Comparing WP_012506439.1 NCBI__GCF_000020625.1:WP_012506439.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
P13009 Methionine synthase; 5-methyltetrahydrofolate--homocysteine methyltransferase; Methionine synthase, vitamin-B12-dependent; MS; EC 2.1.1.13 from Escherichia coli (strain K12) (see 5 papers)
59% identity, 100% coverage: 3:1227/1229 of query aligns to 6:1224/1227 of P13009
Sites not aligning to the query:
Q99707 Methionine synthase; MS; 5-methyltetrahydrofolate--homocysteine methyltransferase; Cobalamin-dependent methionine synthase; Vitamin-B12 dependent methionine synthase; EC 2.1.1.13 from Homo sapiens (Human) (see 6 papers)
55% identity, 100% coverage: 1:1227/1229 of query aligns to 18:1262/1265 of Q99707
4cczA Crystal structure of human 5-methyltetrahydrofolate-homocysteine methyltransferase, the homocysteine and folate binding domains
56% identity, 52% coverage: 1:633/1229 of query aligns to 2:610/611 of 4cczA
3ivaA Structure of the b12-dependent methionine synthase (meth) c-teminal half with adohcy bound (see paper)
56% identity, 47% coverage: 648:1227/1229 of query aligns to 1:574/576 of 3ivaA
3bulA E. Coli i690c/g743c meth c-terminal fragment (649-1227) (see paper)
56% identity, 47% coverage: 648:1227/1229 of query aligns to 1:574/577 of 3bulA
8g3hA Structure of cobalamin-dependent methionine synthase (meth) in a resting state (see paper)
34% identity, 68% coverage: 9:842/1229 of query aligns to 9:806/841 of 8g3hA
Sites not aligning to the query:
3k13C Structure of the pterin-binding domain metr of 5- methyltetrahydrofolate-homocysteine methyltransferase from bacteroides thetaiotaomicron
68% identity, 23% coverage: 354:636/1229 of query aligns to 4:285/287 of 3k13C
6bdyA Crystal structure of the meth reactivation domain bound to sinefungin (see paper)
52% identity, 26% coverage: 904:1227/1229 of query aligns to 4:324/326 of 6bdyA
1mskA Methionine synthase (activation domain) (see paper)
52% identity, 26% coverage: 904:1227/1229 of query aligns to 4:324/327 of 1mskA
1bmtA How a protein binds b12: a 3.O angstrom x-ray structure of the b12- binding domains of methionine synthase (see paper)
62% identity, 20% coverage: 648:894/1229 of query aligns to 1:244/246 of 1bmtA
8sseA Methionine synthase, c-terminal fragment, cobalamin and reactivation domains from thermus thermophilus hb8 (see paper)
30% identity, 44% coverage: 658:1193/1229 of query aligns to 4:504/507 of 8sseA
1q8jA Cobalamin-dependent methionine synthase (1-566) from thermotoga maritima (cd2+, hcy, methyltetrahydrofolate complex) (see paper)
29% identity, 48% coverage: 2:596/1229 of query aligns to 4:538/559 of 1q8jA
3bofA Cobalamin-dependent methionine synthase (1-566) from thermotoga maritima complexed with zn2+ and homocysteine (see paper)
29% identity, 48% coverage: 2:596/1229 of query aligns to 4:538/560 of 3bofA
5vooA Methionine synthase folate-binding domain with methyltetrahydrofolate from thermus thermophilus hb8 (see paper)
32% identity, 22% coverage: 357:632/1229 of query aligns to 5:275/282 of 5vooA
2i2xB Crystal structure of methanol:cobalamin methyltransferase complex mtabc from methanosarcina barkeri (see paper)
32% identity, 14% coverage: 663:839/1229 of query aligns to 46:216/258 of 2i2xB
Sites not aligning to the query:
Q46EH4 Methanol--corrinoid protein; Methanol:corrinoid methyltransferase 1 subunit of 27 kDa; MT1 subunit 27 kDa from Methanosarcina barkeri (strain Fusaro / DSM 804) (see paper)
32% identity, 14% coverage: 663:839/1229 of query aligns to 46:216/258 of Q46EH4
Sites not aligning to the query:
7xcnP Crystal structure of the mttb-mttc complex at 2.7 a resolution (see paper)
30% identity, 14% coverage: 668:839/1229 of query aligns to 14:188/215 of 7xcnP
Sites not aligning to the query:
4jgiB 1.5 angstrom crystal structure of a novel cobalamin-binding protein from desulfitobacterium hafniense dcb-2 (see paper)
32% identity, 11% coverage: 696:834/1229 of query aligns to 44:174/206 of 4jgiB
Sites not aligning to the query:
5dmmA Crystal structure of the homocysteine methyltransferase mmum from escherichia coli, metallated form (see paper)
27% identity, 26% coverage: 6:319/1229 of query aligns to 4:284/288 of 5dmmA
2yckX Methyltransferase bound with tetrahydrofolate (see paper)
31% identity, 20% coverage: 354:595/1229 of query aligns to 11:238/272 of 2yckX
>WP_012506439.1 NCBI__GCF_000020625.1:WP_012506439.1
MRETPQSLLEKKILVLDGAMGTMIQRHKLEEKDFRSERFASHSHPLKGNNDILVLTQPEI
IYDIHCDFLEAGADIIETNTFNANPVSQADYGTEDLIKELNLSAASIARRAADAYTAKNP
SKPRYVAGSMGPTNKTLSLSPDVNNPGYRAVTFQDVVDNYILQLDGLVEGGVDLLLVETV
FDTLNCKAALYAIEEHSRKTGKNLPIMISGTVVDASGRTLSGQTTEAFWISVAHTPNLLS
VGLNCALGSKQMRPFVEALSGIAESYVSVYPNAGLPNEFGEYDDSPEYMASQIADFARSG
FVNIVGGCCGTTPDHIRAIARDVAAIEPRRKPKASHELQLSGLEPLLVNKTTGFINIGER
TNVTGSRKFARLIKEENYDEALSVAREQVENGAQVIDINVDEGMLDSEKVMHEFINLIAS
EPEISKVPLMIDSSKWSVIESGLRCSQGKCIVNSISLKEGEELFKQRAKKILQYGAATVV
MAFDEKGQADSLERRIEICSRAYSILCEEVGFPPEDIIFDPNVLTVATGIEEHDNYAVDF
IESVRWIKQNLPFAKISGGISNVSFSFRGNNPVREAMHAAFLYHAIHAGLDMGIVNAGQL
AIYQDIEPELLERVEDVLLNRRKDATERLVDYAGSMISEDTTKNSPKKAEWRNESVEKRL
EHALIKGIVDFINEDIEEARLKYASPLKVIEGPLMHGMDVIGDLFAAGKMFLPQVVKSAR
VMKKGVAYLIPFIEEEKRKGNDSSAAAKVLLATVKGDVHDIGKNIVSVVLACNNYDVVDI
GVMMPCEKILDAAEKEHADIIGLSGLITPSLDEMVHIAKEMERRGMTIPLLIGGATTSKV
HTAVKIAEHYSGPIVHVLDASRSVPAVNNLVTPSLKTNYVEKLLAGQEELRRKHKEKNAA
KTYLSIAEARKNHAELSWNDAPPAPPLKPGITTFDRVSLDELREYIDWTPFFRVWEIHGL
WPAIKSDPHYGEEATKLYDDANRLLDTMCADTSSLQARGVAGIFPANSNGDDIEVYTDEE
RTTLRCTLHTLRQQAEQKQASPNLALADFIAPKSSGIKDYIGCFTLTTGHGLQEIMDRFA
EDHDDYHRIMAQALADRLAEAFAEMLHRKVRMELWGYAPDESLDHDQLIGEKYRGIRPAP
GYPACPDHTEKPKIFDLLNSEAATGVTLTETFAMNPQASVCGLYFAHPEAKYFILGQIGK
DQVEEYAERKKMTRSEVEKWLAPNLNYTP
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory