Comparing WP_012411979.1 NCBI__GCF_000020025.1:WP_012411979.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
4ij6A Crystal structure of a novel-type phosphoserine phosphatase mutant (h9a) from hydrogenobacter thermophilus tk-6 in complex with l-phosphoserine (see paper)
29% identity, 79% coverage: 3:170/212 of query aligns to 2:169/207 of 4ij6A
1h2fA Bacillus stearothermophilus phoe (previously known as yhfr) in complex with trivanadate (see paper)
24% identity, 95% coverage: 4:204/212 of query aligns to 3:203/207 of 1h2fA
Sites not aligning to the query:
1h2eA Bacillus stearothermophilus phoe (previously known as yhfr) in complex with phosphate (see paper)
24% identity, 95% coverage: 4:204/212 of query aligns to 3:203/207 of 1h2eA
5hr5A Bovine heart 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (pfkfb2) (see paper)
33% identity, 75% coverage: 5:163/212 of query aligns to 226:377/424 of 5hr5A
Sites not aligning to the query:
P26285 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2; 6PF-2-K/Fru-2,6-P2ase 2; PFK/FBPase 2; 6PF-2-K/Fru-2,6-P2ase heart-type isozyme; EC 2.7.1.105; EC 3.1.3.46 from Bos taurus (Bovine) (see paper)
33% identity, 75% coverage: 5:163/212 of query aligns to 253:404/531 of P26285
Sites not aligning to the query:
1k6mA Crystal structure of human liver 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase (see paper)
33% identity, 75% coverage: 4:163/212 of query aligns to 214:366/432 of 1k6mA
Sites not aligning to the query:
5htkA Human heart 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (pfkfb2) (see paper)
32% identity, 75% coverage: 5:163/212 of query aligns to 222:373/425 of 5htkA
Sites not aligning to the query:
O60825 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2; 6PF-2-K/Fru-2,6-P2ase 2; PFK/FBPase 2; 6PF-2-K/Fru-2,6-P2ase heart-type isozyme; EC 2.7.1.105; EC 3.1.3.46 from Homo sapiens (Human) (see 2 papers)
32% identity, 75% coverage: 5:163/212 of query aligns to 252:403/505 of O60825
Sites not aligning to the query:
P9WIC7 Glucosyl-3-phosphoglycerate phosphatase; Mannosyl-3-phosphoglycerate phosphatase; EC 3.1.3.85; EC 3.1.3.70 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
30% identity, 63% coverage: 5:137/212 of query aligns to 6:137/223 of P9WIC7
Sites not aligning to the query:
4qihA The structure of mycobacterial glucosyl-3-phosphoglycerate phosphatase rv2419c complexes with vo3 (see paper)
30% identity, 63% coverage: 5:137/212 of query aligns to 4:135/209 of 4qihA
Sites not aligning to the query:
4pzaB The complex structure of mycobacterial glucosyl-3-phosphoglycerate phosphatase rv2419c with inorganic phosphate (see paper)
30% identity, 63% coverage: 5:137/212 of query aligns to 5:136/217 of 4pzaB
Sites not aligning to the query:
P16118 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1; 6PF-2-K/Fru-2,6-P2ase 1; PFK/FBPase 1; 6PF-2-K/Fru-2,6-P2ase liver isozyme; EC 2.7.1.105; EC 3.1.3.46 from Homo sapiens (Human) (see paper)
33% identity, 75% coverage: 4:163/212 of query aligns to 253:405/471 of P16118
Sites not aligning to the query:
1tipA The bisphosphatase domain of the bifunctional rat liver 6- phosphofructo-2-kinase/fructose-2,6-bisphosphatase (see paper)
33% identity, 75% coverage: 4:163/212 of query aligns to 3:155/191 of 1tipA
1c81A Michaelis complex of fructose-2,6-bisphosphatase
33% identity, 75% coverage: 4:163/212 of query aligns to 3:155/191 of 1c81A
1c80A Regulatory complex of fructose-2,6-bisphosphatase
33% identity, 75% coverage: 4:163/212 of query aligns to 3:155/191 of 1c80A
1c7zA Regulatory complex of fructose-2,6-bisphosphatase
33% identity, 75% coverage: 4:163/212 of query aligns to 3:155/191 of 1c7zA
1fbtA The bisphosphatase domain of the bifunctional rat liver 6- phosphofructo-2-kinase/fructose-2,6-bisphosphatase (see paper)
33% identity, 75% coverage: 4:163/212 of query aligns to 2:154/190 of 1fbtA
P07953 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1; 6PF-2-K/Fru-2,6-P2ase 1; PFK/FBPase 1; 6PF-2-K/Fru-2,6-P2ase liver isozyme; EC 2.7.1.105; EC 3.1.3.46 from Rattus norvegicus (Rat) (see 3 papers)
33% identity, 75% coverage: 4:163/212 of query aligns to 253:405/471 of P07953
Sites not aligning to the query:
6m1xC Crystal structure of phosphoserine phosphatase in complex with 3- phosphoglyceric acid from entamoeba histolytica (see paper)
25% identity, 93% coverage: 5:202/212 of query aligns to 4:196/196 of 6m1xC
5zr2C Crystal structure of phosphoserine phosphatase mutant (h9a) from entamoeba histolytica in complex with phosphoserine (see paper)
25% identity, 93% coverage: 5:202/212 of query aligns to 4:196/198 of 5zr2C
>WP_012411979.1 NCBI__GCF_000020025.1:WP_012411979.1
MTLNLYLLRHGETTFSQSGNFCGETDAELTTEGMQMASGFADVYQKLKWEAVYVSPMKRT
IATAKPFCDAIGMDMQLRDGLREGSYGEWERKSKSFAQENYAQNYVNWMTEPAWNAPKGG
ETAVDIANRSMPVIAEIQEKHHQGNVLVVSHKATIRIMLCSLLGIDLGRYRYRVNILVAS
VSMVKFDVNGPLLEILGDRHHIPDHIRSRPGT
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory