SitesBLAST
Comparing WP_012406585.1 NCBI__GCF_000020045.1:WP_012406585.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
1t9cA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, sulfometuron methyl (see paper)
42% identity, 96% coverage: 26:591/591 of query aligns to 9:582/596 of 1t9cA
- active site: Y29 (= Y46), G31 (= G48), G32 (= G49), A33 (= A50), I34 (≠ V51), E55 (= E72), T78 (= T95), F117 (= F134), Q118 (= Q135), E119 (= E136), K167 (= K184), R227 (≠ E244), M263 (≠ L279), V290 (= V306), V406 (= V413), L431 (= L438), G432 (= G439), M434 (= M441), D459 (= D466), N486 (= N493), E488 (≠ Y495), Q489 (≠ L496), M491 (= M498), V492 (= V499), W495 (≠ L502), L517 (= L525), G522 (= G530), L523 (≠ H531), K556 (≠ P565)
- binding methyl 2-[({[(4,6-dimethylpyrimidin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: G32 (= G49), V107 (= V124), P108 (= P125), F117 (= F134), K167 (= K184), D288 (= D304), R289 (= R305), W495 (≠ L502)
- binding flavin-adenine dinucleotide: R157 (= R174), G216 (= G233), A217 (≠ G234), G218 (= G235), N221 (≠ A238), T243 (= T259), L244 (= L260), Q245 (≠ M261), L261 (≠ P277), M263 (≠ L279), H264 (= H280), G283 (= G299), A284 (= A300), R285 (= R301), D287 (= D303), R289 (= R305), V290 (= V306), E316 (≠ D324), V317 (≠ I325), N321 (≠ T329), G334 (= G342), D335 (= D343), A336 (≠ V344), M411 (= M418), G429 (= G436), G430 (= G437)
- binding magnesium ion: D459 (= D466), N486 (= N493), E488 (≠ Y495)
1t9dA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, metsulfuron methyl (see paper)
42% identity, 96% coverage: 26:591/591 of query aligns to 9:582/596 of 1t9dA
- active site: Y29 (= Y46), G31 (= G48), G32 (= G49), A33 (= A50), I34 (≠ V51), E55 (= E72), T78 (= T95), F117 (= F134), Q118 (= Q135), E119 (= E136), K167 (= K184), R227 (≠ E244), M263 (≠ L279), V290 (= V306), V406 (= V413), L431 (= L438), G432 (= G439), M434 (= M441), D459 (= D466), N486 (= N493), E488 (≠ Y495), Q489 (≠ L496), M491 (= M498), V492 (= V499), W495 (≠ L502), L517 (= L525), G522 (= G530), L523 (≠ H531), K556 (≠ P565)
- binding methyl 2-[({[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: G32 (= G49), A33 (= A50), V107 (= V124), P108 (= P125), F117 (= F134), K167 (= K184), M263 (≠ L279), D288 (= D304), R289 (= R305), W495 (≠ L502)
- binding flavin-adenine dinucleotide: R157 (= R174), G216 (= G233), A217 (≠ G234), G218 (= G235), N221 (≠ A238), T243 (= T259), L244 (= L260), Q245 (≠ M261), M260 (= M276), L261 (≠ P277), H264 (= H280), G283 (= G299), A284 (= A300), R285 (= R301), D287 (= D303), R289 (= R305), V290 (= V306), E316 (≠ D324), V317 (≠ I325), N321 (≠ T329), G334 (= G342), D335 (= D343), A336 (≠ V344), Q410 (= Q417), M411 (= M418), G429 (= G436), G430 (= G437)
- binding magnesium ion: D459 (= D466), N486 (= N493), E488 (≠ Y495)
- binding 2,5-dimethyl-pyrimidin-4-ylamine: E55 (= E72), P81 (= P98), Q118 (= Q135), G432 (= G439), M434 (= M441), M464 (= M471)
1t9aA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, tribenuron methyl (see paper)
42% identity, 96% coverage: 26:591/591 of query aligns to 10:583/597 of 1t9aA
- active site: Y30 (= Y46), G32 (= G48), G33 (= G49), A34 (= A50), I35 (≠ V51), E56 (= E72), T79 (= T95), F118 (= F134), Q119 (= Q135), E120 (= E136), K168 (= K184), R228 (≠ E244), M264 (≠ L279), V291 (= V306), V407 (= V413), L432 (= L438), G433 (= G439), M435 (= M441), D460 (= D466), N487 (= N493), E489 (≠ Y495), Q490 (≠ L496), M492 (= M498), V493 (= V499), W496 (≠ L502), L518 (= L525), G523 (= G530), L524 (≠ H531), K557 (≠ P565)
- binding methyl 2-[4-methoxy-6-methyl-1,3,5-trazin-2-yl(methyl)carbamoylsulfamoyl]benzoate: G33 (= G49), V108 (= V124), P109 (= P125), F118 (= F134), K168 (= K184), M264 (≠ L279), D289 (= D304), R290 (= R305), M492 (= M498), V493 (= V499), W496 (≠ L502)
- binding flavin-adenine dinucleotide: R158 (= R174), G217 (= G233), A218 (≠ G234), G219 (= G235), N222 (≠ A238), T244 (= T259), L245 (= L260), Q246 (≠ M261), L262 (≠ P277), M264 (≠ L279), H265 (= H280), G284 (= G299), A285 (= A300), R286 (= R301), D288 (= D303), R290 (= R305), V291 (= V306), E317 (≠ D324), V318 (≠ I325), N322 (≠ T329), G335 (= G342), D336 (= D343), A337 (≠ V344), Q411 (= Q417), M412 (= M418), G430 (= G436), G431 (= G437)
- binding magnesium ion: D460 (= D466), N487 (= N493), E489 (≠ Y495)
- binding propyl trihydrogen diphosphate: V407 (= V413), G408 (= G414), Q409 (= Q415), H410 (= H416), M435 (= M441), G459 (= G465), D460 (= D466), A461 (≠ G467), S462 (= S468), N487 (= N493), E489 (≠ Y495), Q490 (≠ L496), G491 (= G497), M492 (= M498)
- binding 5-{[ethyl(methyl)amino]methyl}-2-methyl-5,6-dihydropyrimidin-4-amine: G433 (= G439), M435 (= M441), M465 (= M471)
1t9bB Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, chlorsulfuron (see paper)
42% identity, 96% coverage: 26:591/591 of query aligns to 9:581/595 of 1t9bB
- active site: Y29 (= Y46), G31 (= G48), G32 (= G49), A33 (= A50), I34 (≠ V51), E55 (= E72), T78 (= T95), F117 (= F134), Q118 (= Q135), E119 (= E136), K167 (= K184), R226 (≠ E244), M262 (≠ L279), V289 (= V306), V405 (= V413), L430 (= L438), G431 (= G439), M433 (= M441), D458 (= D466), N485 (= N493), E487 (≠ Y495), Q488 (≠ L496), M490 (= M498), V491 (= V499), W494 (≠ L502), L516 (= L525), G521 (= G530), L522 (≠ H531), K555 (≠ P565)
- binding 1-(2-chlorophenylsulfonyl)-3-(4-methoxy-6-methyl-l,3,5-triazin-2-yl)urea: V107 (= V124), P108 (= P125), D287 (= D304), R288 (= R305), M490 (= M498), W494 (≠ L502)
- binding flavin-adenine dinucleotide: R157 (= R174), G215 (= G233), A216 (≠ G234), G217 (= G235), N220 (≠ A238), T242 (= T259), L243 (= L260), Q244 (≠ M261), M259 (= M276), L260 (≠ P277), M262 (≠ L279), H263 (= H280), G282 (= G299), A283 (= A300), R284 (= R301), D286 (= D303), R288 (= R305), V289 (= V306), E315 (≠ D324), V316 (≠ I325), N320 (≠ T329), G333 (= G342), D334 (= D343), A335 (≠ V344), Q409 (= Q417), M410 (= M418), G428 (= G436), G429 (= G437)
- binding magnesium ion: D458 (= D466), N485 (= N493), E487 (≠ Y495)
1n0hA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, chlorimuron ethyl (see paper)
42% identity, 96% coverage: 26:591/591 of query aligns to 11:585/599 of 1n0hA
- active site: Y31 (= Y46), G33 (= G48), G34 (= G49), A35 (= A50), I36 (≠ V51), E57 (= E72), T80 (= T95), F119 (= F134), Q120 (= Q135), E121 (= E136), K169 (= K184), R230 (≠ E244), M266 (≠ L279), V293 (= V306), V409 (= V413), L434 (= L438), G435 (= G439), M437 (= M441), D462 (= D466), N489 (= N493), E491 (≠ Y495), Q492 (≠ L496), M494 (= M498), V495 (= V499), W498 (≠ L502), L520 (= L525), G525 (= G530), L526 (≠ H531), K559 (≠ P565)
- binding 4-{[(4'-amino-2'-methylpyrimidin-5'-yl)methyl]amino}pent-3-enyl diphosphate: V409 (= V413), G410 (= G414), Q411 (= Q415), H412 (= H416), G435 (= G439), M437 (= M441), G461 (= G465), D462 (= D466), A463 (≠ G467), S464 (= S468), M467 (= M471), N489 (= N493), E491 (≠ Y495), Q492 (≠ L496), G493 (= G497), V495 (= V499)
- binding 2-[[[[(4-chloro-6-methoxy-2-pyrimidinyl)amino]carbonyl]amino]sulfonyl]benzoic acid ethyl ester: G34 (= G49), A35 (= A50), V109 (= V124), P110 (= P125), F119 (= F134), K169 (= K184), M266 (≠ L279), D291 (= D304), R292 (= R305), V495 (= V499), W498 (≠ L502)
- binding flavin-adenine dinucleotide: R159 (= R174), G219 (= G233), A220 (≠ G234), G221 (= G235), N224 (≠ A238), T246 (= T259), L247 (= L260), Q248 (≠ M261), L264 (≠ P277), G265 (= G278), M266 (≠ L279), H267 (= H280), G286 (= G299), A287 (= A300), R288 (= R301), D290 (= D303), R292 (= R305), V293 (= V306), E319 (≠ D324), V320 (≠ I325), N324 (≠ T329), G337 (= G342), D338 (= D343), A339 (≠ V344), M414 (= M418), G432 (= G436), G433 (= G437)
- binding magnesium ion: D462 (= D466), N489 (= N493), E491 (≠ Y495)
- binding thiamine diphosphate: Y31 (= Y46), E57 (= E72), P83 (= P98)
P17597 Acetolactate synthase, chloroplastic; AtALS; Acetohydroxy-acid synthase; Protein CHLORSULFURON RESISTANT 1; EC 2.2.1.6 from Arabidopsis thaliana (Mouse-ear cress) (see 8 papers)
41% identity, 94% coverage: 27:583/591 of query aligns to 99:661/670 of P17597
- A122 (= A50) mutation to V: Reduced catalytic activity. Resistant to imidazolinone herbicides but not to sulfonylurea herbicides.
- M124 (≠ L52) mutation to E: Reduced catalytic activity. Resistant to imidazolinone herbicides and reduced sensitivity to sulfonylurea herbicides.; mutation to I: No effect on catalytic activity. Increased resistance to imidazolinone herbicides.
- E144 (= E72) binding
- S186 (= S114) binding
- P197 (= P125) mutation to S: In csr1-1/GH50; resistant to sulfonylurea but not to imidazolinone herbicides.
- R199 (≠ H127) mutation R->A,E: No effect on catalytic activity. Resistant to imidazolinone herbicides but not to sulfonylurea herbicides.
- Q207 (= Q135) binding
- K220 (= K148) binding
- R246 (= R174) binding ; binding
- K256 (= K184) binding
- G308 (= G234) binding
- TL 331:332 (= TL 259:260) binding
- C340 (≠ A268) modified: Cysteine sulfinic acid (-SO2H)
- LGMH 349:352 (≠ PGLH 277:280) binding
- GVRFD 371:375 (≠ GARFD 299:303) binding
- DR 376:377 (= DR 304:305) binding
- DI 395:396 (= DI 324:325) binding
- DV 414:415 (= DV 343:344) binding
- QH 487:488 (= QH 415:416) binding
- GG 508:509 (= GG 436:437) binding
- GAM 511:513 (≠ GTM 439:441) binding
- D538 (= D466) binding
- DGS 538:540 (= DGS 466:468) binding
- N565 (= N493) binding
- NQHLGM 565:570 (≠ NGYLGM 493:498) binding
- H567 (≠ Y495) binding
- W574 (≠ L502) binding ; mutation to L: Increased catalytic activity. Resistant to imidazolinone and sulfonylurea herbicides.; mutation to S: Slightly decreased catalytic activity. Resistant to imidazolinone and sulfonylurea herbicides.
- S653 (≠ A575) binding ; mutation to A: No effect on catalytic activity or sensitivity to herbicides.; mutation to F: No effect on catalytic activity. Resistant to imidazolinone herbicides and also slightly sulfonylurea-resistant.; mutation to N: In csr1-2/GH90; no effect on catalytic activity. Resistant to imidazolinone but not to sulfonylurea herbicides.; mutation to T: No effect on catalytic activity. Resistant to imidazolinone herbicides but not to sulfonylurea herbicides.
P07342 Acetolactate synthase catalytic subunit, mitochondrial; Acetohydroxy-acid synthase catalytic subunit; AHAS; ALS; EC 2.2.1.6 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
41% identity, 99% coverage: 6:591/591 of query aligns to 70:673/687 of P07342
- R241 (= R174) binding
- 355:376 (vs. 280:301, 59% identical) binding
- 407:426 (vs. 324:343, 40% identical) binding
8et4A Crystal structure of wild-type arabidopsis thaliana acetohydroxyacid synthase in complex with amidosulfuron (see paper)
41% identity, 94% coverage: 27:583/591 of query aligns to 14:576/582 of 8et4A
- binding 2-[3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-2-[(1~{S})-1-(dioxidanyl)-1-oxidanyl-ethyl]-4-methyl-1,3-thiazol-5-yl]ethyl phosphono hydrogen phosphate: V400 (= V413), G401 (= G414), Q402 (= Q415), H403 (= H416), G426 (= G439), M428 (= M441), G452 (= G465), D453 (= D466), G454 (= G467), S455 (= S468), M458 (= M471), N480 (= N493), H482 (≠ Y495), L483 (= L496), G484 (= G497), M485 (= M498), V486 (= V499)
- binding flavin-adenine dinucleotide: R161 (= R174), G222 (= G233), G223 (= G234), G224 (= G235), T246 (= T259), L247 (= L260), M248 (= M261), L264 (≠ P277), M266 (≠ L279), H267 (= H280), G286 (= G299), V287 (≠ A300), R288 (= R301), D290 (= D303), R292 (= R305), V293 (= V306), D310 (= D324), I311 (= I325), D329 (= D343), V330 (= V344), M405 (= M418), G423 (= G436)
- binding magnesium ion: F370 (≠ Y383), D453 (= D466), M458 (= M471), Q461 (= Q474), N480 (= N493), H482 (≠ Y495), K533 (≠ P539)
- binding N-{[(4,6-dimethoxypyrimidin-2-yl)carbamoyl]sulfamoyl}-N-methylmethanesulfonamide: M266 (≠ L279), R292 (= R305), M485 (= M498), W489 (≠ L502), S568 (≠ A575)
5wj1A Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a triazolopyrimidine herbicide, penoxsulam (see paper)
41% identity, 94% coverage: 27:583/591 of query aligns to 14:576/582 of 5wj1A
- active site: Y33 (= Y46), G35 (= G48), G36 (= G49), A37 (= A50), S38 (≠ V51), E59 (= E72), T82 (= T95), F121 (= F134), Q122 (= Q135), E123 (= E136), K171 (= K184), M266 (≠ L279), V293 (= V306), V400 (= V413), G426 (= G439), M428 (= M441), D453 (= D466), N480 (= N493), H482 (≠ Y495), L483 (= L496), M485 (= M498), V486 (= V499), W489 (≠ L502), H558 (≠ P565)
- binding flavin-adenine dinucleotide: R161 (= R174), G222 (= G233), G223 (= G234), G224 (= G235), T246 (= T259), L247 (= L260), M248 (= M261), M263 (= M276), L264 (≠ P277), G286 (= G299), R288 (= R301), V293 (= V306), D310 (= D324), I311 (= I325), D329 (= D343), V330 (= V344), M405 (= M418), G423 (= G436), G424 (= G437)
- binding magnesium ion: D453 (= D466), N480 (= N493), H482 (≠ Y495)
- binding 2-(2,2-difluoroethoxy)-N-(5,8-dimethoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)-6-(trifluoromethyl)benzenesulfonamide: M266 (≠ L279), D291 (= D304), R292 (= R305), M485 (= M498), W489 (≠ L502), S568 (≠ A575)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V400 (= V413), G401 (= G414), Q402 (= Q415), H403 (= H416), M428 (= M441), D453 (= D466), G454 (= G467), S455 (= S468), M458 (= M471), N480 (= N493), H482 (≠ Y495), L483 (= L496), G484 (= G497), M485 (= M498), V486 (= V499)
5k6tA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylamino-carbonyl-triazolinone herbicide, propoxycarbazone-sodium (see paper)
41% identity, 94% coverage: 27:583/591 of query aligns to 14:576/582 of 5k6tA
- active site: Y33 (= Y46), G35 (= G48), G36 (= G49), A37 (= A50), S38 (≠ V51), E59 (= E72), T82 (= T95), F121 (= F134), Q122 (= Q135), E123 (= E136), K171 (= K184), M266 (≠ L279), V293 (= V306), V400 (= V413), G426 (= G439), M428 (= M441), D453 (= D466), N480 (= N493), H482 (≠ Y495), L483 (= L496), M485 (= M498), V486 (= V499), W489 (≠ L502), H558 (≠ P565)
- binding methyl 2-[(4-methyl-5-oxidanylidene-3-propoxy-1,2,4-triazol-1-yl)carbonylsulfamoyl]benzoate: H267 (= H280), R292 (= R305), M485 (= M498), W489 (≠ L502), S568 (≠ A575)
- binding flavin-adenine dinucleotide: R161 (= R174), G222 (= G233), G223 (= G234), G224 (= G235), T246 (= T259), L247 (= L260), M248 (= M261), L264 (≠ P277), G286 (= G299), R288 (= R301), D290 (= D303), R292 (= R305), V293 (= V306), D310 (= D324), I311 (= I325), D329 (= D343), V330 (= V344), Q404 (= Q417), M405 (= M418), G423 (= G436)
- binding magnesium ion: D453 (= D466), N480 (= N493), H482 (≠ Y495)
- binding 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-2-oxo-2,3-dihydro-1,3-thiazol-5-yl}ethyl trihydrogendiphosphate: V400 (= V413), G401 (= G414), Q402 (= Q415), H403 (= H416), G426 (= G439), M428 (= M441), G452 (= G465), G454 (= G467), S455 (= S468), N480 (= N493), H482 (≠ Y495), L483 (= L496), G484 (= G497)
5k6rA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylamino-carbonyl-triazolinone herbicide, thiencarbazone-methyl (see paper)
41% identity, 94% coverage: 27:583/591 of query aligns to 14:576/582 of 5k6rA
- active site: Y33 (= Y46), G35 (= G48), G36 (= G49), A37 (= A50), S38 (≠ V51), E59 (= E72), T82 (= T95), F121 (= F134), Q122 (= Q135), E123 (= E136), K171 (= K184), M266 (≠ L279), V293 (= V306), V400 (= V413), G426 (= G439), M428 (= M441), D453 (= D466), N480 (= N493), H482 (≠ Y495), L483 (= L496), M485 (= M498), V486 (= V499), W489 (≠ L502), H558 (≠ P565)
- binding methyl 4-[(3-methoxy-4-methyl-5-oxidanylidene-1,2,4-triazol-1-yl)carbonylsulfamoyl]-5-methyl-thiophene-3-carboxylate: R292 (= R305), W489 (≠ L502), S568 (≠ A575)
- binding flavin-adenine dinucleotide: R161 (= R174), G222 (= G233), G223 (= G234), G224 (= G235), T246 (= T259), L247 (= L260), M248 (= M261), L264 (≠ P277), M266 (≠ L279), G286 (= G299), R288 (= R301), R292 (= R305), V293 (= V306), D310 (= D324), I311 (= I325), G328 (= G342), D329 (= D343), V330 (= V344), M405 (= M418), G423 (= G436)
- binding magnesium ion: D453 (= D466), N480 (= N493), H482 (≠ Y495)
- binding 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-2-oxo-2,3-dihydro-1,3-thiazol-5-yl}ethyl trihydrogendiphosphate: V400 (= V413), G401 (= G414), Q402 (= Q415), H403 (= H416), G426 (= G439), M428 (= M441), D453 (= D466), G454 (= G467), S455 (= S468), M458 (= M471), N480 (= N493), H482 (≠ Y495), L483 (= L496), G484 (= G497), M485 (= M498), V486 (= V499)
1z8nA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with an imidazolinone herbicide, imazaquin (see paper)
41% identity, 94% coverage: 27:583/591 of query aligns to 14:576/582 of 1z8nA
- active site: Y33 (= Y46), G35 (= G48), G36 (= G49), A37 (= A50), S38 (≠ V51), E59 (= E72), T82 (= T95), F121 (= F134), Q122 (= Q135), E123 (= E136), K171 (= K184), M266 (≠ L279), V293 (= V306), V400 (= V413), G426 (= G439), M428 (= M441), D453 (= D466), N480 (= N493), H482 (≠ Y495), L483 (= L496), M485 (= M498), V486 (= V499), W489 (≠ L502), H558 (≠ P565)
- binding 2-(4-isopropyl-4-methyl-5-oxo-4,5-dihydro-1h-imidazol-2-yl)quinoline-3-carboxylic acid: K135 (= K148), R161 (= R174), Y191 (= Y204), R194 (vs. gap), D291 (= D304), R292 (= R305), D312 (= D326), W489 (≠ L502), G569 (= G576)
- binding flavin-adenine dinucleotide: R161 (= R174), G222 (= G233), G224 (= G235), T246 (= T259), L247 (= L260), M248 (= M261), L264 (≠ P277), G265 (= G278), M266 (≠ L279), H267 (= H280), G286 (= G299), V287 (≠ A300), R288 (= R301), D290 (= D303), R292 (= R305), V293 (= V306), D310 (= D324), I311 (= I325), D329 (= D343), V330 (= V344), M405 (= M418), G423 (= G436), G424 (= G437)
- binding magnesium ion: D453 (= D466), N480 (= N493)
- binding thiamine diphosphate: V400 (= V413), G401 (= G414), Q402 (= Q415), H403 (= H416), G426 (= G439), M428 (= M441), G452 (= G465), G454 (= G467), S455 (= S468), N480 (= N493), H482 (≠ Y495), L483 (= L496), G484 (= G497), M485 (= M498), V486 (= V499)
1yi1A Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide, tribenuron methyl (see paper)
41% identity, 94% coverage: 27:583/591 of query aligns to 14:576/582 of 1yi1A
- active site: Y33 (= Y46), G35 (= G48), G36 (= G49), A37 (= A50), S38 (≠ V51), E59 (= E72), T82 (= T95), F121 (= F134), Q122 (= Q135), E123 (= E136), K171 (= K184), M266 (≠ L279), V293 (= V306), V400 (= V413), G426 (= G439), M428 (= M441), D453 (= D466), N480 (= N493), H482 (≠ Y495), L483 (= L496), M485 (= M498), V486 (= V499), W489 (≠ L502), H558 (≠ P565)
- binding methyl 2-[4-methoxy-6-methyl-1,3,5-trazin-2-yl(methyl)carbamoylsulfamoyl]benzoate: D291 (= D304), R292 (= R305), W489 (≠ L502), S568 (≠ A575)
- binding flavin-adenine dinucleotide: R161 (= R174), G223 (= G234), G224 (= G235), T246 (= T259), L247 (= L260), M248 (= M261), M263 (= M276), L264 (≠ P277), G265 (= G278), M266 (≠ L279), H267 (= H280), G286 (= G299), V287 (≠ A300), R288 (= R301), D290 (= D303), V293 (= V306), D310 (= D324), I311 (= I325), D329 (= D343), V330 (= V344), M405 (= M418), G423 (= G436), G424 (= G437)
- binding magnesium ion: D453 (= D466), N480 (= N493), H482 (≠ Y495)
1yi0A Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide, sulfometuron methyl (see paper)
41% identity, 94% coverage: 27:583/591 of query aligns to 14:576/582 of 1yi0A
- active site: Y33 (= Y46), G35 (= G48), G36 (= G49), A37 (= A50), S38 (≠ V51), E59 (= E72), T82 (= T95), F121 (= F134), Q122 (= Q135), E123 (= E136), K171 (= K184), M266 (≠ L279), V293 (= V306), V400 (= V413), G426 (= G439), M428 (= M441), D453 (= D466), N480 (= N493), H482 (≠ Y495), L483 (= L496), M485 (= M498), V486 (= V499), W489 (≠ L502), H558 (≠ P565)
- binding methyl 2-[({[(4,6-dimethylpyrimidin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: D291 (= D304), R292 (= R305), W489 (≠ L502), S568 (≠ A575)
- binding flavin-adenine dinucleotide: R161 (= R174), G222 (= G233), G223 (= G234), G224 (= G235), T246 (= T259), L247 (= L260), M248 (= M261), L264 (≠ P277), G265 (= G278), M266 (≠ L279), H267 (= H280), G286 (= G299), V287 (≠ A300), R288 (= R301), D290 (= D303), R292 (= R305), V293 (= V306), D310 (= D324), I311 (= I325), G328 (= G342), D329 (= D343), V330 (= V344), M405 (= M418), G423 (= G436), G424 (= G437)
- binding magnesium ion: D453 (= D466), N480 (= N493), H482 (≠ Y495)
1yhzA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide, chlorsulfuron (see paper)
41% identity, 94% coverage: 27:583/591 of query aligns to 14:576/582 of 1yhzA
- active site: Y33 (= Y46), G35 (= G48), G36 (= G49), A37 (= A50), S38 (≠ V51), E59 (= E72), T82 (= T95), F121 (= F134), Q122 (= Q135), E123 (= E136), K171 (= K184), M266 (≠ L279), V293 (= V306), V400 (= V413), G426 (= G439), M428 (= M441), D453 (= D466), N480 (= N493), H482 (≠ Y495), L483 (= L496), M485 (= M498), V486 (= V499), W489 (≠ L502), H558 (≠ P565)
- binding 1-(2-chlorophenylsulfonyl)-3-(4-methoxy-6-methyl-l,3,5-triazin-2-yl)urea: D291 (= D304), R292 (= R305), M485 (= M498), W489 (≠ L502), S568 (≠ A575)
- binding flavin-adenine dinucleotide: R161 (= R174), G223 (= G234), G224 (= G235), T246 (= T259), L247 (= L260), M248 (= M261), L264 (≠ P277), M266 (≠ L279), H267 (= H280), G286 (= G299), V287 (≠ A300), R288 (= R301), D290 (= D303), V293 (= V306), D310 (= D324), I311 (= I325), D329 (= D343), V330 (= V344), Q404 (= Q417), M405 (= M418), G423 (= G436), G424 (= G437)
- binding magnesium ion: D453 (= D466), N480 (= N493), H482 (≠ Y495)
1yhyA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide, metsulfuron methyl (see paper)
41% identity, 94% coverage: 27:583/591 of query aligns to 14:576/582 of 1yhyA
- active site: Y33 (= Y46), G35 (= G48), G36 (= G49), A37 (= A50), S38 (≠ V51), E59 (= E72), T82 (= T95), F121 (= F134), Q122 (= Q135), E123 (= E136), K171 (= K184), M266 (≠ L279), V293 (= V306), V400 (= V413), G426 (= G439), M428 (= M441), D453 (= D466), N480 (= N493), H482 (≠ Y495), L483 (= L496), M485 (= M498), V486 (= V499), W489 (≠ L502), H558 (≠ P565)
- binding methyl 2-[({[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: D291 (= D304), R292 (= R305), V486 (= V499), W489 (≠ L502), S568 (≠ A575)
- binding flavin-adenine dinucleotide: R161 (= R174), G222 (= G233), G223 (= G234), G224 (= G235), T246 (= T259), L247 (= L260), M248 (= M261), L264 (≠ P277), G265 (= G278), M266 (≠ L279), H267 (= H280), G286 (= G299), V287 (≠ A300), R288 (= R301), D290 (= D303), V293 (= V306), D310 (= D324), I311 (= I325), D329 (= D343), V330 (= V344), Q404 (= Q417), M405 (= M418), G423 (= G436), G424 (= G437)
- binding magnesium ion: D453 (= D466), N480 (= N493), H482 (≠ Y495)
1ybhA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide chlorimuron ethyl (see paper)
41% identity, 94% coverage: 27:583/591 of query aligns to 14:576/582 of 1ybhA
- active site: Y33 (= Y46), G35 (= G48), G36 (= G49), A37 (= A50), S38 (≠ V51), E59 (= E72), T82 (= T95), F121 (= F134), Q122 (= Q135), E123 (= E136), K171 (= K184), M266 (≠ L279), V293 (= V306), V400 (= V413), G426 (= G439), M428 (= M441), D453 (= D466), N480 (= N493), H482 (≠ Y495), L483 (= L496), M485 (= M498), V486 (= V499), W489 (≠ L502), H558 (≠ P565)
- binding 2-[[[[(4-chloro-6-methoxy-2-pyrimidinyl)amino]carbonyl]amino]sulfonyl]benzoic acid ethyl ester: M266 (≠ L279), D291 (= D304), R292 (= R305), M485 (= M498), W489 (≠ L502), S568 (≠ A575)
- binding flavin-adenine dinucleotide: R161 (= R174), G223 (= G234), G224 (= G235), T246 (= T259), L247 (= L260), M248 (= M261), L264 (≠ P277), M266 (≠ L279), H267 (= H280), G286 (= G299), V287 (≠ A300), R288 (= R301), D290 (= D303), V293 (= V306), D310 (= D324), I311 (= I325), D329 (= D343), V330 (= V344), Q404 (= Q417), M405 (= M418), G423 (= G436), G424 (= G437)
- binding magnesium ion: D453 (= D466), N480 (= N493), H482 (≠ Y495)
6u9dB Saccharomyces cerevisiae acetohydroxyacid synthase (see paper)
42% identity, 96% coverage: 26:591/591 of query aligns to 13:593/607 of 6u9dB
- active site: Y33 (= Y46), G35 (= G48), G36 (= G49), A37 (= A50), I38 (≠ V51), E59 (= E72), T82 (= T95), F121 (= F134), Q122 (= Q135), E123 (= E136), K171 (= K184), M274 (≠ L279), V301 (= V306), V417 (= V413), G443 (= G439), M445 (= M441), D470 (= D466), N497 (= N493), E499 (≠ Y495), Q500 (≠ L496), M502 (= M498), V503 (= V499), W506 (≠ L502)
- binding methyl 2-[(4,6-dimethoxypyrimidin-2-yl)carbamoylsulfamoylmethyl]benzoate: G36 (= G49), V111 (= V124), P112 (= P125), F121 (= F134), K171 (= K184), D299 (= D304), R300 (= R305), M502 (= M498), W506 (≠ L502)
- binding flavin-adenine dinucleotide: R161 (= R174), A228 (≠ G234), G229 (= G235), N232 (≠ A238), T254 (= T259), L255 (= L260), Q256 (≠ M261), L272 (≠ P277), M274 (≠ L279), G294 (= G299), R296 (= R301), D298 (= D303), R300 (= R305), V301 (= V306), E327 (≠ D324), V328 (≠ I325), N332 (≠ T329), D346 (= D343), A347 (≠ V344), M422 (= M418), G440 (= G436), G441 (= G437)
- binding magnesium ion: D470 (= D466), N497 (= N493)
- binding thiamine diphosphate: E59 (= E72), P85 (= P98), V417 (= V413), G418 (= G414), Q419 (= Q415), H420 (= H416), G443 (= G439), M445 (= M441), A471 (≠ G467), S472 (= S468), N497 (= N493), E499 (≠ Y495), Q500 (≠ L496), G501 (= G497), M502 (= M498), V503 (= V499)
5k2oA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a pyrimidinyl-benzoate herbicide, pyrithiobac (see paper)
41% identity, 94% coverage: 27:583/591 of query aligns to 14:576/585 of 5k2oA
- active site: Y33 (= Y46), G35 (= G48), G36 (= G49), A37 (= A50), S38 (≠ V51), E59 (= E72), T82 (= T95), F121 (= F134), Q122 (= Q135), E123 (= E136), K171 (= K184), M266 (≠ L279), V293 (= V306), V400 (= V413), G426 (= G439), M428 (= M441), D453 (= D466), N480 (= N493), H482 (≠ Y495), L483 (= L496), M485 (= M498), V486 (= V499), W489 (≠ L502), H558 (≠ P565)
- binding 2-chloranyl-6-(4,6-dimethoxypyrimidin-2-yl)sulfanyl-benzoic acid: M266 (≠ L279), R292 (= R305), W489 (≠ L502), S568 (≠ A575)
- binding flavin-adenine dinucleotide: R161 (= R174), G222 (= G233), G223 (= G234), G224 (= G235), T246 (= T259), L247 (= L260), M248 (= M261), L264 (≠ P277), G286 (= G299), R288 (= R301), D290 (= D303), V293 (= V306), D310 (= D324), I311 (= I325), D329 (= D343), V330 (= V344), Q404 (= Q417), M405 (= M418), G423 (= G436)
- binding magnesium ion: D453 (= D466), N480 (= N493), H482 (≠ Y495)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V400 (= V413), G401 (= G414), Q402 (= Q415), H403 (= H416), M428 (= M441), D453 (= D466), G454 (= G467), S455 (= S468), N480 (= N493), H482 (≠ Y495), L483 (= L496), G484 (= G497), M485 (= M498), V486 (= V499)
5k3sA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a pyrimidinyl-benzoate herbicide, bispyribac-sodium (see paper)
41% identity, 94% coverage: 27:583/591 of query aligns to 14:576/583 of 5k3sA
- active site: Y33 (= Y46), G35 (= G48), G36 (= G49), A37 (= A50), S38 (≠ V51), E59 (= E72), T82 (= T95), F121 (= F134), Q122 (= Q135), E123 (= E136), K171 (= K184), M266 (≠ L279), V293 (= V306), V400 (= V413), G426 (= G439), M428 (= M441), D453 (= D466), N480 (= N493), H482 (≠ Y495), L483 (= L496), M485 (= M498), V486 (= V499), W489 (≠ L502), H558 (≠ P565)
- binding 2,6-bis[(4,6-dimethoxypyrimidin-2-yl)oxy]benzoic acid: R292 (= R305), M485 (= M498), W489 (≠ L502), G569 (= G576)
- binding flavin-adenine dinucleotide: R161 (= R174), G222 (= G233), G223 (= G234), G224 (= G235), T246 (= T259), L247 (= L260), M248 (= M261), L264 (≠ P277), M266 (≠ L279), G286 (= G299), R288 (= R301), D290 (= D303), V293 (= V306), D310 (= D324), I311 (= I325), D329 (= D343), V330 (= V344), M405 (= M418), G423 (= G436)
- binding magnesium ion: D453 (= D466), N480 (= N493), H482 (≠ Y495)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V400 (= V413), G401 (= G414), Q402 (= Q415), H403 (= H416), G426 (= G439), M428 (= M441), D453 (= D466), G454 (= G467), S455 (= S468), N480 (= N493), H482 (≠ Y495), L483 (= L496), G484 (= G497), M485 (= M498), V486 (= V499)
Query Sequence
>WP_012406585.1 NCBI__GCF_000020045.1:WP_012406585.1
MKIAGAEMQQLAKAGPEALGKNGNASGAQIVLSVLRAEGVDTVWGYPGGAVLPLYDALQE
TVDITHLLVRHEQAAVHAADGFARATGKVGVALVTSGPGVTNTVTGIATAYFDSIPMVVI
SGNVPTHSIGTDAFQECDAVGITRSIVKHNFLVLDISQLAKTLKSAFYIARTGRPGPVLV
DIPKDVLQAKTPLSIAESVALRSYRPRTEPHVGQVRRAAEALARSRRPCILVGGGAVASA
ASEEIAELVRRLDAPVTNTLMALGAFPASDRRCLGMPGLHGTYEANLAMQHCDVLIALGA
RFDDRVIGNTGEFQSDRRTIIHVDIDPATIDKRVQVDIPIVGDVKTAARAILEQLRAQRI
NDGNRNDWWKEIGNWREKRCLAYEPDADVIKPQFVIQQLWEATGGDAYICSDVGQHQMWA
AQLYGFDKPRRWINSGGLGTMGVGLPYAMGVKRALPDADVVAVTGDGSIQMCIQELSTCR
QYDLGVKIVSLNNGYLGMVRQLQHVNYRDRYSHSYMDALPDFVALARAYGHVGFRIERPC
DVEPVLREALAMKQRTVFMDFAIDPSENVWPMVRAGAGLTDMLMNSRDVDR
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory