SitesBLAST

P09342 Acetolactate synthase 1, chloroplastic; ALS I; Acetohydroxy-acid synthase I; Acetolactate synthase I; EC 2.2.1.6 from Nicotiana tabacum (Common tobacco) (see 2 papers)
33% identity, 97% coverage: 4:546/562 of query aligns to 97:642/667 of P09342

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C161 (= C67) modified: Disulfide link with 307
P194 (≠ S100) mutation to Q: In C3; highly resistant to sulfonylurea herbicides.
C307 (≠ T213) modified: Disulfide link with 161

P09114 Acetolactate synthase 2, chloroplastic; ALS II; Acetohydroxy-acid synthase II; Acetolactate synthase II; EC 2.2.1.6 from Nicotiana tabacum (Common tobacco) (see paper)
34% identity, 97% coverage: 4:546/562 of query aligns to 94:639/664 of P09114

query
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P09114

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P191 (≠ S100) mutation to A: In S4-Hra; highly resistant to sulfonylurea herbicides; when associated with L-568.
W568 (vs. gap) mutation to L: In S4-Hra; highly resistant to sulfonylurea herbicides; when associated with A-191.

6wo1A Hybrid acetohydroxyacid synthase complex structure with cryptococcus neoformans ahas catalytic subunit and saccharomyces cerevisiae ahas regulatory subunit (see paper)
32% identity, 98% coverage: 1:550/562 of query aligns to 9:534/551 of 6wo1A

query
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6wo1A

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-

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-

R

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A

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K

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A

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G

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x
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I

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x
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x
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x
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x
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V

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A

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-

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V

A

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I

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E

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A

I

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-

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A

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-

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D

-

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-

A

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x
A

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S

F

F

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M

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G

A

M

M

E

E

V

L

A

A

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A

A

V

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Y

Y

N

D

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M

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Y

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-

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-

D

D

H

F

V

V

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L

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E

A

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M

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A

A

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I

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R

I

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N

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D

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L

E

A

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A

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active site: Y30 (≠ V22), G32 (= G24), G33 (= G25), A34 (= A26), I35 (= I27), E56 (= E47), T79 (= T70), F118 (≠ I109), Q119 (= Q110), E120 (= E111), K168 (≠ A164), M255 (≠ F256), V282 (= V285), V398 (vs. gap), G424 (≠ A419), M426 (= M421), D451 (= D446), N478 (= N473)
binding 2-methylpyrimidin-4-amine: G424 (≠ A419), T425 (≠ S420), M426 (= M421)
binding diphosphate: V398 (vs. gap), G399 (= G394), Q400 (≠ N395), H401 (≠ S396), G450 (= G445), D451 (= D446), A452 (≠ G447), S453 (= S448)
binding flavin-adenine dinucleotide: D97 (= D88), R158 (= R154), G208 (= G210), G210 (= G212), S213 (≠ L215), T235 (≠ S236), L236 (≠ P237), Q237 (≠ K238), I253 (≠ L254), G254 (= G255), M255 (≠ F256), G275 (= G278), V276 (≠ T279), R277 (≠ S280), D279 (≠ N282), R281 (≠ F284), V282 (= V285), E308 (≠ D303), I309 (= I304), D327 (= D322), V328 (≠ A323), Q402 (≠ M397), G421 (≠ L416), G422 (= G417)
binding magnesium ion: D451 (= D446), N478 (= N473)

3ea4A Arabidopsis thaliana acetohydroxyacid synthase in complex with monosulfuron-ester (see paper)
32% identity, 97% coverage: 4:546/562 of query aligns to 14:559/582 of 3ea4A

query
sites
3ea4A

A

A

E

D

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G

A
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A

I
x
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H

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E
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G

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A

A

A

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E

G

G

Y

Y

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A

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C

C

C

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T

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G

G

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P

G

G

A

A

T

T

N

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G

G

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A

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D

A

A

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x
F

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E

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K

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V

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x
H

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L

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V

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x
W

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A

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A

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K

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F

A

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A

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C

G

G

A

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G

A

I

A

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G

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-

R

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A

M

I

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Q

D

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M

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L

A

D

A

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G

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x
H

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E

active site: Y32 (≠ V22), G34 (= G24), G35 (= G25), A36 (= A26), S37 (≠ I27), E58 (= E47), T81 (= T70), F120 (≠ I109), Q121 (= Q110), E122 (= E111), K170 (≠ A164), M265 (≠ F256), V292 (= V285), V399 (≠ N393), G425 (≠ A419), M427 (= M421), D452 (= D446), N479 (= N473), H481 (≠ M475), L482 (= L476), M484 (= M478), V485 (= V479), W488 (vs. gap), H557 (≠ P544)
binding methyl 2-{[(4-methylpyrimidin-2-yl)carbamoyl]sulfamoyl}benzoate: D290 (≠ E283), R291 (≠ F284), W488 (vs. gap)
binding flavin-adenine dinucleotide-n5-isobutyl ketone: R160 (= R154), G221 (= G210), G222 (= G212), G223 (≠ T213), T245 (≠ S236), L246 (≠ P237), M247 (≠ K238), L263 (= L254), G264 (= G255), M265 (≠ F256), H266 (≠ A257), G285 (= G278), R287 (≠ S280), D289 (≠ N282), R291 (≠ F284), D309 (= D303), I310 (= I304), G327 (= G321), D328 (= D322), V329 (≠ A323), M404 (≠ A398), G422 (≠ L416)
binding magnesium ion: D452 (= D446), N479 (= N473), H481 (≠ M475)
binding 2-[(2e)-3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-(1-hydroxyethylidene)-4-methyl-2,3-dihydro-1,3-thiazol-5-yl]ethyltrihydrogen diphosphate: V399 (≠ N393), G400 (= G394), Q401 (≠ N395), H402 (≠ S396), M427 (= M421), G451 (= G445), D452 (= D446), G453 (= G447), S454 (= S448), N479 (= N473), H481 (≠ M475), L482 (= L476), G483 (= G477), M484 (= M478), V485 (= V479)

Sites not aligning to the query:

binding methyl 2-{[(4-methylpyrimidin-2-yl)carbamoyl]sulfamoyl}benzoate: 567

3e9yA Arabidopsis thaliana acetohydroxyacid synthase in complex with monosulfuron (see paper)
32% identity, 97% coverage: 4:546/562 of query aligns to 14:559/582 of 3e9yA

query
sites
3e9yA

A

A

E

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x
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A

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Y

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C

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G

A

A

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active site: Y32 (≠ V22), G34 (= G24), G35 (= G25), A36 (= A26), S37 (≠ I27), E58 (= E47), T81 (= T70), F120 (≠ I109), Q121 (= Q110), E122 (= E111), K170 (≠ A164), M265 (≠ F256), V292 (= V285), V399 (≠ N393), G425 (≠ A419), M427 (= M421), D452 (= D446), N479 (= N473), H481 (≠ M475), L482 (= L476), M484 (= M478), V485 (= V479), W488 (vs. gap), H557 (≠ P544)
binding N-[(4-methylpyrimidin-2-yl)carbamoyl]-2-nitrobenzenesulfonamide: D290 (≠ E283), R291 (≠ F284), W488 (vs. gap)
binding flavin-adenine dinucleotide-n5-isobutyl ketone: R160 (= R154), G221 (= G210), G222 (= G212), G223 (≠ T213), T245 (≠ S236), L246 (≠ P237), M247 (≠ K238), L263 (= L254), G285 (= G278), R287 (≠ S280), D289 (≠ N282), R291 (≠ F284), D309 (= D303), I310 (= I304), G327 (= G321), D328 (= D322), V329 (≠ A323), M404 (≠ A398), G422 (≠ L416)
binding magnesium ion: D452 (= D446), N479 (= N473), H481 (≠ M475)
binding 2-[(2e)-3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-(1-hydroxyethylidene)-4-methyl-2,3-dihydro-1,3-thiazol-5-yl]ethyltrihydrogen diphosphate: V399 (≠ N393), G400 (= G394), Q401 (≠ N395), H402 (≠ S396), M427 (= M421), G451 (= G445), G453 (= G447), S454 (= S448), N479 (= N473), H481 (≠ M475), L482 (= L476), G483 (= G477), M484 (= M478), V485 (= V479)

Sites not aligning to the query:

binding N-[(4-methylpyrimidin-2-yl)carbamoyl]-2-nitrobenzenesulfonamide: 567

7tzzA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase p197t mutant in complex with bispyribac-sodium (see paper)
32% identity, 97% coverage: 4:546/562 of query aligns to 15:560/582 of 7tzzA

query
sites
7tzzA

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E

binding 2,6-bis[(4,6-dimethoxypyrimidin-2-yl)oxy]benzoic acid: M266 (≠ F256), R292 (≠ F284), W489 (vs. gap)
binding 2-[3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-2-[(1~{S})-1-(dioxidanyl)-1-oxidanyl-ethyl]-4-methyl-1,3-thiazol-5-yl]ethyl phosphono hydrogen phosphate: V400 (≠ N393), G401 (= G394), Q402 (≠ N395), H403 (≠ S396), G426 (≠ A419), M428 (= M421), G452 (= G445), D453 (= D446), G454 (= G447), S455 (= S448), L483 (= L476), G484 (= G477), M485 (= M478), V486 (= V479)
binding flavin-adenine dinucleotide: R161 (= R154), G222 (= G210), G223 (= G212), G224 (≠ T213), T246 (≠ S236), L247 (≠ P237), M248 (≠ K238), M263 (≠ V253), L264 (= L254), M266 (≠ F256), H267 (≠ A257), G286 (= G278), R288 (≠ S280), V293 (= V285), D310 (= D303), I311 (= I304), D329 (= D322), V330 (≠ A323), M405 (≠ A398), G423 (≠ L416)
binding magnesium ion: A37 (= A26), T82 (= T70), S83 (≠ A71), Q122 (= Q110), Y381 (≠ R374), D453 (= D446), M458 (= M451), Q461 (≠ M454), N480 (= N473), H482 (≠ M475), K533 (≠ P518)

Sites not aligning to the query:

binding 2,6-bis[(4,6-dimethoxypyrimidin-2-yl)oxy]benzoic acid: 568

6demA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide bensulfuron methyl (see paper)
31% identity, 98% coverage: 1:548/562 of query aligns to 12:560/597 of 6demA

query
sites
6demA

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A

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H

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P

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D

H

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L
|
L

A

A

E

E

A

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x
N

A
x
V

R

K

G

G

I

I

R

R

I

I

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T

N

P

Q

G

Q

E

E

I

L

N

-

R

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E

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M

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K

D

E

I

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L

A

D

A

A

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E

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P

T

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V

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V

I

I

I

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-

E

K

V

V

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P

active site: Y33 (≠ V22), G35 (= G24), G36 (= G25), A37 (= A26), I38 (= I27), E59 (= E47), T82 (= T70), F121 (≠ I109), Q122 (= Q110), E123 (= E111), K171 (≠ A164), K228 (≠ E221), M264 (≠ F256), V291 (= V285), V407 (≠ N393), L432 (≠ F418), G433 (≠ A419), M435 (= M421), D460 (= D446), N487 (= N473), E489 (≠ M475), Q490 (≠ L476), M492 (= M478), V493 (= V479), W496 (≠ G482), L518 (= L504), N523 (≠ G509), V524 (≠ A510)
binding methyl 2-[(4,6-dimethoxypyrimidin-2-yl)carbamoylsulfamoylmethyl]benzoate: M264 (≠ F256), D289 (≠ E283), R290 (≠ F284), M492 (= M478), W496 (≠ G482)
binding flavin-adenine dinucleotide: R161 (= R154), G217 (= G210), A218 (≠ W211), G219 (= G212), N222 (≠ L215), T244 (≠ S236), L245 (≠ P237), Q246 (≠ K238), L262 (= L254), G284 (= G278), A285 (≠ T279), R286 (≠ S280), D288 (≠ N282), R290 (≠ F284), V291 (= V285), E317 (≠ D303), I318 (= I304), N322 (≠ E308), D336 (= D322), V337 (≠ A323), M412 (≠ A398), G430 (≠ L416)
binding magnesium ion: D460 (= D446), N487 (= N473), E489 (≠ M475)
binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V407 (≠ N393), G408 (= G394), Q409 (≠ N395), H410 (≠ S396), M435 (= M421), G459 (= G445), D460 (= D446), A461 (≠ G447), S462 (= S448), M465 (= M451), N487 (= N473), E489 (≠ M475), Q490 (≠ L476), G491 (= G477), M492 (= M478), V493 (= V479)

Sites not aligning to the query:

binding methyl 2-[(4,6-dimethoxypyrimidin-2-yl)carbamoylsulfamoylmethyl]benzoate: 567

6delA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide chlorimuron ethyl (see paper)
31% identity, 98% coverage: 1:548/562 of query aligns to 12:560/597 of 6delA

query
sites
6delA

M

L

N

T

A

G

E

E

V

I

I

F

V

H

R

E

S

M

L

M

E

L

K

R

H

H

G

K

V

V

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D

C

T

V

V

F

F

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G

V
x
Y

P

A

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G

A
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A

I
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I

E

L

S

P

L

V

N

F

T

D

A

A

L

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Y

Y

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N

S

S

S

D

-

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I

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F

I

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V

L

A

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R

H

H

E
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E

E

Q

G

G

A

A

A

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F

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M

A

A

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E

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G

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Y

A

A

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C

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T

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G

A

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x
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E

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A

A

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N

G

I

A

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W

V

V

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M

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N
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E

M
x
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x
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E

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x
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x
V

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G

G

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R

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G

Q

E

E

I

L

N

-

R

K

E

S

L

G

M

V

D

K

D

E

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F

L

L

A

D

A

A

G

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E

P

P

T

V

V

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-

E

K

V

V

P

P

active site: Y33 (≠ V22), G35 (= G24), G36 (= G25), A37 (= A26), I38 (= I27), E59 (= E47), T82 (= T70), F121 (≠ I109), Q122 (= Q110), E123 (= E111), K171 (≠ A164), K228 (≠ E221), M264 (≠ F256), V291 (= V285), V407 (≠ N393), L432 (≠ F418), G433 (≠ A419), M435 (= M421), D460 (= D446), N487 (= N473), E489 (≠ M475), Q490 (≠ L476), M492 (= M478), V493 (= V479), W496 (≠ G482), L518 (= L504), N523 (≠ G509), V524 (≠ A510)
binding 2-[[[[(4-chloro-6-methoxy-2-pyrimidinyl)amino]carbonyl]amino]sulfonyl]benzoic acid ethyl ester: D289 (≠ E283), R290 (≠ F284), W496 (≠ G482)
binding flavin-adenine dinucleotide: R161 (= R154), G217 (= G210), A218 (≠ W211), G219 (= G212), N222 (≠ L215), T244 (≠ S236), L245 (≠ P237), Q246 (≠ K238), L262 (= L254), G284 (= G278), A285 (≠ T279), R286 (≠ S280), D288 (≠ N282), R290 (≠ F284), V291 (= V285), E317 (≠ D303), I318 (= I304), N322 (≠ E308), D336 (= D322), V337 (≠ A323), M412 (≠ A398), G430 (≠ L416)
binding (3Z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl](formyl)amino}-3-sulfanylpent-3-en-1-yl trihydrogen diphosphate: V407 (≠ N393), G408 (= G394), Q409 (≠ N395), H410 (≠ S396), G433 (≠ A419), M435 (= M421), G459 (= G445), D460 (= D446), A461 (≠ G447), S462 (= S448), M465 (= M451), N487 (= N473), E489 (≠ M475), Q490 (≠ L476), G491 (= G477), M492 (= M478), V493 (= V479)
binding magnesium ion: D460 (= D446), N487 (= N473), E489 (≠ M475)
binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V407 (≠ N393), G408 (= G394), Q409 (≠ N395), H410 (≠ S396), G433 (≠ A419), M435 (= M421), G459 (= G445), D460 (= D446), A461 (≠ G447), S462 (= S448), M465 (= M451), N487 (= N473), E489 (≠ M475), Q490 (≠ L476), G491 (= G477), M492 (= M478), V493 (= V479)

5k2oA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a pyrimidinyl-benzoate herbicide, pyrithiobac (see paper)
32% identity, 97% coverage: 4:546/562 of query aligns to 15:560/585 of 5k2oA

query
sites
5k2oA

A

A

E

D

V

I

I

L

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V

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A

L

L

E

E

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H

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G

G

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E

C

T

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F

F

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A

V
x
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P

G
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A
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A

I
x
S

E

M

S

E

L

I

N

H

T

Q

A

A

L

L

Y

T

K

R

S

S

-

S

I

I

S

R

V

N

I

V

V

L

A

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K

R

H

H

E
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E

E

Q

G

G

A

G

A

V

F

F

M

A

A

A

D

E

G

G

Y

Y

A

A

R

R

V

S

S

S

G

G

V

K

I

P

A

G

V

I

C

C

C

I

S

A

T
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T

A

S

G

G

P

P

G

G

A

A

T

T

N

N

M

L

I

V

T

S

G

G

I

L

A

A

S

D

A

A

F

L

G

L

D

D

S

S

I

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P

P

V

L

I

V

A

A

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I

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G

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Q

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V

S

P

T

R

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active site: Y33 (≠ V22), G35 (= G24), G36 (= G25), A37 (= A26), S38 (≠ I27), E59 (= E47), T82 (= T70), F121 (≠ I109), Q122 (= Q110), E123 (= E111), K171 (≠ A164), M266 (≠ F256), V293 (= V285), V400 (≠ N393), G426 (≠ A419), M428 (= M421), D453 (= D446), N480 (= N473), H482 (≠ M475), L483 (= L476), M485 (= M478), V486 (= V479), W489 (vs. gap), H558 (≠ P544)
binding 2-chloranyl-6-(4,6-dimethoxypyrimidin-2-yl)sulfanyl-benzoic acid: M266 (≠ F256), R292 (≠ F284), W489 (vs. gap)
binding flavin-adenine dinucleotide: R161 (= R154), G222 (= G210), G223 (= G212), G224 (≠ T213), T246 (≠ S236), L247 (≠ P237), M248 (≠ K238), L264 (= L254), G286 (= G278), R288 (≠ S280), D290 (≠ N282), V293 (= V285), D310 (= D303), I311 (= I304), D329 (= D322), V330 (≠ A323), Q404 (≠ M397), M405 (≠ A398), G423 (≠ L416)
binding magnesium ion: D453 (= D446), N480 (= N473), H482 (≠ M475)
binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V400 (≠ N393), G401 (= G394), Q402 (≠ N395), H403 (≠ S396), M428 (= M421), D453 (= D446), G454 (= G447), S455 (= S448), N480 (= N473), H482 (≠ M475), L483 (= L476), G484 (= G477), M485 (= M478), V486 (= V479)

Sites not aligning to the query:

binding 2-chloranyl-6-(4,6-dimethoxypyrimidin-2-yl)sulfanyl-benzoic acid: 568

P17597 Acetolactate synthase, chloroplastic; AtALS; Acetohydroxy-acid synthase; Protein CHLORSULFURON RESISTANT 1; EC 2.2.1.6 from Arabidopsis thaliana (Mouse-ear cress) (see 8 papers)
32% identity, 97% coverage: 4:546/562 of query aligns to 100:645/670 of P17597

query
sites
P17597

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E

A122 (= A26) mutation to V: Reduced catalytic activity. Resistant to imidazolinone herbicides but not to sulfonylurea herbicides.
M124 (≠ E28) mutation to E: Reduced catalytic activity. Resistant to imidazolinone herbicides and reduced sensitivity to sulfonylurea herbicides.; mutation to I: No effect on catalytic activity. Increased resistance to imidazolinone herbicides.
E144 (= E47) binding thiamine diphosphate
S186 (= S89) binding FAD
P197 (≠ S100) mutation to S: In csr1-1/GH50; resistant to sulfonylurea but not to imidazolinone herbicides.
R199 (≠ S102) mutation R->A,E: No effect on catalytic activity. Resistant to imidazolinone herbicides but not to sulfonylurea herbicides.
Q207 (= Q110) binding thiamine diphosphate
K220 (= K128) binding (R)-imazaquin
R246 (= R154) binding (R)-imazaquin; binding FAD
K256 (≠ A164) binding chlorimuron-ethyl
G308 (= G212) binding FAD
TL 331:332 (≠ SP 236:237) binding FAD
C340 (≠ E245) modified: Cysteine sulfinic acid (-SO2H)
LGMH 349:352 (≠ LGFA 254:257) binding FAD
GVRFD 371:375 (≠ GTSFN 278:282) binding FAD
DR 376:377 (≠ EF 283:284) binding chlorimuron-ethyl
DI 395:396 (= DI 303:304) binding FAD
DV 414:415 (≠ DA 322:323) binding FAD
QH 487:488 (≠ NS 395:396) binding thiamine diphosphate
GG 508:509 (≠ LG 416:417) binding FAD
GAM 511:513 (≠ ASM 419:421) binding thiamine diphosphate
D538 (= D446) binding Mg(2+)
DGS 538:540 (= DGS 446:448) binding thiamine diphosphate
N565 (= N473) binding Mg(2+)
NQHLGM 565:570 (≠ NAMLGM 473:478) binding thiamine diphosphate
H567 (≠ M475) binding Mg(2+)
W574 (vs. gap) binding chlorimuron-ethyl; mutation to L: Increased catalytic activity. Resistant to imidazolinone and sulfonylurea herbicides.; mutation to S: Slightly decreased catalytic activity. Resistant to imidazolinone and sulfonylurea herbicides.

Sites not aligning to the query:

653 binding chlorimuron-ethyl; S→A: No effect on catalytic activity or sensitivity to herbicides.; S→F: No effect on catalytic activity. Resistant to imidazolinone herbicides and also slightly sulfonylurea-resistant.; S→N: In csr1-2/GH90; no effect on catalytic activity. Resistant to imidazolinone but not to sulfonylurea herbicides.; S→T: No effect on catalytic activity. Resistant to imidazolinone herbicides but not to sulfonylurea herbicides.

8et4A Crystal structure of wild-type arabidopsis thaliana acetohydroxyacid synthase in complex with amidosulfuron (see paper)
32% identity, 97% coverage: 4:546/562 of query aligns to 15:560/582 of 8et4A

query
sites
8et4A

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A

A

D

E

G

G

Y

Y

A

A

R

R

V

S

S

S

G

G

V

K

I

P

A

G

V

I

C

C

C

I

S

A

T

T

A

S

G

G

P

P

G

G

A

A

T

T

N

N

M

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I

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G

G

I

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A

A

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A

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D

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P

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A

A

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I

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T

G

G

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Q

V

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S

R

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I

G

G

K

T

G

D

A

A

I

F

Q

Q

E

E

F

T

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P

V

-

Q

-

S

-

F

-

G

-

I

I

V

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E

I

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R

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I

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K

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Y

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A

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A

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G

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R

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-

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G

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x
G

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-

E

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A

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L

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L

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D

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I

I

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P

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A

A

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x
T

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x
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x
M

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x
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x
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x
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x
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x
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-

G

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D

I
|
I

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N

A

E

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I

I

G

G

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K

N

N

Y

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x
V

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-

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A

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x
F

R

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N

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A

A

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Y

-

S

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N

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x
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G

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x
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x
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x
M

W

W

A

A

I

A

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Q

Y

F

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Y

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N

I

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K

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K

P

P

Y

R

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Q

F

W

Y

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S

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x
G

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x
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M

G

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F

A

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A

P

A

A

P

A

I

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G

A

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K

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A

A

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A

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D

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G

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S

F

F

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M

N

N

G

V

M
x
Q

E

E

V

L

A

A

T

T

A

I

V

R

N

V

Y

E

N

N

I

L

P

P

V

V

I

K

W

V

V

L

I

L

M

L

N

N

N
|
N

A

Q

M
x
H

L
|
L

G
|
G

M
|
M

V
|
V

-

M

-

Q

-
x
W

-

E

-

D

-

R

Y

F

H

Y

G

K

R

A

K

N

L

R

A

A

G

H

I

T

P

F

E

L

G

G

I

D

P

P

S

A

G

Q

F

E

K

D

P

E

V

I

-

F

-

P

D

N

H

M

V

L

K

L

L

F

A

A

E

A

A

A

L

C

G

G

A

I

R

P

G

A

I

A

R

R

I

V

T

T

T

K

P
x
K

G

A

E

D

I

L

N

-

R

R

E

E

L

A

M

I

D

Q

D

T

I

M

L

L

A

D

A

T

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P

V

G

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P

T

Y

V

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L

L

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H

E

Q

E

E

binding 2-[3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-2-[(1~{S})-1-(dioxidanyl)-1-oxidanyl-ethyl]-4-methyl-1,3-thiazol-5-yl]ethyl phosphono hydrogen phosphate: V400 (≠ N393), G401 (= G394), Q402 (≠ N395), H403 (≠ S396), G426 (≠ A419), M428 (= M421), G452 (= G445), D453 (= D446), G454 (= G447), S455 (= S448), M458 (= M451), N480 (= N473), H482 (≠ M475), L483 (= L476), G484 (= G477), M485 (= M478), V486 (= V479)
binding flavin-adenine dinucleotide: R161 (= R154), G222 (= G210), G223 (= G212), G224 (≠ T213), T246 (≠ S236), L247 (≠ P237), M248 (≠ K238), L264 (= L254), M266 (≠ F256), H267 (≠ A257), G286 (= G278), V287 (≠ T279), R288 (≠ S280), D290 (≠ N282), R292 (≠ F284), V293 (= V285), D310 (= D303), I311 (= I304), D329 (= D322), V330 (≠ A323), M405 (≠ A398), G423 (≠ L416)
binding magnesium ion: F370 (≠ T362), D453 (= D446), M458 (= M451), Q461 (≠ M454), N480 (= N473), H482 (≠ M475), K533 (≠ P518)
binding N-{[(4,6-dimethoxypyrimidin-2-yl)carbamoyl]sulfamoyl}-N-methylmethanesulfonamide: M266 (≠ F256), R292 (≠ F284), M485 (= M478), W489 (vs. gap)

Sites not aligning to the query:

binding N-{[(4,6-dimethoxypyrimidin-2-yl)carbamoyl]sulfamoyl}-N-methylmethanesulfonamide: 568

5wj1A Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a triazolopyrimidine herbicide, penoxsulam (see paper)
32% identity, 97% coverage: 4:546/562 of query aligns to 15:560/582 of 5wj1A

query
sites
5wj1A

A

A

E

D

V

I

I

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A

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x
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K

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M

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I

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V

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M

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N

G

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E

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A

A

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A

I

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N

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Y

E

N

N

I

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P

P

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V

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W

V

V

L

I

L

M

L

N

N

N
|
N

A

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x
H

L
|
L

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G

M
|
M

V
|
V

-

M

-

Q

-
x
W

-

E

-

D

-

R

Y

F

H

Y

G

K

R

A

K

N

L

R

A

A

G

H

I

T

P

F

E

L

G

G

I

D

P

P

S

A

G

Q

F

E

K

D

P

E

V

I

-

F

-

P

D

N

H

M

V

L

K

L

L

F

A

A

E

A

A

A

L

C

G

G

A

I

R

P

G

A

I

A

R

R

I

V

T

T

T

K

P

K

G

A

E

D

I

L

N

-

R

R

E

E

L

A

M

I

D

Q

D

T

I

M

L

L

A

D

A

T

G

P

V

G

P

P

T

Y

V

L

L

L

D

D

V

V

I

I

I

C

D

P

P
x
H

E

Q

E

E

active site: Y33 (≠ V22), G35 (= G24), G36 (= G25), A37 (= A26), S38 (≠ I27), E59 (= E47), T82 (= T70), F121 (≠ I109), Q122 (= Q110), E123 (= E111), K171 (≠ A164), M266 (≠ F256), V293 (= V285), V400 (≠ N393), G426 (≠ A419), M428 (= M421), D453 (= D446), N480 (= N473), H482 (≠ M475), L483 (= L476), M485 (= M478), V486 (= V479), W489 (vs. gap), H558 (≠ P544)
binding flavin-adenine dinucleotide: R161 (= R154), G222 (= G210), G223 (= G212), G224 (≠ T213), T246 (≠ S236), L247 (≠ P237), M248 (≠ K238), M263 (≠ V253), L264 (= L254), G286 (= G278), R288 (≠ S280), V293 (= V285), D310 (= D303), I311 (= I304), D329 (= D322), V330 (≠ A323), M405 (≠ A398), G423 (≠ L416), G424 (= G417)
binding magnesium ion: D453 (= D446), N480 (= N473), H482 (≠ M475)
binding 2-(2,2-difluoroethoxy)-N-(5,8-dimethoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)-6-(trifluoromethyl)benzenesulfonamide: M266 (≠ F256), D291 (≠ E283), R292 (≠ F284), M485 (= M478), W489 (vs. gap)
binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V400 (≠ N393), G401 (= G394), Q402 (≠ N395), H403 (≠ S396), M428 (= M421), D453 (= D446), G454 (= G447), S455 (= S448), M458 (= M451), N480 (= N473), H482 (≠ M475), L483 (= L476), G484 (= G477), M485 (= M478), V486 (= V479)

Sites not aligning to the query:

binding 2-(2,2-difluoroethoxy)-N-(5,8-dimethoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)-6-(trifluoromethyl)benzenesulfonamide: 568

5k6tA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylamino-carbonyl-triazolinone herbicide, propoxycarbazone-sodium (see paper)
32% identity, 97% coverage: 4:546/562 of query aligns to 15:560/582 of 5k6tA

query
sites
5k6tA

A

A

E

D

V

I

I

L

V

V

R

E

S

A

L

L

E

E

K

R

H

Q

G

G

V

V

T

E

C

T

V

V

F

F

G

A

V
x
Y

P

P

G
|
G

A
|
A

I
x
S

E

M

S

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N

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C

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I

A

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E

active site: Y33 (≠ V22), G35 (= G24), G36 (= G25), A37 (= A26), S38 (≠ I27), E59 (= E47), T82 (= T70), F121 (≠ I109), Q122 (= Q110), E123 (= E111), K171 (≠ A164), M266 (≠ F256), V293 (= V285), V400 (≠ N393), G426 (≠ A419), M428 (= M421), D453 (= D446), N480 (= N473), H482 (≠ M475), L483 (= L476), M485 (= M478), V486 (= V479), W489 (vs. gap), H558 (≠ P544)
binding methyl 2-[(4-methyl-5-oxidanylidene-3-propoxy-1,2,4-triazol-1-yl)carbonylsulfamoyl]benzoate: H267 (≠ A257), R292 (≠ F284), M485 (= M478), W489 (vs. gap)
binding flavin-adenine dinucleotide: R161 (= R154), G222 (= G210), G223 (= G212), G224 (≠ T213), T246 (≠ S236), L247 (≠ P237), M248 (≠ K238), L264 (= L254), G286 (= G278), R288 (≠ S280), D290 (≠ N282), R292 (≠ F284), V293 (= V285), D310 (= D303), I311 (= I304), D329 (= D322), V330 (≠ A323), Q404 (≠ M397), M405 (≠ A398), G423 (≠ L416)
binding magnesium ion: D453 (= D446), N480 (= N473), H482 (≠ M475)
binding 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-2-oxo-2,3-dihydro-1,3-thiazol-5-yl}ethyl trihydrogendiphosphate: V400 (≠ N393), G401 (= G394), Q402 (≠ N395), H403 (≠ S396), G426 (≠ A419), M428 (= M421), G452 (= G445), G454 (= G447), S455 (= S448), N480 (= N473), H482 (≠ M475), L483 (= L476), G484 (= G477)

Sites not aligning to the query:

binding methyl 2-[(4-methyl-5-oxidanylidene-3-propoxy-1,2,4-triazol-1-yl)carbonylsulfamoyl]benzoate: 568

5k6rA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylamino-carbonyl-triazolinone herbicide, thiencarbazone-methyl (see paper)
32% identity, 97% coverage: 4:546/562 of query aligns to 15:560/582 of 5k6rA

query
sites
5k6rA

A

A

E

D

V

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M

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I

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x
V

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N

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N

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A

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G

G

A

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G

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-

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E

active site: Y33 (≠ V22), G35 (= G24), G36 (= G25), A37 (= A26), S38 (≠ I27), E59 (= E47), T82 (= T70), F121 (≠ I109), Q122 (= Q110), E123 (= E111), K171 (≠ A164), M266 (≠ F256), V293 (= V285), V400 (≠ N393), G426 (≠ A419), M428 (= M421), D453 (= D446), N480 (= N473), H482 (≠ M475), L483 (= L476), M485 (= M478), V486 (= V479), W489 (vs. gap), H558 (≠ P544)
binding methyl 4-[(3-methoxy-4-methyl-5-oxidanylidene-1,2,4-triazol-1-yl)carbonylsulfamoyl]-5-methyl-thiophene-3-carboxylate: R292 (≠ F284), W489 (vs. gap)
binding flavin-adenine dinucleotide: R161 (= R154), G222 (= G210), G223 (= G212), G224 (≠ T213), T246 (≠ S236), L247 (≠ P237), M248 (≠ K238), L264 (= L254), M266 (≠ F256), G286 (= G278), R288 (≠ S280), R292 (≠ F284), V293 (= V285), D310 (= D303), I311 (= I304), G328 (= G321), D329 (= D322), V330 (≠ A323), M405 (≠ A398), G423 (≠ L416)
binding magnesium ion: D453 (= D446), N480 (= N473), H482 (≠ M475)
binding 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-2-oxo-2,3-dihydro-1,3-thiazol-5-yl}ethyl trihydrogendiphosphate: V400 (≠ N393), G401 (= G394), Q402 (≠ N395), H403 (≠ S396), G426 (≠ A419), M428 (= M421), D453 (= D446), G454 (= G447), S455 (= S448), M458 (= M451), N480 (= N473), H482 (≠ M475), L483 (= L476), G484 (= G477), M485 (= M478), V486 (= V479)

Sites not aligning to the query:

binding methyl 4-[(3-methoxy-4-methyl-5-oxidanylidene-1,2,4-triazol-1-yl)carbonylsulfamoyl]-5-methyl-thiophene-3-carboxylate: 568

5k3sA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a pyrimidinyl-benzoate herbicide, bispyribac-sodium (see paper)
32% identity, 97% coverage: 4:546/562 of query aligns to 15:560/583 of 5k3sA

query
sites
5k3sA

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active site: Y33 (≠ V22), G35 (= G24), G36 (= G25), A37 (= A26), S38 (≠ I27), E59 (= E47), T82 (= T70), F121 (≠ I109), Q122 (= Q110), E123 (= E111), K171 (≠ A164), M266 (≠ F256), V293 (= V285), V400 (≠ N393), G426 (≠ A419), M428 (= M421), D453 (= D446), N480 (= N473), H482 (≠ M475), L483 (= L476), M485 (= M478), V486 (= V479), W489 (vs. gap), H558 (≠ P544)
binding 2,6-bis[(4,6-dimethoxypyrimidin-2-yl)oxy]benzoic acid: R292 (≠ F284), M485 (= M478), W489 (vs. gap)
binding flavin-adenine dinucleotide: R161 (= R154), G222 (= G210), G223 (= G212), G224 (≠ T213), T246 (≠ S236), L247 (≠ P237), M248 (≠ K238), L264 (= L254), M266 (≠ F256), G286 (= G278), R288 (≠ S280), D290 (≠ N282), V293 (= V285), D310 (= D303), I311 (= I304), D329 (= D322), V330 (≠ A323), M405 (≠ A398), G423 (≠ L416)
binding magnesium ion: D453 (= D446), N480 (= N473), H482 (≠ M475)
binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V400 (≠ N393), G401 (= G394), Q402 (≠ N395), H403 (≠ S396), G426 (≠ A419), M428 (= M421), D453 (= D446), G454 (= G447), S455 (= S448), N480 (= N473), H482 (≠ M475), L483 (= L476), G484 (= G477), M485 (= M478), V486 (= V479)

Sites not aligning to the query:

binding 2,6-bis[(4,6-dimethoxypyrimidin-2-yl)oxy]benzoic acid: 569

1z8nA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with an imidazolinone herbicide, imazaquin (see paper)
32% identity, 97% coverage: 4:546/562 of query aligns to 15:560/582 of 1z8nA

query
sites
1z8nA

A

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active site: Y33 (≠ V22), G35 (= G24), G36 (= G25), A37 (= A26), S38 (≠ I27), E59 (= E47), T82 (= T70), F121 (≠ I109), Q122 (= Q110), E123 (= E111), K171 (≠ A164), M266 (≠ F256), V293 (= V285), V400 (≠ N393), G426 (≠ A419), M428 (= M421), D453 (= D446), N480 (= N473), H482 (≠ M475), L483 (= L476), M485 (= M478), V486 (= V479), W489 (vs. gap), H558 (≠ P544)
binding 2-(4-isopropyl-4-methyl-5-oxo-4,5-dihydro-1h-imidazol-2-yl)quinoline-3-carboxylic acid: K135 (= K128), R161 (= R154), Y191 (≠ F187), R194 (vs. gap), D291 (≠ E283), R292 (≠ F284), D312 (= D305), W489 (vs. gap)
binding flavin-adenine dinucleotide: R161 (= R154), G222 (= G210), G224 (≠ T213), T246 (≠ S236), L247 (≠ P237), M248 (≠ K238), L264 (= L254), G265 (= G255), M266 (≠ F256), H267 (≠ A257), G286 (= G278), V287 (≠ T279), R288 (≠ S280), D290 (≠ N282), R292 (≠ F284), V293 (= V285), D310 (= D303), I311 (= I304), D329 (= D322), V330 (≠ A323), M405 (≠ A398), G423 (≠ L416), G424 (= G417)
binding magnesium ion: D453 (= D446), N480 (= N473)
binding thiamine diphosphate: V400 (≠ N393), G401 (= G394), Q402 (≠ N395), H403 (≠ S396), G426 (≠ A419), M428 (= M421), G452 (= G445), G454 (= G447), S455 (= S448), N480 (= N473), H482 (≠ M475), L483 (= L476), G484 (= G477), M485 (= M478), V486 (= V479)

Sites not aligning to the query:

binding 2-(4-isopropyl-4-methyl-5-oxo-4,5-dihydro-1h-imidazol-2-yl)quinoline-3-carboxylic acid: 569

1yi1A Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide, tribenuron methyl (see paper)
32% identity, 97% coverage: 4:546/562 of query aligns to 15:560/582 of 1yi1A

query
sites
1yi1A

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E

E

active site: Y33 (≠ V22), G35 (= G24), G36 (= G25), A37 (= A26), S38 (≠ I27), E59 (= E47), T82 (= T70), F121 (≠ I109), Q122 (= Q110), E123 (= E111), K171 (≠ A164), M266 (≠ F256), V293 (= V285), V400 (≠ N393), G426 (≠ A419), M428 (= M421), D453 (= D446), N480 (= N473), H482 (≠ M475), L483 (= L476), M485 (= M478), V486 (= V479), W489 (vs. gap), H558 (≠ P544)
binding methyl 2-[4-methoxy-6-methyl-1,3,5-trazin-2-yl(methyl)carbamoylsulfamoyl]benzoate: D291 (≠ E283), R292 (≠ F284), W489 (vs. gap)
binding flavin-adenine dinucleotide: R161 (= R154), G223 (= G212), G224 (≠ T213), T246 (≠ S236), L247 (≠ P237), M248 (≠ K238), M263 (≠ V253), L264 (= L254), G265 (= G255), M266 (≠ F256), H267 (≠ A257), G286 (= G278), V287 (≠ T279), R288 (≠ S280), D290 (≠ N282), V293 (= V285), D310 (= D303), I311 (= I304), D329 (= D322), V330 (≠ A323), M405 (≠ A398), G423 (≠ L416), G424 (= G417)
binding magnesium ion: D453 (= D446), N480 (= N473), H482 (≠ M475)

Sites not aligning to the query:

binding methyl 2-[4-methoxy-6-methyl-1,3,5-trazin-2-yl(methyl)carbamoylsulfamoyl]benzoate: 568

1yi0A Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide, sulfometuron methyl (see paper)
32% identity, 97% coverage: 4:546/562 of query aligns to 15:560/582 of 1yi0A

query
sites
1yi0A

A

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D

V

V

I

I

I

C

D

P

P
x
H

E

Q

E

E

active site: Y33 (≠ V22), G35 (= G24), G36 (= G25), A37 (= A26), S38 (≠ I27), E59 (= E47), T82 (= T70), F121 (≠ I109), Q122 (= Q110), E123 (= E111), K171 (≠ A164), M266 (≠ F256), V293 (= V285), V400 (≠ N393), G426 (≠ A419), M428 (= M421), D453 (= D446), N480 (= N473), H482 (≠ M475), L483 (= L476), M485 (= M478), V486 (= V479), W489 (vs. gap), H558 (≠ P544)
binding methyl 2-[({[(4,6-dimethylpyrimidin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: D291 (≠ E283), R292 (≠ F284), W489 (vs. gap)
binding flavin-adenine dinucleotide: R161 (= R154), G222 (= G210), G223 (= G212), G224 (≠ T213), T246 (≠ S236), L247 (≠ P237), M248 (≠ K238), L264 (= L254), G265 (= G255), M266 (≠ F256), H267 (≠ A257), G286 (= G278), V287 (≠ T279), R288 (≠ S280), D290 (≠ N282), R292 (≠ F284), V293 (= V285), D310 (= D303), I311 (= I304), G328 (= G321), D329 (= D322), V330 (≠ A323), M405 (≠ A398), G423 (≠ L416), G424 (= G417)
binding magnesium ion: D453 (= D446), N480 (= N473), H482 (≠ M475)

Sites not aligning to the query:

binding methyl 2-[({[(4,6-dimethylpyrimidin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: 568

1yhzA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide, chlorsulfuron (see paper)
32% identity, 97% coverage: 4:546/562 of query aligns to 15:560/582 of 1yhzA

query
sites
1yhzA

A

A

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D

V

I

I

L

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V

R

E

S

A

L

L

E

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K

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G

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C

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V

V

F

F

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G
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G

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x
S

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M

S

E

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T

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A

A

L

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Y

T

K

R

S

S

-

S

I

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S

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I

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E
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E

E

Q

G

G

A

G

A

V

F

F

M

A

A

A

D

E

G

G

Y

Y

A

A

R

R

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S

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S

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G

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K

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P

A

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I

C

C

C

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S

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T
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T

A

S

G

G

P

P

G

G

A

A

T

T

N

N

M

L

I

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T

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G

G

I

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A

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S

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A

A

F

L

G

L

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D

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S

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P

V

L

I

V

A

A

L

I

T

T

G

G

Q

Q

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V

S

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T

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S

R

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M

F

I

G

G

K

T

G

D

A

A

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x
F

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Q

E
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E

F

T

S

P

V

-

Q

-

S

-

F

-

G

-

I

I

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E

I

V

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T

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R

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I

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K

K

Y

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Y

I

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I

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N

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N

E

K

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R

E

A

A

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F

L

L

A

A

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T

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G

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R
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R

K

P

G

G

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P

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L

L

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N

D

L

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x
K

D

D

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K

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A

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I

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P

D

N

S

W

H

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E

Q

R

-

C

-

S

-

T

A

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R

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L

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G

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Y

-

M

-

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M

-

P

-

K

-

P

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A

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K

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K

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A

I

A

V

Q

R

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L

L

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A

S

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K

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K

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P

V

V

I

L

V

Y

A

V

G

G

W

-

G
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G

T
x
G

V

C

L

L

S

N

R

S

A

S

D

D

K

-

E

E

L

L

L

G

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R

L

F

A

V

E

E

L

L

L

T

D

G

I

I

P

P

V

V

A

A

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S
x
T

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x
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x
M

A

G

K

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G

G

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Y

S

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C

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H

D

P

E

L

L

S

S

L

L

G

H

V

M

L
|
L

G

G

F
x
M

A
x
H

G

G

S

T

P

-

V

V

A

Y

K

A

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N

Y

Y

I

A

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V

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E

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H

D

S

V

-

D

D

V

L

L

L

A

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G

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x
V

S
x
R

F

F

N
x
D

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x
D

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x
R

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V

T

T

S

-

G

G

W

K

D

L

K

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A

L

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A

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R

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A

S

K

L

I

I

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I

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D

I
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I

D

D

C

S

N

A

E

E

I

I

G

G

K

K

N

N

Y

K

Y

T

V

P

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H

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G

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D

A
x
V

A

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-

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-

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S

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P

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H

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R

Y

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A

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A

L

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G

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K

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A

L

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Y

I

F

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A

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D

G

N
x
V

G

G

N

Q

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x
Q

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M

W

W

A

A

I

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Y

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Y

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G

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M

G

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F

F

A

G

V

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A

P

A

A

P

A

I

I

G

G

A

A

K

S

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V

A

A

A

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P

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A

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I

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A

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I

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G

G

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D

G

G

S

S

F

F

L

I

M

M

N

N

G

V

M

Q

E

E

V

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A

A

T

T

A

I

V

R

N

V

Y

E

N

N

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L

P

P

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V

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K

W

V

V

L

I

L

M

L

N

N

N
|
N

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Q

M
x
H

L
|
L

G

G

M
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M

V
|
V

-

M

-

Q

-
x
W

-

E

-

D

-

R

Y

F

H

Y

G

K

R

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K

N

L

R

A

A

G

H

I

T

P

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L

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G

I

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A

G

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F

E

K

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P

E

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F

-

P

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N

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L

K

L

L

F

A

A

E

A

A

A

L

C

G

G

A

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G

A

I

A

R

R

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T

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P

K

G

A

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-

R

R

E

E

L

A

M

I

D

Q

D

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A

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A

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L

L

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x
H

E

Q

E

E

active site: Y33 (≠ V22), G35 (= G24), G36 (= G25), A37 (= A26), S38 (≠ I27), E59 (= E47), T82 (= T70), F121 (≠ I109), Q122 (= Q110), E123 (= E111), K171 (≠ A164), M266 (≠ F256), V293 (= V285), V400 (≠ N393), G426 (≠ A419), M428 (= M421), D453 (= D446), N480 (= N473), H482 (≠ M475), L483 (= L476), M485 (= M478), V486 (= V479), W489 (vs. gap), H558 (≠ P544)
binding 1-(2-chlorophenylsulfonyl)-3-(4-methoxy-6-methyl-l,3,5-triazin-2-yl)urea: D291 (≠ E283), R292 (≠ F284), M485 (= M478), W489 (vs. gap)
binding flavin-adenine dinucleotide: R161 (= R154), G223 (= G212), G224 (≠ T213), T246 (≠ S236), L247 (≠ P237), M248 (≠ K238), L264 (= L254), M266 (≠ F256), H267 (≠ A257), G286 (= G278), V287 (≠ T279), R288 (≠ S280), D290 (≠ N282), V293 (= V285), D310 (= D303), I311 (= I304), D329 (= D322), V330 (≠ A323), Q404 (≠ M397), M405 (≠ A398), G423 (≠ L416), G424 (= G417)
binding magnesium ion: D453 (= D446), N480 (= N473), H482 (≠ M475)

Sites not aligning to the query:

binding 1-(2-chlorophenylsulfonyl)-3-(4-methoxy-6-methyl-l,3,5-triazin-2-yl)urea: 568

Query Sequence

>WP_012469185.1 NCBI__GCF_000020385.1:WP_012469185.1
MNAAEVIVRSLEKHGVTCVFGVPGGAIESLNTALYKSSISVIVAKHEEGAAFMADGYARV
SGVIAVCCSTAGPGATNMITGIASAFGDSIPVIALTGQVSTSLFGKGAIQEFSVQSFGIV
SIFRQITKYSDIIINENKAGEMISRARRLALTGRKGPVHLNLPADIMKRKVTDDSHERCS
TTQVLGFDREAVKKAAQLLLGAKRPVIVAGWGTVLSRADKELLELAELLDIPVATSPKAK
GILSEVHPLSLGVLGFAGSPVAKEYILKRDVDVLLAVGTSFNEFVTSGWDKRLLPMKSLI
HVDIDCNEIGKNYYVHVGIAGDAATVLRELVFEIGRIRKGRRIENTRRKEVEQVRAALLV
KTRKQNKALYSPHRLIMDLNEALPKNTLYFADNGNSMAWAIRYLTITEPYSFYVGLGFAS
MGFAVAAPIGAKLAAGDRPVVALVGDGSFLMNGMEVATAVNYNIPVIWVIMNNAMLGMVY
HGRKLAGIPEGIPSGFKPVDHVKLAEALGARGIRITTPGEINRELMDDILAAGVPTVLDV
IIDPEEVPPIHSRISSLEKLYT

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory