SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing WP_012466840.1 NCBI__GCF_000020465.1:WP_012466840.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 10 hits to proteins with known functional sites (download)

7e1sC Crystal structure of dehydrogenase/isomerase fabx from helicobacter pylori in complex with octanoyl-acp (see paper)
32% identity, 69% coverage: 16:305/419 of query aligns to 20:285/366 of 7e1sC

query
sites
7e1sC

I

F

P

P

I

I

V

F

I

Q

G
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G

G
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G

M
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M

G
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G

V

V

N

G

I

I

S

S

T

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T

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E

E

L

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I

binding S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] octanethioate: L104 (≠ M115), A129 (= A146), G130 (= G147), L131 (= L148), I150 (= I170), I151 (= I171), S152 (= S172), E178 (= E197), H185 (= H204), Y280 (= Y300)
binding flavin mononucleotide: G25 (= G21), G26 (= G22), M27 (= M23), G28 (= G24), N102 (= N113), E178 (= E197), S182 (≠ A201), G183 (= G202), G223 (= G241), G224 (= G242), M244 (≠ V262), A245 (= A263), T246 (= T264), L249 (≠ A267)
binding : L131 (= L148), T133 (≠ L150), N134 (≠ R151), K155 (≠ R175), I159 (= I179), K162 (= K182), R163 (= R183), R167 (= R186)

Sites not aligning to the query:

7e1sA Crystal structure of dehydrogenase/isomerase fabx from helicobacter pylori in complex with octanoyl-acp (see paper)
32% identity, 69% coverage: 16:305/419 of query aligns to 20:285/366 of 7e1sA

query
sites
7e1sA

I

F

P

P

I

I

V

F

I

Q

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G

G
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G

M
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G
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V

V

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G

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E

E

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I

binding S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] octanethioate: L104 (≠ M115), A129 (= A146), G130 (= G147), I150 (= I170), I151 (= I171), S152 (= S172), E178 (= E197), H185 (= H204), G187 (= G206), Y280 (= Y300)
binding flavin mononucleotide: G25 (= G21), G26 (= G22), M27 (= M23), G28 (= G24), N102 (= N113), L104 (≠ M115), E178 (= E197), G183 (= G202), G223 (= G241), G224 (= G242), Q243 (= Q261), M244 (≠ V262), A245 (= A263), T246 (= T264)

Sites not aligning to the query:

7e1rA Crystal structure of dehydrogenase/isomerase fabx from helicobacter pylori in complex with holo-acp (see paper)
32% identity, 69% coverage: 16:305/419 of query aligns to 20:285/366 of 7e1rA

query
sites
7e1rA

I

F

P

P

I

I

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I

Q

G
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G

G
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M
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G

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I

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binding flavin mononucleotide: G25 (= G21), G26 (= G22), M27 (= M23), G28 (= G24), N102 (= N113), L104 (≠ M115), E178 (= E197), G183 (= G202), G224 (= G242), Q243 (= Q261), M244 (≠ V262), A245 (= A263), T246 (= T264)
binding N~3~-[(2S)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-N-(2-sulfanylethyl)-beta-alaninamide: G128 (≠ A145), A129 (= A146), G130 (= G147), E178 (= E197), H185 (= H204), G187 (= G206)

Sites not aligning to the query:

binding flavin mononucleotide: 342
binding iron/sulfur cluster: 303, 306, 307, 308, 311, 314, 317, 323, 324

7e1qA Crystal structure of dehydrogenase/isomerase fabx from helicobacter pylori (see paper)
32% identity, 69% coverage: 16:305/419 of query aligns to 20:285/366 of 7e1qA

query
sites
7e1qA

I

F

P

P

I

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F

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G

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I

G

S

T

R

K

E

E

A

C

G

-

L

-

P

D

S

A

P

K

V

V

K

Y

Q

A

E

D

Y

L

I

L

N

P

A

T

E

L

E

K

K

K

D

E

I

D

V

I

V

L

N

L

M

I

A

K

S

S

T
x
P

T

V

G

G

Y

Y

P

P

M

A

R

R

M

A

L

I

binding flavin mononucleotide: G25 (= G21), G26 (= G22), M27 (= M23), G28 (= G24), N102 (= N113), L104 (≠ M115), E178 (= E197), S182 (≠ A201), G183 (= G202), G223 (= G241), G224 (= G242), M244 (≠ V262), A245 (= A263), T246 (= T264)
binding iron/sulfur cluster: P277 (≠ T297)

Sites not aligning to the query:

binding flavin mononucleotide: 342
binding iron/sulfur cluster: 303, 306, 307, 308, 311, 314, 317, 323, 324

2z6iB Crystal structure of s. Pneumoniae enoyl-acyl carrier protein reductase (fabk) (see paper)
33% identity, 37% coverage: 161:315/419 of query aligns to 105:242/321 of 2z6iB

query
sites
2z6iB

R

R

F

F

R

H

D

E

A

A

Q

G

I

I

G

-

I

I

I

V

I

I

S

P

S

V

V

V

R

P

A

S

L

V

A

A

I

L

F

-

L

-

K

-

R

-

A

A

V

K

R

R

L

M

N

E

R

K

L

I

-

G

P

A

D

D

Y

A

I

V

I

I

V

A

E
|
E

G

G

P

M

L

E

A
|
A

G
|
G

G

G

H
|
H

L

I

G

G

F

-

G

-

P

-

L

-

D

-

W

-

H

-

T

K

F

L

D

T

L

T

K

M

T

T

I

L

V

V

T

R

E

Q

V

V

L

-

D

-

F

-

L

-

K

-

K
x
A

E

T

N

A

L
x
I

A

S

I

I

P

P

V

V

I

I

P

A

A

A

G
|
G

G
|
G

I

I

F

A

T

D

G

G

T

E

D

G

A

A

A

A

D

A

Y

G

L

F

T

M

M

L

G

G

A

A

S

E

A

A

V

V

Q

Q

V

V

A
x
G

T
|
T

R

R

F

F

A

V

I

V

S

A

R

K

E

E

A

S

G

N

L

A

P

H

S

P

P

N

V

Y

K

K

Q

E

E

K

Y

I

I

L

N

K

A

A

E

R

E

D

K

I

D

D

I

T

V

T

V

I

N

S

M

-

A

A

S

Q

T

H

T

F

G

G

Y

H

P

A

M

V

R

R

M

A

L

I

V

K

N

N

S

Q

P

L

T

T

L

R

S

D

Y

F

N

E

I

L

binding calcium ion: E137 (= E197), H144 (= H204), A158 (≠ K230), I161 (≠ L233)
binding flavin mononucleotide: E137 (= E197), A141 (= A201), G142 (= G202), G169 (= G241), G170 (= G242), G191 (≠ A263), T192 (= T264)

Sites not aligning to the query:

binding flavin mononucleotide: 18, 19, 20, 21, 69, 281

7l00C Crystal structure of c. Difficile enoyl-acyl carrier protein reductase (fabk) in complex with an inhibitor
37% identity, 30% coverage: 184:307/419 of query aligns to 128:239/315 of 7l00C

query
sites
7l00C

A

A

V

Q

R

R

L

M

N

E

R

K

L

L

-

G

P

A

D

T

Y

A

I

V

I

I

V

A

E
|
E

G

G

P

T

L

E

A
x
G

G
|
G

G

G

H
|
H

L

I

G

G

F

-

G

-

P

-

L

-

D

-

W

-

H

-

T

E

F

L

D

T

L

T

K

M

T

V

I

L

V

V

T

P

E

Q

V

V

L

A

D

D

F

A

L

V

K

N

K

-

E

-

N

-

L

-

A

-

I

I

P

P

V

V

I

I

P

A

A

A

G
|
G

G
|
G

I

I

F

V

T

D

G

G

T

R

D

G

A

I

A

A

D

A

Y

S

L

F

T

A

M

L

G

G

A

A

S

S

A

A

V

V

Q
|
Q

V

V

A
x
G

T
|
T

R

R

F

F

A

I

I

C

S

S

R

E

E

E

A

C

G

S

L

V

P

H

S

S

P

N

V

Y

K

K

Q

N

E

L

Y

V

I

L

N

K

A

A

E

K

E

D

K

R

D

D

I

A

V

I

V

V

N

T

M

-

A

G

S

R

T

S

T

T

G

G

Y

H

P

P

M

V

R

R

M

T

L

L

V

K

N

N

binding flavin mononucleotide: E142 (= E197), G146 (≠ A201), G147 (= G202), G174 (= G241), G175 (= G242), Q194 (= Q261), G196 (≠ A263), T197 (= T264)
binding N-[6-(methylsulfonyl)-1,3-benzothiazol-2-yl]-2-[2-(1H-pyrrol-1-yl)-1,3-thiazol-4-yl]acetamide: H149 (= H204)

Sites not aligning to the query:

binding flavin mononucleotide: 23, 24, 25, 26, 74, 281, 285
binding N-[6-(methylsulfonyl)-1,3-benzothiazol-2-yl]-2-[2-(1H-pyrrol-1-yl)-1,3-thiazol-4-yl]acetamide: 26, 76, 100, 101, 102, 121, 123, 266, 281

2z6jA Crystal structure of s. Pneumoniae enoyl-acyl carrier protein reductase (fabk) in complex with an inhibitor (see paper)
31% identity, 37% coverage: 161:315/419 of query aligns to 105:239/307 of 2z6jA

query
sites
2z6jA

R

R

F

F

R

H

D

E

A

A

Q

G

I

I

G

-

I

I

I

V

I

I

S

P

S
x
V

V

V

R
x
P

A

S

L

V

A

A

I
x
L

F

-

L

-

K

-

R

-

A

A

V

K

R

R

L

M

N

E

R

K

L

I

-

G

P

A

D

D

Y

A

I

V

I

I

V

A

E
|
E

G

G

P

M

L

E

A
|
A

G
|
G

G

G

H
|
H

L

I

G

G

F

-

G

-

P

-

L

-

D

-

W

-

H

-

T

K

F

L

D

T

L

T

K

M

T

T

I

L

V

V

T

R

E

Q

V

V

L

-

D

-

F

-

L

-

K

-

K
x
A

E

T

N

A

L
x
I

A

S

I

I

P

P

V

V

I

I

P

A

A

A

G
|
G

G
|
G

I

I

F

A

T

D

G

G

T

E

D

G

A

A

A

A

D

A

Y

G

L

F

T

M

M

L

G

G

A

A

S

E

A

A

V

V

Q

Q

V

V

A
x
G

T
|
T

R

R

F

F

A

V

I

V

S

A

R

K

E

E

A

S

G

N

L

A

P

H

S

P

P

N

V

Y

K

K

Q

E

E

K

Y

I

I

L

N

K

A

A

E

R

E

D

K

I

D

D

I

T

V

T

V

I

N

-

M

-

A

-

S

-

T

S

T

A

G

Q

Y

H

P

A

M

V

R

R

M

A

L

I

V

K

N

N

S

Q

P

L

T

T

L

R

S

D

Y

F

N

E

I

L

binding calcium ion: A158 (≠ K230), I161 (≠ L233)
binding flavin mononucleotide: E137 (= E197), A141 (= A201), G142 (= G202), G169 (= G241), G170 (= G242), G191 (≠ A263), T192 (= T264)
binding 2-(4-(2-((3-(5-(pyridin-2-ylthio)thiazol-2-yl)ureido)methyl)-1h-imidazol-4-yl)phenoxy)acetic acid: V116 (≠ S173), P118 (≠ R175), L122 (≠ I179), E137 (= E197), H144 (= H204)

Sites not aligning to the query:

5gvhA Structure of fabk from thermotoga maritima (see paper)
37% identity, 27% coverage: 192:305/419 of query aligns to 133:233/311 of 5gvhA

query
sites
5gvhA

D

D

Y

A

I

V

I

I

V

A

E
|
E

G

G

P

M

L

E

A
x
S

G
|
G

G

G

H

H

L

I

G

G

F

-

G

-

P

-

L

-

D

E

W

V

H

T

T

T

F

F

D

V

L

L

K

V

T

N

I

K

V

V

T

S

E

R

V

S

L

V

D

N

F

-

L

-

K

-

K

-

E

-

N

-

L

-

A

-

I

I

P

P

V

V

I

I

P

A

A

A

G
|
G

G
|
G

I

I

F

A

T

D

G

G

T

R

D

G

A

M

A

A

D

A

Y

A

L

F

T

A

M

L

G

G

A

A

S

E

A

A

V

V

Q
|
Q

V

M

A
x
G

T
|
T

R

R

F

F

A

V

I

A

S

S

R

V

E

E

A

S

G

D

L

V

P

H

S

P

P

V

V

Y

K

K

Q

E

E

K

Y

I

I

V

N

K

A

A

E

S

E

I

K

R

D

D

I

T

V

V

V

V

N

T

M

G

A

A

S

K

T

-

T

L

G

G

Y

H

P

P

M

A

R

R

M

V

L

L

binding flavin mononucleotide: E138 (= E197), S142 (≠ A201), G143 (= G202), G170 (= G241), G171 (= G242), Q190 (= Q261), G192 (≠ A263), T193 (= T264)

Sites not aligning to the query:

binding flavin mononucleotide: 19, 20, 21, 22, 70, 72, 275, 279

5lsmA Crystal structure of nitronate monooxygenase (so_0471) from shewanella oneidensis mr-1
34% identity, 32% coverage: 172:307/419 of query aligns to 140:272/339 of 5lsmA

query
sites
5lsmA

S

S

S

K

V

V

R

I

A

S

L

T

A

A

I

T

F

T

L

V

K

E

R

E

A

A

V

L

R

W

L

L

N

E

-

A

R

R

L

G

P

A

D

D

Y

A

I

I

I

I

V

A

E

Q

G

G

P

L

L

E

A
|
A

G
|
G

G

G

H

H

L

R

G

G

F

H

G

F

P

L

L

S

D

E

W

D

H

L

T

T

F

E

D

Q

L

L

K

G

T

T

-

F

-

S

I

L

V

L

T

P

E

Q

V

I

L

I

D

A

F

A

L

V

K

E

K

-

E

-

N

-

L

-

A

-

I

I

P

P

V

V

I

I

P

A

A

A

G
|
G

G
|
G

I

I

F

V

T

D

G

A

T

T

D

T

A

V

A

R

D

A

Y

A

L

M

T

T

M

M

G

G

A

A

S

S

A

A

V

V

Q

Q

V

V

A
x
G

T
|
T

R

A

F

Y

A

L

I

L

S

C

R

P

E

E

A

C

G

N

L

T

P

-

S

S

P

A

V

I

K

H

Q

R

E

E

Y

A

I

L

-

Q

-

S

N

D

A

A

E

A

E

Q

K

H

D

T

I

A

V

L

V

T

N

N

M

L

A

F

S

S

T

-

T

-

G

G

Y

R

P

P

M

A

R

R

M

G

L

I

V

V

N

N

binding flavin mononucleotide: A170 (= A201), G171 (= G202), G207 (= G241), G208 (= G242), G229 (≠ A263), T230 (= T264)

Sites not aligning to the query:

binding flavin mononucleotide: 16, 17, 18, 19, 67, 123, 314

4iqlA Crystal structure of porphyromonas gingivalis enoyl-acp reductase ii (fabk) with cofactors NADPH and fmn (see paper)
37% identity, 28% coverage: 192:307/419 of query aligns to 131:234/313 of 4iqlA

query
sites
4iqlA

D

D

Y

A

I

I

I

V

V

A

E
|
E

G

G

P

F

L

E

A
|
A

G
|
G

G

G

H

H

L

N

G

G

F

-

G

-

P

-

L

-

D

R

W

E

H

E

T

T

F

T

D

T

L

L

K

-

T

C

I

L

V

I

T

P

E

E

V

V

L

V

D

D

F

A

L

V

K

N

K

-

E

-

N

-

L

-

A

-

I

I

P

P

V

V

I

V

P

A

A

A

G
|
G

G
|
G

I

I

F

A

T

S

G

G

T

R

D

A

A

V

A

A

D

A

Y

A

L

L

T

A

M

L

G

G

A

A

S

D

A

A

V

V

Q
|
Q

V

V

A
x
G

T
|
T

R

R

F

F

A

A

I

L

S

S

R

E

E

E

A

S

G
x
S

L

A

P

H

S

E

P

D

V

F

K

K

Q

A

E

H

Y

C

I

R

N

R

A

S

E

V

E

E

K

G

D

D

I

T

V

M

V

L

N

S

M

L

A

K

S

A

T

V

T

S

G

-

Y

-

P

P

M

T

R

R

M

L

L

L

V

K

N

N

binding flavin mononucleotide: E136 (= E197), A140 (= A201), G141 (= G202), G170 (= G241), G171 (= G242), Q190 (= Q261), G192 (≠ A263), T193 (= T264)
binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: S202 (≠ G273)

Sites not aligning to the query:

binding flavin mononucleotide: 18, 19, 20, 68, 94, 277
binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: 21, 21, 25, 44, 45, 45, 46, 49, 52, 53, 73, 74, 75, 263, 267

Query Sequence

>WP_012466840.1 NCBI__GCF_000020465.1:WP_012466840.1
MIVDNFRLQLGGKEFIPIVIGGMGVNISTTELALAAEKLGGVGHISDAEVCYVCDQIFST
SYVSRKRKRYAAYTNNPDKSAVLFDLEEVAEAQKRYIEHTVSQKTGKGAVFLNCMEKLTM
NNASETLKVRLSAALDAGIDGLTLAAGLNLRTLDLIQDHPRFRDAQIGIIISSVRALAIF
LKRAVRLNRLPDYIIVEGPLAGGHLGFGPLDWHTFDLKTIVTEVLDFLKKENLAIPVIPA
GGIFTGTDAADYLTMGASAVQVATRFAISREAGLPSPVKQEYINAEEKDIVVNMASTTGY
PMRMLVNSPTLSYNIKPNCEGLGYLLENGGKCTYIDAYYKALETKQPGQKLTPVEKTCLC
TGMARYDCWTCGHMTYRLKDTTIRLSDGSWLLPSAEHIFLDYQFSKDHQIRLPEPEKSV

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory