Comparing WP_012410848.1 NCBI__GCF_000020025.1:WP_012410848.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
2p3nA Thermotoga maritima impase tm1415 (see paper)
30% identity, 80% coverage: 9:223/268 of query aligns to 4:215/256 of 2p3nA
O33832 Fructose-1,6-bisphosphatase/inositol-1-monophosphatase; FBPase/IMPase; Inositol-1-phosphatase; I-1-Pase; EC 3.1.3.11; EC 3.1.3.25 from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) (see paper)
30% identity, 80% coverage: 9:223/268 of query aligns to 4:215/256 of O33832
3lv0A Crystal structure of extragenic suppressor protein suhb from bartonella henselae, native
27% identity, 81% coverage: 6:222/268 of query aligns to 1:222/258 of 3lv0A
P20456 Inositol monophosphatase 1; IMP 1; IMPase 1; D-galactose 1-phosphate phosphatase; Inositol-1(or 4)-monophosphatase 1; Lithium-sensitive myo-inositol monophosphatase A1; EC 3.1.3.25; EC 3.1.3.94 from Bos taurus (Bovine) (see paper)
26% identity, 96% coverage: 1:258/268 of query aligns to 1:271/277 of P20456
2bjiA High resolution structure of myo-inositol monophosphatase, the target of lithium therapy (see paper)
26% identity, 96% coverage: 3:258/268 of query aligns to 1:269/274 of 2bjiA
4as5A Structure of mouse inositol monophosphatase 1 (see paper)
26% identity, 96% coverage: 3:258/268 of query aligns to 1:269/274 of 4as5A
Q19420 Inositol monophosphatase ttx-7; IMP; IMPase; Abnormal thermotaxis protein 7; D-galactose 1-phosphate phosphatase; Inositol-1(or 4)-monophosphatase; EC 3.1.3.25; EC 3.1.3.94 from Caenorhabditis elegans (see paper)
27% identity, 85% coverage: 9:236/268 of query aligns to 14:257/285 of Q19420
3luzA Crystal structure of extragenic suppressor protein suhb from bartonella henselae, via combined iodide sad molecular replacement (see paper)
26% identity, 81% coverage: 6:222/268 of query aligns to 1:204/238 of 3luzA
O55023 Inositol monophosphatase 1; IMP 1; IMPase 1; D-galactose 1-phosphate phosphatase; Inositol-1(or 4)-monophosphatase 1; Lithium-sensitive myo-inositol monophosphatase A1; EC 3.1.3.25; EC 3.1.3.94 from Mus musculus (Mouse) (see paper)
26% identity, 96% coverage: 1:258/268 of query aligns to 1:271/277 of O55023
Q9M8S8 Inositol-phosphate phosphatase; L-galactose 1-phosphate phosphatase; Myo-inositol monophosphatase; EC 3.1.3.25; EC 3.1.3.93 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
27% identity, 83% coverage: 2:223/268 of query aligns to 4:235/271 of Q9M8S8
P95189 Histidinol-phosphatase; HolPase; Histidinol-phosphate phosphatase; EC 3.1.3.15 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
33% identity, 76% coverage: 29:233/268 of query aligns to 28:237/260 of P95189
5zonA Histidinol phosphate phosphatase from mycobacterium tuberculosis (see paper)
33% identity, 76% coverage: 29:233/268 of query aligns to 26:235/256 of 5zonA
5yhtA Crystal structure of a phosphatase from mycobacterium tuberculosis in complex with its substrate (see paper)
33% identity, 76% coverage: 29:233/268 of query aligns to 25:234/255 of 5yhtA
P29218 Inositol monophosphatase 1; IMP 1; IMPase 1; D-galactose 1-phosphate phosphatase; Inositol-1(or 4)-monophosphatase 1; Lithium-sensitive myo-inositol monophosphatase A1; EC 3.1.3.25; EC 3.1.3.94 from Homo sapiens (Human) (see 5 papers)
27% identity, 88% coverage: 1:236/268 of query aligns to 1:247/277 of P29218
P0ADG4 Nus factor SuhB; Inositol-1-monophosphatase; I-1-Pase; IMPase; Inositol-1-phosphatase; EC 3.1.3.25 from Escherichia coli (strain K12) (see 5 papers)
27% identity, 81% coverage: 8:223/268 of query aligns to 4:226/267 of P0ADG4
Sites not aligning to the query:
6ib8B Structure of a complex of suhb and nusa ar2 domain (see paper)
27% identity, 81% coverage: 8:223/268 of query aligns to 8:230/270 of 6ib8B
2qflA Structure of suhb: inositol monophosphatase and extragenic suppressor from e. Coli (see paper)
27% identity, 81% coverage: 8:223/268 of query aligns to 4:226/262 of 2qflA
3luzB Crystal structure of extragenic suppressor protein suhb from bartonella henselae, via combined iodide sad molecular replacement (see paper)
27% identity, 81% coverage: 6:222/268 of query aligns to 3:200/234 of 3luzB
Sites not aligning to the query:
4as4A Structure of human inositol monophosphatase 1 (see paper)
26% identity, 87% coverage: 3:236/268 of query aligns to 1:245/274 of 4as4A
6giuA Human impase with l-690330 (see paper)
26% identity, 87% coverage: 3:236/268 of query aligns to 1:245/275 of 6giuA
>WP_012410848.1 NCBI__GCF_000020025.1:WP_012410848.1
MNDFWTTILDFAQTTTTRVGKQLMQDFGQVQADQKADGSLVTQADKWADREIRDAIASTF
SGYGILSEESDQSFPGTEWCWVIDPLDGTTNFTRGIPIWTISLGLLYRGTPIFGYVYAPT
LNQAFHGFWAGSSGLATPTGAFLNHHPIHTSIDSPSNNHFFNLCSRSTAAIKNGFPCKIR
MLGVASYNFLTVATGATLGGIEATPKVWDLAGAWVIVQAAGGVWASLKSEPFPLSSGEDY
SDRSFPTLVVSRPELVPVFQPFLDGVKI
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory