Comparing WP_012469812.1 NCBI__GCF_000020385.1:WP_012469812.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
P23533 Phosphoenolpyruvate-protein phosphotransferase; Phosphotransferase system, enzyme I; EC 2.7.3.9 from Staphylococcus carnosus (strain TM300) (see paper)
41% identity, 69% coverage: 210:746/781 of query aligns to 3:540/573 of P23533
2hwgA Structure of phosphorylated enzyme i of the phosphoenolpyruvate:sugar phosphotransferase system (see paper)
40% identity, 70% coverage: 212:761/781 of query aligns to 1:553/572 of 2hwgA
P08839 Phosphoenolpyruvate-protein phosphotransferase; Phosphotransferase system, enzyme I; EC 2.7.3.9 from Escherichia coli (strain K12) (see 2 papers)
40% identity, 70% coverage: 212:761/781 of query aligns to 2:554/575 of P08839
2wqdA Crystal structure of enzyme i of the phosphoenolpyruvate:sugar phosphotransferase system in the dephosphorylated state (see paper)
40% identity, 68% coverage: 209:737/781 of query aligns to 1:531/570 of 2wqdA
2xz7A Crystal structure of the phosphoenolpyruvate-binding domain of enzyme i in complex with phosphoenolpyruvate from the thermoanaerobacter tengcongensis pep-sugar phosphotransferase system (pts) (see paper)
51% identity, 40% coverage: 460:772/781 of query aligns to 5:317/324 of 2xz7A
2xz9A Crystal structure from the phosphoenolpyruvate-binding domain of enzyme i in complex with pyruvate from the thermoanaerobacter tengcongensis pep-sugar phosphotransferase system (pts) (see paper)
51% identity, 40% coverage: 463:772/781 of query aligns to 1:310/317 of 2xz9A
5lu4A C4-type pyruvate phosphate dikinase: conformational intermediate of central domain in the swiveling mechanism (see paper)
27% identity, 46% coverage: 385:743/781 of query aligns to 445:846/850 of 5lu4A
Sites not aligning to the query:
5jvlA C4-type pyruvate phospate dikinase: nucleotide binding domain with bound atp analogue (see paper)
26% identity, 46% coverage: 385:743/781 of query aligns to 445:868/874 of 5jvlA
Sites not aligning to the query:
5jvjB C4-type pyruvate phosphate dikinase: different conformational states of the nucleotide binding domain in the dimer (see paper)
26% identity, 46% coverage: 385:743/781 of query aligns to 372:791/797 of 5jvjB
Sites not aligning to the query:
Q39735 Pyruvate, phosphate dikinase, chloroplastic; Cold-sensitive pyruvate, orthophosphate dikinase; Pyruvate, orthophosphate dikinase; EC 2.7.9.1 from Flaveria bidentis (Coastal plain yellowtops) (Ethulia bidentis) (see 2 papers)
25% identity, 49% coverage: 364:743/781 of query aligns to 505:947/953 of Q39735
Sites not aligning to the query:
O23404 Pyruvate, phosphate dikinase 1, chloroplastic; Pyruvate, orthophosphate dikinase 1; EC 2.7.9.1 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
25% identity, 49% coverage: 364:743/781 of query aligns to 515:956/963 of O23404
1kc7A Pyruvate phosphate dikinase with bound mg-phosphonopyruvate (see paper)
24% identity, 45% coverage: 385:739/781 of query aligns to 443:860/872 of 1kc7A
Sites not aligning to the query:
P22983 Pyruvate, phosphate dikinase; Pyruvate, orthophosphate dikinase; EC 2.7.9.1 from Clostridium symbiosum (Bacteroides symbiosus) (see 4 papers)
24% identity, 45% coverage: 385:739/781 of query aligns to 444:861/874 of P22983
Sites not aligning to the query:
1vbgA Pyruvate phosphate dikinase from maize (see paper)
26% identity, 49% coverage: 364:743/781 of query aligns to 426:868/874 of 1vbgA
Sites not aligning to the query:
P11155 Pyruvate, phosphate dikinase 1, chloroplastic; Pyruvate, orthophosphate dikinase 1; EC 2.7.9.1 from Zea mays (Maize) (see 7 papers)
26% identity, 49% coverage: 364:743/781 of query aligns to 499:941/947 of P11155
Sites not aligning to the query:
5jvlB C4-type pyruvate phospate dikinase: nucleotide binding domain with bound atp analogue (see paper)
26% identity, 45% coverage: 395:743/781 of query aligns to 124:514/520 of 5jvlB
Sites not aligning to the query:
1vbhA Pyruvate phosphate dikinase with bound mg-pep from maize (see paper)
26% identity, 49% coverage: 364:743/781 of query aligns to 417:856/862 of 1vbhA
Sites not aligning to the query:
Q02KR1 Phosphoenolpyruvate synthase; PEP synthase; Pyruvate, water dikinase; EC 2.7.9.2 from Pseudomonas aeruginosa (strain UCBPP-PA14) (see paper)
25% identity, 47% coverage: 369:737/781 of query aligns to 387:777/791 of Q02KR1
P37349 PEP-dependent dihydroxyacetone kinase, phosphoryl donor subunit DhaM; Dihydroxyacetone kinase subunit M; EC 2.7.1.121 from Escherichia coli (strain K12) (see paper)
25% identity, 24% coverage: 244:428/781 of query aligns to 277:462/472 of P37349
Sites not aligning to the query:
4me4B Crystal structure of a hd-gyp domain (a cyclic-di-gmp phosphodiesterase) containing a tri-nuclear metal centre (see paper)
29% identity, 22% coverage: 12:182/781 of query aligns to 8:176/363 of 4me4B
Sites not aligning to the query:
>WP_012469812.1 NCBI__GCF_000020385.1:WP_012469812.1
MQREQSQHFLGLRTLEDISSIILHSHDLQETLDNIVTIVAKRMGSEVCSIYLLEDDGETL
VLKATKGLSKNAVGKIMMKTSEGLSGLVVQTRDMVTTDNAPAHPRYKYFKHSKEERYLSF
LGLPLFERKTPIGVIVVQTVAARSFTEVEISILRTITFQISSIVLNAKLLDSIQSKEQER
AYYEQELARLKTHRPSDGGREQPETKSKTRALGGTAVSPGFSHGKVYILDRFSDKVIKVA
KVGSVEEELHKFRIALEKVTIQTIYMEKRVSELLSEDDASIFHTHLMILEDRGFLNKIND
LIDQGVGATRAVHEVVQGYIEVFSAMEDPYLRERSADMEDIGRRIIDVLEGNENDGVKLK
EKRVIVAEDIFPSDMAMLDHDKILGIVTEKGNIYSHAAIMAKSLGIPAVVGVKGLLHAAN
VKDQVIVDGTSGHIYLNPEKQVREEYLRLEKEYTIRLKELEPLRDLPAVTSDGMRILLRA
NIGLLSDVRTAVANGAEGVGLYRTEFPYMARTTFPNREEQASLYRKILEGFPGQPVNIRT
LDIGGDKGLPYFSYPHEDNPFLGWRSIRVSLDEEEIFREQLAGILLAAPAGQATIMFPLI
SCLDEVRRIRSILNSVVAELCRQGHDVCGGLPMGIMVEVPAAVQIIDRLAAEVDYLSIGT
NDLIQYLLAADRNNAKVKQYYEPYHPAVLHAIKRVADVGQRMGKKVSVCGEMAADPLNAL
LLVGMGVREFSLSAPSIPLVKQALRSHSLRLCQAMARKVLAFDTACDIKRYLAKRRKELF
E
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory