SitesBLAST – Find functional sites

 

SitesBLAST

Comparing WP_012569196.1 NCBI__GCF_000016185.1:WP_012569196.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 3 hits to proteins with known functional sites (download)

3nvtA 1.95 angstrom crystal structure of a bifunctional 3-deoxy-7- phosphoheptulonate synthase/chorismate mutase (aroa) from listeria monocytogenes egd-e (see paper)
32% identity, 27% coverage: 10:87/285 of query aligns to 1:74/345 of 3nvtA

query
sites
3nvtA
E
 
E
L
 
L
R
 
R
S
 
T
E
 
Q
I
 
V
D
 
D
E
 
Q
I
 
L
D
 
N
A
 
I
A
 
D
L
 
L
H
 
L
D
 
E
L
 
L
V
 
I
M
 
S
R
 
K
R
 
R
T
 
A
A
 
N
L
 
L
V
 
V
E
 
Q
Q
 
E
I
 
I
G
 
G
A
 
K
V
 
I
K
 
K
P
 
-
P
 
-
G
 
G
R
 
R
P
 
-
A
 
-
L
 
F
R
 
D
P
 
P
A
 
L
R
 
R
E
 
E
A
 
R
E
 
E
I
 
M
L
 
L
R
 
N
N
 
T
L
 
I
M
 
L
D
 
A
R
 
A
H
 
N
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E
G
 
G
A
 
P
F
 
F
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E
P
 
D
A
 
S
A
 
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K
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E
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I
I
 
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K
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A
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G
T
 
L
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E
L
 
L
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Q

Sites not aligning to the query:

5j6fA Crystal structure of dah7ps-cm complex from geobacillus sp. With prephenate (see paper)
32% identity, 29% coverage: 5:87/285 of query aligns to 1:84/352 of 5j6fA

query
sites
5j6fA
S
 
N
Q
 
E
T
 
R
L
 
L
N
 
D
E
 
E
L
 
L
R
 
R
S
 
A
E
 
R
I
 
V
D
 
D
E
 
E
I
 
I
D
 
N
A
 
L
A
 
Q
L
 
L
H
 
L
D
 
K
L
 
L
V
 
I
M
 
N
R
 
E
R
|
R
T
 
G
A
 
R
L
 
L
V
 
V
E
 
Q
Q
 
E
I
|
I
G
 
G
A
 
K
V
 
I
K
|
K
P
 
E
-
 
A
P
 
Q
G
 
G
R
 
T
P
 
H
A
 
R
L
x
Y
R
x
D
P
 
P
A
 
V
R
|
R
E
 
E
A
 
R
E
 
K
I
x
M
L
 
L
R
 
D
N
 
L
L
 
I
M
 
S
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E
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H
H
 
N
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D
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G
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F
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E
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T
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T
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L
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Q
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H
M
 
I
W
 
F
R
 
K
E
 
E
M
 
I
I
 
F
S
 
K
A
 
A
L
 
A
T
 
L
R
 
E
L
 
L
Q
 
Q

Sites not aligning to the query:

3tfcA 1.95 angstrom crystal structure of a bifunctional 3-deoxy-7- phosphoheptulonate synthase/chorismate mutase (aroa) from listeria monocytogenes egd-e in complex with phosphoenolpyruvate (see paper)
30% identity, 27% coverage: 11:87/285 of query aligns to 1:73/343 of 3tfcA

query
sites
3tfcA
L
 
L
R
 
R
S
 
T
E
 
Q
I
 
V
D
 
D
E
 
Q
I
 
L
D
 
N
A
 
I
A
 
D
L
 
L
H
 
L
D
 
E
L
 
L
V
 
I
M
 
S
R
 
K
R
 
R
T
 
A
A
 
N
L
 
L
V
 
V
E
 
Q
Q
 
E
I
 
I
G
 
G
A
 
K
V
 
I
K
 
K
P
 
-
P
 
-
G
 
-
R
 
-
P
 
-
A
 
-
L
 
L
R
 
R
-
 
F
-
 
D
P
 
P
A
 
L
R
 
R
E
 
E
A
 
R
E
 
E
I
 
M
L
 
L
R
 
N
N
 
T
L
 
I
M
 
L
D
 
A
R
 
A
H
 
N
Q
 
E
G
 
G
A
 
P
F
 
F
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E
P
 
D
A
 
S
A
 
T
L
 
V
S
 
Q
R
 
K
M
 
L
W
 
F
R
 
K
E
 
E
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I
I
 
F
S
 
K
A
 
A
L
 
G
T
 
L
R
 
E
L
 
L
Q
 
Q

Sites not aligning to the query:

Query Sequence

>WP_012569196.1 NCBI__GCF_000016185.1:WP_012569196.1
MVPVSQTLNELRSEIDEIDAALHDLVMRRTALVEQIGAVKPPGRPALRPAREAEILRNLM
DRHQGAFPPAALSRMWREMISALTRLQGPFAVAVYAPDDQRGFWDLARDHYGSATPMQAA
NSSLAVLRLVAEGSATVGVLPWPEDDDPDPWWRYLFTADAKSPRIIARLPFLARAGREEV
EAMAIAALPLEETGDDRTLLGIELREDMSRGRLKDSLEAAGLPPLQLRTFHLPGGAGSVH
LTEVEAFVGPDDPRLAALYQRLGEALVRLLPIGTYATPIGLARRG

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory