Comparing WP_012465631.1 NCBI__GCF_000020465.1:WP_012465631.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
4l0oH Structure determination of cystathionine gamma-synthase from helicobacter pylori
50% identity, 100% coverage: 1:380/381 of query aligns to 1:373/373 of 4l0oH
4iyoD Crystal structure of cystathionine gamma lyase from xanthomonas oryzae pv. Oryzae (xometc) in complex with e-site serine, a-site serine, a- site external aldimine structure with aminoacrylate and a-site iminopropionate intermediates (see paper)
51% identity, 99% coverage: 1:377/381 of query aligns to 2:380/384 of 4iyoD
4iyoB Crystal structure of cystathionine gamma lyase from xanthomonas oryzae pv. Oryzae (xometc) in complex with e-site serine, a-site serine, a- site external aldimine structure with aminoacrylate and a-site iminopropionate intermediates (see paper)
51% identity, 99% coverage: 1:377/381 of query aligns to 2:380/381 of 4iyoB
4iy7B Crystal structure of cystathionine gamma lyase (xometc) from xanthomonas oryzae pv. Oryzae in complex with e-site serine, a-site external aldimine structure with serine and a-site external aldimine structure with aminoacrylate intermediates (see paper)
51% identity, 99% coverage: 1:377/381 of query aligns to 2:380/381 of 4iy7B
4iy7A Crystal structure of cystathionine gamma lyase (xometc) from xanthomonas oryzae pv. Oryzae in complex with e-site serine, a-site external aldimine structure with serine and a-site external aldimine structure with aminoacrylate intermediates (see paper)
51% identity, 99% coverage: 1:377/381 of query aligns to 2:380/381 of 4iy7A
4ixzA Native structure of cystathionine gamma lyase (xometc) from xanthomonas oryzae pv. Oryzae at ph 9.0 (see paper)
51% identity, 99% coverage: 1:377/381 of query aligns to 2:380/381 of 4ixzA
7ba4A Structure of cystathionine gamma-lyase from pseudomonas aeruginosa
51% identity, 99% coverage: 3:381/381 of query aligns to 7:375/377 of 7ba4A
6k1lB E53a mutant of a putative cystathionine gamma-lyase (see paper)
51% identity, 98% coverage: 5:377/381 of query aligns to 7:381/382 of 6k1lB
6k1lA E53a mutant of a putative cystathionine gamma-lyase (see paper)
51% identity, 98% coverage: 5:377/381 of query aligns to 7:381/382 of 6k1lA
7d7oB Crystal structure of cystathionine gamma-lyase from bacillus cereus atcc 14579 (see paper)
46% identity, 99% coverage: 1:378/381 of query aligns to 1:377/377 of 7d7oB
4ixsB Native structure of xometc at ph 5.2 (see paper)
51% identity, 99% coverage: 1:377/381 of query aligns to 1:371/372 of 4ixsB
8j6nA Crystal structure of cystathionine gamma-lyase in complex with compound 1 (see paper)
47% identity, 99% coverage: 2:379/381 of query aligns to 8:387/390 of 8j6nA
6cjaA Crystal structure of cystathionine beta-lyase from legionella pneumophila philadelphia 1 in complex with alanyl-plp and serine
48% identity, 99% coverage: 2:377/381 of query aligns to 3:380/381 of 6cjaA
6nbaA Crystal structure of human cystathionine gamma lyase with s-3- carboxpropyl-l-cysteine (see paper)
48% identity, 95% coverage: 2:362/381 of query aligns to 8:370/389 of 6nbaA
P32929 Cystathionine gamma-lyase; CGL; CSE; Cysteine desulfhydrase; Cysteine-protein sulfhydrase; Gamma-cystathionase; Homocysteine desulfhydrase; EC 4.4.1.1; EC 4.4.1.2 from Homo sapiens (Human) (see 5 papers)
48% identity, 95% coverage: 2:362/381 of query aligns to 17:379/405 of P32929
Sites not aligning to the query:
3cogD Crystal structure of human cystathionase (cystathionine gamma lyase) in complex with dl-propargylglycine (see paper)
48% identity, 95% coverage: 2:362/381 of query aligns to 8:370/392 of 3cogD
6ldoA Crystal structure of cystathionine gamma-lyase from lactobacillus plantarum complexed with l-serine (see paper)
45% identity, 100% coverage: 1:381/381 of query aligns to 1:379/381 of 6ldoA
6le4A Crystal structure of cystathionine gamma-lyase from lactobacillus plantarum complexed with cystathionine (see paper)
45% identity, 100% coverage: 1:381/381 of query aligns to 1:379/380 of 6le4A
5eigC Engineered human cystathionine gamma lyase (e59t, e339v) to deplet cysteine
48% identity, 95% coverage: 2:362/381 of query aligns to 8:368/388 of 5eigC
7mcyH Crystal structure of staphylococcus aureus cystathionine gamma lyase, holoenzyme with bound nl3 (see paper)
44% identity, 99% coverage: 4:380/381 of query aligns to 4:380/380 of 7mcyH
Sites not aligning to the query:
>WP_012465631.1 NCBI__GCF_000020465.1:WP_012465631.1
MQFETLAIHDGQTPDPQTGSVTVPVFQTSTFEREDLSHRREFFYSRIGNPTRQALESTLA
LLENGRFGLAFASGAAATMAALQVLRPGDHIVSALDIYGGTYRIFEQLLRPWGIGISYAD
NEAVESYAACIVPETKLIWLESPSNPLLRLSDIREIASLARERGILVAVDNTFASPYFQR
PLELGADIAVHSTTKYLGGHSDVIGGAVVLNDPALLTTIKNYQAAAGAIPGPWDCWLIMR
GIKTLKIRMKEHEANALHLAQLLEGHPAVERVWYPGLPSHPQHELAKRQMSGFSGMLTFA
LKGGLPAVELLLAKLKLFALADSLGGVESLVASPAKMTLGALSAKERTKRGCSDNLVRMS
VGLEYAGDLEADLLTALSALQ
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory