Comparing WP_012536063.1 NCBI__GCF_000021485.1:WP_012536063.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
P0A7B5 Glutamate 5-kinase; Gamma-glutamyl kinase; GK; EC 2.7.2.11 from Escherichia coli (strain K12) (see paper)
41% identity, 97% coverage: 5:370/376 of query aligns to 1:365/367 of P0A7B5
2j5tD Glutamate 5-kinase from escherichia coli complexed with glutamate (see paper)
42% identity, 97% coverage: 8:370/376 of query aligns to 2:363/365 of 2j5tD
2j5vB Glutamate 5-kinase from escherichia coli complexed with glutamyl-5- phosphate and pyroglutamic acid (see paper)
37% identity, 97% coverage: 8:370/376 of query aligns to 2:323/325 of 2j5vB
2j5vA Glutamate 5-kinase from escherichia coli complexed with glutamyl-5- phosphate and pyroglutamic acid (see paper)
37% identity, 97% coverage: 8:370/376 of query aligns to 2:321/323 of 2j5vA
2akoA Crystal structure of glutamate 5-kinase from campylobacter jejuni
34% identity, 62% coverage: 9:240/376 of query aligns to 1:219/241 of 2akoA
7wx3B Gk domain of drosophila p5cs filament with glutamate, atp, and NADPH (see paper)
33% identity, 68% coverage: 5:259/376 of query aligns to 9:256/258 of 7wx3B
7f5xA Gk domain of drosophila p5cs filament with glutamate (see paper)
32% identity, 68% coverage: 5:259/376 of query aligns to 9:234/236 of 7f5xA
8j0gB Gk monomer complexes with glutamate and atp
33% identity, 68% coverage: 6:259/376 of query aligns to 5:267/274 of 8j0gB
8j0eB Gk monomer complexes with catalytic intermediate
33% identity, 68% coverage: 6:259/376 of query aligns to 8:262/269 of 8j0eB
8j0fA Gk tetramer with adjacent hooks at reaction state (see paper)
32% identity, 68% coverage: 6:259/376 of query aligns to 9:261/270 of 8j0fA
2bmuB Ump kinase from pyrococcus furiosus complexed with its substrate ump and its substrate analog amppnp (see paper)
34% identity, 29% coverage: 153:261/376 of query aligns to 121:226/226 of 2bmuB
Sites not aligning to the query:
Q8U122 Uridylate kinase; UK; Uridine monophosphate kinase; UMP kinase; UMPK; EC 2.7.4.22 from Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1) (see paper)
34% identity, 29% coverage: 153:261/376 of query aligns to 120:225/225 of Q8U122
Sites not aligning to the query:
2ji5A Structure of ump kinase from pyrococcus furiosus complexed with utp
30% identity, 29% coverage: 153:261/376 of query aligns to 122:219/219 of 2ji5A
Sites not aligning to the query:
2btyA Acetylglutamate kinase from thermotoga maritima complexed with its inhibitor arginine (see paper)
25% identity, 67% coverage: 9:260/376 of query aligns to 22:278/282 of 2btyA
Sites not aligning to the query:
Q9X2A4 Acetylglutamate kinase; N-acetyl-L-glutamate 5-phosphotransferase; NAG kinase; NAGK; EC 2.7.2.8 from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) (see paper)
25% identity, 67% coverage: 9:260/376 of query aligns to 22:278/282 of Q9X2A4
8u0mA Crystal structure of isopentenyl phosphate kinase from thermococcus paralvinellae bound to (e)-2-methylbut-2-en-1-yl monophosphate and atp (see paper)
27% identity, 45% coverage: 90:260/376 of query aligns to 85:244/247 of 8u0mA
Sites not aligning to the query:
8u0mB Crystal structure of isopentenyl phosphate kinase from thermococcus paralvinellae bound to (e)-2-methylbut-2-en-1-yl monophosphate and atp (see paper)
27% identity, 45% coverage: 90:260/376 of query aligns to 86:244/247 of 8u0mB
Sites not aligning to the query:
8u0nA Crystal structure of isopentenyl phosphate kinase from thermococcus paralvinellae bound to 2-cyclopentylideneethyl monophosphate and adp (see paper)
27% identity, 45% coverage: 90:260/376 of query aligns to 84:242/245 of 8u0nA
Sites not aligning to the query:
8u0lA Crystal structure of isopentenyl phosphate kinase from thermococcus paralvinellae bound to (e)-but-2-en-1-yl monophosphate and adp (see paper)
27% identity, 45% coverage: 90:260/376 of query aligns to 86:244/247 of 8u0lA
Sites not aligning to the query:
8u0kA Crystal structure of isopentenyl phosphate kinase from thermococcus paralvinellae bound to dmap and adp (see paper)
27% identity, 45% coverage: 90:260/376 of query aligns to 86:244/247 of 8u0kA
Sites not aligning to the query:
>WP_012536063.1 NCBI__GCF_000021485.1:WP_012536063.1
MSRDLKTAQRWVIKIGSSLLTNNGQGLDLAAIEAWVTQILVLRRHGIELVLVSSGAVAAG
MERLGWSTRPTSLHQLQAAASVGQAALIQVYEDFLRRGNVHGSQVLLTHEDLQDRQRYLN
ARSTLRILLEMGVVPIINENDAIASAEIRFGDNDTLAAMVANLLEADLLVILTDQAGLYD
RDPRHDPHAGLLSEVQAGDPELLRMAGGAGTMLGSGGMITKVRAASRAAQSGAATLIAPG
SADNILLRIWSGEEVGTYFRPGVAKLAARKRWLAGQLRPSGTLHLDAGAVRVLREKGSSL
LPVGITASEGDFQRGDLVRCVDPEGHEVARGLVNFAQHEVLLRLGKGSKALCALFGDVDE
FEIIHRDNLVLSSDHG
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory