SitesBLAST
Comparing WP_012385443.1 NCBI__GCF_000019845.1:WP_012385443.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
3iq0B Crystal structure of a putative ribokinase ii in complex with atp and mg+2 from e.Coli
53% identity, 88% coverage: 22:327/349 of query aligns to 4:306/308 of 3iq0B
- active site: G252 (= G273), A253 (= A274), G254 (= G275), D255 (= D276)
- binding adenosine-5'-triphosphate: S192 (= S213), K223 (= K244), G225 (= G246), E247 (= E268), A253 (= A274), G254 (= G275), F257 (= F278), N279 (= N300), G282 (= G303)
2dcnA Crystal structure of 2-keto-3-deoxygluconate kinase from sulfolobus tokodaii complexed with 2-keto-6-phosphogluconate (alpha-furanose form)
29% identity, 87% coverage: 22:326/349 of query aligns to 3:305/308 of 2dcnA
- active site: G252 (= G273), A253 (= A274), G254 (= G275), D255 (= D276)
- binding adenosine-5'-diphosphate: D193 (≠ G214), K223 (= K244), G225 (= G246), P226 (≠ A247), G228 (= G249), V247 (= V266), G254 (= G275), I279 (≠ N300), S282 (≠ G303), V286 (= V307)
- binding 6-O-phosphono-beta-D-psicofuranosonic acid: G33 (= G54), F89 (≠ A110), Y105 (≠ F124), R107 (≠ I126), I136 (≠ S155), R165 (= R187), T251 (= T272), G252 (= G273), D255 (= D276), D291 (≠ P312)
1v1aA 2-keto-3-deoxygluconate kinase from thermus thermophilus with bound 2- keto-3-deoxygluconate and adp (see paper)
32% identity, 87% coverage: 22:326/349 of query aligns to 4:301/301 of 1v1aA
- active site: G248 (= G273), A249 (= A274), G250 (= G275), D251 (= D276)
- binding adenosine-5'-diphosphate: K219 (= K244), G221 (= G246), A222 (= A247), A249 (= A274), G250 (= G275), N275 (= N300), A279 (= A304)
- binding 2-keto-3-deoxygluconate: L11 (≠ V29), G34 (= G54), A35 (= A55), N38 (≠ I58), Y89 (≠ A110), R105 (≠ I126), R167 (= R187), G248 (= G273), D251 (= D276), D287 (≠ P312)
Q53W83 2-dehydro-3-deoxygluconokinase; 2-keto-3-deoxygluconokinase; 3-deoxy-2-oxo-D-gluconate kinase; KDG kinase; EC 2.7.1.45 from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8) (see paper)
31% identity, 88% coverage: 22:327/349 of query aligns to 4:302/309 of Q53W83
- GAEVN 34:38 (≠ GAPAI 54:58) binding substrate
- YYR 103:105 (≠ FNI 124:126) binding substrate
- R167 (= R187) binding substrate
- S193 (= S213) binding ATP
- 219:225 (vs. 244:250, 71% identical) binding ATP
- GAGD 248:251 (= GAGD 273:276) binding ATP
- D251 (= D276) binding substrate
- N275 (= N300) binding ATP
- D287 (≠ P312) binding substrate
1v1bA 2-keto-3-deoxygluconate kinase from thermus thermophilus with bound atp (see paper)
31% identity, 87% coverage: 22:325/349 of query aligns to 4:300/300 of 1v1bA
- active site: G248 (= G273), A249 (= A274), G250 (= G275), D251 (= D276)
- binding adenosine-5'-triphosphate: K219 (= K244), G221 (= G246), A238 (≠ P263), F239 (≠ M264), V241 (= V266), G248 (= G273), A249 (= A274), G250 (= G275), N275 (= N300), A279 (= A304)
2varA Crystal structure of sulfolobus solfataricus 2-keto-3-deoxygluconate kinase complexed with 2-keto-3-deoxygluconate (see paper)
27% identity, 88% coverage: 22:327/349 of query aligns to 3:308/311 of 2varA
- active site: G254 (= G273), A255 (= A274), G256 (= G275), D257 (= D276)
- binding adenosine monophosphate: G227 (= G246), G230 (= G249), M259 (≠ F278), S284 (≠ G303), I288 (≠ V307)
- binding phosphoaminophosphonic acid-adenylate ester: K225 (= K244), G227 (= G246), S228 (≠ A247), G230 (= G249), G254 (= G273), A255 (= A274), G256 (= G275), D257 (= D276), M259 (≠ F278), I281 (≠ N300), S284 (≠ G303), I288 (≠ V307)
- binding 3-deoxy-alpha-D-erythro-hex-2-ulofuranosonic acid: L10 (≠ V29), G33 (= G54), S34 (≠ A55), Y89 (≠ A110), Y105 (≠ F124), R107 (≠ I126), I136 (≠ S155), R165 (= R187), G254 (= G273), D257 (= D276)
- binding 2-keto-3-deoxygluconate: G33 (= G54), S34 (≠ A55), Y89 (≠ A110), L103 (≠ F122), Y105 (≠ F124), R107 (≠ I126), I136 (≠ S155), R165 (= R187), T253 (= T272), G254 (= G273), D257 (= D276), D293 (≠ P312)
Q97U29 2-dehydro-3-deoxygluconokinase/2-dehydro-3-deoxygalactonokinase; 2-dehydro-3-deoxyglucono/galactono-kinase; 2-keto-3-deoxy-galactonokinase; 2-keto-3-deoxygluconokinase; 3-deoxy-2-oxo-D-gluconate kinase; KDG kinase; KDGal kinase; EC 2.7.1.178 from Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (Sulfolobus solfataricus) (see paper)
27% identity, 88% coverage: 22:327/349 of query aligns to 4:309/313 of Q97U29
5eynA Crystal structure of fructokinase from vibrio cholerae o395 in fructose, adp, beryllium trifluoride and calcium ion bound form
29% identity, 79% coverage: 52:326/349 of query aligns to 26:305/306 of 5eynA
- active site: G246 (= G273), A247 (= A274), G248 (= G275), D249 (= D276)
- binding adenosine-5'-diphosphate: H91 (≠ T117), T217 (≠ K244), G219 (= G246), A220 (= A247), A238 (≠ P265), V239 (= V266), T244 (≠ P271), G246 (= G273), A247 (= A274), G248 (= G275), F251 (= F278), N279 (= N300), G282 (= G303), A283 (= A304)
- binding beryllium trifluoride ion: G246 (= G273), G248 (= G275), D249 (= D276)
- binding beta-D-fructofuranose: G28 (= G54), A29 (= A55), N32 (≠ I58), F96 (= F122), F98 (= F124), R159 (= R187), D249 (= D276)
Sites not aligning to the query:
5yggA Crystal structure of fructokinase double-mutant (t261c-h108c) from vibrio cholerae o395 in fructose, adp and potassium ion bound form (see paper)
29% identity, 79% coverage: 52:326/349 of query aligns to 30:309/310 of 5yggA
- binding adenosine-5'-diphosphate: K188 (≠ L211), T221 (≠ K244), G223 (= G246), A242 (≠ P265), V243 (= V266), F255 (= F278), N283 (= N300), G286 (= G303), A287 (= A304)
- binding beta-D-fructofuranose: G32 (= G54), A33 (= A55), F100 (= F122), F102 (= F124), R163 (= R187), D253 (= D276)
Sites not aligning to the query:
3in1A Crystal structure of a putative ribokinase in complex with adp from e.Coli
28% identity, 74% coverage: 63:321/349 of query aligns to 49:305/312 of 3in1A
- active site: R106 (= R120), G255 (= G273), A256 (= A274), G257 (= G275), D258 (= D276)
- binding adenosine-5'-diphosphate: N194 (≠ S213), K225 (= K244), G227 (= G246), G230 (= G249), A244 (= A262), T253 (≠ P271), N282 (= N300), A285 (≠ G303)
Q8ZKR2 Aminoimidazole riboside kinase; AIRs kinase; EC 2.7.1.223 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see paper)
28% identity, 91% coverage: 16:331/349 of query aligns to 1:312/319 of Q8ZKR2
- D16 (≠ E31) binding 5-amino-1-(beta-D-ribosyl)imidazole
- G31 (= G54) binding 5-amino-1-(beta-D-ribosyl)imidazole
- Y101 (≠ F124) binding 5-amino-1-(beta-D-ribosyl)imidazole
- R162 (= R187) binding 5-amino-1-(beta-D-ribosyl)imidazole
- A180 (≠ L204) binding K(+)
- A181 (= A205) binding K(+)
- A183 (≠ T207) binding K(+)
- G213 (= G237) binding K(+)
- D246 (= D270) binding K(+)
- T248 (= T272) binding K(+)
- D252 (= D276) binding 5-amino-1-(beta-D-ribosyl)imidazole
- A287 (= A306) binding K(+)
- A290 (≠ M309) binding K(+)
- G292 (= G311) binding K(+)
3gbuA Crystal structure of an uncharacterized sugar kinase ph1459 from pyrococcus horikoshii in complex with atp
26% identity, 83% coverage: 22:311/349 of query aligns to 2:282/302 of 3gbuA
- active site: G242 (= G273), A243 (= A274), G244 (= G275), D245 (= D276)
- binding adenosine-5'-triphosphate: K188 (≠ L211), T213 (≠ V242), G215 (= G246), V235 (= V266), P237 (≠ E268), A243 (= A274), G244 (= G275), A274 (≠ G303)
3ih0A Crystal structure of an uncharacterized sugar kinase ph1459 from pyrococcus horikoshii in complex with amp-pnp
26% identity, 83% coverage: 22:311/349 of query aligns to 3:283/304 of 3ih0A
A1A6H3 Ribokinase; AtRBSK; RK; EC 2.7.1.15 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
28% identity, 71% coverage: 64:311/349 of query aligns to 116:360/379 of A1A6H3
Sites not aligning to the query:
- 1:74 mutation Missing: Loss of ribokinase activity.
6ilsB Structure of arabidopsis thaliana ribokinase complexed with ribose and atp (see paper)
29% identity, 71% coverage: 64:311/349 of query aligns to 50:294/313 of 6ilsB
- binding adenosine-5'-triphosphate: N189 (≠ S213), K225 (= K244), G227 (= G246), I246 (≠ M264), A248 (≠ V266), A257 (= A274), G258 (= G275), F261 (= F278), A286 (≠ G303), S287 (≠ A304)
- binding alpha-D-ribofuranose: E144 (vs. gap), D259 (= D276)
Sites not aligning to the query:
4xckA Vibrio cholerae o395 ribokinase complexed with adp, ribose and cesium ion. (see paper)
26% identity, 73% coverage: 73:327/349 of query aligns to 58:303/306 of 4xckA
- active site: A249 (≠ G273), A250 (= A274), G251 (= G275), D252 (= D276)
- binding adenosine-5'-diphosphate: T220 (≠ K244), G222 (= G246), S223 (≠ A247), V242 (= V266), T247 (≠ P271), A250 (= A274), F254 (= F278), H276 (≠ N300), A279 (≠ G303), V283 (= V307)
- binding alpha-D-ribofuranose: A95 (= A110), I107 (≠ F122), I109 (≠ F124), E140 (≠ F158), T248 (= T272), D252 (= D276)
Sites not aligning to the query:
1tz6A Crystal structure of aminoimidazole riboside kinase from salmonella enterica complexed with aminoimidazole riboside and atp analog (see paper)
28% identity, 79% coverage: 52:327/349 of query aligns to 25:297/297 of 1tz6A
- active site: F88 (= F122), G238 (= G273), A239 (= A274), G240 (= G275), D241 (= D276)
- binding phosphomethylphosphonic acid adenylate ester: N149 (= N185), K176 (≠ L211), E181 (= E216), S209 (≠ K244), G211 (= G246), A212 (= A247), G214 (= G249), A239 (= A274), G240 (= G275), F243 (= F278), N270 (= N300), G273 (= G303), A274 (= A304)
- binding 5-aminoimidazole ribonucleoside: G27 (= G54), F88 (= F122), Y90 (≠ F124), R151 (= R187), M154 (= M190), D241 (= D276)
Sites not aligning to the query:
1tz3A Crystal structure of aminoimidazole riboside kinase complexed with aminoimidazole riboside (see paper)
28% identity, 79% coverage: 52:327/349 of query aligns to 25:297/299 of 1tz3A
- active site: F88 (= F122), G238 (= G273), A239 (= A274), G240 (= G275), D241 (= D276)
- binding 5-aminoimidazole ribonucleoside: G27 (= G54), L83 (≠ A110), F88 (= F122), Y90 (≠ F124), R151 (= R187), M154 (= M190), D241 (= D276)
Sites not aligning to the query:
P0DX97 Deoxyribokinase; dRK; ATP:2-deoxy-D-ribose 5-phosphotransferase; EC 2.7.1.229 from Salmonella typhi (see paper)
26% identity, 41% coverage: 186:329/349 of query aligns to 152:305/306 of P0DX97
Sites not aligning to the query:
- 10 Important for substrate specificity; M→N: 2.5-fold decrease in Vmax for deoxyribokinase activity and 70-fold increase in KM for deoxyribose. 2-fold increase in KM for ribose.
4wjmA Crystal structure of fructokinase from brucella abortus 2308 with bound amppnp
28% identity, 67% coverage: 52:284/349 of query aligns to 32:263/312 of 4wjmA
- active site: G252 (= G273), A253 (= A274), G254 (= G275), D255 (= D276)
- binding phosphoaminophosphonic acid-adenylate ester: T223 (≠ K244), G225 (= G246), A226 (= A247), G228 (= G249), G252 (= G273), A253 (= A274), G254 (= G275), V257 (≠ F278)
Sites not aligning to the query:
Query Sequence
>WP_012385443.1 NCBI__GCF_000019845.1:WP_012385443.1
MAHFLDLLDDHGAAQLRVVKPVITIGEIVAEIMAVDVGEGFRSPLRLIGPYPSGAPAIFI
DQVAKIGLPCAIISAVGNDDFGWLSIDRLRSDGVDISAIRIDNRLATGSAFVRYRSTGER
DFVFNIVGSACSTIRRDAAASAVIASAGHIHVMGSSLFSPAVVSLVEDAITEIKARGGTV
SFDPNGRKEMLDVPGMRDALARVLAQTDLFLPSGEELTLLTRAHTDDGAIAELLGAGIRS
VVVKQGAAGATYHDRERTCRVAPMPVNEVDPTGAGDSFGGTFVACWLLGLPPEQCLRFAN
ASGARAVMMRGPMEGNSTLAELETFLSVDALGANLWLSMMNTRRSGPRN
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory