SitesBLAST – Find functional sites

 

SitesBLAST

Comparing WP_012537591.1 NCBI__GCF_000021485.1:WP_012537591.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 2 hits to proteins with known functional sites (download)

6sunA Amicoumacin kinase hamin in complex with amp-pnp, ca2+ and ami (see paper)
24% identity, 63% coverage: 32:225/310 of query aligns to 33:236/334 of 6sunA

query
sites
6sunA
A
 
A
G
 
D
V
 
A
E
 
E
N
|
N
S
 
Y
N
x
V
Y
 
Y
F
 
E
L
 
Y
D
 
T
T
 
D
E
 
E
K
 
K
G
 
G
H
 
S
-
 
S
F
 
Y
V
x
I
L
 
L
T
x
K
I
 
I
F
 
T
E
 
H
R
 
T
L
 
I
P
 
R
R
 
R
N
 
S
K
 
S
I
 
T
P
 
-
Y
 
Y
F
 
I
L
 
L
D
 
G
L
 
E
T
 
M
E
 
D
W
 
W
-
 
I
-
 
R
-
 
Y
L
 
L
S
 
S
L
 
Q
H
 
H
G
 
G
I
 
I
P
 
S
C
 
V
P
 
A
R
 
K
P
 
P
V
 
V
H
 
L
T
 
S
T
 
A
A
 
R
G
 
G
T
 
K
S
 
D
L
 
V
S
 
E
T
 
A
L
 
I
C
 
P
G
 
D
K
 
Q
P
 
A
A
 
G
-
 
G
A
 
A
I
 
F
V
 
L
Q
 
L
R
 
R
L
 
V
S
 
Y
G
 
E
A
x
K
S
x
A
I
 
P
E
 
G
G
 
R
R
x
K
V
 
V
P
 
T
S
 
E
V
 
A
T
 
D
E
 
W
I
 
N
G
 
G
M
 
Q
L
 
L
-
 
F
-
 
Q
-
 
A
-
 
L
G
 
G
T
 
A
L
 
Y
L
 
T
A
 
G
R
 
R
M
 
M
H
 
H
L
 
Q
A
 
T
G
 
T
E
 
K
T
 
Q
F
 
Y
P
 
Q
E
 
V
R
 
K
H
 
D
P
 
P
N
 
R
P
 
Y
A
 
K
G
 
R
L
 
Q
L
 
E
W
 
W
W
 
Y
Q
 
E
E
|
E
T
 
E
A
x
Q
R
 
L
H
 
K
L
 
L
V
 
E
P
 
T
H
 
Y
L
 
I
S
 
P
P
 
S
E
 
D
N
 
Q
N
 
T
A
 
V
V
 
V
I
 
L
A
 
Q
D
 
R
E
 
K
I
 
D
A
 
E
Y
 
L
Q
 
M
S
 
Q
A
 
K
L
 
L
N
 
H
R
 
Q
R
 
L
D
 
R
L
 
I
P
 
S
G
 
K
-
 
D
-
 
V
-
 
Y
G
 
G
V
 
L
V
 
V
H
 
H
A
 
A
D
|
D
L
 
L
F
x
H
P
x
H
D
x
G
N
|
N
V
 
F
L
 
H
F
 
Y
E
 
H
K
 
Q
G
 
G
Q
 
E
I
 
I
S
 
I
G
 
A
T
 
-
I
x
F
D
|
D
F
 
F
Y
x
D
Y
x
D
A
 
C
G
 
G
D
 
Y
D
 
H
A
 
W
W
 
F
L
 
I
Y
 
N
D
 
D
L
 
I
A
 
S
V
 
I
V
 
L

Sites not aligning to the query:

6sumA Amicoumacin kinase hamin in complex with amp-pnp, mg2+ and ami (see paper)
24% identity, 63% coverage: 32:225/310 of query aligns to 33:236/335 of 6sumA

query
sites
6sumA
A
 
A
G
 
D
V
 
A
E
|
E
N
|
N
S
 
Y
N
x
V
Y
 
Y
F
 
E
L
 
Y
D
 
T
T
 
D
E
 
E
K
 
K
G
 
G
H
 
S
-
 
S
F
 
Y
V
x
I
L
 
L
T
x
K
I
 
I
F
 
T
E
 
H
R
 
T
L
 
I
P
 
R
R
 
R
N
 
S
K
 
S
I
 
T
P
 
-
Y
 
Y
F
 
I
L
 
L
D
 
G
L
 
E
T
 
M
E
 
D
W
 
W
-
 
I
-
 
R
-
 
Y
L
 
L
S
 
S
L
 
Q
H
 
H
G
 
G
I
 
I
P
 
S
C
 
V
P
 
A
R
 
K
P
 
P
V
 
V
H
 
L
T
 
S
T
 
A
A
 
R
G
 
G
T
 
K
S
 
D
L
 
V
S
 
E
T
 
A
L
 
I
C
 
P
G
 
D
K
 
Q
P
 
A
A
 
G
-
 
G
A
 
A
I
 
F
V
 
L
Q
 
L
R
 
R
L
 
V
S
 
Y
G
 
E
A
x
K
S
x
A
I
 
P
E
 
G
G
 
R
R
x
K
V
 
V
P
 
T
S
 
E
V
 
A
T
 
D
E
 
W
I
 
N
G
 
G
M
 
Q
L
 
L
-
 
F
-
 
Q
-
 
A
-
 
L
G
 
G
T
 
A
L
 
Y
L
 
T
A
 
G
R
 
R
M
 
M
H
 
H
L
 
Q
A
 
T
G
 
T
E
 
K
T
 
Q
F
 
Y
P
 
Q
E
 
V
R
 
K
H
 
D
P
 
P
N
 
R
P
 
Y
A
 
K
G
 
R
L
 
Q
L
 
E
W
 
W
W
 
Y
Q
 
E
E
|
E
T
 
E
A
x
Q
R
 
L
H
 
K
L
 
L
V
 
E
P
 
T
H
 
Y
L
 
I
S
 
P
P
 
S
E
 
D
N
 
Q
N
 
T
A
 
V
V
 
V
I
 
L
A
 
Q
D
 
R
E
 
K
I
 
D
A
 
E
Y
 
L
Q
 
M
S
 
Q
A
 
K
L
 
L
N
 
H
R
 
Q
R
 
L
D
 
R
L
 
I
P
 
S
G
 
K
-
 
D
-
 
V
-
 
Y
G
 
G
V
 
L
V
 
V
H
 
H
A
 
A
D
|
D
L
 
L
F
x
H
P
x
H
D
x
G
N
|
N
V
 
F
L
 
H
F
 
Y
E
 
H
K
 
Q
G
 
G
Q
 
E
I
 
I
S
 
I
G
 
A
T
 
-
I
x
F
D
|
D
F
 
F
Y
 
D
Y
x
D
A
 
C
G
 
G
D
 
Y
D
 
H
A
 
W
W
 
F
L
 
I
Y
 
N
D
 
D
L
 
I
A
 
S
V
 
I
V
 
L

Sites not aligning to the query:

Query Sequence

>WP_012537591.1 NCBI__GCF_000021485.1:WP_012537591.1
MSVYTNVSEHELAQFLRDYELGGACALTGISAGVENSNYFLDTEKGHFVLTIFERLPRNK
IPYFLDLTEWLSLHGIPCPRPVHTTAGTSLSTLCGKPAAIVQRLSGASIEGRVPSVTEIG
MLGTLLARMHLAGETFPERHPNPAGLLWWQETARHLVPHLSPENNAVIADEIAYQSALNR
RDLPGGVVHADLFPDNVLFEKGQISGTIDFYYAGDDAWLYDLAVVANAWCSEADGRFDRA
LVTALWDAYVATRPLQTGEEALWFPLLRAAALRFWLLRLDAMHFRRPGTITQCKDPEEYR
RILLMRQRGA

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory