Comparing WP_012609330.1 NCBI__GCF_000429905.1:WP_012609330.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 7 hits to proteins with known functional sites (download)
Q58667 Methanogen homoaconitase small subunit; HACN; Homoaconitate hydratase; EC 4.2.1.114 from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) (see paper)
51% identity, 95% coverage: 4:161/166 of query aligns to 3:159/170 of Q58667
2pkpA Crystal structure of 3-isopropylmalate dehydratase (leud)from methhanocaldococcus jannaschii dsm2661 (mj1271) (see paper)
51% identity, 95% coverage: 4:161/166 of query aligns to 3:159/167 of 2pkpA
O14289 3-isopropylmalate dehydratase; Alpha-IPM isomerase; IPMI; Isopropylmalate isomerase; EC 4.2.1.33 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
35% identity, 84% coverage: 14:152/166 of query aligns to 554:706/758 of O14289
Sites not aligning to the query:
P9WK95 3-isopropylmalate dehydratase small subunit; Alpha-IPM isomerase; IPMI; Isopropylmalate isomerase; EC 4.2.1.33 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
37% identity, 58% coverage: 14:110/166 of query aligns to 18:119/198 of P9WK95
Sites not aligning to the query:
P20004 Aconitate hydratase, mitochondrial; Aconitase; Citrate hydro-lyase; EC 4.2.1.3 from Bos taurus (Bovine) (see 2 papers)
29% identity, 58% coverage: 13:108/166 of query aligns to 611:711/780 of P20004
Sites not aligning to the query:
P39533 Homocitrate dehydratase, mitochondrial; Aconitase 2; EC 4.2.1.- from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
34% identity, 56% coverage: 51:143/166 of query aligns to 656:752/789 of P39533
Sites not aligning to the query:
P19414 Aconitate hydratase, mitochondrial; Aconitase; Citrate hydro-lyase; EC 4.2.1.3 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 2 papers)
45% identity, 28% coverage: 55:101/166 of query aligns to 655:701/778 of P19414
Sites not aligning to the query:
>WP_012609330.1 NCBI__GCF_000429905.1:WP_012609330.1
MENIKGKVWTFGDDVDTDLIIAARYLTTSDPDELAKHCMEDADPAFAGKVGKGDIMVAGK
NFGCGSSREHAPISIKAAGVTCVIAKSFARIFYRNAFNTGLPILECAEADAIEDGAVLTV
DFDNGVITDESTGKTYQTKPIPPFMQELLDSGGLMEHIAQKIKANG
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory