SitesBLAST

P9WQ73 Phosphoserine aminotransferase; Phosphohydroxythreonine aminotransferase; PSAT; EC 2.6.1.52 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
23% identity, 96% coverage: 7:381/390 of query aligns to 14:375/376 of P9WQ73

query
sites
P9WQ73

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T154 (= T146) binding pyridoxal 5'-phosphate
D176 (= D169) binding pyridoxal 5'-phosphate
Q199 (= Q192) binding pyridoxal 5'-phosphate

Sites not aligning to the query:

1 modified: Initiator methionine, Removed

3ffrA Crystal structure of a phosphoserine aminotransferase serc (chu_0995) from cytophaga hutchinsonii atcc 33406 at 1.75 a resolution
23% identity, 75% coverage: 15:308/390 of query aligns to 7:302/361 of 3ffrA

query
sites
3ffrA

F

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binding serine: F93 (= F100)

Sites not aligning to the query:

binding serine: 328

Q9Y617 Phosphoserine aminotransferase; Phosphohydroxythreonine aminotransferase; PSAT; EC 2.6.1.52 from Homo sapiens (Human) (see 6 papers)
22% identity, 77% coverage: 15:314/390 of query aligns to 10:309/370 of Q9Y617

query
sites
Q9Y617

F

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S43 (= S39) to R: in PSATD; reduced O-phospho-L-serine:2-oxoglutarate aminotransferase catalytic efficiency; 3-fold increase of KM for 3-phosphohydroxypyruvate; 5-fold increase of KM for L-glutamate; decreased function in L-serine biosynthesis shown through in vitro reconstruction of the phosphorylated pathway; does not affect secondary structure; does not affect dimerization; does not affect thermal stability
H44 (= H40) binding in other chain
R45 (= R41) binding in other chain
Y70 (= Y66) to N: in NLS2; uncertain significance
G79 (≠ D75) binding pyridoxal 5'-phosphate; to W: in NLS2; loss of O-phospho-L-serine:2-oxoglutarate aminotransferase activity; loss of function in L-serine biosynthesis shown through in vitro reconstruction of the phosphorylated pathway
C80 (≠ T76) binding pyridoxal 5'-phosphate
P87 (≠ E80) to A: has no effect on O-phospho-L-serine:2-oxoglutarate aminotransferase catalytic efficiency; does not affect KM for 3-phosphohydroxypyruvate; does not affect KM for L-glutamate; no effect on function in L-serine biosynthesis shown through in vitro reconstruction of the phosphorylated pathway; does not affect secondary structure; does not affect dimerization; does not affect thermal stability; dbSNP:rs11540974
A99 (≠ V92) to V: in NLS2; does not affect secondary structure; does not affect dimerization; increased thermal stability; dbSNP:rs587777778
D100 (= D93) to A: in PSATD; has no effect on O-phospho-L-serine:2-oxoglutarate aminotransferase catalytic efficiency; does not affect KM for 3-phosphohydroxypyruvate; does not affect KM for L-glutamate; does not affect secondary structure; results in increased protein aggregation as shown by dynamic light scattering; dbSNP:rs118203967
W107 (= W97) binding pyridoxal 5'-phosphate
E155 (≠ G145) to Q: in NLS2; uncertain significance
T156 (= T146) binding pyridoxal 5'-phosphate
D176 (= D169) binding pyridoxal 5'-phosphate
S179 (= S172) to L: in NLS2; loss of O-phospho-L-serine:2-oxoglutarate aminotransferase activity; loss of function in L-serine biosynthesis shown through in vitro reconstruction of the phosphorylated pathway; dbSNP:rs587777777
Q199 (= Q192) binding pyridoxal 5'-phosphate
K200 (= K193) modified: N6-(pyridoxal phosphate)lysine
N241 (= N246) binding in other chain
T242 (= T247) binding in other chain
C245 (≠ M250) to R: in NLS2; reduced O-phospho-L-serine:2-oxoglutarate aminotransferase catalytic efficiency; 9-fold increase of KM for L-glutamate; does not affect KM for 3-phosphohydroxypyruvate; decreased function in L-serine biosynthesis shown through in vitro reconstruction of the phosphorylated pathway; does not affect secondary structure; does not affect dimerization

Sites not aligning to the query:

335 binding O-phospho-L-serine
336 binding O-phospho-L-serine
342 binding O-phospho-L-serine; R → W: in NLS2; loss of O-phospho-L-serine:2-oxoglutarate aminotransferase activity; loss of function in L-serine biosynthesis shown through in vitro reconstruction of the phosphorylated pathway; dbSNP:rs202103028

8a5wC Crystal structure of the human phosphoserine aminotransferase (psat) in complex with o-phosphoserine (see paper)
22% identity, 77% coverage: 15:314/390 of query aligns to 5:304/365 of 8a5wC

query
sites
8a5wC

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P

I

N

N

V

I

R

V

S

H

L

P

K

K

A

L

G

G

-

S

Y

Y

G

T

E

K

I

I

V

P

D

D

L

P

A

S

T

T

V

W

D

N

F

L

N

N

N

P

D

D

V

A

V

S

F

Y

T

V

W

Y

-

Y

-

C

-

A

N

N

G

E

T
|
T

T

V

S

H

G

G

V

V

K

E

V

F

P

-

N

-

G

-

D

D

W

F

I

I

A

P

A

D

D

V

R

K

Q

G

G

A

L

V

T

L

I

V

C

C

D

D

A

M

T

S

S

S

A

N

A

F

F

L

A

S

Q

K

K

P

L

V

D

D

W

V

P

S

K

K

L

F

D

G

V

V

V

I

T

F

F

A

S

G

W

A

Q

Q

K
|
K

V

N

L

V

G

G

G

-

E

-

A

-

A

S

H

A

G

G

M

V

L

T

I

V

L

V

S

I

P

V

R

R

A

D

V

-

E

D

R

L

L

L

T

G

T

F

Y

A

T

L

P

R

A

E

W

C

P

P

L

S

P

V

K

L

V

E

F

Y

R

K

L

V

T

Q

S

A

G

G

G

N

K

S

L

-

T

-

E

-

G

-

I

-

F

-

V

-

G

-

E

S

T

L

I

Y

N
|
N

T
|
T

P

P

S

P

M

C

L

F

C

S

V

I

E

Y

D

V

Y

M

I

G

D

L

A

V

L

L

N

E

W

W

G

I

K

K

T

N

V

N

G

G

L

A

E

A

G

A

L

M

I

E

A

K

R

L

A

S

D

S

A

I

N

K

T

S

K

Q

A

T

I

I

A

Y

D

E

W

I

V

I

E

D

K

N

T

S

P

Q

W

G

I

F

D

Y

F

V

L

C

A

P

A

V

D

E

P

P

A

Q

I

N

R

R

S

S

N

K

T

M

S

N

V

I

C

P

L

F

K

R

V

I

S

G

D

N

binding (2S)-2-[(E)-[2-methyl-3-oxidanyl-5-(phosphonooxymethyl)pyridin-4-yl]methylideneamino]-3-phosphonooxy-propanoic acid: H39 (= H40), R40 (= R41), N236 (= N246), T237 (= T247)
binding phosphoserine: T151 (= T146), K195 (= K193)

Sites not aligning to the query:

binding phosphoserine: 330, 331, 337

8a5wA Crystal structure of the human phosphoserine aminotransferase (psat) in complex with o-phosphoserine (see paper)
22% identity, 77% coverage: 15:314/390 of query aligns to 5:304/365 of 8a5wA

query
sites
8a5wA

F

F

S

G

S

P

G

G

P

P

C

-

A

A

K

K

R

L

P

P

G

H

W

S

T

V

L

L

S

L

A

E

L

I

Q

Q

D

K

-

E

-

L

-

D

-

Y

-

K

-

G

-

V

-

G

-

I

A

S

A

V

L

L

G

E

R

M

S

S

H
|
H

R
|
R

A

S

K

S

I

D

G

F

K

A

T

K

K

I

L

I

K

N

L

N

A

T

I

E

D

N

L

L

T

V

R

R

E

E

I

L

L

L

Q

A

V

V

P

P

E

D

D

N

Y

Y

R

K

I

V

G

I

I

F

V

L

P

Q

G

G

S
x
G

D
x
G

T
x
C

G

G

-

Q

-

F

-

S

A

A

V

V

E

P

M

L

A

N

L

L

W

I

T

G

L

L

L

K

G

A

A

G

R

R

G

C

V

A

D

D

V

Y

L

V

-

V

-

T

-

G

A

A

W
|
W

E

S

S

A

F

-

G

-

Q

-

G

-

W

K

V

A

T

A

D

E

I

E

V

A

K

K

Q

K

L

F

K

G

L

T

P

I

N

N

V

I

R

V

S

H

L

P

K

K

A

L

G

G

-

S

Y

Y

G

T

E

K

I

I

V

P

D

D

L

P

A

S

T

T

V

W

D

N

F

L

N

N

N

P

D

D

V

A

V

S

F

Y

T

V

W

Y

-

Y

-

C

-

A

N

N

G

E

T
|
T

T

V

S

H

G

G

V

V

K

E

V

F

P

-

N

-

G

-

D

D

W

F

I

I

A

P

A

D

D

V

R

K

Q

G

G

A

L

V

T

L

I

V

C

C

D
|
D

A

M

T
x
S

S

S

A

N

A

F

F

L

A

S

Q

K

K

P

L

V

D

D

W

V

P

S

K

K

L

F

D

G

V

V

V

I

T

F

F

A

S

G

W

A

Q
|
Q

K
|
K

V

N

L

V

G

G

G

-

E

-

A

-

A

S

H

A

G

G

M

V

L

T

I

V

L

V

S

I

P

V

R

R

A

D

V

-

E

D

R

L

L

L

T

G

T

F

Y

A

T

L

P

R

A

E

W

C

P

P

L

S

P

V

K

L

V

E

F

Y

R

K

L

V

T

Q

S

A

G

G

G

N

K

S

L

-

T

-

E

-

G

-

I

-

F

-

V

-

G

-

E

S

T

L

I

Y

N

N

T

T

P

P

S

P

M

C

L

F

C

S

V

I

E

Y

D

V

Y

M

I

G

D

L

A

V

L

L

N

E

W

W

G

I

K

K

T

N

V

N

G

G

L

A

E

A

G

A

L

M

I

E

A

K

R

L

A

S

D

S

A

I

N

K

T

S

K

Q

A

T

I

I

A

Y

D

E

W

I

V

I

E

D

K

N

T

S

P

Q

W

G

I

F

D

Y

F

V

L

C

A

P

A

V

D

E

P

P

A

Q

I

N

R

R

S

S

N

K

T

M

S

N

V

I

C

P

L

F

K

R

V

I

S

G

D

N

binding 4'-deoxy-4'-aminopyridoxal-5'-phosphate: G73 (≠ S74), G74 (≠ D75), C75 (≠ T76), W102 (= W97), T151 (= T146), D171 (= D169), S173 (≠ T171), Q194 (= Q192), K195 (= K193)
binding phosphoserine: H39 (= H40), R40 (= R41)

Sites not aligning to the query:

binding phosphoserine: 330, 337

8a5vA Crystal structure of the human phosposerine aminotransferase (psat) (see paper)
22% identity, 77% coverage: 15:314/390 of query aligns to 5:304/365 of 8a5vA

query
sites
8a5vA

F

F

S

G

S

P

G

G

P

P

C

-

A

A

K

K

R

L

P

P

G

H

W

S

T

V

L

L

S

L

A

E

L

I

Q

Q

D

K

-

E

-

L

-

D

-

Y

-

K

-

G

-

V

-

G

-

I

A

S

A

V

L

L

G

E

R

M

S

S

H

H

R

R

A

S

K

S

I

D

G

F

K

A

T

K

K

I

L

I

K

N

L

N

A

T

I

E

D

N

L

L

T

V

R

R

E

E

I

L

L

L

Q

A

V

V

P

P

E

D

D

N

Y

Y

R

K

I

V

G

I

I

F

V

L

P

Q

G

G

S

G

D

G

T

C

G

G

-

Q

-

F

-

S

A

A

V

V

E

P

M

L

A

N

L

L

W

I

T

G

L

L

L

K

G

A

A

G

R

R

G

C

V

A

D

D

V

Y

L

V

-

V

-

T

-

G

A

A

W

W

E

S

S

A

F

-

G

-

Q

-

G

-

W

K

V

A

T

A

D

E

I

E

V

A

K

K

Q

K

L

F

K

G

L

T

P

I

N

N

V

I

R

V

S

H

L

P

K

K

A

L

G

G

-

S

Y

Y

G

T

E

K

I

I

V

P

D

D

L

P

A

S

T

T

V

W

D

N

F

L

N

N

N

P

D

D

V

A

V

S

F

Y

T

V

W

Y

-

Y

-

C

-

A

N

N

G

E

T

T

T

V

S

H

G

G

V

V

K

E

V

F

P

-

N

-

G

-

D

D

W

F

I

I

A

P

A

D

D

V

R

K

Q

G

G

A

L

V

T

L

I

V

C

C

D

D

A

M

T

S

S

S

A

N

A

F

F

L

A

S

Q

K

K

P

L

V

D

D

W

V

P

S

K

K

L

F

D

G

V

V

V

I

T

F

F

A

S

G

W

A

Q

Q

K

K

V

N

L

V

G

G

G

-

E

-

A

-

A

S

H

A

G

G

M

V

L

T

I

V

L

V

S

I

P

V

R

R

A

D

V

-

E

D

R

L

L

L

T

G

T

F

Y

A

T

L

P

R

A

E

W

C

P

P

L

S

P

V

K

L

V

E

F

Y

R

K

L

V

T

Q

S

A

G

G

G

N

K

S

L

-

T

-

E

-

G

-

I

-

F

-

V

-

G

-

E

S

T

L

I

Y

N
|
N

T
|
T

P

P

S

P

M

C

L

F

C

S

V

I

E

Y

D

V

Y

M

I

G

D

L

A

V

L

L

N

E

W

W

G

I

K

K

T

N

V

N

G

G

L

A

E

A

G

A

L

M

I

E

A

K

R

L

A

S

D

S

A

I

N

K

T

S

K

Q

A

T

I

I

A

Y

D

E

W

I

V

I

E

D

K

N

T

S

P

Q

W

G

I

F

D

Y

F

V

L

C

A

P

A

V

D

E

P

P

A

Q

I

N

R

R

S

S

N

K

T

M

S

N

V

I

C

P

L

F

K

R

V

I

S

G

D

N

binding 4'-deoxy-4'-aminopyridoxal-5'-phosphate: N236 (= N246), T237 (= T247)

8a5vE Crystal structure of the human phosposerine aminotransferase (psat) (see paper)
22% identity, 77% coverage: 15:314/390 of query aligns to 6:305/366 of 8a5vE

query
sites
8a5vE

F

F

S

G

S

P

G

G

P

P

C

-

A

A

K

K

R

L

P

P

G

H

W

S

T

V

L

L

S

L

A

E

L

I

Q

Q

D

K

-

E

-

L

-

D

-

Y

-

K

-

G

-

V

-

G

-

I

A

S

A

V

L

L

G

E

R

M

S

S

H

H

R

R

A

S

K

S

I

D

G

F

K

A

T

K

K

I

L

I

K

N

L

N

A

T

I

E

D

N

L

L

T

V

R

R

E

E

I

L

L

L

Q

A

V

V

P

P

E

D

D

N

Y

Y

R

K

I

V

G

I

I

F

V

L

P

Q

G

G

S

G

D

G

T

C

G

G

-

Q

-

F

-

S

A

A

V

V

E

P

M

L

A

N

L

L

W

I

T

G

L

L

L

K

G

A

A

G

R

R

G

C

V

A

D

D

V

Y

L

V

-

V

-

T

-

G

A

A

W
|
W

E

S

S

A

F

-

G

-

Q

-

G

-

W

K

V

A

T

A

D

E

I

E

V

A

K

K

Q

K

L

F

K

G

L

T

P

I

N

N

V

I

R

V

S

H

L

P

K

K

A

L

G

G

-

S

Y

Y

G

T

E

K

I

I

V

P

D

D

L

P

A

S

T

T

V

W

D

N

F

L

N

N

N

P

D

D

V

A

V

S

F

Y

T

V

W

Y

-

Y

-

C

-

A

N

N

G

E

T

T

T

V

S

H

G

G

V

V

K

E

V

F

P

-

N

-

G

-

D

D

W

F

I

I

A

P

A

D

D

V

R

K

Q

G

G

A

L

V

T

L

I

V

C

C

D

D

A

M

T

S

S

S

A

N

A

F

F

L

A

S

Q

K

K

P

L

V

D

D

W

V

P

S

K

K

L

F

D

G

V

V

V

I

T

F

F

A

S

G

W

A

Q

Q

K

K

V

N

L

V

G

G

G

-

E

-

A

-

A

S

H

A

G

G

M

V

L

T

I

V

L

V

S

I

P

V

R

R

A

D

V

-

E

D

R

L

L

L

T

G

T

F

Y

A

T

L

P

R

A

E

W

C

P

P

L

S

P

V

K

L

V

E

F

Y

R

K

L

V

T

Q

S

A

G

G

G

N

K

S

L

-

T

-

E

-

G

-

I

-

F

-

V

-

G

-

E

S

T

L

I

Y

N

N

T

T

P

P

S

P

M

C

L

F

C

S

V

I

E

Y

D

V

Y

M

I

G

D

L

A

V

L

L

N

E

W

W

G

I

K

K

T

N

V

N

G

G

L

A

E

A

G

A

L

M

I

E

A

K

R

L

A

S

D

S

A

I

N

K

T

S

K

Q

A

T

I

I

A

Y

D

E

W

I

V

I

E

D

K

N

T

S

P

Q

W

G

I

F

D

Y

F

V

L

C

A

P

A

V

D

E

P

P

A

Q

I

N

R

R

S

S

N

K

T

M

S

N

V

I

C

P

L

F

K

R

V

I

S

G

D

N

binding sulfate ion: W103 (= W97)

Sites not aligning to the query:

binding sulfate ion: 332

8a5wE Crystal structure of the human phosphoserine aminotransferase (psat) in complex with o-phosphoserine (see paper)
22% identity, 77% coverage: 15:314/390 of query aligns to 6:304/365 of 8a5wE

query
sites
8a5wE

F

F

S

G

S

P

G

G

P

P

C

-

A

A

K

K

R

L

P

P

G

H

W

S

T

V

L

L

S

L

A

E

L

I

Q

Q

D

K

-

E

-

L

-

D

-

Y

-

K

-

G

-

V

-

G

-

I

A

S

A

V

L

L

G

E

R

M

S

S

H
|
H

R
|
R

A

S

K

S

I

D

G

F

K

A

T

K

K

I

L

I

K

N

L

N

A

T

I

E

D

N

L

L

T

V

R

R

E

E

I

L

L

L

Q

A

V

V

P

P

E

D

D

N

Y

Y

R

K

I

V

G

I

I

F

V

L

P

Q

G

G

S
x
G

D
x
G

T
x
C

G

G

-

Q

-

F

-

S

A

A

V

V

E

P

M

L

A

N

L

L

W

I

T

G

L

L

L

K

G

A

A

G

R

R

G

C

V

A

D

D

V

Y

L

V

-

V

-

T

-

G

A

A

W
|
W

E

S

S

A

F

-

G

-

Q

-

G

-

W

K

V

A

T

A

D

E

I

E

V

A

K

K

Q

K

L

F

K

G

L

T

P

I

N

N

V

I

R

V

S

H

L

P

K

K

A

L

G

G

-

S

Y

Y

G

T

E

K

I

I

V

P

D

D

L

P

A

S

T

T

V

W

D

N

F

L

N

N

N

P

D

D

V

A

V

S

F

Y

T

V

W

Y

-

Y

-

C

-

A

N

N

G

E

T
|
T

T

V

S

H

G

G

V

V

K

E

V

F

P

-

N

-

G

-

D

D

W

F

I

I

A

P

A

D

D

V

R

K

Q

G

G

A

L

V

T

L

I

V

C

C

D

D

A

M

T
x
S

S

S

A

N

A

F

F

L

A

S

Q

K

K

P

L

V

D

D

W

V

P

S

K

K

L

F

D

G

V

V

V

I

T

F

F

A

S

G

W
x
A

Q
|
Q

K
x
N

V

V

L

-

G

-

G

G

E

S

A

A

A

G

H

V

G

T

M

V

L

V

I

I

L

V

S

R

P

D

R

-

A

-

V

-

E

D

R

L

L

L

T

G

T

F

Y

A

T

L

P

R

A

E

W

C

P

P

L

S

P

V

K

L

V

E

F

Y

R

K

L

V

T

Q

S

A

G

G

G

N

K

S

L

-

T

-

E

-

G

-

I

-

F

-

V

-

G

-

E

S

T

L

I

Y

N
|
N

T
|
T

P

P

S

P

M

C

L

F

C

S

V

I

E

Y

D

V

Y

M

I

G

D

L

A

V

L

L

N

E

W

W

G

I

K

K

T

N

V

N

G

G

L

A

E

A

G

A

L

M

I

E

A

K

R

L

A

S

D

S

A

I

N

K

T

S

K

Q

A

T

I

I

A

Y

D

E

W

I

V

I

E

D

K

N

T

S

P

Q

W

G

I

F

D

Y

F

V

L

C

A

P

A

V

D

E

P

P

A

Q

I

N

R

R

S

S

N

K

T

M

S

N

V

I

C

P

L

F

K

R

V

I

S

G

D

N

binding (2S)-2-[(E)-[2-methyl-3-oxidanyl-5-(phosphonooxymethyl)pyridin-4-yl]methylideneamino]-3-phosphonooxy-propanoic acid: H40 (= H40), R41 (= R41), N236 (= N246), T237 (= T247)
binding (2~{S})-2-[[(~{R})-[[(5~{S})-5-azanyl-6-oxidanylidene-hexyl]amino]-[2-methyl-3-oxidanyl-5-(phosphonooxymethyl)pyridin-4-yl]methyl]amino]-3-phosphonooxy-propanoic acid: G74 (≠ S74), G75 (≠ D75), C76 (≠ T76), W103 (= W97), T152 (= T146), S174 (≠ T171), A194 (≠ W191), Q195 (= Q192), N196 (≠ K193)

Sites not aligning to the query:

binding (2~{S})-2-[[(~{R})-[[(5~{S})-5-azanyl-6-oxidanylidene-hexyl]amino]-[2-methyl-3-oxidanyl-5-(phosphonooxymethyl)pyridin-4-yl]methyl]amino]-3-phosphonooxy-propanoic acid: 330, 331, 337, 341

3e77A Human phosphoserine aminotransferase in complex with plp
22% identity, 72% coverage: 34:314/390 of query aligns to 31:302/363 of 3e77A

query
sites
3e77A

A

S

A

V

L

L

G

E

R

M

S

S

H

H

R

R

A

S

K

S

I

D

G

F

K

A

T

K

K

I

L

I

K

N

L

N

A

T

I

E

D

N

L

L

T

V

R

R

E

E

I

L

L

L

Q

A

V

V

P

P

E

D

D

N

Y

Y

R

K

I

V

G

I

I

F

V

L

P

Q

G

G

S
x
G

D
x
G

T
x
C

G

G

-

Q

-

F

-

S

A

A

V

V

E

P

M

L

A

N

L

L

W

I

T

G

L

L

L

K

G

A

A

G

R

R

G

C

V

A

D

D

V

Y

L

V

-

V

-

T

-

G

A

A

W
|
W

E

S

S

A

F

-

G

-

Q

-

G

-

W

K

V

A

T

A

D

E

I

E

V

A

K

K

Q

K

L

F

K

G

L

T

P

I

N

N

V

I

R

V

S

H

L

P

K

K

A

L

G

G

-

S

Y

Y

G

T

E

K

I

I

V

P

D

D

L

P

A

S

T

T

V

W

D

N

F

L

N

N

N

P

D

D

V

A

V

S

F

Y

T

V

W

Y

-

Y

-

C

-

A

N

N

G

E

T
|
T

T

V

S

H

G

G

V

V

K

E

V

F

P

-

N

-

G

-

D

D

W

F

I

I

A

P

A

D

D

V

R

K

Q

G

G

A

L

V

T

L

I

V

C

C

D
|
D

A

M

T
x
S

S

S

A

N

A

F

F

L

A

S

Q

K

K

P

L

V

D

D

W

V

P

S

K

K

L

F

D

G

V

V

V

I

T

F

F

A

S

G

W

A

Q
|
Q

K
|
K

V

N

L

V

G

G

G

-

E

-

A

-

A

S

H

A

G

G

M

V

L

T

I

V

L

V

S

I

P

V

R

R

A

D

V

-

E

D

R

L

L

L

T

G

T

F

Y

A

T

L

P

R

A

E

W

C

P

P

L

S

P

V

K

L

V

E

F

Y

R

K

L

V

T

Q

S

A

G

G

G

N

K

-

L

-

T

-

E

-

G

-

I

-

F

-

V

-

G

S

E

S

T

L

I

Y

N
|
N

T
|
T

P

P

S

P

M

C

L

F

C

S

V

I

E

Y

D

V

Y

M

I

G

D

L

A

V

L

L

N

E

W

W

G

I

K

K

T

N

V

N

G

G

L

A

E

A

G

A

L

M

I

E

A

K

R

L

A

S

D

S

A

I

N

K

T

S

K

Q

A

T

I

I

A

Y

D

E

W

I

V

I

E

D

K

N

T

S

P

Q

W

G

I

F

D

Y

F

V

L

C

A

P

A

V

D

E

P

P

A

Q

I

N

R

R

S

S

N

K

T

M

S

N

V

I

C

P

L

F

K

R

V

I

S

G

D

N

active site: W100 (= W97), D169 (= D169), K193 (= K193)
binding pyridoxal-5'-phosphate: G71 (≠ S74), G72 (≠ D75), C73 (≠ T76), W100 (= W97), T149 (= T146), D169 (= D169), S171 (≠ T171), Q192 (= Q192), K193 (= K193), N234 (= N246), T235 (= T247)

Query Sequence

>WP_012384268.1 NCBI__GCF_000019845.1:WP_012384268.1
MTDTLPAARPANACFSSGPCAKRPGWTLSALQDAALGRSHRAKIGKTKLKLAIDLTREIL
QVPEDYRIGIVPGSDTGAVEMALWTLLGARGVDVLAWESFGQGWVTDIVKQLKLPNVRSL
KAGYGEIVDLATVDFNNDVVFTWNGTTSGVKVPNGDWIAADRQGLTICDATSAAFAQKLD
WPKLDVVTFSWQKVLGGEAAHGMLILSPRAVERLTTYTPAWPLPKVFRLTSGGKLTEGIF
VGETINTPSMLCVEDYIDALNWGKTVGGLEGLIARADANTKAIADWVEKTPWIDFLAADP
AIRSNTSVCLKVSDPAITALSDEAQAAFAKTLASLLEKEKVAYDIGAYRDAPPGLRIWCG
ATVETSDIIALTAWLDYAYAKAKSDLPKAA

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory