Comparing WP_012631353.1 NCBI__GCF_000022085.1:WP_012631353.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
7uoiA Crystallographic structure of dape from enterococcus faecium (see paper)
28% identity, 100% coverage: 1:373/373 of query aligns to 5:383/383 of 7uoiA
8uw6B Acetylornithine deacetylase from escherichia coli, di-zinc form. (see paper)
30% identity, 92% coverage: 30:372/373 of query aligns to 37:379/381 of 8uw6B
Sites not aligning to the query:
Q03154 Aminoacylase-1; ACY-1; N-acyl-L-amino-acid amidohydrolase; EC 3.5.1.14 from Homo sapiens (Human) (see 6 papers)
27% identity, 70% coverage: 7:268/373 of query aligns to 15:291/408 of Q03154
Sites not aligning to the query:
P44514 Succinyl-diaminopimelate desuccinylase; SDAP desuccinylase; N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase; EC 3.5.1.18 from Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) (see 3 papers)
28% identity, 66% coverage: 7:253/373 of query aligns to 8:258/377 of P44514
Sites not aligning to the query:
5vo3A Crystal structure of dape in complex with the products (succinic acid and diaminopimelic acid) (see paper)
28% identity, 66% coverage: 7:253/373 of query aligns to 12:262/380 of 5vo3A
Sites not aligning to the query:
P37111 Aminoacylase-1; ACY-1; N-acyl-L-amino-acid amidohydrolase; EC 3.5.1.14 from Sus scrofa (Pig) (see paper)
29% identity, 71% coverage: 7:271/373 of query aligns to 15:289/407 of P37111
Sites not aligning to the query:
3rzaA Crystal structure of a tripeptidase (sav1512) from staphylococcus aureus subsp. Aureus mu50 at 2.10 a resolution
28% identity, 92% coverage: 9:350/373 of query aligns to 13:349/373 of 3rzaA
7lgpB Dape enzyme from shigella flexneri
26% identity, 98% coverage: 7:373/373 of query aligns to 10:377/377 of 7lgpB
3pfoA Crystal structure of a putative acetylornithine deacetylase (rpa2325) from rhodopseudomonas palustris cga009 at 1.90 a resolution
31% identity, 59% coverage: 67:286/373 of query aligns to 99:326/426 of 3pfoA
Sites not aligning to the query:
7t1qA Crystal structure of the succinyl-diaminopimelate desuccinylase (dape) from acinetobacter baumannii in complex with succinic acid
28% identity, 62% coverage: 23:253/373 of query aligns to 22:258/377 of 7t1qA
Sites not aligning to the query:
4o23A Crystal structure of mono-zinc form of succinyl diaminopimelate desuccinylase from neisseria meningitidis mc58 (see paper)
29% identity, 66% coverage: 7:253/373 of query aligns to 8:258/376 of 4o23A
4pqaA Crystal structure of succinyl-diaminopimelate desuccinylase from neisseria meningitidis mc58 in complex with the inhibitor captopril (see paper)
29% identity, 66% coverage: 7:253/373 of query aligns to 8:258/375 of 4pqaA
Sites not aligning to the query:
4h2kA Crystal structure of the catalytic domain of succinyl-diaminopimelate desuccinylase from haemophilus influenzae (see paper)
37% identity, 35% coverage: 7:138/373 of query aligns to 10:137/258 of 4h2kA
Sites not aligning to the query:
1q7lA Zn-binding domain of the t347g mutant of human aminoacylase-i (see paper)
30% identity, 36% coverage: 7:140/373 of query aligns to 9:144/192 of 1q7lA
Sites not aligning to the query:
Q8P8J5 N-acetyl-L-citrulline deacetylase; ACDase; Acetylcitrulline deacetylase; EC 3.5.1.- from Xanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25) (see paper)
30% identity, 92% coverage: 11:352/373 of query aligns to 15:346/366 of Q8P8J5
P06621 Carboxypeptidase G2; CPDG2; Folate hydrolase G2; Glutamate carboxypeptidase; Pteroylmonoglutamic acid hydrolase G2; Glucarpidase; EC 3.4.17.11 from Pseudomonas sp. (strain RS-16) (see paper)
26% identity, 92% coverage: 24:366/373 of query aligns to 64:404/415 of P06621
1cg2A Carboxypeptidase g2 (see paper)
26% identity, 91% coverage: 24:364/373 of query aligns to 39:377/389 of 1cg2A
2f7vA Structure of acetylcitrulline deacetylase complexed with one co (see paper)
30% identity, 92% coverage: 11:352/373 of query aligns to 16:341/360 of 2f7vA
7m6uB Crystal structure of a circular permutation and computationally designed pro-enzyme of carboxypeptidase g2 (see paper)
26% identity, 80% coverage: 67:364/373 of query aligns to 17:312/392 of 7m6uB
Q8C165 N-fatty-acyl-amino acid synthase/hydrolase PM20D1; Peptidase M20 domain-containing protein 1; PM20D1; EC 3.5.1.114; EC 3.5.1.14 from Mus musculus (Mouse) (see paper)
26% identity, 70% coverage: 49:310/373 of query aligns to 102:424/503 of Q8C165
Sites not aligning to the query:
>WP_012631353.1 NCBI__GCF_000022085.1:WP_012631353.1
MNNPEVLALDLVRFDTISPPGSESACAAHLAVLLRRAGFDVTDYPFAPGRTSLVARLPGT
NPALAPLVFTGHLDTVPLGSAPWSFDPRGEIRDGRLYGRGASDMKAGVAAFVAAVLDVAH
SAAVLTRGVTLVLTAGEETGCLGAADLARRGVLGEASGLVVAEPTSNRLALAHKGALHLR
ARTHGATAHGSMPELGDNAVLKATRAVEALRNFEFGVPTHPLLGSPTLAVTSLHGGEAVN
VIPDSCTLTLDLRTLPGQDHARTLAMLQDQLGPDVVFDPPLADLPAVGTEPSDGFAMAAA
RSVRKVTQEVGEAIGMPYFTDGSVLQGAFGGCPTVILGPGEPGQAHQTNEWCATSAITIA
HRIYGALVQEWCA
Or try a new SitesBLAST search
SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory