Comparing WP_012536544.1 NCBI__GCF_000021485.1:WP_012536544.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
6j5yA Crystal structure of fumarylpyruvate hydrolase from pseudomonas aeruginosa in complex with mn2+ and pyruvate (see paper)
46% identity, 99% coverage: 2:226/227 of query aligns to 1:230/233 of 6j5yA
6fogA X-ray structure of homo sapiens fumarylacetoacetate hydrolase domain containing protein 1 (fahd1) in complex with inhibitor oxalate at 1.94a resolution. (see paper)
43% identity, 86% coverage: 24:219/227 of query aligns to 13:207/218 of 6fogA
Q6P587 Oxaloacetate tautomerase FAHD1, mitochondrial; Acylpyruvase FAHD1; Fumarylacetoacetate hydrolase domain-containing protein 1; FAH domain-containing protein 1; Oxaloacetate decarboxylase; OAA decarboxylase; ODx; YisK-like protein; EC 5.3.2.2; EC 3.7.1.5; EC 4.1.1.112 from Homo sapiens (Human) (see 4 papers)
43% identity, 86% coverage: 24:219/227 of query aligns to 15:209/221 of Q6P587
6sbiA X-ray structure of murine fumarylacetoacetate hydrolase domain containing protein 1 (fahd1) in complex with inhibitor oxalate (see paper)
43% identity, 86% coverage: 24:219/227 of query aligns to 12:206/216 of 6sbiA
Q8R0F8 Oxaloacetate tautomerase FAHD1, mitochondrial; Acylpyruvase FAHD1; Acylpyruvate hydrolase; ApH; Fumarylacetoacetate hydrolase domain-containing protein 1; Oxaloacetate decarboxylase; OAA decarboxylase; ODx; EC 5.3.2.2; EC 3.7.1.5; EC 4.1.1.112 from Mus musculus (Mouse) (see paper)
43% identity, 86% coverage: 24:219/227 of query aligns to 15:209/221 of Q8R0F8
P76004 Oxaloacetate tautomerase YcgM; EC 5.3.2.2 from Escherichia coli (strain K12)
39% identity, 87% coverage: 21:218/227 of query aligns to 14:211/219 of P76004
3v77A Crystal structure of a putative fumarylacetoacetate isomerase/hydrolase from oleispira antarctica (see paper)
34% identity, 93% coverage: 16:225/227 of query aligns to 6:218/224 of 3v77A
1nkqA Crystal structure of yeast ynq8, a fumarylacetoacetate hydrolase family protein
33% identity, 85% coverage: 24:216/227 of query aligns to 9:222/247 of 1nkqA
O06724 Oxaloacetate tautomerase YisK; Oxaloacetate decarboxylase YisK; EC 5.3.2.2; EC 4.1.1.112 from Bacillus subtilis (strain 168) (see paper)
36% identity, 92% coverage: 20:227/227 of query aligns to 88:301/301 of O06724
Sites not aligning to the query:
8sutA Crystal structure of yisk from bacillus subtilis in complex with reaction product 4-hydroxy-2-oxoglutaric acid (see paper)
36% identity, 92% coverage: 20:227/227 of query aligns to 89:302/303 of 8sutA
8skyB Crystal structure of yisk from bacillus subtilis in complex with oxalate (see paper)
36% identity, 92% coverage: 20:227/227 of query aligns to 88:301/303 of 8skyB
6v77B Crystal structure of a putative hpce protein from mycobacterium smegmatis
35% identity, 87% coverage: 7:204/227 of query aligns to 53:246/279 of 6v77B
3qdfA Crystal structure of 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase from mycobacterium marinum (see paper)
31% identity, 89% coverage: 20:222/227 of query aligns to 58:243/252 of 3qdfA
4dbhA Crystal structure of cg1458 with inhibitor (see paper)
31% identity, 87% coverage: 25:222/227 of query aligns to 63:262/269 of 4dbhA
6iymA Fumarylacetoacetate hydrolase (eafah) from psychrophilic exiguobacterium antarcticum (see paper)
31% identity, 98% coverage: 1:222/227 of query aligns to 45:270/277 of 6iymA
8gstC Crystal structure of l-2,4-diketo-3-deoxyrhamnonate hydrolase from sphingomonas sp. (Pyruvate bound-form) (see paper)
31% identity, 87% coverage: 23:219/227 of query aligns to 70:271/290 of 8gstC
8gsrA Crystal structure of l-2,4-diketo-3-deoxyrhamnonate hydrolase from sphingomonas sp. (Apo-form) (see paper)
31% identity, 87% coverage: 23:219/227 of query aligns to 70:271/290 of 8gsrA
6j5xB Crystal structure of fumarylpyruvate hydrolase from corynebacterium glutamicum in complex with mn2+ and pyruvate (see paper)
30% identity, 91% coverage: 13:219/227 of query aligns to 60:269/280 of 6j5xB
6j5xA Crystal structure of fumarylpyruvate hydrolase from corynebacterium glutamicum in complex with mn2+ and pyruvate (see paper)
30% identity, 91% coverage: 13:219/227 of query aligns to 60:269/280 of 6j5xA
Q1NEI7 2,4-didehydro-3-deoxy-L-rhamnonate hydrolase; L-2,4-diketo-3-deoxyrhamnonate hydrolase; L-DKDR hydrolase; SpLRA6; EC 3.7.1.26 from Sphingomonas sp. (strain SKA58) (see paper)
30% identity, 87% coverage: 23:219/227 of query aligns to 65:266/285 of Q1NEI7
>WP_012536544.1 NCBI__GCF_000021485.1:WP_012536544.1
MNYAFPPAPVVTLDAMSSNPFPVRRIFCVGQNYADHAREMGSAPDTEPFFFMKPASAILR
NNSVLPYPPGTTDLQPEVELVVALHKGGKHIPTGKVDDDYVFGYAVGLDMTRRDLQRAAR
EKGQPWEMAKAFDHSAPCTAITPEFYSGTIARGKVELKVNGQIRQSADVGDMLWKIPQIV
HFLSNQVELFPGDLLFTGTPAGVGPVVKGDVIEATVAGLEPLIITIG
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory