SitesBLAST
Comparing WP_012591496.1 NCBI__GCF_000021745.1:WP_012591496.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
4rosA Crystal structure of methylobacterium extorquens malate dehydrogenase complexed with oxaloacetate and adenosine-5-diphosphoribose
82% identity, 99% coverage: 2:319/321 of query aligns to 1:318/318 of 4rosA
- active site: R88 (= R89), D148 (= D149), R151 (= R152), H175 (= H176)
- binding adenosine-5-diphosphoribose: G11 (= G12), Q12 (= Q13), I13 (= I14), D33 (= D34), I34 (= I35), T77 (= T78), A78 (= A79), G79 (= G80), V80 (= V81), P81 (= P82), V98 (= V99), T119 (= T120), N120 (= N121)
- binding oxaloacetate ion: R82 (= R83), R88 (= R89), N120 (= N121), L147 (= L148), R151 (= R152), H175 (= H176), G218 (= G219)
5ujkA Malate dehydrogenase from methylobacterium extorquens, complexed with NAD (see paper)
82% identity, 98% coverage: 2:316/321 of query aligns to 1:315/315 of 5ujkA
- active site: R88 (= R89), D148 (= D149), R151 (= R152), H175 (= H176)
- binding nicotinamide-adenine-dinucleotide: G11 (= G12), Q12 (= Q13), I13 (= I14), D33 (= D34), I34 (= I35), T77 (= T78), A78 (= A79), G79 (= G80), V98 (= V99), I118 (= I119), N120 (= N121), M143 (= M144), L147 (= L148), H175 (= H176)
3gvhA Crystal structure of lactate/malate dehydrogenase from brucella melitensis
79% identity, 99% coverage: 2:319/321 of query aligns to 1:318/318 of 3gvhA
- active site: R88 (= R89), D148 (= D149), R151 (= R152), H175 (= H176)
- binding nicotinamide-adenine-dinucleotide: G11 (= G12), I13 (= I14), D33 (= D34), I34 (= I35), T77 (= T78), A78 (= A79), I118 (= I119), N120 (= N121), M143 (= M144), L147 (= L148), H175 (= H176)
3gviA Crystal structure of lactate/malate dehydrogenase from brucella melitensis in complex with adp
78% identity, 99% coverage: 2:319/321 of query aligns to 1:313/314 of 3gviA
4plyA Crystal structure of ancestral apicomplexan malate dehydrogenase with malate. (see paper)
66% identity, 97% coverage: 3:313/321 of query aligns to 2:317/318 of 4plyA
- active site: D153 (= D149), R156 (= R152), H180 (= H176)
- binding 1,4-dihydronicotinamide adenine dinucleotide: G11 (= G12), N12 (≠ Q13), I13 (= I14), D33 (= D34), I34 (= I35), Y65 (= Y66), T77 (= T78), A78 (= A79), G79 (= G80), I80 (≠ V81), P81 (= P82), I103 (≠ V99), V123 (≠ I119), N125 (= N121), M148 (= M144), L152 (= L148), H180 (= H176), P239 (= P235)
- binding pyruvic acid: W91 (≠ M87), R93 (= R89), N125 (= N121), R156 (= R152), H180 (= H176), G223 (= G219)
4pltB Crystal structure of ancestral apicomplexan malate dehydrogenase with oxamate. (see paper)
66% identity, 97% coverage: 3:313/321 of query aligns to 3:318/319 of 4pltB
- active site: R94 (= R89), D154 (= D149), R157 (= R152), H181 (= H176)
- binding 1,4-dihydronicotinamide adenine dinucleotide: G12 (= G12), N13 (≠ Q13), I14 (= I14), F33 (= F33), D34 (= D34), I35 (= I35), T78 (= T78), A79 (= A79), G80 (= G80), I81 (≠ V81), P82 (= P82), I104 (≠ V99), V124 (≠ I119), N126 (= N121), M149 (= M144), H181 (= H176), P240 (= P235)
4plfB Crystal structure of ancestral apicomplexan lactate dehydrogenase with lactate. (see paper)
59% identity, 98% coverage: 3:315/321 of query aligns to 4:321/330 of 4plfB
- active site: R95 (= R89), D155 (= D149), R158 (= R152), H182 (= H176)
- binding nicotinamide-adenine-dinucleotide: G13 (= G12), M14 (≠ Q13), I15 (= I14), F34 (= F33), D35 (= D34), V36 (≠ I35), T79 (= T78), A80 (= A79), G81 (= G80), L82 (≠ V81), T83 (≠ P82), I105 (≠ V99), I125 (= I119), N127 (= N121), M150 (= M144), H182 (= H176), P241 (= P235)
- binding pyruvic acid: W93 (≠ M87), R95 (= R89), N127 (= N121), R158 (= R152), H182 (= H176)
4plcA Crystal structure of ancestral apicomplexan lactate dehydrogenase with malate. (see paper)
59% identity, 98% coverage: 3:315/321 of query aligns to 4:321/324 of 4plcA
- active site: R95 (= R89), D155 (= D149), R158 (= R152), H182 (= H176)
- binding 1,4-dihydronicotinamide adenine dinucleotide: G13 (= G12), M14 (≠ Q13), I15 (= I14), D35 (= D34), V36 (≠ I35), T79 (= T78), A80 (= A79), G81 (= G80), L82 (≠ V81), T83 (≠ P82), I125 (= I119), N127 (= N121), M150 (= M144), H182 (= H176), P241 (= P235)
- binding pyruvic acid: W93 (≠ M87), R95 (= R89), N127 (= N121), R158 (= R152), H182 (= H176), G225 (= G219)
6vdjA Crystal structure of ancestral apicomplexan lactate dehydrogenase with sulfate and nadh4.
63% identity, 98% coverage: 3:316/321 of query aligns to 2:308/308 of 6vdjA
- binding 1,4,5,6-tetrahydronicotinamide adenine dinucleotide: G11 (= G12), M12 (≠ Q13), I13 (= I14), D33 (= D34), V34 (≠ I35), A78 (= A79), I91 (≠ V99), I111 (= I119), T112 (= T120), N113 (= N121), M136 (= M144), H168 (= H176)
7byaA Malate dehydrogenase from geobacillus stearothermophilus (gs-mdh) complexed with oxaloacetic acid (oaa) and adenosine 5'- diphosphoribose (apr) (see paper)
55% identity, 96% coverage: 1:309/321 of query aligns to 2:307/311 of 7byaA
7by9A Malate dehydrogenase from geobacillus stearothermophilus (gs-mdh) complexed with oxaloacetic acid (oaa) and nicotinamide adenine dinucleotide (NAD) (see paper)
55% identity, 96% coverage: 1:309/321 of query aligns to 2:307/311 of 7by9A
- binding nicotinamide-adenine-dinucleotide: G11 (= G10), G13 (= G12), F14 (≠ Q13), T15 (≠ I14), D35 (= D34), I36 (= I35), T81 (= T78), A82 (= A79), I102 (≠ V99), Q105 (≠ A102), V106 (= V103), L122 (≠ I119), N124 (= N121), V126 (≠ L123)
- binding oxaloacetate ion: L151 (= L148), R155 (= R152), H179 (= H176), G217 (= G219)
P49814 Malate dehydrogenase; Vegetative protein 69; VEG69; EC 1.1.1.37 from Bacillus subtilis (strain 168) (see 2 papers)
54% identity, 96% coverage: 2:310/321 of query aligns to 4:309/312 of P49814
- S149 (≠ A145) modified: Phosphoserine
Sites not aligning to the query:
- 1 modified: Initiator methionine, Removed
7f8dA Malate dehydrogenase from geobacillus stearothermophilus (gs-mdh) g218y mutant (see paper)
55% identity, 96% coverage: 1:309/321 of query aligns to 4:309/313 of 7f8dA
- binding nicotinamide-adenine-dinucleotide: G15 (= G12), F16 (≠ Q13), T17 (≠ I14), D37 (= D34), I38 (= I35), L41 (vs. gap), Y71 (= Y66), T83 (= T78), A84 (= A79), G85 (= G80), L124 (≠ I119), T125 (= T120), N126 (= N121), Q149 (≠ M144), L153 (= L148), P235 (= P235)
1uxgA Large improvement in the thermal stability of a tetrameric malate dehydrogenase by single point mutations at the dimer-dimer interface. (see paper)
55% identity, 97% coverage: 3:313/321 of query aligns to 1:306/308 of 1uxgA
- active site: R87 (= R89), D147 (= D149), R150 (= R152), H174 (= H176)
- binding fumaric acid: R81 (= R83), R87 (= R89), L146 (= L148), R150 (= R152), H174 (= H176), G212 (= G219), S223 (= S230)
- binding nicotinamide-adenine-dinucleotide: G10 (= G12), F11 (≠ Q13), V12 (≠ I14), D32 (= D34), T76 (= T78), S77 (≠ A79), G78 (= G80), A79 (≠ V81), P80 (= P82), C101 (≠ V103), V117 (≠ I119), N119 (= N121), Q142 (≠ M144), H174 (= H176), P228 (= P235)
P80040 Malate dehydrogenase; EC 1.1.1.37 from Chloroflexus aurantiacus (strain ATCC 29366 / DSM 635 / J-10-fl) (see 2 papers)
54% identity, 97% coverage: 3:313/321 of query aligns to 2:307/309 of P80040
2hjrB Crystal structure of cryptosporidium parvum malate dehydrogenase (see paper)
55% identity, 97% coverage: 3:313/321 of query aligns to 2:312/314 of 2hjrB
- active site: R88 (= R89), D148 (= D149), R151 (= R152), H175 (= H176)
- binding adenosine-5-diphosphoribose: G11 (= G12), Q12 (= Q13), I13 (= I14), D33 (= D34), I34 (= I35), I35 (≠ A36), Y65 (= Y66), T77 (= T78), A78 (= A79), G79 (= G80), V80 (= V81), P81 (= P82), T119 (= T120), N120 (= N121)
P80039 Malate dehydrogenase; EC 1.1.1.37 from Chlorobaculum tepidum (strain ATCC 49652 / DSM 12025 / NBRC 103806 / TLS) (Chlorobium tepidum) (see paper)
51% identity, 97% coverage: 5:316/321 of query aligns to 2:306/310 of P80039
1sowA T. Gondii bradyzoite-specific ldh (ldh2) in complex with NAD and oxalate
50% identity, 94% coverage: 3:305/321 of query aligns to 5:312/322 of 1sowA
- active site: R96 (= R89), D156 (= D149), R159 (= R152), H183 (= H176)
- binding nicotinamide-adenine-dinucleotide: G14 (= G12), M15 (≠ Q13), I16 (= I14), D36 (= D34), V37 (≠ I35), T80 (= T78), A81 (= A79), G82 (= G80), L83 (≠ V81), T84 (≠ P82), I106 (≠ V99), E109 (≠ A102), V126 (≠ I119), T127 (= T120), N128 (= N121), M151 (= M144), L155 (= L148), H183 (= H176), P242 (= P235)
- binding oxalate ion: W94 (≠ M87), R96 (= R89), R159 (= R152), H183 (= H176), G226 (= G219)
3czmB T. Gondii bradyzoite-specific ldh (ldh2) in complex with NAD and oxq
50% identity, 94% coverage: 3:305/321 of query aligns to 6:313/323 of 3czmB
- active site: R97 (= R89), D157 (= D149), R160 (= R152), H184 (= H176)
- binding nicotinamide-adenine-dinucleotide: G15 (= G12), M16 (≠ Q13), I17 (= I14), D37 (= D34), V38 (≠ I35), T81 (= T78), A82 (= A79), G83 (= G80), L84 (≠ V81), T85 (≠ P82), I107 (≠ V99), V127 (≠ I119), N129 (= N121), M152 (= M144), H184 (= H176)
- binding 4-hydroxy-1,2,5-oxadiazole-3-carboxylic acid: W95 (≠ M87), R97 (= R89), N129 (= N121), R160 (= R152), H184 (= H176), G227 (= G219), S238 (= S230)
1guzA Structural basis for thermophilic protein stability: structures of thermophilic and mesophilic malate dehydrogenases (see paper)
50% identity, 97% coverage: 5:315/321 of query aligns to 2:305/305 of 1guzA
- active site: D147 (= D149), R150 (= R152), H174 (= H176)
- binding nicotinamide-adenine-dinucleotide: G9 (= G12), N10 (≠ Q13), V11 (≠ I14), D32 (= D34), V33 (≠ I35), T76 (= T78), G78 (= G80), L79 (≠ V81), P80 (= P82), I97 (≠ V99), V117 (≠ I119), N119 (= N121), M142 (= M144), L146 (= L148), H174 (= H176), P228 (= P235)
Query Sequence
>WP_012591496.1 NCBI__GCF_000021745.1:WP_012591496.1
MARSKIALIGAGQIGGTLAHLAALKELGDIVLFDIAEGTPQGKALDLAESGPVEGFNASL
KGANSYADIAGADVIIVTAGVPRKPGMSRDDLLGINLKVMDAVGGGIKQYAPDAFVICIT
NPLDAMVWALQKSSGLAPAKIVGMAGVLDSARFRYFLSEEFKVSVEDVTAFVLGGHGDDM
VPSLRYSTVAGIPLTDLVKLGWTTQERLDAIVERTRKGGGEIVNLLKTGSAFYAPAASAI
AMAEAYLKDKRRVLPCAAQLSGQYGVDNLYVGVPVVIGANGVEKIVEVTLDESEKAMFAK
SVESVRGLVEACKVINPALAG
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SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory