SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing WP_012402388.1 NCBI__GCF_000020045.1:WP_012402388.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

1g6hA Crystal structure of the adp conformation of mj1267, an atp-binding cassette of an abc transporter (see paper)
36% identity, 40% coverage: 354:591/594 of query aligns to 12:253/254 of 1g6hA

query
sites
1g6hA

K

K

Q

Y

F
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F

G

G

G

E

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x
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A

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N

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A

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G

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E

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E

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N

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Y

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N

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G

binding adenosine-5'-diphosphate: F14 (= F356), F17 (≠ L359), N39 (= N381), G40 (= G382), G42 (= G384), K43 (= K385), S44 (= S386), T45 (= T387)

1g9xB Characterization of the twinning structure of mj1267, an atp-binding cassette of an abc transporter (see paper)
36% identity, 40% coverage: 354:591/594 of query aligns to 12:253/253 of 1g9xB

query
sites
1g9xB

K

K

Q

Y

F
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F

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G

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E

L
x
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A

A

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N

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C

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G

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x
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G

K
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K

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S

T
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T

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I

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N

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E

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H

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D

F

I

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N

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M

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E

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F

N

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A

A

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E

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R

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G

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E

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N

N

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E

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G

binding adenosine-5'-diphosphate: F14 (= F356), F17 (≠ L359), G40 (= G382), S41 (≠ A383), G42 (= G384), K43 (= K385), S44 (= S386), T45 (= T387)
binding magnesium ion: S44 (= S386), E176 (= E518)

6mjpA Lptb(e163q)fgc from vibrio cholerae (see paper)
32% identity, 40% coverage: 354:591/594 of query aligns to 10:235/240 of 6mjpA

query
sites
6mjpA

K

K

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S

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Y

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K

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G

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P

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N

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E

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D

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K

E

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Y

L

L

G

G

binding calcium ion: E111 (≠ A473), D115 (≠ I477)

4ymuJ Crystal structure of an amino acid abc transporter complex with arginines and atps (see paper)
29% identity, 39% coverage: 346:579/594 of query aligns to 1:223/240 of 4ymuJ

query
sites
4ymuJ

L

M

L

I

V

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V

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Y

K

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x
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x
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K

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T

T

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L

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N

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A

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E

M

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D

G

F

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E

L

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D

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E

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G

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E

D

E

V

I

binding adenosine-5'-triphosphate: F11 (= F356), V16 (≠ A361), S36 (≠ N381), G37 (= G382), S38 (≠ A383), G39 (= G384), K40 (= K385), S41 (= S386), T42 (= T387), E162 (= E518), H194 (= H550)
binding magnesium ion: S41 (= S386), E162 (= E518)

4yerA Crystal structure of an abc transporter atp-binding protein (tm_1403) from thermotoga maritima msb8 at 2.35 a resolution
34% identity, 40% coverage: 344:580/594 of query aligns to 2:224/285 of 4yerA

query
sites
4yerA

E

E

P

D

L

I

L

I

V

V

V

V

D

E

K

N

A

L

R

V

K

K

Q

K

F
|
F

G

G

G

D

L
x
F

V

E

A

A

V

V

N

K

D

G

V

V

S

S

F

F

E

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K

A

K

G

G

Q

E

I

I

I

F

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A

L

F

I

L

G

G

P

P

N
|
N

G
|
G

A

A

G
|
G

K
|
K

S
x
T

T
|
T

T

T

F

I

N

H

L

M

V

L

T

T

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T

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L

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S

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G

A

K

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E

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Y

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E

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N

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Y

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G

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A

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D
x
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L

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K

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K

E

K

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E

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H

G

N

M

M

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T

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F

L

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T

E

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H

H

D

Y

M

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D

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D

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K

binding adenosine-5'-diphosphate: F14 (= F356), F17 (≠ L359), N39 (= N381), G40 (= G382), G42 (= G384), K43 (= K385), T44 (≠ S386), T45 (= T387), T135 (≠ D488), F136 (≠ E489), S137 (≠ A490)

6mhzA Vanadate trapped cryo-em structure of e.Coli lptb2fg transporter (see paper)
33% identity, 40% coverage: 354:591/594 of query aligns to 10:235/235 of 6mhzA

query
sites
6mhzA

K

K

Q

A

F
x
Y

G

K

G

G

L

R

V

R

A

V

V

V

N

E

D

D

V

V

S

S

F

L

E

T

V

V

K

N

A

S

G

G

Q

E

I

I

I

V

G

G

L

L

I

L

G

G

P

P

N
|
N

G
|
G

A

A

G
|
G

K
|
K

S
x
T

T
|
T

T

T

F

F

N

Y

L

M

V

V

T

V

G

G

V

I

L

V

Q

P

A

R

T

D

S

A

G

G

A

N

I

I

T

I

F

I

R

D

G

D

E

D

R

D

I

I

D

S

A

L

L

L

N

P

S

L

R

H

E

A

I

R

V

A

K

R

R

R

G

G

I

I

G

G

R

Y

T

L

F

P

Q
|
Q

H

E

V

A

K

S

L

I

L

F

P

R

G

R

M

L

T

S

V

V

L

Y

E

D

N

N

V

L

A

M

I

A

G

V

G

L

H

Q

L

I

R

R

G

D

R

D

A

L

G

S

V

A

W

E

R

Q

S

R

V

E

A

D

R

R

L

A

N

N

G

-

A

-

E

-

E

-

G

-

R

E

L

L

M

M

A

E

E

E

A

F

A

H

R

I

Q

-

I

-

R

-

R

-

V

-

G

-

L

-

E

-

E

E

H

H

M

L

Y

R

D

D

E

S

A

M

G

G

-

Q

S
|
S

L

L

A
x
S

L
x
G

G
|
G

K

E

Q

R

R

R

I

R

L

V

E

E

I

I

A

A

R

R

A

A

L

L

C

A

C

A

D

N

P

P

T

K

L

F

L

I

L

L

L

L

D

D

E
|
E

P

P

A

F

A

A

G
|
G

L

V

R

D

Y

P

Q

I

E

S

K

V

Q

I

Q

D

L

I

A

K

T

R

L

I

L

I

R

E

K

H

L

L

R

R

E

D

E

S

G

G

M

L

S

G

L

V

L

L

L

I

V

T

E

D

H
|
H

D

N

M

V

D

R

F

E

V

T

M

L

N

A

L

V

T

C

D

E

R

R

L

A

V

Y

V

I

M

V

E

S

F

Q

G

G

T

H

R

L

I

I

A

A

E

H

G

G

L

T

P

P

Q

T

D

E

V

I

Q

L

N

Q

D

D

P

E

A

H

V

V

L

K

E

R

A

V

Y

Y

L

L

G

G

binding adp orthovanadate: Y12 (≠ F356), N37 (= N381), G38 (= G382), G40 (= G384), K41 (= K385), T42 (≠ S386), T43 (= T387), Q84 (= Q428), S136 (= S492), S138 (≠ A494), G139 (≠ L495), G140 (= G496), E162 (= E518), G166 (= G522), H194 (= H550)

6s8nB Cryo-em structure of lptb2fgc in complex with lipopolysaccharide (see paper)
33% identity, 40% coverage: 354:591/594 of query aligns to 10:235/238 of 6s8nB

query
sites
6s8nB

K

K

Q

A

F

Y

G

K

G

G

L

R

V

R

A

V

V

V

N

E

D

D

V

V

S

S

F

L

E

T

V

V

K

N

A

S

G

G

Q

E

I

I

I

V

G

G

L

L

I

L

G

G

P

P

N

N

G

G

A

A

G

G

K

K

S

T

T

T

T

T

F

F

N

Y

L

M

V

V

T

V

G

G

V

I

L

V

Q

P

A

R

T

D

S

A

G

G

A

N

I

I

T

I

F

I

R

D

G

D

E

D

R

D

I

I

D

S

A

L

L

L

N

P

S

L

R

H

E

A

I

R

V

A

K

R

R

R

G

G

I

I

G

G

R

Y

T

L

F

P

Q

Q

H

E

V

A

K

S

L

I

L

F

P
x
R

G

R

M

L

T

S

V

V

L

Y

E

D

N

N

V

L

A

M

I

A

G

V

G

L

H

Q

L

I

R

R

G

D

R

D

A

L

G

S

V

A

W

E

R

Q

S

R

V

E

A

D

R

R

L

A

N

N

G

-

A

-

E

-

E

-

G

-

R

E

L

L

M

M

A

E

E

E

A

F

A

H

R

I

Q

-

I

-

R

-

R

-

V

-

G

-

L

-

E

-

E

E

H

H

M

L

Y

R

D

D

E

S

A
x
M

G
|
G

-
x
Q

S

S

L

L

A

S

L

G

G

G

K

E

Q

R

R

R

I

R

L

V

E

E

I

I

A

A

R

R

A

A

L

L

C

A

C

A

D

N

P

P

T

K

L

F

L

I

L

L

L

L

D

D

E

E

P

P

A

F

A

A

G

G

L

V

R

D

Y

P

Q

I

E

S

K

V

Q

I

Q

D

L

I

A

K

T

R

L

I

L

I

R

E

K

H

L

L

R

R

E

D

E

S

G

G

M

L

S

G

L

V

L

L

L

I

V

T

E

D

H

H

D

N

M

V

D

R

F

E

V

T

M

L

N

A

L

V

T

C

D

E

R

R

L

A

V

Y

V

I

M

V

E

S

F

Q

G

G

T

H

R

L

I

I

A

A

E

H

G

G

L

T

P

P

Q

T

D

E

V

I

Q

L

N

Q

D

D

P

E

A

H

V

V

L

K

E

R

A

V

Y

Y

L

L

G

G

binding 2-decyl-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione: R90 (≠ P434), M133 (≠ A490), G134 (= G491), Q135 (vs. gap)

6s8gA Cryo-em structure of lptb2fgc in complex with amp-pnp (see paper)
33% identity, 40% coverage: 354:591/594 of query aligns to 10:235/238 of 6s8gA

query
sites
6s8gA

K

K

Q

A

F
x
Y

G

K

G

G

L
x
R

V

R

A

V

V

V

N

E

D

D

V

V

S

S

F

L

E

T

V

V

K

N

A

S

G

G

Q

E

I

I

I

V

G

G

L

L

I

L

G

G

P

P

N
|
N

G

G

A

A

G
|
G

K
|
K

S
x
T

T
|
T

T

T

F

F

N

Y

L

M

V

V

T

V

G

G

V

I

L

V

Q

P

A

R

T

D

S

A

G

G

A

N

I

I

T

I

F

I

R

D

G

D

E

D

R

D

I

I

D

S

A

L

L

L

N

P

S

L

R

H

E

A

I

R

V

A

K

R

R

R

G

G

I

I

G

G

R

Y

T

L

F

P

Q
|
Q

H

E

V

A

K

S

L

I

L

F

P

R

G

R

M

L

T

S

V

V

L

Y

E

D

N

N

V

L

A

M

I

A

G

V

G

L

H

Q

L

I

R

R

G

D

R

D

A

L

G

S

V

A

W

E

R

Q

S

R

V

E

A

D

R

R

L

A

N

N

G

-

A

-

E

-

E

-

G

-

R

E

L

L

M

M

A

E

E

E

A

F

A

H

R

I

Q

-

I

-

R

-

R

-

V

-

G

-

L

-

E

-

E

E

H

H

M

L

Y

R

D

D

E

S

A

M

G

G

-

Q

S
|
S

L

L

A
x
S

L

G

G

G

K
x
E

Q

R

R

R

I

R

L

V

E

E

I

I

A

A

R

R

A

A

L

L

C

A

C

A

D

N

P

P

T

K

L

F

L

I

L

L

L

L

D

D

E

E

P

P

A

F

A

A

G

G

L

V

R

D

Y

P

Q

I

E

S

K

V

Q

I

Q

D

L

I

A

K

T

R

L

I

L

I

R

E

K

H

L

L

R

R

E

D

E

S

G

G

M

L

S

G

L

V

L

L

L

I

V

T

E

D

H

H

D

N

M

V

D

R

F

E

V

T

M

L

N

A

L

V

T

C

D

E

R

R

L

A

V

Y

V

I

M

V

E

S

F

Q

G

G

T

H

R

L

I

I

A

A

E

H

G

G

L

T

P

P

Q

T

D

E

V

I

Q

L

N

Q

D

D

P

E

A

H

V

V

L

K

E

R

A

V

Y

Y

L

L

G

G

binding phosphoaminophosphonic acid-adenylate ester: Y12 (≠ F356), R15 (≠ L359), N37 (= N381), G40 (= G384), K41 (= K385), T42 (≠ S386), T43 (= T387), Q84 (= Q428), S136 (= S492), S138 (≠ A494), E141 (≠ K497)

P69874 Spermidine/putrescine import ATP-binding protein PotA; EC 7.6.2.11 from Escherichia coli (strain K12) (see 3 papers)
30% identity, 42% coverage: 338:586/594 of query aligns to 9:242/378 of P69874

query
sites
P69874

S

K

K

Q

P

P

A

S

T

S

G

L

E

S

P

P

L

L

L

V

V

Q

V

L

D

A

K

G

A

I

R

R

K

K

Q
x
C

F
|
F

G

D

G

G

L

K

V

E

A

V

V

I

N

P

D

Q

V

L

S

D

F

L

E

T

V

I

K

N

A

N

G

G

Q

E

I
x
F

I

L

G

T

L

L

I

L

G

G

P

P

N

S

G

G

A
x
C

G

G

K

K

S

T

T

T

T

V

F
x
L

N

R

L

L

V

I

T

A

G

G

V

L

L

E

Q

T

A

V

T

D

S

S

G

G

A

R

I

I

T

M

F
x
L

R

D

G

N

E

E

R

D

I

I

D

T

A

H

L

V

N

P

S

A

R

E

E

-

I

-

V

-

K

N

R

R

G

Y

I

V

G

N

R

T

T

V

F

F

Q

Q

H

S

V

Y

K

A

L

L

L

F

P

P

G

H

M

M

T

T

V

V

L

F

E

E

N

N

V

V

A

A

I

F

G

G

G

-

H

-

L

-

R

-

G

-

R

-

A

-

G

-

V

-

W

-

R

-

S

-

V

-

A

L

R

R

L

M

N

Q

G

K

A

T

E

P

E

A

G

A

R

E

L

I

M

T

A

P

E

R

A

V

A

M

R

E

Q

A

I

L

R

R

R

M

V
|
V

G

Q

L

L

E

E

E

T

H

F

M

A

Y

Q

D

R

E

K

A

P

G

H

S

Q

L

L

A

S

L

G

G

G

K

Q

Q

Q

R

Q

I

R

L

V

E

A

I

I

A

A

R

R

A

A

L

V

C

V

C

N

D

K

P

P

T

R

L

L

L

L

L

L

L

L

D
|
D

E

E

P

S

A

L

A

S

G

A

L

L

R

D

Y

Y

Q

K

E

L

K

R

Q

K

Q

Q

L

M

A

Q

T

N

L

E

L

L

R

K

K

A

L

L

-

Q

R

R

E

K

E

L

G

G

M

I

S

T

L

F

L

V

L

F

V

V

E

T

H

H

D

D

M

Q

D

E

F

E

V

A

M

L

N

T

L

M

T

S

D

D

R

R

L

I

V

V

V

V

M

M

E

R

F

D

G

G

T

R

R

I

I

E

A

Q

E

D

G

G

L

T

P

P

Q

R

D

E

V

I

Q

Y

N

E

D

E

P

P

A

K

V

N

L

L

C26 (≠ Q355) mutation to A: Lower ATPase activity and transport efficiency.
F27 (= F356) mutation to L: Lower ATPase activity and transport efficiency.
F45 (≠ I374) mutation to L: Lower ATPase activity and transport efficiency.
C54 (≠ A383) mutation to T: Loss of ATPase activity and transport.
L60 (≠ F389) mutation to F: Lower ATPase activity and transport efficiency.
L76 (≠ F405) mutation to P: Lower ATPase activity and transport efficiency.
V135 (= V480) mutation to M: Loss of ATPase activity and transport.
D172 (= D517) mutation to N: Loss of ATPase activity and transport.

Sites not aligning to the query:

276 C→A: Lower ATPase activity and transport efficiency.
297 mutation E->K,D: Lower ATPase activity and transport efficiency.; E→Q: Loss of ATPase activity and transport.

6mbnA Lptb e163q in complex with atp (see paper)
32% identity, 40% coverage: 354:591/594 of query aligns to 11:236/241 of 6mbnA

query
sites
6mbnA

K

K

Q

A

F
x
Y

G

K

G

G

L
x
R

V

R

A
x
V

V

V

N

E

D

D

V

V

S

S

F

L

E

T

V

V

K

N

A

S

G

G

Q

E

I

I

I

V

G

G

L

L

I

L

G

G

P

P

N
|
N

G
|
G

A

A

G
|
G

K
|
K

S
x
T

T
|
T

T

T

F

F

N

Y

L

M

V

V

T

V

G

G

V

I

L

V

Q

P

A

R

T

D

S

A

G

G

A

N

I

I

T

I

F

I

R

D

G

D

E

D

R

D

I

I

D

S

A

L

L

L

N

P

S

L

R

H

E

A

I

R

V

A

K

R

R

R

G

G

I

I

G

G

R

Y

T

L

F

P

Q

Q

H

E

V

A

K

S

L

I

L

F

P

R

G

R

M

L

T

S

V

V

L

Y

E

D

N

N

V

L

A

M

I

A

G

V

G

L

H

Q

L

I

R

R

G

D

R

D

A

L

G

S

V

A

W

E

R

Q

S

R

V

E

A

D

R

R

L

A

N

N

G

-

A

-

E

-

E

-

G

-

R

E

L

L

M

M

A

E

E

E

A

F

A

H

R

-

Q

-

I

-

R

-

R

-

V

-

G

-

L

-

E

I

E

E

H

H

M

L

Y

R

D

D

E

S

A

M

G

G

-

Q

S

S

L

L

A

S

L

G

G

G

K

E

Q

R

R

R

I

R

L

V

E

E

I

I

A

A

R

R

A

A

L

L

C

A

C

A

D

N

P

P

T

K

L

F

L

I

L

L

L

L

D

D

E

Q

P

P

A

F

A

A

G

G

L

V

R

D

Y

P

Q

I

E

S

K

V

Q

I

Q

D

L

I

A

K

T

R

L

I

L

I

R

E

K

H

L

L

R

R

E

D

E

S

G

G

M

L

S

G

L

V

L

L

L

I

V

T

E

D

H
|
H

D

N

M

V

D

R

F

E

V

T

M

L

N

A

L

V

T

C

D

E

R

R

L

A

V

Y

V

I

M

V

E

S

F

Q

G

G

T

H

R

L

I

I

A

A

E

H

G

G

L

T

P

P

Q

T

D

E

V

I

Q

L

N

Q

D

D

P

E

A

H

V

V

L

K

E

R

A

V

Y

Y

L

L

G

G

binding adenosine-5'-triphosphate: Y13 (≠ F356), R16 (≠ L359), V18 (≠ A361), N38 (= N381), G39 (= G382), G41 (= G384), K42 (= K385), T43 (≠ S386), T44 (= T387), H195 (= H550)

3c4jA Abc protein artp in complex with atp-gamma-s
29% identity, 40% coverage: 346:583/594 of query aligns to 3:229/242 of 3c4jA

query
sites
3c4jA

L

M

L

I

V

D

V

V

D

H

K

Q

A

L

R

K

K

K

Q

S

F
|
F

G

G

G

S

L

L

V

E

A
x
V

V

L

N

K

D

G

V

I

S

N

F

V

E

H

V

I

K

R

A

E

G

G

Q

E

I

V

I

V

G

V

L

V

I

I

G

G

P

P

N
x
S

G
|
G

A
x
S

G
|
G

K
|
K

S
|
S

T
|
T

T

F

F

L

N

R

L

C

V

L

T

N

G

L

V

L

L

E

Q

D

A

F

T

D

S

E

G

G

A

E

I

I

T

I

F

I

R

D

G

G

E

I

R

N

I

L

D

K

A

A

L

K

N

D

S

T

R

N

-

L

E

N

I

K

V

V

K

R

R

E

G

E

I

V

G

G

R

M

T

V

F

F

Q

Q

H

R

V

F

K

N

L

L

L

F

P

P

G

H

M

M

T

T

V

V

L

L

E

N

N

N

V

I

A

T

I

L

G

A

G

P

H

M

L

-

R

-

G

-

R

K

A

V

G

R

V

K

W

W

-

P

R

R

S

E

V

K

A

A

R

E

L

-

N

-

G

-

A

-

E

-

E

-

G

-

R

-

L

-

M

-

A

A

E

K

A

A

A

M

R

E

Q

L

I

L

R

D

R

K

V

V

G

G

L

L

E

K

E

D

H

K

M

A

Y

H

D

A

E

Y

A

P

G

D

S

S

L

L

A

S

L

G

G

G

K

Q

Q

A

R

Q

I

R

L

V

E

A

I

I

A

A

R

R

A

A

L

L

C

A

C

M

D

E

P

P

T

K

L

I

L

M

L

L

L

F

D

D

E

E

P

P

A

T

A

S

G

A

L

L

R

D

Y

P

Q

E

E

M

K

V

Q

G

Q

E

L

V

A

L

T

S

L

V

L

M

R

K

K

Q

L

L

R

A

E

N

E

E

G

G

M

M

S

T

L

M

L

V

L

V

V

V

E

T

H

H

D

E

M

M

D

G

F

F

V

A

M

R

N

E

L

V

T

G

D

D

R

R

L

V

V

L

V

F

M

M

E

D

F

G

G

G

T

Y

R

I

I

I

A

E

E

E

G

G

L

K

P

P

Q

E

D

D

V

L

Q

F

N

D

D

R

P

P

binding phosphothiophosphoric acid-adenylate ester: F13 (= F356), V18 (≠ A361), S38 (≠ N381), G39 (= G382), S40 (≠ A383), G41 (= G384), K42 (= K385), S43 (= S386), T44 (= T387)

3c41J Abc protein artp in complex with amp-pnp/mg2+
29% identity, 40% coverage: 346:583/594 of query aligns to 3:229/242 of 3c41J

query
sites
3c41J

L

M

L

I

V

D

V

V

D

H

K

Q

A

L

R

K

K

K

Q

S

F
|
F

G

G

G

S

L

L

V

E

A
x
V

V

L

N

K

D

G

V

I

S

N

F

V

E

H

V

I

K

R

A

E

G

G

Q

E

I

V

I

V

G

V

L

V

I

I

G

G

P

P

N
x
S

G
|
G

A

S

G
|
G

K
|
K

S
|
S

T
|
T

T

F

F

L

N

R

L

C

V

L

T

N

G

L

V

L

L

E

Q

D

A

F

T

D

S

E

G

G

A

E

I

I

T

I

F

I

R

D

G

G

E

I

R

N

I

L

D

K

A

A

L

K

N

D

S

T

R

N

-

L

E

N

I

K

V

V

K

R

R

E

G

E

I

V

G

G

R

M

T

V

F

F

Q

Q

H

R

V

F

K

N

L

L

L

F

P

P

G

H

M

M

T

T

V

V

L

L

E

N

N

N

V

I

A

T

I

L

G

A

G

P

H

M

L

-

R

-

G

-

R

K

A

V

G

R

V

K

W

W

-

P

R

R

S

E

V

K

A

A

R

E

L

-

N

-

G

-

A

-

E

-

E

-

G

-

R

-

L

-

M

-

A

A

E

K

A

A

A

M

R

E

Q

L

I

L

R

D

R

K

V

V

G

G

L

L

E

K

E

D

H

K

M

A

Y

H

D

A

E

Y

A

P

G

D

S

S

L

L

A

S

L

G

G

G

K

Q

Q

A

R

Q

I

R

L

V

E

A

I

I

A

A

R

R

A

A

L

L

C

A

C

M

D

E

P

P

T

K

L

I

L

M

L

L

L

F

D
|
D

E

E

P

P

A

T

A

S

G

A

L

L

R

D

Y

P

Q

E

E

M

K

V

Q

G

Q

E

L

V

A

L

T

S

L

V

L

M

R

K

K

Q

L

L

R

A

E

N

E

E

G

G

M

M

S

T

L

M

L

V

L

V

V

V

E

T

H

H

D

E

M

M

D

G

F

F

V

A

M

R

N

E

L

V

T

G

D

D

R

R

L

V

V

L

V

F

M

M

E

D

F

G

G

G

T

Y

R

I

I

I

A

E

E

E

G

G

L

K

P

P

Q

E

D

D

V

L

Q

F

N

D

D

R

P

P

binding phosphoaminophosphonic acid-adenylate ester: F13 (= F356), V18 (≠ A361), S38 (≠ N381), G39 (= G382), G41 (= G384), K42 (= K385), S43 (= S386), T44 (= T387)
binding magnesium ion: S43 (= S386), D163 (= D517)

2olkA Abc protein artp in complex with adp-beta-s
29% identity, 40% coverage: 346:583/594 of query aligns to 3:229/242 of 2olkA

query
sites
2olkA

L

M

L

I

V

D

V

V

D

H

K

Q

A

L

R

K

K

K

Q

S

F
|
F

G

G

G

S

L

L

V

E

A
x
V

V

L

N

K

D

G

V

I

S

N

F

V

E

H

V

I

K

R

A

E

G

G

Q

E

I

V

I

V

G

V

L

V

I

I

G

G

P

P

N
x
S

G
|
G

A
x
S

G
|
G

K
|
K

S
|
S

T
|
T

T

F

F

L

N

R

L

C

V

L

T

N

G

L

V

L

L

E

Q

D

A

F

T

D

S

E

G

G

A

E

I

I

T

I

F

I

R

D

G

G

E

I

R

N

I

L

D

K

A

A

L

K

N

D

S

T

R

N

-

L

E

N

I

K

V

V

K

R

R

E

G

E

I

V

G

G

R

M

T

V

F

F

Q

Q

H

R

V

F

K

N

L

L

L

F

P

P

G

H

M

M

T

T

V

V

L

L

E

N

N

N

V

I

A

T

I

L

G

A

G

P

H

M

L

-

R

-

G

-

R

K

A

V

G

R

V

K

W

W

-

P

R

R

S

E

V

K

A

A

R

E

L

-

N

-

G

-

A

-

E

-

E

-

G

-

R

-

L

-

M

-

A

A

E

K

A

A

A

M

R

E

Q

L

I

L

R

D

R

K

V

V

G

G

L

L

E

K

E

D

H

K

M

A

Y

H

D

A

E

Y

A

P

G

D

S

S

L

L

A

S

L

G

G

G

K

Q

Q

A

R

Q

I

R

L

V

E

A

I

I

A

A

R

R

A

A

L

L

C

A

C

M

D

E

P

P

T

K

L

I

L

M

L

L

L

F

D

D

E

E

P

P

A

T

A

S

G

A

L

L

R

D

Y

P

Q

E

E

M

K

V

Q

G

Q

E

L

V

A

L

T

S

L

V

L

M

R

K

K

Q

L

L

R

A

E

N

E

E

G

G

M

M

S

T

L

M

L

V

L

V

V

V

E

T

H

H

D

E

M

M

D

G

F

F

V

A

M

R

N

E

L

V

T

G

D

D

R

R

L

V

V

L

V

F

M

M

E

D

F

G

G

G

T

Y

R

I

I

I

A

E

E

E

G

G

L

K

P

P

Q

E

D

D

V

L

Q

F

N

D

D

R

P

P

binding 5'-o-[(r)-hydroxy(thiophosphonooxy)phosphoryl]adenosine: F13 (= F356), V18 (≠ A361), S38 (≠ N381), G39 (= G382), S40 (≠ A383), G41 (= G384), K42 (= K385), S43 (= S386), T44 (= T387)

2oljA Abc protein artp in complex with adp/mg2+
29% identity, 40% coverage: 346:583/594 of query aligns to 3:229/242 of 2oljA

query
sites
2oljA

L

M

L

I

V

D

V

V

D

H

K

Q

A

L

R

K

K

K

Q

S

F
|
F

G

G

G

S

L

L

V

E

A
x
V

V

L

N

K

D

G

V

I

S

N

F

V

E

H

V

I

K

R

A

E

G

G

Q

E

I

V

I

V

G

V

L

V

I

I

G

G

P

P

N
x
S

G
|
G

A
x
S

G
|
G

K
|
K

S
|
S

T
|
T

T

F

F

L

N

R

L

C

V

L

T

N

G

L

V

L

L

E

Q

D

A

F

T

D

S

E

G

G

A

E

I

I

T

I

F

I

R

D

G

G

E

I

R

N

I

L

D

K

A

A

L

K

N

D

S

T

R

N

-

L

E

N

I

K

V

V

K

R

R

E

G

E

I

V

G

G

R

M

T

V

F

F

Q

Q

H

R

V

F

K

N

L

L

L

F

P

P

G

H

M

M

T

T

V

V

L

L

E

N

N

N

V

I

A

T

I

L

G

A

G

P

H

M

L

-

R

-

G

-

R

K

A

V

G

R

V

K

W

W

-

P

R

R

S

E

V

K

A

A

R

E

L

-

N

-

G

-

A

-

E

-

E

-

G

-

R

-

L

-

M

-

A

A

E

K

A

A

A

M

R

E

Q

L

I

L

R

D

R

K

V

V

G

G

L

L

E

K

E

D

H

K

M

A

Y

H

D

A

E

Y

A

P

G

D

S

S

L

L

A

S

L

G

G

G

K

Q

Q

A

R

Q

I

R

L

V

E

A

I

I

A

A

R

R

A

A

L

L

C

A

C

M

D

E

P

P

T

K

L

I

L

M

L

L

L

F

D

D

E

E

P

P

A

T

A

S

G

A

L

L

R

D

Y

P

Q

E

E

M

K

V

Q

G

Q

E

L

V

A

L

T

S

L

V

L

M

R

K

K

Q

L

L

R

A

E

N

E

E

G

G

M

M

S

T

L

M

L

V

L

V

V

V

E

T

H

H

D

E

M

M

D

G

F

F

V

A

M

R

N

E

L

V

T

G

D

D

R

R

L

V

V

L

V

F

M

M

E

D

F

G

G

G

T

Y

R

I

I

I

A

E

E

E

G

G

L

K

P

P

Q

E

D

D

V

L

Q

F

N

D

D

R

P

P

binding adenosine-5'-diphosphate: F13 (= F356), V18 (≠ A361), S38 (≠ N381), G39 (= G382), S40 (≠ A383), G41 (= G384), K42 (= K385), S43 (= S386), T44 (= T387)

6b89A E. Coli lptb in complex with adp and novobiocin (see paper)
32% identity, 40% coverage: 354:590/594 of query aligns to 10:234/234 of 6b89A

query
sites
6b89A

K

K

Q

A

F
x
Y

G

K

G

G

L
x
R

V

R

A
x
V

V

V

N

E

D

D

V

V

S

S

F

L

E

T

V

V

K

N

A

S

G

G

Q

E

I

I

I

V

G

G

L

L

I

L

G

G

P

P

N
|
N

G
|
G

A

A

G
|
G

K
|
K

S
x
T

T
|
T

T

T

F

F

N

Y

L

M

V

V

T

V

G

G

V

I

L

V

Q

P

A

R

T

D

S

A

G

G

A

N

I

I

T

I

F

I

R

D

G

D

E

D

R

D

I

I

D

S

A

L

L

L

N

P

S
x
L

R
x
H

E

A

I

R

V

A

K

R

R

R

G

G

I

I

G

G

R

Y

T

L

F
x
P

Q
|
Q

H

E

V
x
A

K
x
S

L

I

L
x
F

P
x
R

G
x
R

M
x
L

T

S

V

V

L

Y

E

D

N

N

V

L

A

M

I

A

G
x
V

G

L

H

Q

L

I

R

R

G

D

R

D

A

L

G

S

V

A

W

E

R

Q

S

R

V

E

A

D

R

R

L

A

N

N

G

-

A

-

E

-

E

-

G

-

R

E

L

L

M

M

A

E

E

E

A

F

A

H

R

-

Q

-

I

-

R

-

R

-

V

-

G

-

L

-

E

I

E

E

H

H

M

L

Y

R

D

D

E

S

A

M

G

G

-
x
Q

S

S

L

L

A

S

L

G

G

G

K

E

Q

R

R

R

I

R

L

V

E

E

I

I

A

A

R
|
R

A

A

L

L

C

A

C

A

D

N

P

P

T

K

L

F

L

I

L

L

L

L

D

D

E

E

P

P

A

F

A

A

G

G

L

V

R

D

Y

P

Q

I

E

S

K

V

Q

I

Q

D

L

I

A

K

T

R

L

I

L

I

R

E

K

H

L

L

R

R

E

D

E

S

G

G

M

L

S

G

L

V

L

L

L

I

V

T

E

D

H

H

D

N

M

V

D

R

F

E

V

T

M

L

N

A

L

V

T

C

D

E

R

R

L

A

V

Y

V

I

M

V

E

S

F

Q

G

G

T

H

R

L

I

I

A

A

E

H

G

G

L

T

P

P

Q

T

D

E

V

I

Q

L

N

Q

D

D

P

E

A

H

V

V

L

K

E

R

A

V

Y

Y

L

L

binding adenosine-5'-diphosphate: Y12 (≠ F356), R15 (≠ L359), V17 (≠ A361), N37 (= N381), G38 (= G382), G40 (= G384), K41 (= K385), T42 (≠ S386), T43 (= T387)
binding magnesium ion: T42 (≠ S386), Q84 (= Q428)
binding novobiocin: L71 (≠ S415), H72 (≠ R416), P83 (≠ F427), A86 (≠ V430), S87 (≠ K431), F89 (≠ L433), R90 (≠ P434), R91 (≠ G435), L92 (≠ M436), V101 (≠ G445), Q135 (vs. gap), R149 (= R505)

4p31A Crystal structure of a selenomethionine derivative of e. Coli lptb in complex with adp-magensium (see paper)
32% identity, 40% coverage: 354:590/594 of query aligns to 10:234/234 of 4p31A

query
sites
4p31A

K

K

Q

A

F
x
Y

G

K

G

G

L
x
R

V

R

A
x
V

V

V

N

E

D

D

V

V

S

S

F

L

E

T

V

V

K

N

A

S

G

G

Q

E

I

I

I

V

G

G

L

L

I

L

G

G

P

P

N

N

G
|
G

A

A

G
|
G

K
|
K

S
x
T

T
|
T

T

T

F

F

N

Y

L

M

V

V

T

V

G

G

V

I

L

V

Q

P

A

R

T

D

S

A

G

G

A

N

I

I

T

I

F

I

R

D

G

D

E

D

R

D

I

I

D

S

A

L

L

L

N

P

S

L

R

H

E

A

I

R

V

A

K

R

R

R

G

G

I

I

G

G

R

Y

T

L

F

P

Q
|
Q

H

E

V

A

K

S

L

I

L

F

P

R

G

R

M

L

T

S

V

V

L

Y

E

D

N

N

V

L

A

M

I

A

G

V

G

L

H

Q

L

I

R

R

G

D

R

D

A

L

G

S

V

A

W

E

R

Q

S

R

V

E

A

D

R

R

L

A

N

N

G

-

A

-

E

-

E

-

G

-

R

E

L

L

M

M

A

E

E

E

A

F

A

H

R

-

Q

-

I

-

R

-

R

-

V

-

G

-

L

-

E

I

E

E

H

H

M

L

Y

R

D

D

E

S

A

M

G

G

-

Q

S

S

L

L

A

S

L

G

G

G

K

E

Q

R

R

R

I

R

L

V

E

E

I

I

A

A

R

R

A

A

L

L

C

A

C

A

D

N

P

P

T

K

L

F

L

I

L

L

L

L

D

D

E

E

P

P

A

F

A

A

G

G

L

V

R

D

Y

P

Q

I

E

S

K

V

Q

I

Q

D

L

I

A

K

T

R

L

I

L

I

R

E

K

H

L

L

R

R

E

D

E

S

G

G

M

L

S

G

L

V

L

L

L

I

V

T

E

D

H

H

D

N

M

V

D

R

F

E

V

T

M

L

N

A

L

V

T

C

D

E

R

R

L

A

V

Y

V

I

M

V

E

S

F

Q

G

G

T

H

R

L

I

I

A

A

E

H

G

G

L

T

P

P

Q

T

D

E

V

I

Q

L

N

Q

D

D

P

E

A

H

V

V

L

K

E

R

A

V

Y

Y

L

L

binding adenosine-5'-diphosphate: Y12 (≠ F356), R15 (≠ L359), V17 (≠ A361), G38 (= G382), G40 (= G384), K41 (= K385), T42 (≠ S386), T43 (= T387)
binding magnesium ion: T42 (≠ S386), Q84 (= Q428)

6b8bA E. Coli lptb in complex with adp and a novobiocin derivative (see paper)
32% identity, 40% coverage: 354:589/594 of query aligns to 10:233/233 of 6b8bA

query
sites
6b8bA

K

K

Q

A

F
x
Y

G

K

G

G

L
x
R

V

R

A
x
V

V

V

N

E

D

D

V

V

S

S

F

L

E

T

V

V

K

N

A

S

G

G

Q

E

I

I

I

V

G

G

L

L

I

L

G

G

P

P

N

N

G
|
G

A

A

G
|
G

K
|
K

S
x
T

T
|
T

T

T

F

F

N

Y

L

M

V

V

T

V

G

G

V

I

L

V

Q

P

A

R

T

D

S

A

G

G

A

N

I

I

T

I

F

I

R

D

G

D

E

D

R

D

I

I

D

S

A

L

L

L

N

P

S

L

R

H

E

A

I

R

V

A

K

R

R

R

G

G

I

I

G

G

R

Y

T

L

F

P

Q

Q

H

E

V

A

K

S

L

I

L
x
F

P
x
R

G
x
R

M

L

T

S

V

V

L

Y

E

D

N

N

V

L

A

M

I

A

G

V

G

L

H

Q

L

I

R

R

G

D

R

D

A

L

G

S

V

A

W

E

R

Q

S

R

V

E

A

D

R

R

L

A

N

N

G

-

A

-

E

-

E

-

G

-

R

E

L

L

M

M

A

E

E

E

A

F

A

H

R

-

Q

-

I

-

R

-

R

-

V

-

G

-

L

-

E

I

E

E

H

H

M

L

Y

R

D

D

E

S

A

M

G

G

-

Q

S

S

L

L

A

S

L

G

G

G

K

E

Q

R

R

R

I

R

L

V

E

E

I

I

A

A

R

R

A

A

L

L

C

A

C

A

D

N

P

P

T

K

L

F

L

I

L

L

L

L

D

D

E

E

P

P

A

F

A

A

G

G

L

V

R

D

Y

P

Q

I

E

S

K

V

Q

I

Q

D

L

I

A

K

T

R

L

I

L

I

R

E

K

H

L

L

R

R

E

D

E

S

G

G

M

L

S

G

L

V

L

L

L

I

V

T

E

D

H

H

D

N

M

V

D

R

F

E

V

T

M

L

N

A

L

V

T

C

D

E

R

R

L

A

V

Y

V

I

M

V

E

S

F

Q

G

G

T

H

R

L

I

I

A

A

E

H

G

G

L

T

P

P

Q

T

D

E

V

I

Q

L

N

Q

D

D

P

E

A

H

V

V

L

K

E

R

A

V

Y

Y

binding adenosine-5'-diphosphate: Y12 (≠ F356), R15 (≠ L359), V17 (≠ A361), G38 (= G382), G40 (= G384), K41 (= K385), T42 (≠ S386), T43 (= T387)
binding (3s,5s,7s)-N-{7-[(3-O-carbamoyl-6-deoxy-5-methyl-4-O-methyl-beta-D-gulopyranosyl)oxy]-4-hydroxy-8-methyl-2-oxo-2H-1-benzopyran-3-yl}tricyclo[3.3.1.1~3,7~]decane-1-carboxamide: F89 (≠ L433), R90 (≠ P434), R91 (≠ G435)

4u00A Crystal structure of ttha1159 in complex with adp (see paper)
28% identity, 40% coverage: 345:584/594 of query aligns to 1:228/241 of 4u00A

query
sites
4u00A

P

P

L

I

L

I

V

R

V

I

D

R

K

N

A

L

R

H

K

K

Q

W

F
|
F

G

G

G

P

L

L

V

H

A
x
V

V

L

N

K

D

G

V

I

S

H

F

L

E

E

V

V

K

A

A

P

G

G

Q

E

I

K

I

L

G

V

L

I

I

I

G

G

P

P

N
x
S

G
|
G

A
x
S

G
|
G

K
|
K

S
|
S

T
|
T

T

L

F

I

N

R

L

T

V

I

T

N

G

R

V

L

L

E

Q

D

A

F

T

Q

S

E

G

G

A

E

I

V

T

V

F

V

R

D

G

G

E

L

R

S

I

V

D

K

A

D

L

D

N

R

S

A

R

L

E

R

I

E

V

I

K

R

R

R

G

E

I

V

G

G

R

M

T

V

F

F

Q

Q

H

Q

V

F

K

N

L

L

L

F

P

P

G

H

M

M

T

T

V

V

L

L

E

E

N

N

V

V

A

T

I

L

G

-

G

-

H

-

L

-

R

-

G

-

R

-

A

-

G

-

V

-

W

-

R

-

S

A

V

P

A

M

R

R

L

V

N

R

G

R

A

W

E

P

E

R

G

E

R

K

L

A

M

E

A

K

E

K

A

A

A

L

R

E

Q

L

I

L

R

E

R

R

V

V

G

G

L

I

E

L

E

D

H

Q

M

A

Y

R

D

K

E

Y

A

P

G

A

S

Q

L

L

A

S

L

G

G

G

K

Q

Q

Q

R

Q

I

R

L

V

E

A

I

I

A

A

R

R

A

A

L

L

C

A

C

M

D

E

P

P

T

K

L

I

L

M

L

L

L

F

D

D

E

E

P

P

A

T

A

S

G

A

L

L

R

D

Y

P

Q

E

E

M

K

V

Q

G

Q

E

L

V

A

L

T

D

L

V

L

M

R

R

K

D

L

L

R

A

E

Q

E

G

G

G

M

M

S

T

L

M

L

V

L

V

V

V

E

T

H

H

D

E

M

M

D

G

F

F

V

A

M

R

N

E

L

V

T

A

D

D

R

R

L

V

V

V

V

F

M

M

E

D

F

G

G

G

T

Q

R

I

I

V

A

E

E

E

G

G

L

R

P

P

Q

E

D

E

V

I

Q

F

N

T

D

R

P

P

A

K

binding adenosine-5'-diphosphate: F12 (= F356), V17 (≠ A361), S37 (≠ N381), G38 (= G382), S39 (≠ A383), G40 (= G384), K41 (= K385), S42 (= S386), T43 (= T387)

1ji0A Crystal structure analysis of the abc transporter from thermotoga maritima
30% identity, 40% coverage: 356:591/594 of query aligns to 16:238/240 of 1ji0A

query
sites
1ji0A

F
x
Y

G

G

G

A

L

I

V

H

A

A

V

I

N

K

D

G

V

I

S

D

F

L

E

K

V

V

K

P

A

R

G

G

Q

Q

I

I

I

V

G

T

L

L

I

I

G

G

P

A

N

N

G
|
G

A

A

G
|
G

K
|
K

S
x
T

T
|
T

T

T

F

L

N

S

L

A

V

I

T

A

G

G

V

L

L

V

Q

R

A

A

T

Q

S

K

G

G

A

K

I

I

T

I

F

F

R

N

G

G

E

Q

R

D

I

I

D

T

A

N

L

K

N

P

S

A

R

H

E

V

I

I

V

N

K

R

R

M

G

G

I

I

G

A

R

L

T

V

F

P

Q
x
E

H

G

V

R

K

R

L

I

L

F

P

P

G

E

M

L

T

T

V

V

L

Y

E

E

N

N

V