Comparing WP_012590286.1 NCBI__GCF_000021745.1:WP_012590286.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
4mz0A Structure of a ketosynthase-acyltransferase di-domain from module curl of the curacin a polyketide synthase (see paper)
37% identity, 33% coverage: 3:890/2684 of query aligns to 29:896/896 of 4mz0A
O30409 Tyrocidine synthase 3; Tyrocidine synthase III from Brevibacillus parabrevis (see paper)
35% identity, 38% coverage: 1628:2650/2684 of query aligns to 1057:2070/6486 of O30409
Sites not aligning to the query:
P27206 Surfactin synthase subunit 1 from Bacillus subtilis (strain 168) (see paper)
31% identity, 40% coverage: 1582:2665/2684 of query aligns to 1011:2095/3587 of P27206
Sites not aligning to the query:
B2HIL7 Phenolphthiocerol synthesis polyketide synthase type I Pks15/1; Beta-ketoacyl-acyl-carrier-protein synthase I; EC 2.3.1.41 from Mycobacterium marinum (strain ATCC BAA-535 / M) (see paper)
39% identity, 33% coverage: 13:889/2684 of query aligns to 44:914/2104 of B2HIL7
Sites not aligning to the query:
I6XD69 Mycoketide-CoA synthase; Polyketide synthase Pks12; EC 2.3.1.295 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
39% identity, 33% coverage: 13:895/2684 of query aligns to 2059:2926/4151 of I6XD69
P40806 Polyketide synthase PksJ; PKS from Bacillus subtilis (strain 168) (see paper)
30% identity, 38% coverage: 1622:2650/2684 of query aligns to 685:1722/5043 of P40806
Q04747 Surfactin synthase subunit 2 from Bacillus subtilis (strain 168) (see paper)
32% identity, 38% coverage: 1628:2659/2684 of query aligns to 1059:2082/3583 of Q04747
Sites not aligning to the query:
4mz0B Structure of a ketosynthase-acyltransferase di-domain from module curl of the curacin a polyketide synthase (see paper)
34% identity, 33% coverage: 3:890/2684 of query aligns to 20:823/823 of 4mz0B
7s6cB Cryoem structure of modular pks holo-lsd14 stalled at the condensation step and bound to antibody fragment 1b2, composite structure (see paper)
36% identity, 33% coverage: 7:891/2684 of query aligns to 28:890/891 of 7s6cB
Q03131 6-deoxyerythronolide-B synthase EryA1, modules 1 and 2; DEBS 1; 6-deoxyerythronolide B synthase I; Erythronolide synthase; ORF C; EC 2.3.1.94 from Saccharopolyspora erythraea (Streptomyces erythraeus) (see paper)
37% identity, 33% coverage: 8:906/2684 of query aligns to 500:1398/3491 of Q03131
Sites not aligning to the query:
7m7fA 6-deoxyerythronolide b synthase (debs) module 1 in complex with antibody fragment 1b2: state 1 (see paper)
37% identity, 33% coverage: 13:906/2684 of query aligns to 35:926/1390 of 7m7fA
2qo3B Crystal structure of [ks3][at3] didomain from module 3 of 6- deoxyerthronolide b synthase (see paper)
36% identity, 33% coverage: 8:891/2684 of query aligns to 1:873/873 of 2qo3B
Q03133 6-deoxyerythronolide-B synthase EryA3, modules 5 and 6; DEBS 3; 6-deoxyerythronolide B synthase III; Erythronolide synthase; ORF C; EC 2.3.1.94 from Saccharopolyspora erythraea (Streptomyces erythraeus) (see 2 papers)
38% identity, 33% coverage: 13:893/2684 of query aligns to 41:902/3172 of Q03133
Sites not aligning to the query:
Q9ZGI5 Narbonolide/10-deoxymethynolide synthase PikA1, modules 1 and 2; Narbonolide/10-deoxymethynolide synthase PikAI; Pikromycin polyketide synthase component PikAI; Pikromycin PKS component PikAI; Type I modular polyketide synthase PikAI; PKS; EC 2.3.1.239; EC 2.3.1.240 from Streptomyces venezuelae (see paper)
37% identity, 33% coverage: 13:890/2684 of query aligns to 91:974/4613 of Q9ZGI5
Sites not aligning to the query:
7vefA The structure of gfsa ksq-at didomain in complex with a malonate substrate analog (see paper)
37% identity, 33% coverage: 13:891/2684 of query aligns to 6:828/828 of 7vefA
8in9A The structure of the gfsa ksq-at didomain in complex with the gfsa acp domain (see paper)
37% identity, 33% coverage: 13:891/2684 of query aligns to 6:820/820 of 8in9A
Q03132 6-deoxyerythronolide-B synthase EryA2, modules 3 and 4; DEBS 2; 6-deoxyerythronolide B synthase II; Erythronolide synthase; ORF B; EC 2.3.1.94 from Saccharopolyspora erythraea (Streptomyces erythraeus) (see 4 papers)
36% identity, 33% coverage: 7:901/2684 of query aligns to 28:916/3567 of Q03132
Sites not aligning to the query:
6mfzA Crystal structure of dimodular lgra in a condensation state (see paper)
31% identity, 38% coverage: 1641:2650/2684 of query aligns to 789:1773/1789 of 6mfzA
Sites not aligning to the query:
4zxiA Crystal structure of holo-ab3403 a four domain nonribosomal peptide synthetase bound to amp and glycine (see paper)
30% identity, 37% coverage: 1617:2619/2684 of query aligns to 7:1003/1314 of 4zxiA
4zxhA Crystal structure of holo-ab3403 a four domain nonribosomal peptide synthetase from acinetobacter baumanii (see paper)
30% identity, 37% coverage: 1617:2619/2684 of query aligns to 7:1003/1314 of 4zxhA
>WP_012590286.1 NCBI__GCF_000021745.1:WP_012590286.1
MKENVAVETPPGVAIIGMAGRFPGADDVAAFWRNLRENVESISHFTDAELEDAFDPSVRG
DPNFVRARSILEGVENFDAGFFAMHAREAELTDPQHRVFLECAWQALEDAGYDPATYKDA
IGVFAGCSMSTYFLRNVLKDRAAVELFTSNYQVGSYGELIGALPDVFATRLSYKLGLRGP
AMTIQTACSTSLVAIAEACKSLLLYESDMALAGGVSITFPQKRGYLALEGAMVSPTGHVR
SFDAKADGTVFGSGAGVVLLKRVEDAIADGDTIYAVIRGTALNNDGAARAGFTAPSVNGQ
WEVIAAALANAEVEARSISYVECHGTATPLGDPIEVAGLTRAFRASTDDTGFCALGSVKP
NVGHLDAAAGVAGVIKTALALKTKQLPATLHFETPNPHIAFEGGPFYVNKTWRDWPQEAE
PRRAGVSAFGVGGTNAHIVLEEAPLAVSEASGRPTQIICVSARSAAALEKSRENLAAYLA
EKPQAPLADVAFTMAVGRRAFAHRAAIVADDAAAASAALISGRDLVFGVPKAEPRKIAFM
FPGQGAQYPAMGHGLFETEPAFADSMRRSAEILRPILNADLCALLYGDEPGRLSAQALQA
TEFAQPALFSVGLALAELWRQRGVAPQMMIGHSVGEFVGACLAGVFSHEDALRLIAARGR
LMQEMPSGSMMAVRLPEAELLPYLKGDVALAAVNGPKLCVAAGPDEAIAALDAQLSAQGV
MTRRLHTSHAFHSPMMEPAANALRKVVEGVKLSPPTAPLISSTTGGWLTAEEAVSPHYWA
AHCREPVRFAAGLKTLLDAAGVDPILIEAGPGLALSALARQCGAGNAPDAVVASLPEASR
EASDMEVFARATAQLWCAGVAIDWRAVYSNERRLRVPLPTYPFERARHWLEAPPVAHAAA
AVSNIAPREPEVLASLAAGASPAFPTHEIFPPMAAAPMTTSQFDSAPAAAGTIEKLQKHL
VDLLESLSGESVADAAPDATFLEMGFDSLFLSQVTQQLQRDFKVKLTFRQLLGDLATIPA
LAAHIEEVLPPEIRAAYQPSAPAPAVAAAQAPAAAPLAAAAFATPAASSLPLLGAGASGV
EQIIRDQLETMSRLMANQLAALGGAPAAAASPAAAVAAPAPAARAPTPAPSLAAAASAAA
APSGDEPKSRFELLAAARSAPAADMNEIQQRALAELTERFNARSPSSKRMTAEYRPVLAD
PRAAAGFRPEWKDLVYPVVSDRAAGSRIYDVDGNDYIDLVNGYGQTFFGHAAPFVVDAVA
AQLKQGFAIGPQSHLAGKVAALFSEMTGNERVTFCNTGSEAVMAAMRIARTVTGRSTIVT
FTGDYHGQFDEVLVKGALRSGVARAMPAAAGIPNKSVENMVVLPYGAPDSLDWIRTHADD
LAAVLVEPVQSRHPDLRPLEFLKEIRAITEKSGAALIFDEVVTGFRMHPGGMQHLFGIRA
DLATYGKVVGGGLPVGILAGKAAFMDALDGGQWRYGDDSYPETGMTFFAGTFVRHPLVMA
AVWAVLNHLKEKGPALQEAVSARTAGLVQRLSDFLRQRGVDLQIESFGSLFFFNFGNISR
YAGLFYPLMLERGVYIQEHYPCFLTTAHSEADVEAIARAFEDSVTAMQKADFLPAPAGLG
PEPETDGPLTEAQTEIWLSAQLSDEASCAFNESVTLRLRGDLNRDALEAALNKVIARHDA
LRAVFTADGARMQIQPELTLTLEPRDLSDLPRAEAEASWRAALAQDARTPFDLVAGPVIR
ASLARFAADDHALALTAHHIVCDGWSFNVIIDEVTKLYEEIVADVAADLPPPMSFLRYGA
EERARQKREGAAVDAFWLPQFTPPPPPLELPTDRPRRLQKSFAGATLTRRIDADLTQRFR
KATAKQGCTLFVALLASFEVMLARLAGQNEVVVGIPAAGQSLAEADSLVGHCVNFLPLRA
RWSDGATMAEHLAATRQGVLAAYEHQSFTLGTLVRKMDRPREAGRRPLVEVQFNLEKLGD
KIHLKGLEVEAQSNPKAAVIFDFFFNVTEQDGGLRIDCDYNTDLYDEATVERWIGHYRSL
LGAVADDAARPIAALPLLSAEQRNWLTKGLNDTAADDLDLRPVHELFAAQAAKTPDAVAA
RFGESALTYRQLDERANRLANHLAAVVKDSSARIGVAAERSLDMLVVLLAVMKTGCAYVP
LDPSHPAARLRLVLDNAAVSAIVSDNAFMGAMASGTPVVRLDADAAAIAARPATAPAFPS
DGARPAYVIFTSGSTGVPKGVEIAHRSVANLLWSIARKLEAGPRDTLVAATTISFDIAAL
ELYMPLITGGTVVIASRDDVRGGFGLAALIEKPETTIVQATPSLWRMLTEAGFKPRPGLR
MLCGGEALPRDLADLLLANDGELWNVYGPTETTIWSSIGRVKPAPAPITIGEPVANTGLY
VLDKAHQLAAPGVVGELFIGGLGLAIGYFRRPDLDTAAFFNIAVDDSGPQRLYRTGDLAR
RLADGSIEVLGRVDAQVKLRGFRIELEEIEAAMRQCPGVSAFAAAVQTPPQGTPRLVGYY
VAAQPILAQELSSYAAQRLPDYMAPALWMRLDALPFTPNAKLDRKALPQPEVGSGEHKRI
VTAPRTPLEAKLAAIWGEVLQLDEIGVNDNIFALGADSIHLFRIAARMMAENLGLEARHL
MRFPTIAELAGAAGDKSVSAAKAPSAAPSLKSFRRGAQIKETSA
Or try a new SitesBLAST search
SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory