SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing WP_012401933.1 NCBI__GCF_000020045.1:WP_012401933.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

4ij6A Crystal structure of a novel-type phosphoserine phosphatase mutant (h9a) from hydrogenobacter thermophilus tk-6 in complex with l-phosphoserine (see paper)
27% identity, 92% coverage: 3:207/223 of query aligns to 2:201/207 of 4ij6A

query
sites
4ij6A

T

V

Q

K

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L

L

I

F

L

I

V

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R

H
x
A

G

A

E

E

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active site: R8 (= R9), A9 (≠ H10), N15 (= N16), R58 (= R64), E82 (= E88), H150 (= H156)
binding phosphoserine: R8 (= R9), Q21 (= Q22), R58 (= R64), E82 (= E88), H85 (≠ Y91), H150 (= H156), T151 (≠ G157)

6m1xC Crystal structure of phosphoserine phosphatase in complex with 3- phosphoglyceric acid from entamoeba histolytica (see paper)
28% identity, 91% coverage: 3:206/223 of query aligns to 2:196/196 of 6m1xC

query
sites
6m1xC

T

T

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I

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H

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binding 3-phosphoglyceric acid: R8 (= R9), H9 (= H10), Q21 (= Q22), R57 (= R64), E79 (= E88), H146 (= H156), G147 (= G157)

1h2fA Bacillus stearothermophilus phoe (previously known as yhfr) in complex with trivanadate (see paper)
32% identity, 92% coverage: 2:206/223 of query aligns to 1:201/207 of 1h2fA

query
sites
1h2fA

A
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x
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I

active site: R8 (= R9), H9 (= H10), N15 (= N16), R58 (= R64), E82 (= E88), H150 (= H156)
binding phosphate ion: A1 (= A2), T2 (= T3), T3 (≠ Q4), G142 (≠ D148), E143 (≠ G149)
binding trivanadate: R8 (= R9), H9 (= H10), N15 (= N16), Q21 (= Q22), R58 (= R64), E82 (= E88), H150 (= H156), G151 (= G157), V152 (≠ G158)

1h2eA Bacillus stearothermophilus phoe (previously known as yhfr) in complex with phosphate (see paper)
32% identity, 92% coverage: 2:206/223 of query aligns to 1:201/207 of 1h2eA

query
sites
1h2eA

A

A

T

T

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T

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Y

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H

G

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E

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W

N
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N

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K

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D

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active site: R8 (= R9), H9 (= H10), N15 (= N16), R58 (= R64), E82 (= E88), H150 (= H156)
binding phosphate ion: R8 (= R9), H9 (= H10), R58 (= R64), E82 (= E88), H150 (= H156)

5zr2C Crystal structure of phosphoserine phosphatase mutant (h9a) from entamoeba histolytica in complex with phosphoserine (see paper)
28% identity, 91% coverage: 3:206/223 of query aligns to 2:196/198 of 5zr2C

query
sites
5zr2C

T

T

Q

K

V

L

L

I

F

L

I

I

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H

A

G

G

E

E

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E

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W

N

N

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I

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Q

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G

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C

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D

D

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E

L

L

A

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N

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Q

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A

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A

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C

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D

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L

binding phosphoserine: R8 (= R9), Q21 (= Q22), G22 (= G23), R57 (= R64), E79 (= E88), H146 (= H156), G147 (= G157)

P36623 Phosphoglycerate mutase; PGAM; BPG-dependent PGAM; MPGM; Phosphoglyceromutase; EC 5.4.2.11 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
29% identity, 76% coverage: 5:173/223 of query aligns to 10:180/211 of P36623

query
sites
P36623

V

L

L

V

F

L

I

T

R

R

H

H

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G

E

E

T

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D

E

W

W

N

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T

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G

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x
T

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A

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L

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A

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E

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A

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C

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E

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G

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H

H

-

I

-

L

P

K

D

G

G

E

R

K

I

V

A

L

C

I

V

A

A

A

H

H

G

G

G

N

V
x
S

L

L

D

R

C

A

V

L

Y

I

R

M

F

D

A

L

N

E

G

G

L

L

S

T

L

G

D

D

T37 (≠ S32) modified: Phosphothreonine
S62 (= S60) modified: Phosphoserine
Y96 (= Y91) modified: Phosphotyrosine
S166 (≠ V159) modified: Phosphoserine

1e59A E.Coli cofactor-dependent phosphoglycerate mutase complexed with vanadate (see paper)
34% identity, 55% coverage: 3:124/223 of query aligns to 2:123/239 of 1e59A

query
sites
1e59A

T

T

Q

K

V

L

L

V

F

L

I

V

R
|
R

H
|
H

G

G

E

E

T

S

D

Q

W

W

N
|
N

R

K

I

E

K

N

R

R

I
x
F

Q
x
T

G
|
G

H

W

I

Y

D

D

I

V

P

D

L

L

A

S

T

E

S

K

G

G

V

V

E

S

Q

E

A

A

K

K

R

A

L

A

A

G

E

K

R

L

F

L

A

-

C

-

E

-

A

K

H

E

E

E

G

G

A

Y

R

S

L

F

D

D

A

F

V

A

Y

Y

S

T

S

S

D

V

L

L

M

K

R
|
R

A

A

R

I

Q

H

T

T

A

L

Q

W

P

N

F

V

A

L

D

D

V

E

L

L

G

D

-

Q

-

A

-

W

L

L

R

P

L

V

Q

E

L

K

R

S

E

W

G

K

L

L

R

N

E
|
E

R

R

N

H

Y
|
Y

G

G

A

A

F

L

Q

Q

G

G

H

L

D

N

S
x
K

D

A

E

E

I

T

S

A

L

E

R

K

F

Y

P

G

D

D

E

E

Y

Q

A

V

R

K

W

Q

Q

W

T
x
R

R
|
R

D

G

P

F

G

A

F

V

S

T

P

P

E

E

active site: H9 (= H10), R60 (= R64), E87 (= E88)
binding tetrametavanadate: R8 (= R9), N15 (= N16), F20 (≠ I21), T21 (≠ Q22), G22 (= G23), Y90 (= Y91), K98 (≠ S99), R114 (≠ T115), R115 (= R116)

Sites not aligning to the query:

active site: 182
binding tetrametavanadate: 184

P62707 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase; BPG-dependent PGAM; PGAM; Phosphoglyceromutase; dPGM; EC 5.4.2.11 from Escherichia coli (strain K12) (see 6 papers)
33% identity, 55% coverage: 2:124/223 of query aligns to 3:125/250 of P62707

query
sites
P62707

A

V

T

T

Q

K

V

L

L

V

F

L

I

V

R
|
R

H
|
H

G
|
G

E
|
E

T
x
S

D
x
Q

W
|
W

N
|
N

R
x
K

I

E

K

N

R

R

I

F

Q
x
T

G
|
G

H

W

I

Y

D

D

I

V

P

D

L

L

A

S

T

E

S

K

G

G

V

V

E

S

Q

E

A

A

K

K

R

A

L

A

A

G

E

K

R

L

F

L

A

-

C

-

E

-

A

K

H

E

E

E

G

G

A

Y

R

S

L

F

D

D

A

F

V

A

Y

Y

S

T

S

S

D

V

L

L

M

K

R

R

A

A

R

I

Q

H

T

T

A

L

Q

W

P

N

F

V

A

L

D

D

V

E

L

L

G

D

-

Q

-

A

-

W

L

L

R

P

L

V

Q

E

L

K

R

S

E

W

G

K

L

L

R

N

E
|
E

R
|
R

N
x
H

Y
|
Y

G

G

A

A

F

L

Q

Q

G

G

H

L

D

N

S
x
K

D

A

E

E

I

T

S

A

L

E

R
x
K

F

Y

P

G

D

D

E

E

Y

Q

A

V

R

K

W

Q

Q

W

T
x
R

R
|
R

D

G

P

F

G

A

F

V

S

T

P

P

E

E

10:17 (vs. 9:16, 75% identical) binding
H11 (= H10) active site, Tele-phosphohistidine intermediate
K18 (≠ R17) modified: N6-acetyllysine
TG 23:24 (≠ QG 22:23) binding
E89 (= E88) active site, Proton donor/acceptor
ERHY 89:92 (≠ ERNY 88:91) binding
K100 (≠ S99) binding ; modified: N6-acetyllysine
K106 (≠ R105) modified: N6-acetyllysine
RR 116:117 (≠ TR 115:116) binding

Sites not aligning to the query:

1 modified: Initiator methionine, Removed
184 Transition state stabilizer
185:186 binding

P9WIC7 Glucosyl-3-phosphoglycerate phosphatase; Mannosyl-3-phosphoglycerate phosphatase; EC 3.1.3.85; EC 3.1.3.70 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
32% identity, 70% coverage: 2:158/223 of query aligns to 3:161/223 of P9WIC7

query
sites
P9WIC7

A

A

T

R

Q

R

V

L

L

V

F

M

I

L

R
|
R

H
|
H

G

G

E

Q

T

T

D

D

W

Y

N
|
N

R

V

I

G

K

S

R

R

I

M

Q

Q

G

G

H

Q

I

L

D

D

I

T

P

E

L

L

A

S

T

E

S

L

G

G

V

R

E

T

Q

Q

A

A

K

V

R

A

L

A

A

A

E

E

R

V

F

L

A

-

C

-

E

-

A

-

H

-

E

-

G

G

A
x
K

R

R

L

Q

D

P

-

L

A

L

V

I

Y

V

S

S

D

D

L

L

M

R

R
|
R

A

A

R

Y

Q

D

T

T

A

A

Q

V

P

K

F

L

A

G

D

E

V

R

L

T

G

G

L

L

R

V

L

V

Q

R

L

V

R

D

E

T

G

R

L

L

R

R

E

E

R

T

N

H

Y

L

G

G

A

D

F

W

Q

Q

G

G

H

L

D

T

S

H

D

A

E

Q

I

I

S

D

L

A

R

D

F

A

P

P

D

G

E

A

Y

R

A

L

R

A

W

W

Q

R

T

-

R

E

D

D

P

A

G

T

F

W

S

A

P

P

P

H

E

G

G

G

E

E

S

S

Q

R

R

V

V

D

F

V

Y

A

H

A

R

R

V

S

L

R

H

P

A

L

L

V

E

A

P

E

I

L

V

V

A

A

A

S

-

E

-

P

-

E

-

W

-

G

-

A

-

D

H

E

P

P

D

D

G

R

R

P

I

V

A

V

C

L

V

V

A

A

H
|
H

G

G

R10 (= R9) mutation to A: Loss of phosphatase activity.
H11 (= H10) active site, Tele-phosphohistidine intermediate; mutation to A: Almost completely abolished phosphatase activity.
N17 (= N16) mutation to A: About 5% of wild-type phosphatase activity.
K47 (≠ A52) modified: Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)
R60 (= R64) mutation to A: Loss of phosphatase activity.
H159 (= H156) mutation to A: About 5% of wild-type phosphatase activity.

Sites not aligning to the query:

209 L→E: Disrupts dimerization of the enzyme, which exists as a monomer and has lost its ability to perform dephosphorylation.

4qihA The structure of mycobacterial glucosyl-3-phosphoglycerate phosphatase rv2419c complexes with vo3 (see paper)
32% identity, 70% coverage: 2:158/223 of query aligns to 1:159/209 of 4qihA

query
sites
4qihA

A

A

T

R

Q

R

V

L

L

V

F

M

I

L

R
|
R

H
|
H

G

G

E

Q

T

T

D

D

W

Y

N

N

R

V

I

G

K

S

R

R

I

M

Q
|
Q

G

G

H

Q

I

L

D

D

I

T

P

E

L

L

A

S

T

E

S

L

G

G

V

R

E

T

Q

Q

A

A

K

V

R

A

L

A

A

A

E

E

R

V

F

L

A

-

C

-

E

-

A

-

H

-

E

-

G

G

A

K

R

R

L

Q

D

P

-

L

A

L

V

I

Y

V

S

S

D

D

L

L

M

R

R
|
R

A

A

R

Y

Q

D

T

T

A

A

Q

V

P

K

F

L

A

G

D

E

V

R

L

T

G

G

L

L

R

V

L

V

Q

R

L

V

R

D

E

T

G

R

L

L

R

R

E
|
E

R

T

N

H

Y

L

G

G

A

D

F

W

Q

Q

G

G

H

L

D

T

S

H

D

A

E

Q

I

I

S

D

L

A

R

D

F

A

P

P

D

G

E

A

Y

R

A

L

R

A

W

W

Q

R

T

-

R

E

D

D

P

A

G

T

F

W

S

A

P

P

P

H

E

G

G

G

E

E

S

S

Q

R

R

V

V

D

F

V

Y

A

H

A

R

R

V

S

L

R

H

P

A

L

L

V

E

A

P

E

I

L

V

V

A

A

A

S

-

E

-

P

-

E

-

W

-

G

-

A

-

D

H

E

P

P

D

D

G

R

R

P

I

V

A

V

C

L

V

V

A

A

H
|
H

G

G

active site: H9 (= H10), R58 (= R64), E82 (= E88)
binding vanadate ion: R8 (= R9), H9 (= H10), Q21 (= Q22), R58 (= R64), H157 (= H156)

4pzaB The complex structure of mycobacterial glucosyl-3-phosphoglycerate phosphatase rv2419c with inorganic phosphate (see paper)
32% identity, 70% coverage: 2:158/223 of query aligns to 2:160/217 of 4pzaB

query
sites
4pzaB

A

A

T

R

Q

R

V

L

L

V

F

M

I

L

R
|
R

H
|
H

G

G

E

Q

T

T

D

D

W

Y

N

N

R

V

I

G

K

S

R

R

I

M

Q

Q

G

G

H

Q

I

L

D

D

I

T

P

E

L

L

A

S

T

E

S

L

G

G

V

R

E

T

Q

Q

A

A

K

V

R

A

L

A

A

A

E

E

R

V

F

L

A

-

C

-

E

-

A

-

H

-

E

-

G

G

A

K

R

R

L

Q

D

P

-

L

A

L

V

I

Y

V

S

S

D

D

L

L

M

R

R
|
R

A

A

R

Y

Q

D

T

T

A

A

Q

V

P

K

F

L

A

G

D

E

V

R

L

T

G

G

L

L

R

V

L

V

Q

R

L

V

R

D

E

T

G

R

L

L

R

R

E
|
E

R

T

N

H

Y

L

G

G

A

D

F

W

Q

Q

G

G

H

L

D

T

S

H

D

A

E

Q

I

I

S

D

L

A

R

D

F

A

P

P

D

G

E

A

Y

R

A

L

R

A

W

W

Q

R

T

-

R

E

D

D

P

A

G

T

F

W

S

A

P

P

P

H

E

G

G

G

E

E

S

S

Q

R

R

V

V

D

F

V

Y

A

H

A

R

R

V

S

L

R

H

P

A

L

L

V

E

A

P

E

I

L

V

V

A

A

A

S

-

E

-

P

-

E

-

W

-

G

-

A

-

D

H

E

P

P

D

D

G

R

R

P

I

V

A

V

C

L

V

V

A

A

H
|
H

G
|
G

G

G

active site: H10 (= H10), R59 (= R64), E83 (= E88)
binding phosphate ion: R9 (= R9), H10 (= H10), R59 (= R64), E83 (= E88), H158 (= H156), G159 (= G157)

1qhfA Yeast phosphoglycerate mutase-3pg complex structure to 1.7 a (see paper)
26% identity, 75% coverage: 4:171/223 of query aligns to 2:196/240 of 1qhfA

query
sites
1qhfA

Q

K

V

L

L

V

F

L

I

V

R
|
R

H
|
H

G
|
G

E
x
Q

T
x
S

D

E

W

W

N
|
N

R

E

I

K

K

N

R

L

I

F

Q
x
T

G

G

H

W

I

V

D

D

I

V

P

K

L

L

A

S

T

A

S

K

G

G

V

Q

E

Q

Q

E

A

A

K

A

R

R

L

A

A

G

E

E

R

L

F

L

A

-

C

-

E

-

A

K

H

E

E

K

G

K

A

V

R

Y

L

P

D

D

A

V

V

L

Y

Y

S

T

S

S

D

K

L

L

M

S

R
|
R

A

A

R

I

Q

Q

T

T

A

A

Q

N

-

I

-

A

-

L

P

E

F

K

A

A

D

D

V

R

L

L

G

W

L

I

R

P

L

V

Q

N

L

R

R

S

E

W

G

R

L

L

R

N

E
|
E

R

R

N

H

Y

Y

G

G

A

D

F

L

Q

Q

G

G

H

K

D

D

S

K

D

A

E

E

I

T

S

L

L

K

R

K

F

F

P

G

D

E

E

E

Y

K

-

F

-

N

-

T

-

Y

-

R

-

S

-

F

-

D

-

V

-

P

-

I

-

D

-

A

-

S

-

P

-

F

-

S

-

Q

-

K

-

G

-

D

A

E

R

R

W

Y

Q

K

T

Y

R

V

D

D

P

P

G

N

F

V

S

L

P

-

P

P

E

E

G

T

E

E

S

S

Q

L

R

A

V

L

F

V

Y

I

H

D

R

R

V

L

L

L

H

P

A

Y

L

W

E

Q

P

D

I

V

V

I

A

A

A

K

H

D

-

L

P

S

D

G

G

K

R

T

I

V

A

M

C

I

V

A

A

A

H
|
H

G

G

G

N

V

S

L

L

D

R

C

G

V

L

Y

V

R

K

F

H

A

L

N

E

G

G

L

I

S

S

active site: H8 (= H10), R59 (= R64), E86 (= E88), H181 (= H156)
binding 3-phosphoglyceric acid: R7 (= R9), H8 (= H10), G9 (= G11), Q10 (≠ E12), S11 (≠ T13), N14 (= N16), T20 (≠ Q22), R59 (= R64)

Sites not aligning to the query:

binding 3-phosphoglyceric acid: 207

5pgmE Saccharomyces cerevisiae phosphoglycerate mutase (see paper)
26% identity, 75% coverage: 4:171/223 of query aligns to 2:196/234 of 5pgmE

query
sites
5pgmE

Q

K

V

L

L

V

F

L

I

V

R

R

H
|
H

G

G

E

Q

T

S

D

E

W

W

N

N

R

E

I

K

K

N

R

L

I

F

Q

T

G

G

H

W

I

V

D

D

I

V

P

K

L

L

A

S

T

A

S

K

G

G

V

Q

E

Q

Q

E

A

A

K

A

R

R

L

A

A

G

E

E

R

L

F

L

A

-

C

-

E

-

A

K

H

E

E

K

G

K

A

V

R

Y

L

P

D

D

A

V

V

L

Y

Y

S

T

S

S

D

K

L

L

M

S

R
|
R

A

A

R

I

Q

Q

T

T

A

A

Q

N

-

I

-

A

-

L

P

E

F

K

A

A

D

D

V

R

L

L

G

W

L

I

R

P

L

V

Q

N

L

R

R

S

E

W

G

R

L

L

R

N

E
|
E

R

R

N

H

Y

Y

G

G

A

D

F

L

Q

Q

G

G

H

K

D

D

S

K

D

A

E

E

I

T

S

L

L

K

R

K

F

F

P

G

D

E

E

E

Y

K

-

F

-

N

-

T

-

Y

-

R

-

S

-

F

-

D

-

V

-

P

-

I

-

D

-

A

-

S

-

P

-

F

-

S

-

Q

-

K

-

G

-

D

A

E

R

R

W

Y

Q

K

T

Y

R

V

D

D

P

P

G

N

F

V

S

L

P

-

P

P

E

E

G

T

E

E

S

S

Q

L

R

A

V

L

F

V

Y

I

H

D

R

R

V

L

L

L

H

P

A

Y

L

W

E

Q

P

D

I

V

V

I

A

A

A

K

H

D

-

L

P

S

D

G

G

K

R

T

I

V

A

M

C

I

V

A

A

A

H
|
H

G

G

G

N

V

S

L

L

D

R

C

G

V

L

Y

V

R

K

F

H

A

L

N

E

G

G

L

I

S

S

active site: H8 (= H10), R59 (= R64), E86 (= E88), H181 (= H156)

Sites not aligning to the query:

binding alanine: 231, 234

1bq4A Saccharomyces cerevisiae phosphoglycerate mutase in complex with benzene hexacarboxylate (see paper)
26% identity, 75% coverage: 4:171/223 of query aligns to 2:196/234 of 1bq4A

query
sites
1bq4A

Q

K

V

L

L

V

F

L

I

V

R

R

H
|
H

G

G

E

Q

T

S

D

E

W

W

N

N

R

E

I

K

K

N

R

L

I

F

Q

T

G

G

H

W

I

V

D

D

I

V

P

K

L

L

A

S

T

A

S

K

G

G

V

Q

E

Q

Q

E

A

A

K

A

R

R

L

A

A

G

E

E

R

L

F

L

A

-

C

-

E

-

A

K

H

E

E

K

G

K

A

V

R

Y

L

P

D

D

A

V

V

L

Y

Y

S

T

S

S

D

K

L

L

M

S

R
|
R

A

A

R

I

Q

Q

T

T

A

A

Q

N

-

I

-

A

-

L

P

E

F

K

A

A

D

D

V

R

L

L

G

W

L

I

R

P

L

V

Q

N

L

R

R

S

E

W

G

R

L

L

R

N

E
|
E

R

R

N

H

Y
|
Y

G

G

A

D

F

L

Q

Q

G

G

H

K

D

D

S

K

D

A

E

E

I

T

S

L

L

K

R

K

F

F

P

G

D

E

E

E

Y

K

-

F

-

N

-

T

-

Y

-
x
R

-

S

-

F

-

D

-

V

-

P

-

I

-

D

-

A

-

S

-

P

-

F

-

S

-

Q

-

K

-

G

-

D

A

E

R

R

W

Y

Q

K

T

Y

R

V

D

D

P

P

G

N

F

V

S

L

P

-

P

P

E

E

G

T

E

E

S

S

Q

L

R

A

V

L

F

V

Y

I

H

D

R

R

V

L

L

L

H

P

A

Y

L

W

E

Q

P

D

I

V

V

I

A

A

A

K

H

D

-

L

P

S

D

G

G

K

R

T

I

V

A

M

C

I

V

A

A

A

H
|
H

G

G

G
x
N

V

S

L

L

D

R

C

G

V

L

Y

V

R

K

F

H

A

L

N

E

G

G

L

I

S

S

active site: H8 (= H10), R59 (= R64), E86 (= E88), H181 (= H156)
binding benzene hexacarboxylic acid: Y89 (= Y91), R113 (vs. gap), R114 (vs. gap), N183 (≠ G158)

Sites not aligning to the query:

binding benzene hexacarboxylic acid: 204

1bq3A Saccharomyces cerevisiae phosphoglycerate mutase in complex with inositol hexakisphosphate (see paper)
26% identity, 75% coverage: 4:171/223 of query aligns to 2:196/234 of 1bq3A

query
sites
1bq3A

Q

K

V

L

L

V

F

L

I

V

R
|
R

H
|
H

G

G

E

Q

T
x
S

D

E

W

W

N
|
N

R

E

I

K

K

N

R
x
L

I
x
F

Q
x
T

G

G

H

W

I

V

D

D

I

V

P

K

L

L

A

S

T

A

S

K

G

G

V

Q

E

Q

Q

E

A

A

K

A

R

R

L

A

A

G

E

E

R

L

F

L

A

-

C

-

E

-

A

K

H

E

E

K

G

K

A

V

R

Y

L

P

D

D

A

V

V

L

Y

Y

S

T

S

S

D

K

L

L

M

S

R
|
R

A

A

R

I

Q

Q

T

T

A

A

Q

N

-

I

-

A

-

L

P

E

F

K

A

A

D

D

V

R

L

L

G

W

L

I

R

P

L

V

Q

N

L

R

R

S

E

W

G

R

L

L

R

N

E
|
E

R

R

N

H

Y
|
Y

G

G

A

D

F

L

Q

Q

G

G

H

K

D

D

S
x
K

D

A

E

E

I

T

S

L

L

K

R

K

F

F

P

G

D

E

E

E

Y

K

-

F

-

N

-

T

-

Y

-
x
R

-

R

-

S

-

F

-

D

-

V

-

P

-

I

-

D

-

A

-

S

-

P

-

F

-

S

-

Q

-

K

-

G

-

D

A

E

R

R

W

Y

Q

K

T

Y

R

V

D

D

P

P

G

N

F

V

S

L

P

-

P

P

E

E

G

T

E

E

S

S

Q

L

R

A

V

L

F

V

Y

I

H

D

R

R

V

L

L

L

H

P

A

Y

L

W

E

Q

P

D

I

V

V

I

A

A

A

K

H

D

-

L

P

S

D

G

G

K

R

T

I

V

A

M

C

I

V

A

A

A

H
|
H

G

G

G

N

V

S

L

L

D

R

C

G

V

L

Y

V

R

K

F

H

A

L

N

E

G

G

L

I

S

S

active site: H8 (= H10), R59 (= R64), E86 (= E88), H181 (= H156)
binding inositol hexakisphosphate: R7 (= R9), S11 (≠ T13), N14 (= N16), L18 (≠ R20), F19 (≠ I21), T20 (≠ Q22), Y89 (= Y91), K97 (≠ S99), R113 (vs. gap)

P00950 Phosphoglycerate mutase 1; PGAM 1; BPG-dependent PGAM 1; MPGM 1; Phosphoglyceromutase 1; EC 5.4.2.11 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 7 papers)
26% identity, 75% coverage: 4:171/223 of query aligns to 3:197/247 of P00950

query
sites
P00950

Q

K

V

L

L

V

F

L

I

V

R
|
R

H
|
H

G
|
G

E
x
Q

T
x
S

D
x
E

W
|
W

N
|
N

R

E

I

K

K

N

R

L

I

F

Q
x
T

G
|
G

H

W

I

V

D

D

I

V

P

K

L

L

A

S

T

A

S

K

G

G

V

Q

E

Q

Q

E

A

A

K

A

R

R

L

A

A

G

E

E

R

L

F

L

A

-

C

-

E

-

A

K

H

E

E

K

G

K

A

V

R

Y

L

P

D

D

A

V

V

L

Y

Y

S

T

S

S

D

K

L

L

M

S

R
|
R

A

A

R

I

Q

Q

T

T

A

A

Q

N

-

I

-

A

-

L

P

E

F

K

A

A

D

D

V

R

L

L

G

W

L

I

R

P

L

V

Q

N

L

R

R

S

E

W

G

R

L

L

R

N

E
|
E

R
|
R

N
x
H

Y
|
Y

G

G

A

D

F

L

Q

Q

G

G

H

K

D

D

S
x
K

D

A

E

E

I

T

S

L

L

K

R

K

F

F

P

G

D

E

E

E

Y

K

-

F

-

N

-

T

-

Y

-
x
R

-

S

-

F

-

D

-

V

-

P

-

I

-

D

-

A

-

S

-

P

-

F

-

S

-

Q

-

K

-

G

-

D

A

E

R

R

W

Y

Q

K

T

Y

R

V

D

D

P

P

G

N

F

V

S

L

P

-

P

P

E

E

G

T

E

E

S

S

Q

L

R

A

V

L

F

V

Y

I

H

D

R

R

V

L

L

L

H

P

A

Y

L

W

E

Q

P

D

I

V

V

I

A

A

A
x
K

H

D

-

L

P

S

D

G

G

K

R

T

I

V

A

M

C

I

V

A

A

A

H
|
H

G
|
G

G
x
N

V

S

L

L

D

R

C

G

V

L

Y

V

R

K

F

H

A

L

N

E

G

G

L

I

S

S

8:15 (vs. 9:16, 63% identical) binding
H9 (= H10) active site, Tele-phosphohistidine intermediate
TG 21:22 (≠ QG 22:23) binding
R60 (= R64) binding
ERHY 87:90 (≠ ERNY 88:91) binding
K98 (≠ S99) binding
RR 114:115 (vs. gap) binding
K169 (≠ A145) mutation to P: Causes dissociation of the homotetramer to dimers at low concentrations.
H182 (= H156) mutation to A: Reduces kcat of the mutase reaction 10000-fold.
GN 183:184 (≠ GG 157:158) binding

Sites not aligning to the query:

1 modified: Initiator methionine, Removed

7n3rB The ternary complex of human bisphosphoglycerate mutase with 3- phosphoglycerate and 2-phosphoglycolate (see paper)
28% identity, 59% coverage: 4:135/223 of query aligns to 3:134/239 of 7n3rB

query
sites
7n3rB

Q

K

V

L

L

I

F

M

I

L

R

R

H

H

G

G

E

E

T

G

D

A

W

W

N

N

R

K

I

E

K

N

R

R

I

F

Q
x
C

G
x
S

H

W

I

V

D

D

I

Q

P

K

L

L

A

N

T

S

S

E

G

G

V

M

E

E

Q

E

A

A

K

R

R

N

L

C

A

G

E

K

R

Q

F

L

A

K

C

A

E

L

A

N

H

F

E

E

G

-

A

-

R

-

L

F

D

D

A

L

V

V

Y

F

S

T

S

S

D

V

L

L

M

N

R

R

A

S

R

I

Q

H

T

T

A

A

Q

W

P

L

F

I

A

L

D

E

V

E

L

L

G

G

L

Q

R

E

L

W

Q

V

L

P

R

V

E

E

G

S

-

S

-

W

-

R

L

L

R

N

E
|
E

R

R

N

H

Y

Y

G

G

A

A

F

L

Q

I

G

G

H

L

D

N

S

R

D

E

E

Q

I

M

S

A

L

L

R

N

F

H

P

G

D

E

E

E

Y

Q

A

V

R

R

W

L

Q

W

T

R

R

R

D

S

P

Y

G

N

F

V

S

T

P

P

E

P

G

I

E

E

S

E

Q

S

R

H

V

P

F

Y

Y

Y

H

Q

R

E

V

I

binding 2-phosphoglycolic acid: C21 (≠ Q22), S22 (≠ G23), E87 (= E88)

2h4zA Human bisphosphoglycerate mutase complexed with 2,3- bisphosphoglycerate (see paper)
28% identity, 59% coverage: 4:135/223 of query aligns to 4:135/255 of 2h4zA

query
sites
2h4zA

Q

K

V

L

L

I

F

M

I

L

R
|
R

H
|
H

G

G

E

E

T

G

D

A

W

W

N

N

R

K

I

E

K

N

R

R

I

F

Q
x
C

G
x
S

H

W

I

V

D

D

I

Q

P

K

L

L

A

N

T

S

S

E

G

G

V

M

E

E

Q

E

A

A

K

R

R

N

L

C

A

G

E

K

R

Q

F

L

A

K

C

A

E

L

A

N

H

F

E

E

G

-

A

-

R

-

L

F

D

D

A

L

V

V

Y

F

S

T

S

S

D

V

L

L

M

N

R
|
R

A

S

R

I

Q

H

T

T

A

A

Q

W

P

L

F

I

A

L

D

E

V

E

L

L

G

G

L

Q

R

E

L

W

Q

V

L

P

R

V

E

E

G

S

-

S

-

W

-

R

L

L

R

N

E
|
E

R

R

N

H

Y
|
Y

G

G

A

A

F

L

Q

I

G

G

H

L

D

N

S
x
R

D

E

E

Q

I

M

S

A

L

L

R

N

F

H

P

G

D

E

E

E

Y

Q

A

V

R

R

W

L

Q

W

T
x
R

R
|
R

D

S

P

Y

G

N

F

V

S

T

P

P

E

P

G

I

E

E

S

E

Q

S

R

H

V

P

F

Y

Y

Y

H

Q

R

E

V

I

active site: H10 (= H10), R61 (= R64), E88 (= E88)
binding (2R)-2,3-diphosphoglyceric acid: R9 (= R9), H10 (= H10), C22 (≠ Q22), S23 (≠ G23), R61 (= R64), E88 (= E88), Y91 (= Y91), R99 (≠ S99), R115 (≠ T115), R116 (= R116)

Sites not aligning to the query:

active site: 187
binding (2R)-2,3-diphosphoglyceric acid: 187, 189

P07738 Bisphosphoglycerate mutase; BPGM; 2,3-bisphosphoglycerate mutase, erythrocyte; 2,3-bisphosphoglycerate synthase; 2,3-diphosphoglycerate mutase; DPGM; BPG-dependent PGAM; EC 5.4.2.4; EC 5.4.2.11 from Homo sapiens (Human) (see 5 papers)
28% identity, 59% coverage: 4:135/223 of query aligns to 5:136/259 of P07738

query
sites
P07738

Q
x
K

V

L

L

I

F

M

I

L

R
|
R

H
|
H

G
|
G

E
|
E

T
x
G

D
x
A

W
|
W

N
|
N

R
x
K

I

E

K

N

R

R

I

F

Q
x
C

G
x
S

H

W

I

V

D

D

I

Q

P
x
K

L

L

A

N

T

S

S

E

G

G

V

M

E

E

Q

E

A

A

K

R

R

N

L

C

A

G

E
x
K

R

Q

F

L

A
x
K

C

A

E

L

A

N

H

F

E

E

G

-

A

-

R

-

L

F

D

D

A

L

V

V

Y

F

S

T

S

S

D

V

L

L

M

N

R
|
R

A

S

R

I

Q

H

T

T

A

A

Q

W

P

L

F

I

A

L

D

E

V

E

L

L

G

G

L

Q

R

E

L

W

Q

V

L

P

R

V

E

E

G

S

-

S

-

W

-

R

L

L

R

N

E
|
E

R
|
R

N
x
H

Y
|
Y

G

G

A

A

F

L

Q

I

G

G

H

L

D

N

S
x
R

D

E

E

Q

I

M

S

A

L

L

R

N

F

H

P

G

D

E

E

E

Y

Q

A

V

R

R

W

L

Q

W

T
x
R

R
|
R

D

S

P

Y

G

N

F

V

S

T

P

P

E

P

G

I

E

E

S

E

Q

S

R

H

V

P

F

Y

Y

Y

H

Q

R

E

V

I

K5 (≠ Q4) modified: carbohydrate, N-linked (Glc) (glycation) lysine; in vitro
10:17 (vs. 9:16, 75% identical) binding
H11 (= H10) active site, Tele-phosphohistidine intermediate
K18 (≠ R17) modified: carbohydrate, N-linked (Glc) (glycation) lysine; in vitro
CS 23:24 (≠ QG 22:23) binding
K29 (≠ P28) Not glycated
K43 (≠ E42) modified: carbohydrate, N-linked (Glc) (glycation) lysine; in vitro
K46 (≠ A45) Not glycated
R62 (= R64) binding
E89 (= E88) active site, Proton donor/acceptor
ERHY 89:92 (≠ ERNY 88:91) binding
R90 (= R89) to C: in ECYT8; mutation identified at protein level; marked decrease in synthase and mutase activities; no effect on phosphatase activity; dbSNP:rs121964925
R100 (≠ S99) binding
RR 116:117 (≠ TR 115:116) binding

Sites not aligning to the query:

1 modified: Initiator methionine, Removed
3 modified: carbohydrate, N-linked (Glc) (glycation) lysine; in vitro
143 Not glycated
159 modified: carbohydrate, N-linked (Glc) (glycation) lysine
181 Not glycated
188 Transition state stabilizer
189:190 binding
197 modified: carbohydrate, N-linked (Glc) (glycation) lysine; in vitro
246 Not glycated
247 Not glycated
253 Not glycated
258 Not glycated
259 Not glycated

2f90A Crystal structure of bisphosphoglycerate mutase in complex with 3- phosphoglycerate and alf4- (see paper)
28% identity, 59% coverage: 4:135/223 of query aligns to 3:134/254 of 2f90A

query
sites
2f90A

Q

K

V

L

L

I

F

M

I

L

R
|
R

H
|
H

G

G

E

E

T

G

D

A

W

W

N

N

R

K

I

E

K

N

R

R

I

F

Q

C

G

S

H

W

I

V

D

D

I

Q

P

K

L

L

A

N

T

S

S

E

G

G

V

M

E

E

Q

E

A

A

K

R

R

N

L

C

A

G

E

K

R

Q

F

L

A

K

C

A

E

L

A

N

H

F

E

E

G

-

A

-

R

-

L

F

D

D

A

L

V

V

Y

F

S

T

S

S

D

V

L

L

M

N

R
|
R

A

S

R

I

Q

H

T

T

A

A

Q

W

P

L

F

I

A

L

D

E

V

E

L

L

G

G

L

Q

R

E

L

W

Q

V

L

P

R

V

E

E

G

S

-

S

-

W

-

R

L

L

R

N

E
|
E

R

R

N

H

Y

Y

G

G

A

A

F

L

Q

I

G

G

H

L

D

N

S

R

D

E

E

Q

I

M

S

A

L

L

R

N

F

H

P

G

D

E

E

E

Y

Q

A

V

R

R

W

L

Q

W

T

R

R

R

D

S

P

Y

G

N

F

V

S

T

P

P

E

P

G

I

E

E

S

E

Q

S

R

H

V

P

F

Y

Y

Y

H

Q

R

E

V

I

active site: H9 (= H10), R60 (= R64), E87 (= E88)
binding tetrafluoroaluminate ion: R8 (= R9), H9 (= H10), R60 (= R64), E87 (= E88)

Sites not aligning to the query:

active site: 186
binding tetrafluoroaluminate ion: 186, 187

Query Sequence

>WP_012401933.1 NCBI__GCF_000020045.1:WP_012401933.1
MATQVLFIRHGETDWNRIKRIQGHIDIPLATSGVEQAKRLAERFACEAHEGARLDAVYSS
DLMRARQTAQPFADVLGLRLQLREGLRERNYGAFQGHDSDEISLRFPDEYARWQTRDPGF
SPPEGESQRVFYHRVLHALEPIVAAHPDGRIACVAHGGVLDCVYRFANGLSLDAPRNYQL
LNTSVNVVDFEGGRATVVSWADVVHLGGHAKDDSFKTTPRPER

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory