SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing WP_012471169.1 NCBI__GCF_000020385.1:WP_012471169.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

P23893 Glutamate-1-semialdehyde 2,1-aminomutase; GSA; Glutamate-1-semialdehyde aminotransferase; GSA-AT; EC 5.4.3.8 from Escherichia coli (strain K12) (see paper)
62% identity, 98% coverage: 4:424/428 of query aligns to 2:423/426 of P23893

query
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P23893

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K265 (= K267) mutation to R: 2% of wild-type activity.

3bs8A Crystal structure of glutamate 1-semialdehyde aminotransferase complexed with pyridoxamine-5'-phosphate from bacillus subtilis (see paper)
62% identity, 100% coverage: 2:427/428 of query aligns to 3:427/430 of 3bs8A

query
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3bs8A

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active site: V22 (= V21), Y145 (= Y144), E207 (= E206), D240 (= D239), M243 (= M242), K268 (= K267), G401 (≠ T401)
binding 4'-deoxy-4'-aminopyridoxal-5'-phosphate: G118 (= G117), T119 (= T118), Y145 (= Y144), H146 (= H145), E207 (= E206), N212 (= N211), D240 (= D239), V242 (= V241), K268 (= K267)

5i92F Crystal structure of glutamate-1-semialdehyde 2,1- aminomutase (gsa) from pseudomonas aeruginosa
60% identity, 98% coverage: 4:424/428 of query aligns to 2:418/420 of 5i92F

query
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5i92F

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x
A

F
|
F

active site: V19 (= V21), Y142 (= Y144), E201 (= E206), D234 (= D239), M237 (= M242), K262 (= K267), A395 (≠ T401)
binding leucine: A417 (≠ C423), F418 (= F424)

Sites not aligning to the query:

binding leucine: 420

Q42522 Glutamate-1-semialdehyde 2,1-aminomutase 2, chloroplastic; GSA 2; Glutamate-1-semialdehyde aminotransferase 2; GSA-AT 2; EC 5.4.3.8 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
58% identity, 99% coverage: 2:424/428 of query aligns to 47:469/472 of Q42522

query
sites
Q42522

T

T

H

L

T

Q

R

K

S

S

H

E

T

E

L

A

F

F

D

N

Q

A

A

A

R

K

R

N

I

L

I

M

P

P

G

G

G

G

V

V

N

N

S

S

P

P

V

V

R

R

A

A

F

F

K

K

S

S

V

V

G

G

A

G

D

Q

P

P

L

V

F

V

I

M

K

D

R

S

A

A

S

K

G

G

S

S

K

R

I

I

F
x
R

D

D

E

I

D

D

N

G

N

N

T

E

Y

Y

I

I

D

D

Y

Y

V

V

G

G

S

S

W

W

G

G

P

P

M

A

I

I

L

I

G

G

H

H

C

A

F

D

P

D

E

E

V

V

V

L

N

A

A

A

V

L

K

A

Q

E

C

T

M

M

E

K

N

K

G

G

S

T

S

S

F

F

G

G

A

A

P

P

T

C

E

L

L

L

E

E

I

N

T

V

L

L

A

A

Q

E

M

M

V

V

I

I

D

S

A

A

M

V

P

P

S

S

I

I

E

E

M

M

V

V

R

R

M

F

V

V

S

N

S

S

G
|
G

T

T

E

E

A

A

T

C

M

M

S

G

A

V

I

L

R

R

L

L

A

A

R

R

G

A

Y

F

T

T

G

G

R

K

D

Q

K

K

I

F

L

I

K

K

F

F

S

E

G

G

C

C

Y

Y

H

H

G

G

H

H

A

A

D

N

A

S

L

F

L

L

V

V

K

K

A

A

G

G

S

S

G

G

A

V

A

A

T

T

F

L

G

G

V

L

P

P

D

D

S

S

P

P

G

G

V

V

P

P

A

K

D

A

F

A

A

T

K

S

H

D

T

T

L

L

T

T

A

A

E

P

Y

Y

N

N

S

D

L

I

A

A

S

A

V

V

K

E

T

K

L

L

I

F

T

E

E

A

N

N

S

K

G

G

Q

E

I

I

A

A

C

A

I

I

I

I

L

L

E

E

P

P

V

V

A

V

G

G

N

N

M

S

G

G

T

F

V

I

P

T

P

P

R

K

P

P

G

E

F

F

L

I

E

E

G

G

L

I

R

R

E

R

L

I

C

T

T

K

N

D

E

N

G

G

I

A

I

L

L

L

I

I

F

F

D

D

E

E

V

V

M

M

S

T

G

G

F

F

R

R

V

L

A

A

Y

Y

G

G

G

G

A

A

Q

Q

S

E

L

Y

Y

F

G

G

V

I

T

T

P

P

D

D

M

L

T

T

T

T

L

L

G

G

K

K

I

I

I

I

G

G

G

G

G

G

L

L

P

P

V

V

G

G

A

A

F

Y

G

G

G

G

K

R

R

R

E

D

I

I

M

M

E

E

K

M

L

V

S

A

P

P

S

A

G

G

G

P

V

M

Y

Y

Q

Q

A

A

G

G

T

T

L

L

S

S

G

G

N

N

P

P

L

L

A

A

M

M

T

T

A

A

G

G

I

I

E

H

T

T

L

L

K

K

F

R

L

L

Q

S

Q

Q

P

P

G

G

F

T

Y

Y

D

E

R

Y

L

L

E

D

E

K

K

I

S

T

S

K

Q

E

L

L

S

T

E

N

G

G

I

I

S

L

L

E

A

A

A

G

R

K

D

K

A

T

G

G

Y

H

P

A

L

M

Y

C

S

G

T

G

R

Y

V

I

G

S

S

G

M

M

F

F

C

G

A

F

F

F

F

F

T

T

P

E

H

G

E

P

V

V

F

Y

D

D

W

F

T

S

T

D

A

A

A

K

A

K

C

S

D

D

T

T

K

E

A

K

F

F

A

G

R

K

Y

F

F

F

L

R

A

G

M

M

L

L

E

E

E

E

G

G

V

V

Y

Y

L

L

A

A

P

P

S

S

Q

Q

F

F

E

E

T

A

A

G

F

F

M

T

S

S

A

L

A

A

H

H

S

T

Q

S

Q

E

D

D

I

I

E

Q

A

F

T

T

I

I

A

A

A

A

A

A

R

E

K

K

C

V

F

L

R92 (≠ F47) mutation to K: In gsa2-1; suppression of enf1 mutant pleiotropic developmental phenotypes; when associated with S-162.
G162 (= G117) mutation to S: In gsa2-1; suppression of enf1 mutant pleiotropic developmental phenotypes; when associated with K-92.

2gsaB Crystal structure of glutamate-1-semialdehyde aminomutase (aminotransferase, wild-type form) (see paper)
58% identity, 97% coverage: 5:421/428 of query aligns to 5:421/427 of 2gsaB

query
sites
2gsaB

R

K

S

S

H

D

T

E

L

I

F

F

D

A

Q

A

A

A

R

Q

R

K

I

L

I

M

P

P

G

G

G

G

V
|
V

N

S

S

S

P

P

V

V

R

R

A

A

F

F

K

K

S

S

V

V

G

G

A

G

D

Q

P

P

L

I

F

V

I

F

K

D

R

R

A

V

S

K

G

D

S

A

K

Y

I

A

F

W

D

D

E

V

D

D

N

G

N

N

T

R

Y

Y

I

I

D

D

Y

Y

V

V

G

G

S

T

W

W

G

G

P

P

M

A

I

I

L

C

G

G

H

H

C

A

F

H

P

P

E

E

V

V

V

I

N

E

A

A

V

L

K

K

Q

V

C

A

M

M

E

E

N

K

G

G

S

T

S

S

F

F

G

G

A

A

P

P

T

C

E

A

L

L

E

E

I

N

T

V

L

L

A

A

Q

E

M

M

V

V

I

N

D

D

A

A

M

V

P

P

S

S

I

I

E

E

M

M

V

V

R

R

M

F

V

V

S

N

S

S

G
|
G

T
|
T

E

E

A

A

T

C

M

M

S

A

A

V

I

L

R

R

L

L

A

M

R

R

G

A

Y

Y

T

T

G

G

R

R

D

D

K

K

I

I

L

I

K

K

F

F

S

E

G

G

C

C

Y
|
Y

H

H

G

G

H

H

A

A

D

D

A

M

L

F

L

L

V

V

K

K

A

A

G

G

S

S

G

G

A

V

A

A

T

T

F

L

G

G

V

L

P

P

D

S

S

S

P

P

G

G

V

V

P

P

A

K

D

K

F

T

A

T

K

A

H

N

T

T

L

L

T

T

A

T

E

P

Y

Y

N

N

S

D

L

L

A

E

S

A

V

V

K

K

T

A

L

L

I

F

T

A

E

E

N

N

S

P

G

G

Q

E

I

I

A

A

C

G

I

V

I

I

L

L

E
|
E

P

P

V

I

A

V

G

G

N
|
N

M

S

G

G

T

F

V

I

P

V

P

P

R

D

P

A

G

G

F

F

L

L

E

E

G

G

L

L

R

R

E

E

L

I

C

T

T

L

N

E

E

H

G

D

I

A

I

L

L

L

I

V

F

F

D
|
D

E

E

V
|
V

M
|
M

S

T

G

G

F

F

R

R

V

I

A

A

Y

Y

G

G

G

G

A

V

Q

Q

S

E

L

K

Y

F

G

G

V

V

T

T

P

P

D

D

M

L

T

T

T

T

L

L

G

G

K
|
K

I

I

I

I

G

G

G

G

G

G

L

L

P

P

V

V

G

G

A

A

F

Y

G

G

G

G

K

K

R

R

E

E

I

I

M

M

E

Q

K

L

L

V

S

A

P

P

S

A

G

G

G

P

V

M

Y

Y

Q

Q

A

A

G

G

T

T

L

L

S

S

G

G

N

N

P

P

L

L

A

A

M

M

T

T

A

A

G

G

I

I

E

K

T

T

L

L

K

E

F

L

L

L

Q

R

Q

Q

P

P

G

G

F

T

Y

Y

D

E

R

Y

L

L

E

D

E

Q

K

I

S

T

S

K

Q

R

L

L

S

S

E

D

G

G

I

L

S

L

L

A

A

I

A

A

R

Q

D

E

A

T

G

G

Y

H

P

A

L

A

Y

C

S

G

T

G

R

Q

V

V

G

S

S

G

M

M

F

F

C

G

A

F

F

F

F

F

T

T

P

E

H

G

E

P

V

V

F

H

D

N

W

Y

T

E

T

D

A

A

A

K

A

K

C

S

D

D

T

L

K

Q

A

K

F

F

A

S

R

R

Y

F

F

H

L

R

A

G

M

M

L

L

E

E

E

Q

G

G

V

I

Y

Y

L

L

A

A

P

P

S

S

Q

Q

F

F

E

E

T
x
A

A

G

F

F

M

T

S

S

A

L

A

A

H

H

S

T

Q

E

Q

E

D

D

I

I

E

D

A

A

T

T

I

L

A

A

A

A

A

A

R

R

active site: V21 (= V21), Y144 (= Y144), E206 (= E206), D239 (= D239), M242 (= M242), K267 (= K267), A401 (≠ T401)
binding pyridoxal-5'-phosphate: G117 (= G117), T118 (= T118), Y144 (= Y144), E206 (= E206), N211 (= N211), D239 (= D239), V241 (= V241), M242 (= M242), K267 (= K267)

2gsaA Crystal structure of glutamate-1-semialdehyde aminomutase (aminotransferase, wild-type form) (see paper)
58% identity, 97% coverage: 5:421/428 of query aligns to 5:421/427 of 2gsaA

query
sites
2gsaA

R

K

S

S

H

D

T

E

L

I

F

F

D

A

Q

A

A

A

R

Q

R

K

I

L

I

M

P

P

G

G

G

G

V
|
V

N

S

S

S

P

P

V

V

R

R

A

A

F

F

K

K

S

S

V

V

G

G

A

G

D

Q

P

P

L

I

F

V

I

F

K

D

R

R

A

V

S

K

G

D

S

A

K

Y

I

A

F

W

D

D

E

V

D

D

N

G

N

N

T

R

Y

Y

I

I

D

D

Y

Y

V

V

G

G

S

T

W

W

G

G

P

P

M

A

I

I

L

C

G

G

H

H

C

A

F

H

P

P

E

E

V

V

V

I

N

E

A

A

V

L

K

K

Q

V

C

A

M

M

E

E

N

K

G

G

S

T

S

S

F

F

G

G

A

A

P

P

T

C

E

A

L

L

E

E

I

N

T

V

L

L

A

A

Q

E

M

M

V

V

I

N

D

D

A

A

M

V

P

P

S

S

I

I

E

E

M

M

V

V

R

R

M

F

V

V

S

N

S

S

G
|
G

T
|
T

E

E

A

A

T

C

M

M

S

A

A

V

I

L

R

R

L

L

A

M

R

R

G

A

Y

Y

T

T

G

G

R

R

D

D

K

K

I

I

L

I

K

K

F

F

S

E

G

G

C

C

Y
|
Y

H
|
H

G
|
G

H

H

A

A

D

D

A

M

L

F

L

L

V

V

K

K

A

A

G

G

S

S

G

G

A

V

A

A

T

T

F

L

G

G

V

L

P

P

D

S

S

S

P

P

G

G

V

V

P

P

A

K

D

K

F

T

A

T

K

A

H

N

T

T

L

L

T

T

A

T

E

P

Y

Y

N

N

S

D

L

L

A

E

S

A

V

V

K

K

T

A

L

L

I

F

T

A

E

E

N

N

S

P

G

G

Q

E

I

I

A

A

C

G

I

V

I

I

L

L

E
|
E

P

P

V

I

A

V

G

G

N
|
N

M

S

G

G

T

F

V

I

P

V

P

P

R

D

P

A

G

G

F

F

L

L

E

E

G

G

L

L

R

R

E

E

L

I

C

T

T

L

N

E

E

H

G

D

I

A

I

L

L

L

I

V

F

F

D
|
D

E

E

V
|
V

M
|
M

S

T

G

G

F

F

R

R

V

I

A

A

Y

Y

G

G

G

G

A

V

Q

Q

S

E

L

K

Y

F

G

G

V

V

T

T

P

P

D

D

M

L

T

T

T

T

L

L

G

G

K
|
K

I

I

I

I

G

G

G

G

G

G

L

L

P

P

V

V

G

G

A

A

F

Y

G

G

G

G

K

K

R

R

E

E

I

I

M

M

E

Q

K

L

L

V

S

A

P

P

S

A

G

G

G

P

V

M

Y

Y

Q

Q

A

A

G

G

T

T

L

L

S

S

G

G

N

N

P

P

L

L

A

A

M

M

T

T

A

A

G

G

I

I

E

K

T

T

L

L

K

E

F

L

L

L

Q

R

Q

Q

P

P

G

G

F

T

Y

Y

D

E

R

Y

L

L

E

D

E

Q

K

I

S

T

S

K

Q

R

L

L

S

S

E

D

G

G

I

L

S

L

L

A

A

I

A

A

R

Q

D

E

A

T

G

G

Y

H

P

A

L

A

Y

C

S

G

T

G

R

Q

V

V

G

S

S

G

M

M

F

F

C

G

A

F

F

F

F

F

T

T

P

E

H

G

E

P

V

V

F

H

D

N

W

Y

T

E

T

D

A

A

A

K

A

K

C

S

D

D

T

L

K

Q

A

K

F

F

A

S

R

R

Y

F

F

H

L

R

A

G

M

M

L

L

E

E

E

Q

G

G

V

I

Y

Y

L

L

A

A

P

P

S

S

Q

Q

F

F

E

E

T
x
A

A

G

F

F

M

T

S

S

A

L

A

A

H

H

S

T

Q

E

Q

E

D

D

I

I

E

D

A

A

T

T

I

L

A

A

A

A

A

A

R

R

active site: V21 (= V21), Y144 (= Y144), E206 (= E206), D239 (= D239), M242 (= M242), K267 (= K267), A401 (≠ T401)
binding 4'-deoxy-4'-aminopyridoxal-5'-phosphate: G117 (= G117), T118 (= T118), Y144 (= Y144), H145 (= H145), G146 (= G146), N211 (= N211), D239 (= D239), V241 (= V241), K267 (= K267)

P42799 Glutamate-1-semialdehyde 2,1-aminomutase 1, chloroplastic; AtGSA1; GSA 1; Glutamate-1-semialdehyde aminotransferase 1; GSA-AT 1; EC 5.4.3.8 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
57% identity, 99% coverage: 5:427/428 of query aligns to 52:474/474 of P42799

query
sites
P42799

R

K

S

S

H

E

T

E

L

A

F

F

D

N

Q

A

A

A

R

K

R

N

I

L

I

M

P

P

G

G

G

G

V

V

N

N

S

S

P

P

V

V

R

R

A

A

F

F

K

K

S

S

V

V

G

G

A

G

D

Q

P

P

L

V

F

L

I

I

K

D

R

S

A

V

S

K

G

G

S

S

K

K

I

M

F

W

D

D

E

I

D

D

N

G

N

N

T

E

Y

Y

I

I

D

D

Y

Y

V

V

G

G

S

S

W

W

G

G

P

P

M

A

I

I

L

I

G

G

H

H

C

A

F

D

P

D

E

E

V

V

V

L

N

A

A

A

V

L

K

A

Q

E

C

T

M

M

E

K

N

K

G

G

S

T

S

S

F

F

G

G

A

A

P

P

T

C

E

L

L

L

E

E

I

N

T

V

L

L

A

A

Q

E

M

M

V

V

I

I

D

S

A

A

M

V

P

P

S

S

I

I

E

E

M

M

V

V

R

R

M

F

V

V

S

N

S

S

G

G

T

T

E

E

A

A

T

C

M

M

S

G

A

V

I

L

R

R

L

L

A

A

R

R

G

A

Y

F

T

T

G

N

R

K

D

E

K

K

I

F

L

I

K

K

F

F

S

E

G

G

C

C

Y

Y

H

H

G

G

H

H

A

A

D

N

A

A

L

F

L

L

V

V

K

K

A

A

G

G

S

S

G

G

A

V

A

A

T

T

F

L

G

G

V

L

P

P

D

D

S

S

P

P

G

G

V

V

P

P

A

K

D

A

F

A

A

T

K

S

H

D

T

T

L

L

T

T

A

A

E

P

Y

Y

N

N

S

D

L

L

A

E

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A

V

V

K

E

T

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L

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I

F

T

A

E

A

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G

G

Q

E

I

I

A

S

C

A

I

V

I

I

L

L

E

E

P

P

V

V

A

V

G

G

N

N

M

S

G

G

T

F

V

I

P

P

P

P

R

T

P

P

G

E

F

F

L

I

E

N

G

G

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L

R

R

E

Q

L

L

C

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T

K

N

D

E

N

G

G

I

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I

L

L

L

I

I

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D

E

E

V

V

M

M

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T

G

G

F

F

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R

V

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A

A

Y

Y

G

G

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G

A

A

Q

Q

S

E

L

Y

Y

F

G

G

V

I

T

T

P

P

D

D

M

L

T

T

T

T

L

L

G

G

K
|
K

I

I

I

I

G

G

G

G

G

G

L

L

P

P

V

V

G

G

A

A

F

Y

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G

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G

K

R

R

R

E

D

I

I

M

M

E

E

K

M

L

V

S

A

P

P

S

A

G

G

G

P

V

M

Y

Y

Q

Q

A

A

G

G

T

T

L

L

S

S

G

G

N

N

P

P

L

L

A

A

M

M

T

T

A

A

G

G

I

I

E

H

T

T

L

L

K

K

F

R

L

L

Q

K

Q

Q

P

A

G

G

F

T

Y

Y

D

E

R

Y

L

L

E

D

E

K

K

I

S

T

S

K

Q

E

L

L

S

T

E

N

G

G

I

I

S

L

L

E

A

A

A

G

R

K

D

K

A

T

G

G

Y

H

P

P

L

M

Y

C

S

G

T

G

R

Y

V

I

G

S

S

G

M

M

F

F

C

G

A

F

F

F

F

F

T

A

P

E

H

G

E

P

V

V

F

Y

D

N

W

F

T

A

T

D

A

S

A

K

A

K

C

S

D

D

T

T

K

E

A

K

F

F

A

G

R

R

Y

F

F

F

L

R

A

G

M

M

L

L

E

E

E

E

G

G

V

V

Y

Y

L

F

A

A

P

P

S

S

Q

Q

F

F

E

E

T

A

A

G

F

F

M

T

S

S

A

L

A

A

H

H

S

T

Q

P

Q

E

D

D

I

I

E

Q

A

L

T

T

I

I

A

A

A

A

A

A

R

E

K

R

C

V

F

L

K

S

L

R

I

I

K314 (= K267) modified: N6-(pyridoxal phosphate)lysine

3usfA Crystal structure of dava-4
58% identity, 97% coverage: 5:421/428 of query aligns to 5:421/427 of 3usfA

query
sites
3usfA

R

K

S

S

H

D

T

E

L

I

F

F

D

A

Q

A

A

A

R

Q

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I

L

I

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P

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G

G

G

G

V
|
V

N

S

S
|
S

P

P

V
|
V

R

R

A

A

F

F

K

K

S

S

V

V

G

G

A

G

D

Q

P

P

L

I

F

V

I

F

K

D

R

R

A

V

S

K

G

D

S

A

K

Y

I

A

F

W

D

D

E

V

D

D

N

G

N

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T

R

Y

Y

I

I

D

D

Y

Y

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T

W

W

G

G

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P

M

A

I

I

L

C

G

G

H

H

C

A

F

H

P

P

E

E

V

V

V

I

N

E

A

A

V

L

K

K

Q

V

C

A

M

M

E

E

N

K

G

G

S

T

S

S

F

F

G

G

A

A

P

P

T

C

E

A

L

L

E

E

I

N

T

V

L

L

A

A

Q

E

M

M

V

V

I

N

D

D

A

A

M

V

P

P

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S

I

I

E

E

M

M

V

V

R

R

M

F

V

V

S

N

S

S

G
|
G

T
|
T

E

E

A

A

T

C

M

M

S

A

A

V

I

L

R

R

L

I

A

M

R

R

G

A

Y

Y

T

T

G

G

R

R

D

D

K

K

I

I

L

I

K

K

F

F

S

E

G

G

C

C

Y
|
Y

H

H

G

G

H

H

A

A

D

D

A

M

L

F

L

L

V

V

K

K

A

A

G

G

S
|
S

G

G

A

V

A

A

T

T

F

L

G

G

V

L

P

P

D

S

S

S

P

P

G

G

V

V

P

P

A

K

D

K

F

T

A

T

K

A

H

N

T

T

L

L

T

T

A

T

E

P

Y

Y

N

N

S

D

L

L

A

E

S

A

V

V

K

K

T

A

L

L

I

F

T

A

E

E

N

N

S

P

G

G

Q

E

I

I

A

A

C

G

I

V

I

I

L

L

E

E

P

P

V

I

A

V

G

G

N
|
N

M

S

G

G

T

F

V

I

P

V

P

P

R

D

P

A

G

G

F

F

L

L

E

E

G

G

L

L

R

R

E

E

L

I

C

T

T

L

N

E

E

H

G

D

I

A

I

L

L

L

I

V

F

F

D
|
D

E

E

V
|
V

M
|
M

S

T

G

G

F

F

R

R

V

I

A

A

Y

Y

G

G

G

G

A

V

Q

Q

S

E

L

K

Y

F

G

G

V

V

T

T

P

P

D

D

M

L

T

T

T

T

L

L

G

G

K
|
K

I

I

I

I

G

G

G

G

G

G

L

L

P

P

V

V

G

G

A

A

F

Y

G

G

G

G

K

K

R

R

E

E

I

I

M

M

E

Q

K

L

L

V

S

A

P

P

S

A

G

G

G

P

V

M

Y

Y

Q

Q

A

A

G

G

T

T

L

L

S

S

G

G

N

N

P

P

L

L

A

A

M

M

T

T

A

A

G

G

I

I

E

K

T

T

L

L

K

E

F

L

L

L

Q

R

Q

Q

P

P

G

G

F

T

Y

Y

D

E

R

Y

L

L

E

D

E

Q

K

I

S

T

S

K

Q

R

L

L

S

S

E

D

G

G

I

L

S

L

L

A

A

I

A

A

R

Q

D

E

A

T

G

G

Y

H

P

A

L

A

Y

C

S

G

T

G

R

Q

V

V

G

S

S

G

M

M

F

F

C

G

A

F

F

F

F

F

T

T

P

E

H

G

E

P

V

V

F

H

D

N

W

Y

T

E

T

D

A

A

A

K

A

K

C

S

D

D

T

L

K

Q

A

K

F

F

A

S

R

R

Y

F

F

H

L

R

A

G

M

M

L

L

E

E

E

Q

G

G

V

I

Y

Y

L

L

A

A

P

P

S

S

Q

Q

F

F

E
|
E

T
x
A

A

G

F

F

M

T

S

S

A

L

A

A

H

H

S

T

Q

E

Q

E

D

D

I

I

E

D

A

A

T

T

I

L

A

A

A

A

A

A

R

R

active site: V21 (= V21), Y144 (= Y144), D239 (= D239), M242 (= M242), K267 (= K267), A401 (≠ T401)
binding (4s)-4,5-diaminopentanoic acid: S23 (= S23), V25 (= V25), S157 (= S157), K267 (= K267), E400 (= E400)
binding (5-hydroxy-4,6-dimethylpyridin-3-yl)methyl dihydrogen phosphate: G117 (= G117), T118 (= T118), Y144 (= Y144), N211 (= N211), D239 (= D239), V241 (= V241), K267 (= K267)

3fq7A Gabaculine complex of gsam (see paper)
58% identity, 97% coverage: 5:421/428 of query aligns to 5:421/427 of 3fq7A

query
sites
3fq7A

R

K

S

S

H

D

T

E

L

I

F

F

D

A

Q

A

A

A

R

Q

R

K

I

L

I

M

P

P

G

G

G

G

V
|
V

N

S

S
|
S

P

P

V
|
V

R

R

A

A

F

F

K

K

S

S

V

V

G

G

A

G

D

Q

P

P

L

I

F

V

I

F

K

D

R

R

A

V

S

K

G

D

S

A

K

Y

I

A

F

W

D

D

E

V

D

D

N

G

N

N

T

R

Y

Y

I

I

D

D

Y

Y

V

V

G

G

S

T

W
|
W

G

G

P

P

M

A

I

I

L

C

G

G

H

H

C

A

F

H

P

P

E

E

V

V

V

I

N

E

A

A

V

L

K

K

Q

V

C

A

M

M

E

E

N

K

G

G

S

T

S

S

F

F

G

G

A

A

P

P

T

C

E

A

L

L

E

E

I

N

T

V

L

L

A

A

Q

E

M

M

V

V

I

N

D

D

A

A

M

V

P

P

S

S

I

I

E

E

M

M

V

V

R

R

M

F

V

V

S

N

S

S

G
|
G

T
|
T

E

E

A

A

T

C

M

M

S

A

A

V

I

L

R

R

L

I

A

M

R

R

G

A

Y

Y

T

T

G

G

R

R

D

D

K

K

I

I

L

I

K

K

F

F

S

E

G

G

C

C

Y
|
Y

H
|
H

G

G

H

H

A

A

D

D

A

M

L

F

L

L

V

V

K

K

A

A

G

G

S

S

G

G

A

V

A

A

T

T

F

L

G

G

V

L

P

P

D

S

S

S

P

P

G

G

V

V

P

P

A

K

D

K

F

T

A

T

K

A

H

N

T

T

L

L

T

T

A

T

E

P

Y

Y

N

N

S

D

L

L

A

E

S

A

V

V

K

K

T

A

L

L

I

F

T

A

E

E

N

N

S

P

G

G

Q

E

I

I

A

A

C

G

I

V

I

I

L

L

E
|
E

P

P

V

I

A

V

G

G

N
|
N

M

S

G

G

T

F

V

I

P

V

P

P

R

D

P

A

G

G

F

F

L

L

E

E

G

G

L

L

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R

E

E

L

I

C

T

T

L

N

E

E

H

G

D

I

A

I

L

L

L

I

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F

F

D
|
D

E

E

V
|
V

M
|
M

S

T

G

G

F

F

R

R

V

I

A

A

Y

Y

G

G

G

G

A

V

Q

Q

S

E

L

K

Y

F

G

G

V

V

T

T

P

P

D

D

M

L

T

T

T

T

L

L

G

G

K
|
K

I

I

I

I

G

G

G

G

G

G

L

L

P

P

V

V

G

G

A

A

F

Y

G

G

G

G

K

K

R

R

E

E

I

I

M

M

E

Q

K

L

L

V

S

A

P

P

S

A

G

G

G

P

V

M

Y

Y

Q

Q

A

A

G
|
G

T
|
T

L

L

S

S

G

G

N

N

P

P

L

L

A

A

M

M

T

T

A

A

G

G

I

I

E

K

T

T

L

L

K

E

F

L

L

L

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R

Q

Q

P

P

G

G

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Y

Y

D

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Y

L

L

E

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E

Q

K

I

S

T

S

K

Q

R

L

L

S

S

E

D

G

G

I

L

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L

L

A

A

I

A

A

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E

A

T

G

G

Y

H

P

A

L

A

Y

C

S

G

T

G

R

Q

V

V

G

S

S

G

M

M

F

F

C

G

A

F

F

F

F

F

T

T

P

E

H

G

E

P

V

V

F

H

D

N

W

Y

T

E

T

D

A

A

A

K

A

K

C

S

D

D

T

L

K

Q

A

K

F

F

A

S

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R

Y

F

F

H

L

R

A

G

M

M

L

L

E

E

E

Q

G

G

V

I

Y

Y

L

L

A

A

P

P

S

S

Q

Q

F

F

E
|
E

T
x
A

A

G

F

F

M

T

S

S

A

L

A

A

H

H

S

T

Q

E

Q

E

D

D

I

I

E

D

A

A

T

T

I

L

A

A

A

A

A

A

R

R

active site: V21 (= V21), Y144 (= Y144), D239 (= D239), M242 (= M242), K267 (= K267), A401 (≠ T401)
binding 3-[o-phosphonopyridoxyl]--amino-benzoic acid: S23 (= S23), V25 (= V25), W61 (= W61), G117 (= G117), T118 (= T118), Y144 (= Y144), H145 (= H145), E206 (= E206), N211 (= N211), D239 (= D239), V241 (= V241), M242 (= M242), K267 (= K267), G298 (= G298), T299 (= T299), E400 (= E400)

2hp2A Inter-subunit signaling in gsam (see paper)
58% identity, 97% coverage: 5:421/428 of query aligns to 5:421/427 of 2hp2A

query
sites
2hp2A

R

K

S

S

H

D

T

E

L

I

F

F

D

A

Q

A

A

A

R

Q

R

K

I

L

I

M

P

P

G

G

G

G

V
|
V

N

S

S
|
S

P

P

V

V

R

R

A

A

F

F

K

K

S

S

V

V

G

G

A

G

D

Q

P

P

L

I

F

V

I

F

K

D

R

R

A

V

S

K

G

D

S

A

K

Y

I

A

F

W

D

D

E

V

D

D

N

G

N

N

T

R

Y

Y

I

I

D

D

Y

Y

V

V

G

G

S

T

W

W

G

G

P

P

M

A

I

I

L

C

G

G

H

H

C

A

F

H

P

P

E

E

V

V

V

I

N

E

A

A

V

L

K

K

Q

V

C

A

M

M

E

E

N

K

G

G

S

T

S

S

F

F

G

G

A

A

P

P

T

C

E

A

L

L

E

E

I

N

T

V

L

L

A

A

Q

E

M

M

V

V

I

N

D

D

A

A

M

V

P

P

S

S

I

I

E

E

M

M

V

V

R

R

M

F

V

V

S

N

S

S

G
|
G

T
|
T

E

E

A

A

T

C

M

M

S

A

A

V

I

L

R

R

L

I

A

M

R

R

G

A

Y

Y

T

T

G

G

R

R

D

D

K

K

I

I

L

I

K

K

F

F

S

E

G

G

C

C

Y
|
Y

H
|
H

G

G

H

H

A

A

D

D

A

M

L

F

L

L

V

V

K

K

A

A

G

G

S

S

G

G

A

V

A

A

T

T

F

L

G

G

V

L

P

P

D

S

S

S

P

P

G

G

V

V

P

P

A

K

D

K

F

T

A

T

K

A

H

N

T

T

L

L

T

T

A

T

E

P

Y

Y

N

N

S

D

L

L

A

E

S

A

V

V

K

K

T

A

L

L

I

F

T

A

E

E

N

N

S

P

G

G

Q

E

I

I

A

A

C

G

I

V

I

I

L

L

E
|
E

P

P

V

I

A

V

G

G

N
|
N

M

S

G

G

T

F

V

I

P

V

P

P

R

D

P

A

G

G

F

F

L

L

E

E

G

G

L

L

R

R

E

E

L

I

C

T

T

L

N

E

E

H

G

D

I

A

I

L

L

L

I

V

F

F

D
|
D

E

E

V
|
V

M
|
M

S

T

G

G

F

F

R

R

V

I

A

A

Y

Y

G

G

G

G

A

V

Q

Q

S

E

L

K

Y

F

G

G

V

V

T

T

P

P

D

D

M

L

T

T

T

T

L

L

G

G

K
|
K

I

I

I

I

G

G

G

G

G

G

L

L

P

P

V

V

G

G

A

A

F

Y

G

G

G

G

K

K

R

R

E

E

I

I

M

M

E

Q

K

L

L

V

S

A

P

P

S

A

G

G

G

P

V

M

Y

Y

Q

Q

A

A

G
|
G

T
|
T

L

L

S

S

G

G

N

N

P

P

L

L

A

A

M

M

T

T

A

A

G

G

I

I

E

K

T

T

L

L

K

E

F

L

L

L

Q

R

Q

Q

P

P

G

G

F

T

Y

Y

D

E

R

Y

L

L

E

D

E

Q

K

I

S

T

S

K

Q

R

L

L

S

S

E

D

G

G

I

L

S

L

L

A

A

I

A

A

R

Q

D

E

A

T

G

G

Y

H

P

A

L

A

Y

C

S

G

T

G

R

Q

V

V

G

S

S

G

M

M

F

F

C

G

A

F

F

F

F

F

T

T

P

E

H

G

E

P

V

V

F

H

D

N

W

Y

T

E

T

D

A

A

A

K

A

K

C

S

D

D

T

L

K

Q

A

K

F

F

A

S

R

R

Y

F

F

H

L

R

A

G

M

M

L

L

E

E

E

Q

G

G

V

I

Y

Y

L

L

A

A

P

P

S

S

Q

Q

F

F

E

E

T
x
A

A

G

F

F

M

T

S

S

A

L

A

A

H

H

S

T

Q

E

Q

E

D

D

I

I

E

D

A

A

T

T

I

L

A

A

A

A

A

A

R

R

active site: V21 (= V21), Y144 (= Y144), D239 (= D239), M242 (= M242), K267 (= K267), A401 (≠ T401)
binding (4s)-4,5-diaminopentanoic acid: G298 (= G298), T299 (= T299)
binding (4r)-5-amino-4-[({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)amino]pentanoic acid: S23 (= S23), G117 (= G117), T118 (= T118), Y144 (= Y144), H145 (= H145), E206 (= E206), N211 (= N211), D239 (= D239), V241 (= V241), M242 (= M242), K267 (= K267)
binding pyridoxal-5'-phosphate: G298 (= G298), T299 (= T299)

2hp1A Inter-subunit signaling in gsam (see paper)
58% identity, 97% coverage: 5:421/428 of query aligns to 5:421/427 of 2hp1A

query
sites
2hp1A

R

K

S

S

H

D

T

E

L

I

F

F

D

A

Q

A

A

A

R

Q

R

K

I

L

I

M

P

P

G

G

G

G

V
|
V

N

S

S
|
S

P

P

V
|
V

R

R

A

A

F

F

K

K

S

S

V

V

G

G

A

G

D

Q

P

P

L

I

F

V

I

F

K

D

R

R

A

V

S

K

G

D

S

A

K

Y

I

A

F

W

D

D

E

V

D

D

N

G

N

N

T

R

Y

Y

I

I

D

D

Y

Y

V

V

G

G

S

T

W
|
W

G

G

P

P

M

A

I

I

L

C

G

G

H

H

C

A

F

H

P

P

E

E

V

V

V

I

N

E

A

A

V

L

K

K

Q

V

C

A

M

M

E

E

N

K

G

G

S

T

S

S

F

F

G

G

A

A

P

P

T

C

E

A

L

L

E

E

I

N

T

V

L

L

A

A

Q

E

M

M

V

V

I

N

D

D

A

A

M

V

P

P

S

S

I

I

E

E

M

M

V

V

R

R

M

F

V

V

S

N

S
|
S

G
|
G

T
|
T

E

E

A

A

T

C

M

M

S

A

A

V

I

L

R

R

L

I

A

M

R

R

G

A

Y

Y

T

T

G

G

R

R

D

D

K

K

I

I

L

I

K

K

F

F

S

E

G

G

C

C

Y
|
Y

H
|
H

G
|
G

H

H

A

A

D

D

A

M

L

F

L

L

V

V

K

K

A

A

G

G

S

S

G

G

A

V

A

A

T

T

F

L

G

G

V

L

P

P

D

S

S

S

P

P

G

G

V

V

P

P

A

K

D

K

F

T

A

T

K

A

H

N

T

T

L

L

T

T

A

T

E

P

Y

Y

N

N

S

D

L

L

A

E

S

A

V

V

K

K

T

A

L

L

I

F

T

A

E

E

N

N

S

P

G

G

Q

E

I

I

A

A

C

G

I

V

I

I

L

L

E
|
E

P

P

V

I

A

V

G

G

N
|
N

M

S

G

G

T

F

V

I

P

V

P

P

R

D

P

A

G

G

F

F

L

L

E

E

G

G

L

L

R

R

E

E

L

I

C

T

T

L

N

E

E

H

G

D

I

A

I

L

L

L

I

V

F

F

D
|
D

E

E

V
|
V

M
|
M

S

T

G

G

F

F

R

R

V

I

A

A

Y

Y

G

G

G

G

A

V

Q

Q

S

E

L

K

Y

F

G

G

V

V

T

T

P

P

D

D

M

L

T

T

T

T

L

L

G

G

K
|
K

I

I

I

I

G

G

G

G

G

G

L

L

P

P

V

V

G

G

A

A

F

Y

G

G

G

G

K

K

R

R

E

E

I

I

M

M

E

Q

K

L

L

V

S

A

P

P

S

A

G

G

G

P

V

M

Y

Y

Q

Q

A

A

G

G

T

T

L

L

S

S

G

G

N

N

P

P

L

L

A

A

M

M

T

T

A

A

G

G

I

I

E

K

T

T

L

L

K

E

F

L

L

L

Q

R

Q

Q

P

P

G

G

F

T

Y

Y

D

E

R

Y

L

L

E

D

E

Q

K

I

S

T

S

K

Q

R

L

L

S

S

E

D

G

G

I

L

S

L

L

A

A

I

A

A

R

Q

D

E

A

T

G

G

Y

H

P

A

L

A

Y

C

S

G

T

G

R

Q

V

V

G

S

S

G

M

M

F

F

C

G

A

F

F

F

F

F

T

T

P

E

H

G

E

P

V

V

F

H

D

N

W

Y

T

E

T

D

A

A

A

K

A

K

C

S

D

D

T

L

K

Q

A

K

F

F

A

S

R

R

Y

F

F

H

L

R

A

G

M

M

L

L

E

E

E

Q

G

G

V

I

Y

Y

L

L

A

A

P

P

S

S

Q

Q

F

F

E
|
E

T
x
A

A

G

F

F

M

T

S

S

A

L

A

A

H

H

S

T

Q

E

Q

E

D

D

I

I

E

D

A

A

T

T

I

L

A

A

A

A

A

A

R

R

active site: V21 (= V21), Y144 (= Y144), D239 (= D239), M242 (= M242), K267 (= K267), A401 (≠ T401)
binding (4s)-4-amino-5-[({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)amino]pentanoic acid: S23 (= S23), V25 (= V25), W61 (= W61), S116 (= S116), G117 (= G117), T118 (= T118), Y144 (= Y144), H145 (= H145), G146 (= G146), E206 (= E206), N211 (= N211), D239 (= D239), V241 (= V241), M242 (= M242), K267 (= K267), E400 (= E400)

2hozA Inter-subunit signaling in gsam (see paper)
58% identity, 97% coverage: 5:421/428 of query aligns to 5:421/427 of 2hozA

query
sites
2hozA

R

K

S

S

H

D

T

E

L

I

F

F

D

A

Q

A

A

A

R

Q

R

K

I

L

I

M

P

P

G

G

G

G

V
|
V

N

S

S

S

P

P

V

V

R

R

A

A

F

F

K

K

S

S

V

V

G

G

A

G

D

Q

P

P

L

I

F

V

I

F

K

D

R

R

A

V

S

K

G

D

S

A

K

Y

I

A

F

W

D

D

E

V

D

D

N

G

N

N

T

R

Y

Y

I

I

D

D

Y

Y

V

V

G

G

S

T

W

W

G

G

P

P

M

A

I

I

L

C

G

G

H

H

C

A

F

H

P

P

E

E

V

V

V

I

N

E

A

A

V

L

K

K

Q

V

C

A

M

M

E

E

N

K

G

G

S

T

S

S

F

F

G

G

A

A

P

P

T

C

E

A

L

L

E

E

I

N

T

V

L

L

A

A

Q

E

M

M

V

V

I

N

D

D

A

A

M

V

P

P

S

S

I

I

E

E

M

M

V

V

R

R

M

F

V

V

S

N

S

S

G
|
G

T
|
T

E

E

A

A

T

C

M

M

S

A

A

V

I

L

R

R

L

I

A

M

R

R

G

A

Y

Y

T

T

G

G

R

R

D

D

K

K

I

I

L

I

K

K

F

F

S
x
E

G

G

C

C

Y
|
Y

H
|
H

G
|
G

H

H

A

A

D

D

A

M

L

F

L

L

V

V

K

K

A

A

G
|
G

S
|
S

G

G

A

V

A

A

T

T

F

L

G

G

V

L

P

P

D

S

S

S

P

P

G

G

V

V

P

P

A

K

D

K

F

T

A

T

K

A

H

N

T

T

L

L

T

T

A

T

E
x
P

Y

Y

N

N

S

D

L

L

A

E

S

A

V

V

K

K

T

A

L

L

I

F

T

A

E

E

N

N

S

P

G

G

Q

E

I

I

A

A

C

G

I

V

I

I

L

L

E
|
E

P

P

V

I

A

V

G

G

N
|
N

M

S

G

G

T

F

V

I

P

V

P

P

R

D

P

A

G

G

F

F

L

L

E

E

G

G

L

L

R

R

E

E

L

I

C

T

T

L

N

E

E

H

G

D

I

A

I

L

L

L

I

V

F

F

D
|
D

E

E

V

V

M
|
M

S

T

G

G

F

F

R

R

V

I

A

A

Y

Y

G

G

G

G

A

V

Q

Q

S

E

L

K

Y

F

G

G

V

V

T

T

P

P

D

D

M

L

T

T

T

T

L

L

G

G

K
|
K

I

I

I

I

G

G

G

G

G

G

L

L

P

P

V

V

G

G

A

A

F

Y

G

G

G

G

K

K

R

R

E

E

I

I

M

M

E

Q

K

L

L

V

S

A

P

P

S

A

G

G

G

P

V

M

Y

Y

Q

Q

A

A

G
|
G

T
|
T

L

L

S

S

G

G

N

N

P

P

L

L

A

A

M

M

T

T

A

A

G

G

I

I

E

K

T

T

L

L

K

E

F

L

L

L

Q

R

Q

Q

P

P

G

G

F

T

Y

Y

D

E

R

Y

L

L

E

D

E

Q

K

I

S

T

S

K

Q

R

L

L

S

S

E

D

G

G

I

L

S

L

L

A

A

I

A

A

R

Q

D

E

A

T

G

G

Y

H

P

A

L

A

Y

C

S

G

T

G

R

Q

V

V

G

S

S

G

M

M

F

F

C

G

A

F

F

F

F

F

T

T

P

E

H

G

E

P

V

V

F

H

D
x
N

W

Y

T
x
E

T

D

A

A

A
x
K

A

K

C

S

D

D

T

L

K

Q

A

K

F

F

A

S

R

R

Y

F

F

H

L

R

A

G

M

M

L

L

E

E

E

Q

G

G

V

I

Y

Y

L

L

A

A

P

P

S

S

Q

Q

F

F

E

E

T
x
A

A

G

F

F

M

T

S

S

A

L

A

A

H

H

S

T

Q

E

Q

E

D

D

I

I

E

D

A

A

T

T

I

L

A

A

A

A

A

A

R

R

active site: V21 (= V21), Y144 (= Y144), D239 (= D239), M242 (= M242), K267 (= K267), A401 (≠ T401)
binding (4s)-4,5-diaminopentanoic acid: E141 (≠ S141), G156 (= G156), S157 (= S157), P182 (≠ E182), N368 (≠ D368), E370 (≠ T370), K373 (≠ A373)
binding 4'-deoxy-4'-aminopyridoxal-5'-phosphate: G117 (= G117), T118 (= T118), Y144 (= Y144), H145 (= H145), G146 (= G146), E206 (= E206), N211 (= N211), D239 (= D239), G298 (= G298), T299 (= T299)

5hdmB Crystal structure of arabidopsis thaliana glutamate-1-semialdehyde-2, 1-aminomutase (see paper)
57% identity, 99% coverage: 5:427/428 of query aligns to 6:428/428 of 5hdmB

query
sites
5hdmB

R

K

S

S

H

E

T

E

L

A

F

F

D

N

Q

A

A

A

R

K

R

N

I

L

I

M

P

P

G

G

G

G

V
|
V

N

N

S

S

P

P

V

V

R

R

A

A

F

F

K

K

S

S

V

V

G

G

A

G

D

Q

P

P

L

V

F

L

I

I

K

D

R

S

A

V

S

K

G

G

S

S

K

K

I

M

F

W

D

D

E

I

D

D

N

G

N

N

T

E

Y

Y

I

I

D

D

Y

Y

V

V

G

G

S

S

W

W

G

G

P

P

M

A

I

I

L

I

G

G

H

H

C

A

F

D

P

D

E

E

V

V

V

L

N

A

A

A

V

L

K

A

Q

E

C

T

M

M

E

K

N

K

G

G

S

T

S

S

F

F

G

G

A

A

P

P

T

C

E

L

L

L

E

E

I

N

T

V

L

L

A

A

Q

E

M

M

V

V

I

I

D

S

A

A

M

V

P

P

S

S

I

I

E

E

M

M

V

V

R

R

M

F

V

V

S

N

S

S

G
|
G

T
|
T

E

E

A

A

T

C

M

M

S

G

A

V

I

L

R

R

L

L

A

A

R

R

G

A

Y

F

T

T

G

N

R

K

D

E

K

K

I

F

L

I

K

K

F

F

S

E

G

G

C

C

Y
|
Y

H

H

G

G

H

H

A

A

D

N

A

A

L

F

L

L

V

V

K

K

A

A

G

G

S

S

G

G

A

V

A

A

T

T

F

L

G

G

V

L

P

P

D

D

S

S

P

P

G

G

V

V

P

P

A

K

D

A

F

A

A

T

K

S

H

D

T

T

L

L

T

T

A

A

E

P

Y

Y

N

N

S

D

L

L

A

E

S

A

V

V

K

E

T

K

L

L

I

F

T

A

E

A

N

H

S

K

G

G

Q

E

I

I

A

S

C

A

I

V

I

I

L

L

E
|
E

P

P

V

V

A

V

G

G

N
|
N

M

S

G

G

T

F

V

I

P

P

P

P

R

T

P

P

G

E

F

F

L

I

E

N

G

G

L

L

R

R

E

Q

L

L

C

T

T

K

N

D

E

N

G

G

I

V

I

L

L

L

I

I

F

F

D
|
D

E

E

V
|
V

M
|
M

S

T

G

G

F

F

R

R

V

L

A

A

Y

Y

G

G

G

G

A

A

Q

Q

S

E

L

Y

Y

F

G

G

V

I

T

T

P

P

D

D

M

L

T

T

T

T

L

L

G

G

K
|
K

I

I

I

I

G

G

G

G

G

G

L

L

P

P

V

V

G

G

A

A

F

Y

G

G

G

G

K

R

R

R

E

D

I

I

M

M

E

E

K

M

L

V

S

A

P

P

S

A

G

G

G

P

V

M

Y

Y

Q

Q

A

A

G

G

T

T

L

L

S

S

G

G

N

N

P

P

L

L

A

A

M

M

T

T

A

A

G

G

I

I

E

H

T

T

L

L

K

K

F

R

L

L

Q

K

Q

Q

P

A

G

G

F

T

Y

Y

D

E

R

Y

L

L

E

D

E

K

K

I

S

T

S

K

Q

E

L

L

S

T

E

N

G

G

I

I

S

L

L

E

A

A

A

G

R

K

D

K

A

T

G

G

Y

H

P

P

L

M

Y

C

S

G

T

G

R

Y

V

I

G

S

S

G

M

M

F

F

C

G

A

F

F

F

F

F

T

A

P

E

H

G

E

P

V

V

F

Y

D

N

W

F

T

A

T

D

A

S

A

K

A

K

C

S

D

D

T

T

K

E

A

K

F

F

A

G

R

R

Y

F

F

F

L

R

A

G

M

M

L

L

E

E

E

E

G

G

V

V

Y

Y

L

F

A

A

P

P

S

S

Q

Q

F

F

E

E

T
x
A

A

G

F

F

M

T

S

S

A

L

A

A

H

H

S

T

Q

P

Q

E

D

D

I

I

E

Q

A

L

T

T

I

I

A

A

A

A

A

A

R

E

K

R

C

V

F

L

K

S

L

R

I

I

active site: V22 (= V21), Y145 (= Y144), E207 (= E206), D240 (= D239), M243 (= M242), K268 (= K267), A402 (≠ T401)
binding pyridoxal-5'-phosphate: G118 (= G117), T119 (= T118), Y145 (= Y144), E207 (= E206), N212 (= N211), D240 (= D239), V242 (= V241), M243 (= M242), K268 (= K267)
binding 4'-deoxy-4'-aminopyridoxal-5'-phosphate: G118 (= G117), T119 (= T118), Y145 (= Y144), E207 (= E206), N212 (= N211), D240 (= D239), V242 (= V241), M243 (= M242), K268 (= K267)

5hdmA Crystal structure of arabidopsis thaliana glutamate-1-semialdehyde-2, 1-aminomutase (see paper)
57% identity, 99% coverage: 5:427/428 of query aligns to 6:428/428 of 5hdmA

query
sites
5hdmA

R

K

S

S

H

E

T

E

L

A

F

F

D

N

Q

A

A

A

R

K

R

N

I

L

I

M

P

P

G

G

G

G

V
|
V

N

N

S

S

P

P

V

V

R

R

A

A

F

F

K

K

S

S

V

V

G

G

A

G

D

Q

P

P

L

V

F

L

I

I

K

D

R

S

A

V

S

K

G

G

S

S

K

K

I

M

F

W

D

D

E

I

D

D

N

G

N

N

T

E

Y

Y

I

I

D

D

Y

Y

V

V

G

G

S

S

W

W

G

G

P

P

M

A

I

I

L

I

G

G

H

H

C

A

F

D

P

D

E

E

V

V

V

L

N

A

A

A

V

L

K

A

Q

E

C

T

M

M

E

K

N

K

G

G

S

T

S

S

F

F

G

G

A

A

P

P

T

C

E

L

L

L

E

E

I

N

T

V

L

L

A

A

Q

E

M

M

V

V

I

I

D

S

A

A

M

V

P

P

S

S

I

I

E

E

M

M

V

V

R

R

M

F

V

V

S

N

S

S

G
|
G

T
|
T

E

E

A

A

T

C

M

M

S

G

A

V

I

L

R

R

L

L

A

A

R

R

G

A

Y

F

T

T

G

N

R

K

D

E

K

K

I

F

L

I

K

K

F

F

S

E

G

G

C

C

Y
|
Y

H

H

G
|
G

H

H

A

A

D

N

A

A

L

F

L

L

V

V

K

K

A

A

G

G

S

S

G

G

A

V

A

A

T

T

F

L

G

G

V

L

P

P

D

D

S

S

P

P

G

G

V

V

P

P

A

K

D

A

F

A

A

T

K

S

H

D

T

T

L

L

T

T

A

A

E

P

Y

Y

N

N

S

D

L

L

A

E

S

A

V

V

K

E

T

K

L

L

I

F

T

A

E

A

N

H

S

K

G

G

Q

E

I

I

A

S

C

A

I

V

I

I

L

L

E
|
E

P

P

V

V

A

V

G

G

N
|
N

M

S

G

G

T

F

V

I

P

P

P

P

R

T

P

P

G

E

F

F

L

I

E

N

G

G

L

L

R

R

E

Q

L

L

C

T

T

K

N

D

E

N

G

G

I

V

I

L

L

L

I

I

F

F

D
|
D

E

E

V
|
V

M
|
M

S

T

G

G

F

F

R

R

V

L

A

A

Y

Y

G

G

G

G

A

A

Q

Q

S

E

L

Y

Y

F

G

G

V

I

T

T

P

P

D

D

M

L

T

T

T

T

L

L

G

G

K
|
K

I

I

I

I

G

G

G

G

G

G

L

L

P

P

V

V

G

G

A

A

F

Y

G

G

G

G

K

R

R

R

E

D

I

I

M

M

E

E

K

M

L

V

S

A

P

P

S

A

G

G

G

P

V

M

Y

Y

Q

Q

A

A

G

G

T

T

L

L

S

S

G

G

N

N

P

P

L

L

A

A

M

M

T

T

A

A

G

G

I

I

E

H

T

T

L

L

K

K

F

R

L

L

Q

K

Q

Q

P

A

G

G

F

T

Y

Y

D

E

R

Y

L

L

E

D

E

K

K

I

S

T

S

K

Q

E

L

L

S

T

E

N

G

G

I

I

S

L

L

E

A

A

A

G

R

K

D

K

A

T

G

G

Y

H

P

P

L

M

Y

C

S

G

T

G

R

Y

V

I

G

S

S

G

M

M

F

F

C

G

A

F

F

F

F

F

T

A

P

E

H

G

E

P

V

V

F

Y

D

N

W

F

T

A

T

D

A

S

A

K

A

K

C

S

D

D

T

T

K

E

A

K

F

F

A

G

R

R

Y

F

F

F

L

R

A

G

M

M

L

L

E

E

E

E

G

G

V

V

Y

Y

L

F

A

A

P

P

S

S

Q

Q

F

F

E

E

T
x
A

A

G

F

F

M

T

S

S

A

L

A

A

H

H

S

T

Q

P

Q

E

D

D

I

I

E

Q

A

L

T

T

I

I

A

A

A

A

A

A

R

E

K

R

C

V

F

L

K

S

L

R

I

I

active site: V22 (= V21), Y145 (= Y144), E207 (= E206), D240 (= D239), M243 (= M242), K268 (= K267), A402 (≠ T401)
binding 4'-deoxy-4'-aminopyridoxal-5'-phosphate: G118 (= G117), T119 (= T118), Y145 (= Y144), G147 (= G146), E207 (= E206), N212 (= N211), D240 (= D239), V242 (= V241), K268 (= K267)

3fqaA Gabaculien complex of gabaculine resistant gsam version (see paper)
58% identity, 97% coverage: 5:421/428 of query aligns to 4:420/426 of 3fqaA

query
sites
3fqaA

R

K

S

S

H

D

T

E

L

I

F

F

D

A

Q

A

A

A

R

Q

R

K

I

L

I

M

P

P

G

G

G

G

V
|
V

N

S

S
|
S

P

P

V

V

R
|
R

A

A

F

F

K

K

S

S

V

V

G

G

A

G

D

Q

P

P

L

I

F

V

I

F

K

D

R

R

A

V

S

K

G

D

S

A

K

Y

I

A

F

W

D

D

E

V

D

D

N

G

N

N

T

R

Y

Y

I

I

D

D

Y

Y

V

V

G

G

S

T

W
|
W

G

G

P

P

M

A

I

I

L

C

G

G

H

H

C

A

F

H

P

P

E

E

V

V

V

I

N

E

A

A

V

L

K

K

Q

V

C

A

M

M

E

E

N

K

G

G

S

T

S

S

F

F

G

G

A

A

P

P

T

C

E

A

L

L

E

E

I

N

T

V

L

L

A

A

Q

E

M

M

V

V

I

N

D

D

A

A

M

V

P

P

S

S

I

I

E

E

M

M

V

V

R

R

M

F

V

V

S

N

S

S

G
|
G

T
|
T

E

E

A

A

T

C

M

M

S

A

A

V

I

L

R

R

L

L

A

M

R

R

G

A

Y

Y

T

T

G

G

R

R

D

D

K

K

I

I

L

I

K

K

F

F

S

E

G

G

C

C

Y
|
Y

H

H

G

G

H

H

A

A

D

D

A

M

L

F

L

L

V

V

K

K

A

A

G

G

S

S

G

G

A

V

A

A

T

T

F

L

G

G

V

L

P

P

D

S

S

S

P

P

G

G

V

V

P

P

A

K

D

K

F

T

A

T

K

A

H

N

T

T

L

L

T

T

A

T

E

P

Y

Y

N

N

S

D

L

L

A

E

S

A

V

V

K

K

T

A

L

L

I

F

T

A

E

E

N

N

S

P

G

G

Q

E

I

I

A

A

C

G

I

V

I

I

L

L

E
|
E

P

P

V

I

A

V

G

G

N
|
N

M

S

G

G

T

F

V

I

P

V

P

P

R

D

P

A

G

G

F

F

L

L

E

E

G

G

L

L

R

R

E

E

L

I

C

T

T

L

N

E

E

H

G

D

I

A

I

L

L

L

I

V

F

F

D
|
D

E

E

V
|
V

M
x
I

S

T

G

G

F

F

R

R

V

I

A

A

Y

Y

G

G

G

G

A

V

Q

Q

S

E

L

K

Y

F

G

G

V

V

T

T

P

P

D

D

M

L

T

T

T

T

L

L

G

G

K
|
K

I

I

I

I

G

G

G

G

G

G

L

L

P

P

V

V

G

G

A

A

F

Y

G

G

G

G

K

K

R

R

E

E

I

I

M

M

E

Q

K

L

L

V

S

A

P

P

S

A

G

G

G

P

V

M

Y

Y

Q

Q

A

A

G

G

T

T

L

L

S

S

G

G

N

N

P

P

L

L

A

A

M

M

T

T

A

A

G

G

I

I

E

K

T

T

L

L

K

E

F

L

L

L

Q

R

Q

Q

P

P

G

G

F

T

Y

Y

D

E

R

Y

L

L

E

D

E

Q

K

I

S

T

S

K

Q

R

L

L

S

S

E

D

G

G

I

L

S

L

L

A

A

I

A

A

R

Q

D

E

A

T

G

G

Y

H

P

A

L

A

Y

C

S

G

T

G

R

Q

V

V

G

S

S

G

M

M

F

F

C

G

A

F

F

F

F

F

T

T

P

E

H

G

E

P

V

V

F

H

D

N

W

Y

T

E

T

D

A

A

A

K

A

K

C

S

D

D

T

L

K

Q

A

K

F

F

A

S

R

R

Y

F

F

H

L

R

A

G

M

M

L

L

E

E

E

Q

G

G

V

I

Y

Y

L

L

A

A

P

P

S

S

Q

Q

F

F

E

E

T
x
A

A

G

F

F

M

T

S

S

A

L

A

A

H

H

S

T

Q

E

Q

E

D

D

I

I

E

D

A

A

T

T

I

L

A

A

A

A

A

A

R

R

active site: V20 (= V21), Y143 (= Y144), D238 (= D239), I241 (≠ M242), K266 (= K267), A400 (≠ T401)
binding 3-aminobenzoic acid: S22 (= S23), R25 (= R26), W60 (= W61)
binding 4'-deoxy-4'-aminopyridoxal-5'-phosphate: G116 (= G117), T117 (= T118), Y143 (= Y144), E205 (= E206), N210 (= N211), D238 (= D239), V240 (= V241), I241 (≠ M242)

6w80A Crystal structure of glutamate-1-semialdehyde 2,1-aminomutase from stenotrophomonas maltophilia k279a in complex with plp
58% identity, 97% coverage: 1:417/428 of query aligns to 6:419/430 of 6w80A

query
sites
6w80A

M

M

T

N

H

H

T

D

R

Q

S

S

H

H

T

A

L

L

F

F

D

S

Q

R

A

A

R

Q

R

Q

I

L

I

L

P

P

G

G

G

G

V
|
V

N

N

S

S

P

P

V

V

R

R

A

A

F

F

K

K

S

S

V

V

G

G

A

G

D

E

P

P

L

F

F

F

I

V

K

E

R

R

A

A

S

D

G

G

S

A

K

Y

I

L

F

Y

D

D

E

V

D

D

N

G

N

N

T

R

Y

Y

I

I

D

D

Y

Y

V

V

G

G

S

S

W

W

G

G

P

P

M

M

I

I

L

V

G

G

H

H

C

N

F

H

P

P

E

A

V

V

V

R

N

Q

A

A

V

V

K

K

Q

K

C

A

M

I

E

D

N

N

G

G

S

L

S

S

F

F

G

G

A

A

P

P

T

C

E

A

L

G

E

E

I

V

T

T

L

M

A

A

Q

E

M

T

V

I

I

T

D

R

A

L

M

V

P

P

S

S

I

C

E

E

M

M

V

V

R

R

M

M

V

V

S

N

S
|
S

G
|
G

T
|
T

E

E

A

A

T

T

M

L

S

S

A

A

I

I

R

R

L

L

A

A

R

R

G

G

Y

A

T

T

G

G

R

R

D

N

K

R

I

I

L

V

K

K

F

F

S

E

G

G

C

C

Y
|
Y

H
|
H

G

G

H

H

A

G

D

D

A

S

L

F

L

L

V

V

K

K

A

A

G

-

S

-

G

-

A

M

A

L

T

T

F

L

G

G

V

V

P

P

D

T

S

S

P

P

G

G

V

V

P

P

A

A

D

G

F

L

A

S

K

E

H

L

T

T

L

L

T

T

A

L

E

P

Y

Y

N

N

S

D

L

F

A

E

S

A

V

A

K

T

T

A

L

L

I

F

T

E

E

Q

N

Q

S

G

G

D

Q

D

I

I

A

A

C

G

I

L

I

I

L

I

E
|
E

P

P

V

V

A

V

G

G

N
|
N

M

A

G

N

T

C

V

I

P

P

P

P

R

R

P

E

G

G

F

Y

L

L

E

Q

G

H

L

L

R

R

E

A

L

L

C

C

T

T

N

K

E

H

G

G

I

A

I

L

L

L

I

I

F

F

D
|
D

E

E

V
|
V

M

M

S

T

G

G

F

F

R

R

V

V

A

A

Y

L

G

G

G

G

A

A

Q

Q

S

A

L

H

Y

Y

G

G

V

I

T

T

P

P

D

D

M

L

T

T

T

T

L

F

G

G

K
|
K

I

I

I

I

G

G

G

G

G

G

L

M

P

P

V

V

G

G

A

A

F

Y

G

G

G

G

K

R

R

R

E

E

I

L

M

M

E

Q

K

Q

L

I

S

A

P

P

S

A

G

G

G

P

V

I

Y

Y

Q

Q

A

A

G

G

T

T

L

L

S

S

G

G

N

N

P

P

L

V

A

A

M

M

T

A

A

A

G

G

I

L

E

A

T

M

L

L

K

E

F

L

L

V

Q

Q

Q

Q

P

P

G

G

F

F

Y

H

D

A

R

D

L

L

E

A

E

E

K

R

S

T

S

A

Q

R

L

L

S

C

E

A

G

G

I

L

S

E

L

A

A

A

A

A

R

A

D

D

A

A

G

G

Y

V

P

A

L

V

Y

T

S

T

T

T

R

R

V

V

G

G

S

A

M

M

F

F

C

G

A

L

F

F

F

F

T

T

P

S

H

E

E

K

V

V

F

E

D

T

W

Y

T

A

T

Q

A

A

A

T

A

A

C

C

D

D

T

I

K

P

A

A

F

F

A

N

R

R

Y

F

F

F

L

H

A

A

M

M

L

L

E

E

E

Q

G

G

V

V

Y

F

L

L

A

A

P

P

S

S

Q

A

F

Y

E

E

T

A

A

G

F

F

M

L

S

S

A

S

A

A

H

H

S

D

Q

D

Q

A

D

V

I

I

E

E

A

A

T

T

I

L

active site: V26 (= V21), Y149 (= Y144), D241 (= D239), K269 (= K267)
binding pyridoxal-5'-phosphate: S121 (= S116), G122 (= G117), T123 (= T118), Y149 (= Y144), H150 (= H145), E208 (= E206), N213 (= N211), D241 (= D239), V243 (= V241), K269 (= K267)

3k28A Crystal structure of a glutamate-1-semialdehyde aminotransferase from bacillus anthracis with bound pyridoxal 5'phosphate
60% identity, 95% coverage: 5:412/428 of query aligns to 6:407/423 of 3k28A

query
sites
3k28A

R

K

S

S

H

I

T

A

L

A

F

F

D

E

Q

E

A

A

R

Q

R

D

I

L

I

M

P

P

G

G

G

G

V
|
V

N

N

S

S

P

P

V

V

R

R

A

A

F

F

K

K

S

S

V

V

G

G

A

M

D

N

P

P

L

L

F

F

I

M

K

E

R

R

A

G

S

K

G

G

S

S

K

K

I

V

F

Y

D

D

E

I

D

D

N

G

N

N

T

E

Y

Y

I

I

D

D

Y

Y

V

V

G

L

S

S

W

W

G

G

P

P

M

L

I

I

L

H

G

G

H

H

C

A

F

N

P

D

E

R

V

V

V

V

N

E

A

A

V

L

K

K

Q

A

C

V

M

A

E

E

N

R

G

G

S

T

S

S

F

F

G

G

A

A

P

P

T

T

E

E

L

I

E

E

I

N

T

K

L

L

A

A

Q

K

M

L

V

V

I
|
I

D

E

A

R

M
x
V

P
|
P

S

S

I
|
I

E

E

M

I

V

V

R

R

M

M

V

V

S

N

S

S

G
|
G

T
|
T

E

E

A

A

T

T

M

M

S

S

A

A

I

L

R

R

L

L

A

A

R

R

G

G

Y

Y

T

T

G

G

R

R

D

N

K

K

I

I

L

L

K

K

F

F

S

I

G

G

C

C

Y
|
Y

H
|
H

G
|
G

H

H

A

G

D

D

A

S

L

L

L

L

V

I

K

K

A

A

G

G

S

S

G

G

A

-

A

-

T

-

F

-

G

-

V

V

P

P

D

D

S

S

P

P

G

G

V

V

P

P

A

E

D

G

F

V

A

A

K

K

H

N

T

T

L

I

T

T

A

V

E

A

Y

Y

N

N

S

D

L

L

A

E

S

S

V

V

K

K

T

Y

L

A

I

F

T

E

E

Q

N

F

S

G

G

D

Q

D

I

I

A

A

C

C

I

V

I

I

L

V

E
|
E

P

P

V

V

A

A

G

G

N

N

M

M

G

G

T

V

V

V

P

P

P

P

R

Q

P

P

G

G

F

F

L

L

E

E

G

G

L

L

R

R

E

E

L

V

C

T

T

E

N

Q

E

N

G

G

I

A

I

L

L

L

I

I

F

F

D
|
D

E

E

V
|
V

M
|
M

S

T

G

G

F

F

R

R

V

V

A

A

Y

Y

G

N

G

C

A

G

Q

Q

S

G

L

Y

Y

Y

G

G

V

V

T

T

P

P

D

D

M

L

T

T

T

C

L

L

G

G

K
|
K

I

V

I

I

G

G

G

G

G

G

L

L

P

P

V

V

G

G

A

A

F

Y

G

G

G

G

K

K

R

A

E

E

I

I

M

M

E

R

K

Q

L

V

S

A

P

P

S

S

G

G

G

P

V

I

Y

Y

Q

Q

A

A

G

G

T

T

L

L

S

S

G

G

N

N

P

P

L

L

A

A

M

M

T

A

A

A

G

G

I

Y

E

E

T

T

L

L

K

V

F

Q

L

L

Q

-

Q

T

P

P

G

E

F

S

Y

Y

D

V

R

E

L

F

E

E

E

R

K

K

S

A

S

E

Q

M

L

L

S

E

E

A

G

G

I

L

S

R

L

K

A

A

A

A

R

E

D

K

A

H

G

G

Y

I

P

P

L

H

Y

H

S

I

T

N

R

R

V

A

G

G

S

S

M

M

F

I

C

G

A

I

F

F

F

F

T

T

P

D

H

E

E

P

V

V

F

I

D

N

W

Y

T

D

T

A

A

A

A

K

A

S

C

S

D

N

T

L

K

Q

A

F

F

F

A

A

R

A

Y

Y

F

Y

L

R

A

E

M

M

L

V

E

E

E

Q

G

G

V

V

Y

F

L

L

A

P

P

P

S

S

Q

Q

F

F

E

E

T
x
G

A

L

F

F

M

L

S

S

A

T

A

V

H

H

S

S

Q

D

Q

A

D

D

active site: V22 (= V21), Y145 (= Y144), E202 (= E206), D235 (= D239), M238 (= M242), K263 (= K267), G396 (≠ T401)
binding calcium ion: I103 (= I102), V106 (≠ M105), P107 (= P106), I109 (= I108)
binding pyridoxal-5'-phosphate: G118 (= G117), T119 (= T118), Y145 (= Y144), H146 (= H145), G147 (= G146), E202 (= E206), D235 (= D239), V237 (= V241), M238 (= M242), K263 (= K267)

3usfB Crystal structure of dava-4
54% identity, 97% coverage: 5:421/428 of query aligns to 5:396/402 of 3usfB

query
sites
3usfB

R

K

S

S

H

D

T

E

L

I

F

F

D

A

Q

A

A

A

R

Q

R

K

I

L

I

M

P

P

G

G

G

G

V
|
V

N

S

S

S

P

P

V

V

R

R

A

A

F

F

K

K

S

S

V

V

G

G

A

G

D

Q

P

P

L

I

F

V

I

F

K

D

R

R

A

V

S

K

G

D

S

A

K

Y

I

A

F

W

D

D

E

V

D

D

N

G

N

N

T

R

Y

Y

I

I

D

D

Y

Y

V

V

G

G

S

T

W

W

G

G

P

P

M

A

I

I

L

C

G

G

H

H

C

A

F

H

P

P

E

E

V

V

V

I

N

E

A

A

V

L

K

K

Q

V

C

A

M

M

E

E

N

K

G

G

S

T

S

S

F

F

G

G

A

A

P

P

T

C

E

A

L

L

E

E

I

N

T

V

L

L

A

A

Q

E

M

M

V

V

I

N

D

D

A

A

M

V

P

P

S

S

I

I

E

E

M

M

V

V

R

R

M

F

V

V

S

N

S

S

G
|
G

T
|
T

E

E

A

A

T

C

M

M

S

A

A

V

I

L

R

R

L

I

A

M

R

R

G

A

Y

Y

T

T

G

G

R

R

D

D

K

K

I

I

L

I

K

K

F

F

S

E

G

G

C

C

Y
|
Y

H

H

G

G

H

H

A

A

D

D

A

T

L

-

L

-

V

-

K

-

A

-

G

-

S

-

G

-

A

-

A

-

T

-

F

-

G

-

V

-

P

-

D

-

S

-

P

-

G

-

V

-

P

-

A

-

D

-

F

-

A

-

K

A

H

N

T

T

L

L

T

T

A

T

E

P

Y

Y

N

N

S

D

L

L

A

E

S

A

V

V

K

K

T

A

L

L

I

F

T

A

E

E

N

N

S

P

G

G

Q

E

I

I

A

A

C

G

I

V

I

I

L

L

E
|
E

P

P

V

I

A

V

G

G

N
|
N

M

S

G

G

T

F

V

I

P

V

P

P

R

D

P

A

G

G

F

F

L

L

E

E

G

G

L

L

R

R

E

E

L

I

C

T

T

L

N

E

E

H

G

D

I

A

I

L

L

L

I

V

F

F

D
|
D

E

E

V
|
V

M
|
M

S

T

G

G

F

F

R

R

V

I

A

A

Y

Y

G

G

G

G

A

V

Q

Q

S

E

L

K

Y

F

G

G

V

V

T

T

P

P

D

D

M

L

T

T

T

T

L

L

G

G

K
|
K

I

I

I

I

G

G

G

G

G

G

L

L

P

P

V

V

G

G

A

A

F

Y

G

G

G

G

K

K

R

R

E

E

I

I

M

M

E

Q

K

L

L

V

S

A

P

P

S

A

G

G

G

P

V

M

Y

Y

Q

Q

A

A

G
|
G

T
|
T

L

L

S

S

G

G

N

N

P

P

L

L

A

A

M

M

T

T

A

A

G

G

I

I

E

K

T

T

L

L

K

E

F

L

L

L

Q

R

Q

Q

P

P

G

G

F

T

Y

Y

D

E

R

Y

L

L

E

D

E

Q

K

I

S

T

S

K

Q

R

L

L

S

S

E

D

G

G

I

L

S

L

L

A

A

I

A

A

R

Q

D

E

A

T

G

G

Y

H

P

A

L

A

Y

C

S

G

T

G

R

Q

V

V

G

S

S

G

M

M

F

F

C

G

A

F

F

F

F

F

T

T

P

E

H

G

E

P

V

V

F

H

D

N

W

Y

T

E

T

D

A

A

A

K

A

K

C

S

D

D

T

L

K

Q

A

K

F

F

A

S

R

R

Y

F

F

H

L

R

A

G

M

M

L

L

E

E

E

Q

G

G

V

I

Y

Y

L

L

A

A

P

P

S

S

Q

Q

F

F

E

E

T
x
A

A

G

F

F

M

T

S

S

A

L

A

A

H

H

S

T

Q

E

Q

E

D

D

I

I

E

D

A

A

T

T

I

L

A

A

A

A

A

A

R

R

active site: V21 (= V21), Y144 (= Y144), E181 (= E206), D214 (= D239), M217 (= M242), K242 (= K267), A376 (≠ T401)
binding (4s)-4,5-diaminopentanoic acid: G273 (= G298), T274 (= T299)
binding (5-hydroxy-4,6-dimethylpyridin-3-yl)methyl dihydrogen phosphate: G117 (= G117), T118 (= T118), Y144 (= Y144), E181 (= E206), N186 (= N211), D214 (= D239), V216 (= V241), M217 (= M242), K242 (= K267)

2hp1B Inter-subunit signaling in gsam (see paper)
54% identity, 97% coverage: 5:421/428 of query aligns to 5:392/398 of 2hp1B

query
sites
2hp1B

R

K

S

S

H

D

T

E

L

I

F

F

D

A

Q

A

A

A

R

Q

R

K

I

L

I

M

P

P

G

G

G

G

V
|
V

N

S

S
|
S

P

P

V
|
V

R
|
R

A

A

F

F

K

K

S

S

V

V

G

G

A

G

D

Q

P

P

L

I

F

V

I

F

K

D

R

R

A

V

S

K

G

D

S

A

K

Y

I

A

F

W

D

D

E

V

D

D

N

G

N

N

T

R

Y

Y

I

I

D

D

Y

Y

V

V

G

G

S

T

W
|
W

G

G

P

P

M

A

I

I

L

C

G

G

H

H

C

A

F

H

P

P

E

E

V

V

V

I

N

E

A

A

V

L

K

K

Q

V

C

A

M

M

E

E

N

K

G

G

S

T

S

S

F

F

G

G

A

A

P

P

T

C

E

A

L

L

E

E

I

N

T

V

L

L

A

A

Q

E

M

M

V

V

I

N

D

D

A

A

M

V

P

P

S

S

I

I

E

E

M

M

V

V

R

R

M

F

V

V

S

N

S
|
S

G
|
G

T
|
T

E

E

A

A

T

C

M

M

S

A

A

V

I

L

R

R

L

I

A

M

R

R

G

A

Y

Y

T

T

G

G

R

R

D

D

K

K

I

I

L

I

K

K

F

F

S

E

G

G

C

C

Y
|
Y

H

H

G

G

H

H

A

-

D

-

A

-

L

-

L

-

V

-

K

-

A

-

G

-

S

-

G

-

A

-

A

-

T

-

F

-

G

-

V

-

P

-

D

-

S

-

P

-

G

-

V

-

P

-

A

-

D

-

F

-

A

-

K

-

H

N

T

T

L

L

T

T

A

T

E

P

Y

Y

N

N

S

D

L

L

A

E

S

A

V

V

K

K

T

A

L

L

I

F

T

A

E

E

N

N

S

P

G

G

Q

E

I

I

A

A

C

G

I

V

I

I

L

L

E
|
E

P

P

V

I

A

V

G

G

N
|
N

M

S

G

G

T

F

V

I

P

V

P

P

R

D

P

A

G

G

F

F

L

L

E

E

G

G

L

L

R

R

E

E

L

I

C

T

T

L

N

E

E

H

G

D

I

A

I

L

L

L

I

V

F

F

D
|
D

E

E

V
|
V

M
|
M

S

T

G

G

F

F

R

R

V

I

A

A

Y

Y

G

G

G

G

A

V

Q

Q

S

E

L

K

Y

F

G

G

V

V

T

T

P

P

D

D

M

L

T

T

T

T

L

L

G

G

K
|
K

I

I

I

I

G

G

G

G

G

G

L

L

P

P

V

V

G

G

A

A

F

Y

G

G

G

G

K

K

R

R

E

E

I

I

M

M

E

Q

K

L

L

V

S

A

P

P

S

A

G

G

G

P

V

M

Y

Y

Q

Q

A

A

G
|
G

T
|
T

L

L

S

S

G

G

N

N

P

P

L

L

A

A

M

M

T

T

A

A

G

G

I

I

E

K

T

T

L

L

K

E

F

L

L

L

Q

R

Q

Q

P

P

G

G

F

T

Y

Y

D

E

R

Y

L

L

E

D

E

Q

K

I

S

T

S

K

Q

R

L

L

S

S

E

D

G

G

I

L

S

L

L

A

A

I

A

A

R

Q

D

E

A

T

G

G

Y

H

P

A

L

A

Y

C

S

G

T

G

R

Q

V

V

G

S

S

G

M

M

F

F

C

G

A

F

F

F

F

F

T

T

P

E

H

G

E

P

V

V

F

H

D

N

W

Y

T

E

T

D

A

A

A

K

A

K

C

S

D

D

T

L

K

Q

A

K

F

F

A

S

R

R

Y

F

F

H

L

R

A

G

M

M

L

L

E

E

E

Q

G

G

V

I

Y

Y

L

L

A

A

P

P

S

S

Q

Q

F

F

E

E

T
x
A

A

G

F

F

M

T

S

S

A

L

A

A

H

H

S

T

Q

E

Q

E

D

D

I

I

E

D

A

A

T

T

I

L

A

A

A

A

A

A

R

R

active site: V21 (= V21), Y144 (= Y144), E177 (= E206), D210 (= D239), M213 (= M242), K238 (= K267), A372 (≠ T401)
binding (4s)-4-amino-5-[({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)amino]pentanoic acid: G269 (= G298), T270 (= T299)
binding (4s)-4,5-diaminopentanoic acid: S23 (= S23), V25 (= V25), R26 (= R26), W61 (= W61), Y144 (= Y144)
binding pyridoxal-5'-phosphate: S116 (= S116), G117 (= G117), T118 (= T118), Y144 (= Y144), E177 (= E206), N182 (= N211), D210 (= D239), V212 (= V241), M213 (= M242), K238 (= K267)

2e7uA Crystal structure of glutamate-1-semialdehyde 2,1-aminomutase from thermus thermophilus hb8
52% identity, 99% coverage: 1:424/428 of query aligns to 1:424/424 of 2e7uA

query
sites
2e7uA

M

M

T

E

H

R

T

P

R

I

S

S

H

E

T

A

L

Y

F

F

D

Q

Q

E

A

A

R

K

R

R

I

H

I

I

P

P

G

G

G

G

V
|
V

N

S

S

S

P

P

V

V

R

R

A

A

F

F

K

K

S

A

V

V

G

G

A

G

D

T

P

P

L

P

F

F

I

L

K

V

R

R

A

G

S

E

G

G

S

A

K

Y

I

V

F

W

D

D

E

A

D

D

N

G

N

N

T

R

Y

Y

I

L

D

D

Y

Y

V

V

G

M

S

S

W

W

G

G

P

P

M

L

I

I

L

L

G

G

H

H

C

A

F

H

P

P

E

K

V

V

V

L

N

A

A

R

V

V

K

R

Q

E

C

T

M

L

E

E

N

R

G

G

S

L

S

T

F

F

G

G

A

A

P

P

T

S

E

P

L

L

E

E

I

V

T

A

L

L

A

A

Q

K

M

K

V

V

I

K

D

R

A

A

M

Y

P

P

S

F

I

V

E

D

M

L

V

V

R

R

M

F

V

V

S

N

S

S

G
|
G

T
|
T

E

E

A

A

T

T

M

M

S

S

A

A

I

L

R

R

L

L

A

A

R

R

G

G

Y

Y

T

T

G

G

R

R

D

P

K

Y

I

I

L

V

K

K

F

F

S

R

G

G

C

N

Y
|
Y

H
|
H

G

G

H

H

A

A

D

D

A

G

L

L

L

L

V

V

K

E

A

A

G

G

S

S

G

G

A

A

A

L

T

T

F

L

G

G

V

V

P

P

D

S

S

S

P

A

G

G

V

V

P

P

A

E

D

E

F

Y

A

A

K

K

H

L

T

T

L

L

T

V

A

L

E

E

Y

Y

N

N

S

D

L

P

A

E

S

G

V

L

K

R

T

E

L

V

I

L

T

K

E

R

N

R

S

G

G

E

Q

E

I

I

A

A

C

A

I

I

I

I

L

F

E
|
E

P

P

V

V

A

V

G

G

N
|
N

M

A

G

G

T

V

V

L

P

V

P

P

R

T

P

E

G

D

F

F

L

L

E

K

G

A

L

L

R

H

E

E

L

-

C

A

T

K

N

A

E

Y

G

G

I

V

I

L

L

L

I

I

F

A

D
|
D

E

E

V
|
V

M
|
M

S

T

G

G

F

F

R

R

V

L

A

A

Y

F

G

G

G

G

A

A

Q

T

S

E

L

L

Y

L

G

G

V

L

T

K

P

P

D

D

M

L

T

V

T

T

L

L

G

G

K
|
K

I

I

I

L

G

G

G

G

G

G

L

L

P

P

V

A

G

A

A

A

F

Y

G

A

G

G

K

R

R

R

E

E

I

I

M

M

E

E

K

K

L

V

S

A

P

P

S

L

G

G

G

P

V

V

Y

Y

Q

Q

A

A

G

G

T

T

L

L

S

S

G

G

N

N

P

P

L

L

A

A

M

M

T

A

A

A

G

G

I

L

E

A

T

T

L

L

K

E

F

L

L

L

Q

E

Q

E

-

N

P

P

G

G

F

Y

Y

Y

D

A

R

Y

L

L

E

E

E

D

K

L

S

G

S

A

Q

R

L

L

S

E

E

A

G

G

I

L

S

K

L

E

A

V

A

L

R

K

D

E

A

K

G

G

Y

L

P

P

L

H

Y

T

S

V

T

N

R

R

V

V

G

G

S

S

M

M

F

I

C

T

A

V

F

F

F

F

T

T

P

E

H

G

E

P

V

V

F

V

D

T

W

F

T

Q

T

D

A

A

A

R

A

R

C

T

D

D

T

T

K

E

A

L

F

F

A

K

R

R

Y

F

F

F

L

H

A

G

M

L

L

L

E

D

E

R

G

G

V

I

Y

Y

L

W

A

P

P

P

S

S

Q

N

F

F

E

E

T
x
A

A

A

F

F

M

L

S

S

A

V

A

A

H

H

S

R

Q

E

Q

E

D

D

I

V

E

E

A

K

T

T

I

L

A

E

A

A

A

L

R

R

K

K

C

A

F

L

active site: V21 (= V21), Y144 (= Y144), E206 (= E206), D238 (= D239), M241 (= M242), K266 (= K267), A401 (≠ T401)
binding 4'-deoxy-4'-aminopyridoxal-5'-phosphate: G117 (= G117), T118 (= T118), Y144 (= Y144), H145 (= H145), N211 (= N211), D238 (= D239), V240 (= V241)

Query Sequence

>WP_012471169.1 NCBI__GCF_000020385.1:WP_012471169.1
MTHTRSHTLFDQARRIIPGGVNSPVRAFKSVGADPLFIKRASGSKIFDEDNNTYIDYVGS
WGPMILGHCFPEVVNAVKQCMENGSSFGAPTELEITLAQMVIDAMPSIEMVRMVSSGTEA
TMSAIRLARGYTGRDKILKFSGCYHGHADALLVKAGSGAATFGVPDSPGVPADFAKHTLT
AEYNSLASVKTLITENSGQIACIILEPVAGNMGTVPPRPGFLEGLRELCTNEGIILIFDE
VMSGFRVAYGGAQSLYGVTPDMTTLGKIIGGGLPVGAFGGKREIMEKLSPSGGVYQAGTL
SGNPLAMTAGIETLKFLQQPGFYDRLEEKSSQLSEGISLAARDAGYPLYSTRVGSMFCAF
FTPHEVFDWTTAAACDTKAFARYFLAMLEEGVYLAPSQFETAFMSAAHSQQDIEATIAAA
RKCFKLIR

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory