structure of human pycr-1 complexed with NADPH (see paper)
33% identity, 95% coverage: 13:274/276 of query aligns to 6:272/277 of 5uatC
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: A12 (= A19), G13 (= G20), Q14 (≠ K21), L15 (≠ M22), S38 (≠ H46), P39 (= P47), D40 (≠ S48), N60 (≠ A66), A73 (= A75), V74 (≠ I76), K75 (= K77), P76 (= P78), I82 (≠ A84), C99 (≠ I101), A100 (≠ L102), A101 (= A103), M125 (= M124), T128 (≠ L127)
6xp3A Structure of human pycr1 complexed with cyclopentanecarboxylic acid (see paper)
33% identity, 95% coverage: 13:274/276 of query aligns to 5:271/276 of 6xp3A
8tdbA Structure of pycr1 complexed with nadh and 1-hydroxyethane-1-sulfonate (see paper)
33% identity, 95% coverage: 13:274/276 of query aligns to 2:268/275 of 8tdbA
- binding (1R)-1-hydroxyethane-1-sulfonic acid: V231 (= V236), S233 (= S238), T238 (= T243)
- binding 1,4-dihydronicotinamide adenine dinucleotide: G7 (= G18), A8 (= A19), G9 (= G20), Q10 (≠ K21), L11 (≠ M22), S34 (≠ H46), P35 (= P47), N56 (≠ A66), V70 (≠ I76), K71 (= K77), P72 (= P78), I78 (≠ A84), A96 (≠ L102), A97 (= A103), T122 (≠ P125), T124 (≠ L127)
8tddA Structure of pycr1 complexed with nadh and 2-(furan-2-yl)acetic acid (see paper)
33% identity, 95% coverage: 13:274/276 of query aligns to 5:271/278 of 8tddA
- binding 1,4-dihydronicotinamide adenine dinucleotide: G10 (= G18), A11 (= A19), G12 (= G20), Q13 (≠ K21), L14 (≠ M22), S37 (≠ H46), P38 (= P47), N59 (≠ A66), A72 (= A75), V73 (≠ I76), P75 (= P78), I81 (≠ A84), C98 (≠ I101), A99 (≠ L102), A100 (= A103), M124 (= M124), T125 (≠ P125), T127 (≠ L127)
- binding (furan-2-yl)acetic acid: M124 (= M124), T174 (= T175), G178 (= G179)
6xp0A Structure of human pycr1 complexed with n-formyl l-proline (see paper)
34% identity, 95% coverage: 13:274/276 of query aligns to 4:267/272 of 6xp0A