Comparing WP_012468984.1 NCBI__GCF_000020385.1:WP_012468984.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
4grsA Crystal structure of a chimeric dah7ps (see paper)
53% identity, 97% coverage: 1:330/341 of query aligns to 1:329/333 of 4grsA
3pg9A Thermotoga maritima dah7p synthase in complex with inhibitor (see paper)
50% identity, 98% coverage: 1:334/341 of query aligns to 1:333/338 of 3pg9A
1rzmA Crystal structure of 3-deoxy-d-arabino-heptulosonate-7-phosphate synthase (dahps) from thermotoga maritima complexed with cd2+, pep and e4p (see paper)
50% identity, 98% coverage: 1:334/341 of query aligns to 1:333/338 of 1rzmA
1zcoB Crystal structure of pyrococcus furiosus 3-deoxy-d-arabino- heptulosonate 7-phosphate synthase (see paper)
57% identity, 74% coverage: 77:330/341 of query aligns to 7:258/262 of 1zcoB
1zcoA Crystal structure of pyrococcus furiosus 3-deoxy-d-arabino- heptulosonate 7-phosphate synthase (see paper)
57% identity, 74% coverage: 77:330/341 of query aligns to 7:258/262 of 1zcoA
4c1kA Crystal structure of pyrococcus furiosus 3-deoxy-d-arabino- heptulosonate 7-phosphate synthase (see paper)
57% identity, 74% coverage: 77:330/341 of query aligns to 7:258/262 of 4c1kA
5j6fA Crystal structure of dah7ps-cm complex from geobacillus sp. With prephenate (see paper)
55% identity, 77% coverage: 71:331/341 of query aligns to 93:352/352 of 5j6fA
Sites not aligning to the query:
3tfcA 1.95 angstrom crystal structure of a bifunctional 3-deoxy-7- phosphoheptulonate synthase/chorismate mutase (aroa) from listeria monocytogenes egd-e in complex with phosphoenolpyruvate (see paper)
50% identity, 86% coverage: 32:324/341 of query aligns to 35:334/343 of 3tfcA
3nvtA 1.95 angstrom crystal structure of a bifunctional 3-deoxy-7- phosphoheptulonate synthase/chorismate mutase (aroa) from listeria monocytogenes egd-e (see paper)
50% identity, 86% coverage: 32:324/341 of query aligns to 36:335/345 of 3nvtA
P39912 Protein AroA(G); EC 2.5.1.54; EC 5.4.99.5 from Bacillus subtilis (strain 168) (see paper)
49% identity, 87% coverage: 32:328/341 of query aligns to 48:351/358 of P39912
Sites not aligning to the query:
1vs1D Crystal structure of 3-deoxy-d-arabino-heptulosonate-7-phosphate synthase (dahp synthase) from aeropyrum pernix in complex with mn2+ and pep
60% identity, 77% coverage: 67:328/341 of query aligns to 6:266/271 of 1vs1D
1jcxA Aquifex aeolicus kdo8p synthase in complex with api and cadmium (see paper)
30% identity, 70% coverage: 94:332/341 of query aligns to 1:246/255 of 1jcxA
1pcwA Aquifex aeolicus kdo8ps in complex with cadmium and app, a bisubstrate inhibitor (see paper)
30% identity, 70% coverage: 94:332/341 of query aligns to 1:248/257 of 1pcwA
1pe1A Aquifex aeolicus kdo8ps in complex with cadmium and 2-pga (see paper)
30% identity, 70% coverage: 94:332/341 of query aligns to 2:249/258 of 1pe1A
3e12A Cu2+ substituted aquifex aeolicus kdo8ps in complex with kdo8p (see paper)
29% identity, 70% coverage: 94:332/341 of query aligns to 1:249/258 of 3e12A
1pckA Aquifex aeolicus kdo8ps in complex with z-methyl-pep (see paper)
29% identity, 70% coverage: 94:332/341 of query aligns to 1:249/258 of 1pckA
3e0iA Cu2+ substituted aquifex aeolicus kdo8ps in complex with pep (see paper)
29% identity, 70% coverage: 94:332/341 of query aligns to 1:254/263 of 3e0iA
2a21A Aquifex aeolicus kdo8ps in complex with pep, po4, and zn2+ (see paper)
29% identity, 70% coverage: 94:332/341 of query aligns to 1:254/263 of 2a21A
1jcyA Aquifex aeolicus kdo8p synthase in complex with r5p, pep and cadmium (see paper)
29% identity, 70% coverage: 94:332/341 of query aligns to 1:254/263 of 1jcyA
1fwwA Aquifex aeolicus kdo8p synthase in complex with pep, a5p and cadmium (see paper)
29% identity, 70% coverage: 94:332/341 of query aligns to 1:254/263 of 1fwwA
>WP_012468984.1 NCBI__GCF_000020385.1:WP_012468984.1
MLIVMNHTASQADIDKVIEVVSGMGFTAAPIPGGERTAIGVLGNKGYVDDSTIRDLPGVQ
QAIHVSKPYKLVSRDFHPDNTIVDVAGVKIGEGERPVVVGGPCAVESEEQILKTARFVKQ
CGADLLRGGAFKPRTGPHTFQGLREEGLKLLAKARAATGLPIVTEVMSPDNVALVAEYAD
LLQVGARNMQNFDLLRELGRIRKPILLKRGMSATIEEFLAAAEYILAEGNDQVILCERGI
RTFETATRNTLDLAMVPLVKELTHLPVMVDPSHATGKRSLVTPMSKAALVAGAHGVLVEV
HPEPEKALSDGPQSLTFPGFEALMADLRRLQQCLACCDIAP
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory