SitesBLAST

Q7WTT9 Arsenate respiratory reductase iron-sulfur subunit ArrB; Arsenate respiratory reductase small subunit; ARR small subunit from Shewanella sp. (strain ANA-3) (see paper)
35% identity, 87% coverage: 1:183/211 of query aligns to 1:230/234 of Q7WTT9

query
sites
Q7WTT9

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C12 (= C12) binding [4Fe-4S] cluster
C15 (= C15) binding [4Fe-4S] cluster
C18 (= C18) binding [4Fe-4S] cluster
C22 (= C22) binding [4Fe-4S] cluster
C57 (= C57) binding [4Fe-4S] cluster
C60 (= C60) binding [4Fe-4S] cluster
C65 (= C65) binding [4Fe-4S] cluster
C69 (= C69) binding [4Fe-4S] cluster
C89 (= C89) binding [4Fe-4S] cluster
C92 (= C92) binding [4Fe-4S] cluster
C95 (= C95) binding [4Fe-4S] cluster
C99 (= C99) binding [4Fe-4S] cluster
C164 (= C116) binding [4Fe-4S] cluster
C167 (= C119) binding [4Fe-4S] cluster
C179 (= C131) binding [4Fe-4S] cluster
C183 (= C135) binding [4Fe-4S] cluster

6lodB Cryo-em structure of the air-oxidized photosynthetic alternative complex iii from roseiflexus castenholzii (see paper)
29% identity, 84% coverage: 2:178/211 of query aligns to 682:917/929 of 6lodB

query
sites
6lodB

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binding fe3-s4 cluster: V758 (≠ I68), C759 (= C69), P760 (= P70), C779 (= C89), V780 (≠ I90), G781 (= G91), T782 (≠ C92), C785 (= C95), M838 (vs. gap)
binding heme c: N777 (= N87), R778 (= R88), R852 (vs. gap), I853 (vs. gap), R856 (vs. gap)
binding iron/sulfur cluster: C692 (= C12), N693 (≠ M13), S694 (≠ G14), C695 (= C15), N696 (≠ M16), A697 (= A17), C698 (= C18), C702 (= C22), N706 (= N26), W724 (≠ S32), I727 (≠ L35), L746 (≠ R56), C747 (= C57), Q748 (≠ N58), Q749 (≠ H59), C750 (= C60), P754 (= P64), C755 (= C65), N772 (≠ V82), C789 (= C99), Y791 (= Y101), V793 (vs. gap), R794 (vs. gap), K840 (= K115), C841 (= C116), F843 (≠ Y118), C844 (= C119), T869 (≠ P129), C871 (= C131), C875 (= C135), I880 (≠ N140)

P18776 Anaerobic dimethyl sulfoxide reductase chain B; DMSO reductase iron-sulfur subunit from Escherichia coli (strain K12) (see 2 papers)
32% identity, 93% coverage: 1:197/211 of query aligns to 3:195/205 of P18776

query
sites
P18776

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C102 (= C92) mutation C->F,S,W,Y: Loss of electron transfer from menaquinol to DMSO.

Sites not aligning to the query:

1 modified: Initiator methionine, Removed

6f0kB Alternative complex iii (see paper)
30% identity, 83% coverage: 4:178/211 of query aligns to 725:948/961 of 6f0kB

query
sites
6f0kB

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binding fe3-s4 cluster: C803 (= C69), V805 (= V71), M818 (≠ V84), C823 (= C89), I824 (= I90), G825 (= G91), C829 (= C95), M869 (≠ A113)
binding heme c: N821 (= N87), R822 (= R88), R884 (vs. gap), N887 (vs. gap)
binding iron/sulfur cluster: C733 (= C12), T734 (≠ M13), G735 (= G14), C736 (= C15), N737 (≠ M16), A738 (= A17), C739 (= C18), C743 (= C22), W765 (≠ S32), I768 (≠ L35), C791 (= C57), M792 (≠ N58), H793 (= H59), C794 (= C60), P798 (= P64), C799 (= C65), N816 (≠ V82), C833 (= C99), C872 (= C116), Y874 (= Y118), C875 (= C119), A901 (= A130), C902 (= C131), C906 (= C135)

Sites not aligning to the query:

binding heme c: 719

5ch7B Crystal structure of the perchlorate reductase pcrab - phe164 gate switch intermediate - from azospira suillum ps (see paper)
39% identity, 64% coverage: 43:178/211 of query aligns to 119:255/329 of 5ch7B

query
sites
5ch7B

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binding fe3-s4 cluster: C145 (= C69), I150 (≠ L74), C166 (= C89), K167 (≠ I90), G168 (= G91), A169 (≠ C92), Q170 (≠ A93), A171 (≠ S94), C172 (= C95), A190 (= A113)
binding iron/sulfur cluster: P130 (= P54), C133 (= C57), N134 (= N58), C136 (= C60), P139 (≠ A63), C141 (= C65), C176 (= C99), C193 (= C116), G195 (≠ Y118), C196 (= C119), C208 (= C131), C212 (= C135), V213 (≠ P136), G214 (≠ T137)

Sites not aligning to the query:

binding iron/sulfur cluster: 17, 18, 19, 20, 21, 23, 27, 31, 43, 45

8k9fB Cryo-em structure of the photosynthetic alternative complex iii from chloroflexus aurantiacus at 2.9 angstrom (see paper)
29% identity, 83% coverage: 4:178/211 of query aligns to 711:939/951 of 8k9fB

query
sites
8k9fB

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L

T

V

I

D

N

L

L

S

N

R

A

C
|
C

M

I

G
|
G

C
|
C

M
x
N

A

A

C
|
C

A

V

V

V

S

A

C
|
C

K

Q

A

A

E

E

N
|
N

D

N

V

I

P

A

-

V

-

G

-

K

-

D

-

Q

-

V

-

S

-

R

-

G

-

R

-

E

L

M

H

H

S
x
W

W
x
I

R

R

L

I

R

D

V

-

K

R

Y

Y

I

F

D

A

Q

G

G

E

E

D

F

L

P

D

E

N

V

P

K

S

R

I

H

Y

F

M

V

M

P
|
P

L

V

R

N

C
|
C

N
x
M

H
x
Q

C
|
C

E

E

N

K

A

A

P

P

C
|
C

E

E

R

V

I

V

C
|
C

P
|
P

V

V

S

A

A

A

L

T

H

V

Y

H

L

D

P

Y

N

E

G

G

I

L

V
x
N

N

N

V
x
M

D

V

H

Y

N
|
N

R
|
R

C
|
C

I

V

G
|
G

C
x
T

A
x
K

S
x
Y

C
|
C

M

S

M

N

A

N

C
|
C

P

P

Y
|
Y

N

K

A
x
V

-

R

-

F

-

N

-

F

-

L

I

Q

Y

Y

I

S

D

D

P

T

I

T

T

T

N

E

S

T

-

F

-

K

-

L

-

A

-

F

-

N

-

P

-

D

-

V

-

T

-

V

-

R

-

I

-

R

-

G

-

V

A

M

D

E

K

K

C
|
C

T

T

Y
|
Y

C
|
C

A

V

H

Q

R

R

I

I

-

S

-

G

-

A

-
x
R

-

I

-

A

-
x
K

-

R

-

A

-

V

-

Q

-

A

-

G

-

Q

-

S

-

Y

-

V

-

I

-

S

E

D

V

G

G

A

M

I

M

Q

P
x
T

A

A

C
|
C

V

E

V

Q

A

A

C
|
C

P
|
P

T
|
T

H

G

A

A

N

I

I

V

F

F

G

G

D

D

L

I

D

N

D

D

P

S

E

N

S

S

E

R

I

V

S

A

K

K

Y

W

L

K

K

A

E

E

H

G

K

H

D

N

V

Y

M

G

V

L

R

L

K

G

P

-

E

F

L

L

N

N

T

T

K

V

P

P

K

R

H

T

F

T

Y

Y

V

L

binding fe3-s4 cluster: C787 (= C69), P788 (= P70), M802 (≠ V84), C807 (= C89), G809 (= G91), T810 (≠ C92), K811 (≠ A93), Y812 (≠ S94), C813 (= C95)
binding heme c: N805 (= N87), R806 (= R88), R867 (vs. gap), K871 (vs. gap)
binding iron/sulfur cluster: C719 (= C12), G721 (= G14), C722 (= C15), N723 (≠ M16), C725 (= C18), C729 (= C22), N733 (= N26), W751 (≠ S32), I752 (≠ W33), P772 (= P54), C775 (= C57), M776 (≠ N58), Q777 (≠ H59), C778 (= C60), C783 (= C65), N800 (≠ V82), C817 (= C99), Y819 (= Y101), V821 (≠ A103), C856 (= C116), Y858 (= Y118), C859 (= C119), T891 (≠ P129), C893 (= C131), C897 (= C135), P898 (= P136), T899 (= T137)

Sites not aligning to the query:

8k9eB Cryo-em structure of the photosynthetic alternative complex iii from chloroflexus aurantiacus at 3.3 angstrom (see paper)
29% identity, 83% coverage: 4:178/211 of query aligns to 711:939/951 of 8k9eB

query
sites
8k9eB

G

G

F

M

L

T

V

I

D

N

L

L

S

N

R

A

C
|
C

M
x
I

G
|
G

C
|
C

M
x
N

A

A

C
|
C

A

V

V

V

S

A

C
|
C

K

Q

A

A

E

E

N
|
N

D

N

V

I

P

A

-

V

-

G

-

K

-

D

-

Q

-

V

-

S

-

R

-

G

-

R

-

E

L

M

H

H

S

W

W

I

R

R

L
x
I

R

D

V

-

K

R

Y

Y

I

F

D

A

Q

G

G

E

E

D

F

L

P

D

E

N

V

P

K

S

R

I

H

Y

F

M

V

M

P

P

L

V

R

N

C
|
C

N
x
M

H

Q

C
|
C

E

E

N

K

A

A

P
|
P

C
|
C

E

E

R

V

I

V

C
|
C

P

P

V

V

S

A

A

A

L

T

H

V

Y

H

L

D

P

Y

N

E

G

G

I

L

V
x
N

N

N

V
x
M

D

V

H

Y

N
|
N

R

R

C
|
C

I
x
V

G
|
G

C
x
T

A
x
K

S
x
Y

C
|
C

M

S

M

N

A

N

C
|
C

P

P

Y
|
Y

N

K

A
x
V

-
x
R

-

R

-

F

-

N

-

F

-

L

I

Q

Y

Y

I

S

D

D

P

T

I

T

T

T

N

E

S

T

-

F

-

K

-

L

-

A

-

F

-

N

-

P

-

D

-

V

-

T

-

V

-

R

-

I

-

R

-

G

-

V

A
x
M

D

E

K

K

C
|
C

T

T

Y
|
Y

C
|
C

A

V

H

Q

R

R

I

I

-

S

-

G

-

A

-
x
R

-

I

-

A

-
x
K

-

R

-

A

-

V

-

Q

-

A

-

G

-

Q

-

S

-

Y

-

V

-

I

-

S

E

D

V

G

G

A

M

I

M

Q

P
x
T

A

A

C
|
C

V

E

V

Q

A

A

C
|
C

P

P

T
|
T

H

G

A

A

N

I

I

V

F

F

G

G

D

D

L

I

D

N

D

D

P

S

E

N

S

S

E

R

I

V

S

A

K

K

Y

W

L

K

K

A

E

E

H

G

K

H

D

N

V

Y

M

G

V

L

R

L

K

G

P

-

E

F

L

L

N

N

T

T

K

V

P

P

K

R

H

T

F

T

Y

Y

V

L

binding fe3-s4 cluster: C787 (= C69), M802 (≠ V84), C807 (= C89), V808 (≠ I90), G809 (= G91), T810 (≠ C92), K811 (≠ A93), Y812 (≠ S94), C813 (= C95), M853 (≠ A113)
binding heme c: N805 (= N87), R867 (vs. gap), K871 (vs. gap)
binding iron/sulfur cluster: C719 (= C12), I720 (≠ M13), G721 (= G14), C722 (= C15), N723 (≠ M16), C725 (= C18), C729 (= C22), N733 (= N26), I754 (≠ L35), C775 (= C57), M776 (≠ N58), C778 (= C60), P782 (= P64), C783 (= C65), N800 (≠ V82), C817 (= C99), Y819 (= Y101), V821 (≠ A103), R822 (vs. gap), C856 (= C116), Y858 (= Y118), C859 (= C119), T891 (≠ P129), C893 (= C131), C897 (= C135), T899 (= T137)

Sites not aligning to the query:

binding heme c: 3

2ivfB Ethylbenzene dehydrogenase from aromatoleum aromaticum (see paper)
39% identity, 64% coverage: 43:178/211 of query aligns to 122:258/337 of 2ivfB

query
sites
2ivfB

G

G

E

K

F

W

P

P

E

N

V

P

K

F

R

F

H

F

F

Y

V

L

P

A

L

R

R
x
M

C
|
C

N
|
N

H
|
H

C
|
C

E

T

N

N

A
x
P

P

A

C
|
C

E

L

R

A

I

A

C
|
C

P

P

V
x
T

S

G

A

A

L
x
I

H

Y

Y

K

L

R

P

E

-

D

N

N

G

G

I

I

V
|
V

N

L

V

V

D

D

H

Q

N

E

R

R

C
|
C

I
x
K

G
|
G

C
x
H

A
x
R

S
x
H

C
|
C

M

V

M

E

A

A

C
|
C

P

P

Y

Y

N

K

A
|
A

I
|
I

Y

Y

I

F

D

N

P

P

I

V

T

S

N

Q

S

T

A
x
S

D

E

K
|
K

C
|
C

T
x
I

Y
x
L

C
|
C

A

Y

H

P

R

R

I

I

E

E

V

K

G

G

M

I

M

A

P
x
N

A

A

C
|
C

V

N

V

R

A

Q

C
|
C

P

P

T

G

H

R

A
x
V

N
x
R

I

A

F

F

G

G

D

Y

L

L

D

D

P

T

E

T

S

S

E

H

I

V

S

H

K

K

Y

L

L

V

K

K

E

K

H

W

K

K

D

V

V

A

M

L

V

P

R

L

K

H

P

A

E

E

L

Y

N

G

T

T

K

G

P

P

K

N

H

I

F

Y

Y

Y

V

V

binding fe3-s4 cluster: C148 (= C69), T150 (≠ V71), I153 (≠ L74), C169 (= C89), K170 (≠ I90), G171 (= G91), H172 (≠ C92), R173 (≠ A93), H174 (≠ S94), C175 (= C95), S193 (≠ A113)
binding protoporphyrin ix containing fe: T150 (≠ V71), K170 (≠ I90), H172 (≠ C92)
binding iron/sulfur cluster: M135 (≠ R56), C136 (= C57), N137 (= N58), H138 (= H59), C139 (= C60), P142 (≠ A63), C144 (= C65), V162 (= V82), C179 (= C99), A183 (= A103), I184 (= I104), K195 (= K115), C196 (= C116), I197 (≠ T117), L198 (≠ Y118), C199 (= C119), N209 (≠ P129), C211 (= C131), C215 (= C135), V219 (≠ A139), R220 (≠ N140)

Sites not aligning to the query:

binding iron/sulfur cluster: 13, 14, 15, 16, 17, 19, 23, 27, 38, 39, 41

P0AAJ3 Formate dehydrogenase, nitrate-inducible, iron-sulfur subunit; Anaerobic formate dehydrogenase iron-sulfur subunit; Formate dehydrogenase-N subunit beta; FDH-N subunit beta from Escherichia coli (strain K12) (see paper)
33% identity, 65% coverage: 6:143/211 of query aligns to 33:187/294 of P0AAJ3

query
sites
P0AAJ3

L

L

V

I

D

D

L

V

S

S

R

T

C
|
C

M

I

G

G

C
|
C

M

K

A

A

C
|
C

A

Q

V

V

S

A

C
|
C

K

S

A

E

E

W

N

N

D

D

V

I

-

R

-

D

-

E

-

V

-

G

-

H

-

C

-

V

-

G

-

V

-

Y

-

D

-

N

-

P

-

A

-

D

-

L

P

S

L

A

H

K

S

S

W

W

R

T

L

V

R

-

V

M

K

R

Y

F

I

S

D

E

Q

T

G

E

E

Q

F

N

P

G

E

K

V

L

K

E

R

W

H

L

F

I

V

R

P

K

L

D

R

G

C
|
C

N

M

H

H

C
|
C

E

E

N

D

A

P

P

G

C
|
C

E

L

R

K

I

A

C
|
C

P

P

-

S

V

A

S

G

A

A

L

I

H

I

Y

Q

L

Y

P

A

N

N

G

G

I

I

V

V

N

D

V

F

D

Q

H

S

N

E

R

N

C
|
C

I

I

G

G

C
|
C

A

G

S

Y

C
|
C

M

I

M

A

A

G

C
|
C

P

P

Y

F

N

N

A

I

I

P

Y

R

I

L

D

N

P

K

I

E

T

D

N

N

S

R

A

V

D

Y

K

K

C
|
C

T

T

Y

L

C
|
C

A

V

H

D

R

R

I

V

E

S

V

V

G

G

M

Q

M

E

P

P

A

A

C
|
C

V

V

V

K

A

T

C
|
C

P

P

T

T

H

G

A

A

N

I

I

H

F

F

G

G

C39 (= C12) binding [4Fe-4S] cluster
C42 (= C15) binding [4Fe-4S] cluster
C45 (= C18) binding [4Fe-4S] cluster
C49 (= C22) binding [4Fe-4S] cluster
C100 (= C57) binding [4Fe-4S] cluster
C103 (= C60) binding [4Fe-4S] cluster
C108 (= C65) binding [4Fe-4S] cluster
C112 (= C69) binding [4Fe-4S] cluster
C133 (= C89) binding [4Fe-4S] cluster
C136 (= C92) binding [4Fe-4S] cluster
C139 (= C95) binding [4Fe-4S] cluster
C143 (= C99) binding [4Fe-4S] cluster
C160 (= C116) binding [4Fe-4S] cluster
C163 (= C119) binding [4Fe-4S] cluster
C175 (= C131) binding [4Fe-4S] cluster
C179 (= C135) binding [4Fe-4S] cluster

1kqfB Formate dehydrogenase n from e. Coli (see paper)
33% identity, 65% coverage: 6:143/211 of query aligns to 32:186/289 of 1kqfB

query
sites
1kqfB

L

L

V

I

D

D

L

V

S

S

R

T

C
|
C

M
x
I

G
|
G

C
|
C

M
x
K

A

A

C
|
C

A

Q

V

V

S

A

C
|
C

K

S

A

E

E

W

N
|
N

D

D

V

I

-

R

-

D

-

E

-

V

-

G

-

H

-

C

-

V

-

G

-

V

-

Y

-

D

-

N

-

P

-

A

-

D

-

L

P

S

L

A

H

K

S

S

W

W

R
x
T

L

V

R

-

V
x
M

K

R

Y

F

I

S

D

E

Q

T

G

E

E

Q

F

N

P

G

E

K

V

L

K

E

R

W

H

L

F

I

V

R

P

K

L

D

R

G

C
|
C

N
x
M

H
|
H

C
|
C

E

E

N

D

A
x
P

P

G

C
|
C

E

L

R

K

I

A

C
|
C

P
|
P

-

S

V

A

S

G

A

A

L
x
I

H

I

Y

Q

L

Y

P

A

N

N

G

G

I

I

V
|
V

N

D

V

F

D

Q

H

S

N

E

R

N

C
|
C

I
|
I

G
|
G

C
|
C

A
x
G

S
x
Y

C
|
C

M

I

M

A

A

G

C
|
C

P

P

Y

F

N

N

A
x
I

I
x
P

Y

R

I

L

D

N

P

K

I

E

T

D

N

N

S

R

A
x
V

D

Y

K
|
K

C
|
C

T

T

Y
x
L

C
|
C

A

V

H

D

R

R

I

V

E

S

V

V

G

G

M

Q

M

E

P
|
P

A

A

C
|
C

V

V

V

K

A

T

C
|
C

P
|
P

T

T

H

G

A

A

N
x
I

I

H

F

F

G

G

binding protoporphyrin ix containing fe: Y137 (≠ S94)
binding iron/sulfur cluster: C38 (= C12), I39 (≠ M13), G40 (= G14), C41 (= C15), K42 (≠ M16), C44 (= C18), C48 (= C22), N52 (= N26), T77 (≠ R34), M79 (≠ V37), C99 (= C57), M100 (≠ N58), H101 (= H59), C102 (= C60), P105 (≠ A63), C107 (= C65), C111 (= C69), P112 (= P70), I117 (≠ L74), V125 (= V82), C132 (= C89), I133 (= I90), G134 (= G91), C135 (= C92), G136 (≠ A93), Y137 (≠ S94), C138 (= C95), C142 (= C99), I146 (≠ A103), P147 (≠ I104), V156 (≠ A113), K158 (= K115), C159 (= C116), L161 (≠ Y118), C162 (= C119), P172 (= P129), C174 (= C131), C178 (= C135), P179 (= P136), I183 (≠ N140)

Sites not aligning to the query:

6btmB Structure of alternative complex iii from flavobacterium johnsoniae (wild type) (see paper)
25% identity, 81% coverage: 7:177/211 of query aligns to 688:942/948 of 6btmB

query
sites
6btmB

V

I

D

D

L

L

S

N

R

A

C

C

M

T

G

G

C

C

M

G

A

A

C

C

A

V

V

I

S

A

C

C

K

H

A

A

E

E

N

N

D

N

V

V

P

P

-

V

-

G

-

K

-

A

-

E

-

V

-

R

-

S

-

R

-

D

L

M

H

H

S

W

W

L

R

R

L

I

R

D

V

R

K

Y

Y

Y

I

S

D

S

Q

E

G

S

E

T

F

F

-

E

-

G

-

D

-

N

-

E

-

R

-

K

-

E

-

G

-

I

-

A

-

G

-

L

-

S

-

L

-

S

-

T

-

F

-

N

-

E

-

M

-

E

-

K

-

P

-

G

-

D

-

N

P

P

E

Q

V

V

K

A

R

-

H

-

F

F

V

Q

P

P

L

V

R

M

C
|
C

N
x
Q

H

H

C
|
C

E

N

N

H

A

A

P

P

C
|
C

E

E

R

T

I

V

C
|
C

P

P

V

V

S

A

A

A

L

T

H

S

Y

H

L

G

P

R

N

Q

G

G

I

Q

V
x
N

N

H

V

M

D

A

H

Y

N

N

R

R

C
|
C

I
x
V

G

G

C
x
T

A

R

S

Y

C
|
C

M

A

M

N

A

N

C
|
C

P

P

Y

Y

N

K

A

V

-
x
R

-

R

-

F

-

N

-

W

-

F

-

L

-

Y

-

N

-

K

-

N

-

S

-

E

-

F

-

D

-

Y

-

H

-

M

-

N

-

D

-

L

-

G

-

R

I

M

Y

V

I

L

D

N

P

P

I

D

T

V

N

N

-

V

-

R

-

S

-

R

-

G

S

V

A
x
M

D

E

K

K

C

C

T

S

Y

F

C

C

A

I

H

Q

R

S

I

T

E

Q

V

A

G

V

M

I

M

L

P

E

A

A

C

K

-

R

-

Q

-

G

-

R

V

V

A

G

C

K

P

D

T

E

H

F

A

N

N

N

-

A

-

C

-

A

-

C

-

S

-

A

-

C

-

S

-

G

-

A

-

M

I

V

F

F

G

G

D

D

L

V

D

N

D

D

P

K

E

E

S

S

E

E

I

V

S

A

K

K

Y

-

L

L

K

A

E

E

H

S

K

E

D

R

V

M

M

Y

V

H

R

L

K

L

P

E

E

H

L

V

N

G

T

T

K

K

P

P

K

N

H

V

F

F

Y

Y

binding fe3-s4 cluster: C789 (= C69), C809 (= C89), V810 (≠ I90), T812 (≠ C92), C815 (= C95), M862 (≠ A113)
binding iron/sulfur cluster: C777 (= C57), Q778 (≠ N58), C780 (= C60), C785 (= C65), N802 (≠ V82), C819 (= C99), R824 (vs. gap)

Sites not aligning to the query:

binding (2R)-3-{[(2R)-2-(decanoylamino)-3-hydroxypropyl]sulfanyl}propane-1,2-diyl ditetradecanoate: 1, 2

7qv7A Cryo-em structure of hydrogen-dependent co2 reductase. (see paper)
34% identity, 76% coverage: 6:165/211 of query aligns to 6:167/174 of 7qv7A

query
sites
7qv7A

L

I

V

A

D

D

L

P

S

K

R

R

C
|
C

M
x
L

G
|
G

C
|
C

M
x
Y

A

T

C
|
C

A

I

V

A

S

A

C
|
C

K

A

-

F

A

V

E
x
H

N

E

D

E

V

Q

P

G

L

L

H

Q

S

P

W

F

-

P

R

R

L
|
L

R

Y

V

L

K

T

Y

Y

I

T

D

S

Q

E

G

G

E

-

F

-

P

-

E

-

V

-

K

-

R

-

H

-

F

I

V

M

P

P

L

I

R

Q

C
|
C

N
x
R

H

H

C
|
C

E

E

N

D

A

A

P

P

C
|
C

E

A

R

E

I

V

C
|
C

P

P

V

V

S

E

A

A

L

I

H

K

Y

K

L

E

P

G

N

N

G

A

I

I

V

I

N

-

V

I

D

D

H

E

N

K

R

A

C
|
C

I
|
I

G
|
G

C
|
C

A

K

S

T

C
|
C

M

L

A

A

C
|
C

P

S

Y

F

N

G

A

A

I
|
I

Y

D

I
x
F

-

S

-

V

-

Q

D

D

P

S

I

L

T

E

N

Q

S

S

-

I

-

F

-

K

-

D

-

I

-

K

-

E

-

N

-

L

-

M

-

R

-

I

-

V

A

A

D

V

K

K

C
|
C

T

D

Y
x
L

C
|
C

A

N

H

F

R

R

I

E

E

E

V

-

G

-

M

-

M

G

P

P

A
|
A

C
|
C

V

V

V

Q

A

F

C
|
C

P

P

T

T

H

K

A

A

N

L

I

K

F

L

G

V

D

D

L

G

D

D

D

-

P

-

E

-

S

-

E

E

I

I

S

N

K

K

Y

M

L

V

K

K

E

N

H

K

K

R

D

T

V

V

M

N

V

V

R

E

binding iron/sulfur cluster: C12 (= C12), L13 (≠ M13), G14 (= G14), C15 (= C15), Y16 (≠ M16), C18 (= C18), C22 (= C22), H26 (≠ E25), L37 (= L35), C51 (= C57), R52 (≠ N58), C54 (= C60), C59 (= C65), C63 (= C69), C82 (= C89), I83 (= I90), G84 (= G91), C85 (= C92), C88 (= C95), C92 (= C99), I97 (= I104), F99 (≠ I106), C125 (= C116), L127 (≠ Y118), C128 (= C119), A136 (= A130), C137 (= C131), C141 (= C135)

8cm6D W-formate dehydrogenase c872a from desulfovibrio vulgaris - with formamide (see paper)
29% identity, 74% coverage: 5:160/211 of query aligns to 4:181/214 of 8cm6D

query
sites
8cm6D

F
|
F

L

F

V

V

D

D

L

L

S

S

R

R

C
|
C

M
x
T

G
x
A

C
|
C

M
x
R

A

G

C
|
C

A

Q

V

I

S

A

C
|
C

K

K

A

Q

E

W

N
x
K

D

N

V

L

P

P

L

A

H

E

S

E

W

T

R

R

-

N

-

T

-

G

-

S

-

H

-

Q

-

N

-

P

-

D

-

L

-

S

-

Y

-

V

-

T

-

L

L
x
K

R

T

V

V

K

R

Y

F

I

T

D

E

Q

K

G

S

-
x
R

E

K

F

G

P
|
P

E

G

V

I

K

D

R

W

H

L

F

F

V

F

P

P

L

E

R

Q

C
|
C

N
x
R

H

H

C
|
C

E

V

N

E

A
x
P

P
|
P

C
|
C

E

K

R

G

I

Q

C

A

P

D

V

V

S

D

-

L

-

E

-

G

-

A

-

V

A

V

L

K

H

D

Y

E

L

T

P

T

N

G

G

A

I
x
V

V

L

N

F

V

T

D

E

H

L

N

T

R

A

C

K

I

V

G

D

C

G

A

E

S

S

C

V

M

R

M

S

A

A

C
|
C

P

P

Y

Y

N

D

A
x
I

I
x
P

Y

R

I

I

D

D

P

P

I

V

T

T

N

K

S

R

A

L

D

S

K
|
K

C
|
C

T
x
D

Y
x
M

C
|
C

A

N

H

D

R

R

I

V

E

Q

V

N

G

G

M

L

P

P

A

A

C
|
C

V

V

V

K

A

T

C
|
C

P
|
P

T
|
T

H

G

A
x
T

N
x
M

I

N

F

F

G

G

D

D

L

E

D

Q

D

E

P

M

E

L

S

A

E

L

I

A

S

E

K

K

Y

R

L

L

K

A

E

E

H

V

K

K

binding formamide: R59 (vs. gap), P62 (= P46)
binding iron/sulfur cluster: F4 (= F5), C11 (= C12), T12 (≠ M13), A13 (≠ G14), C14 (= C15), R15 (≠ M16), C17 (= C18), C21 (= C22), K25 (≠ N26), K50 (≠ L35), C73 (= C57), R74 (≠ N58), C76 (= C60), P79 (≠ A63), P80 (= P64), C81 (= C65), V102 (≠ I81), C120 (= C99), I124 (≠ A103), P125 (≠ I104), K136 (= K115), C137 (= C116), D138 (≠ T117), M139 (≠ Y118), C140 (= C119), C152 (= C131), C156 (= C135), P157 (= P136), T158 (= T137), T160 (≠ A139), M161 (≠ N140)

8bqgB W-formate dehydrogenase from desulfovibrio vulgaris - soaking with formate 1 min (see paper)
29% identity, 74% coverage: 5:160/211 of query aligns to 4:181/214 of 8bqgB

query
sites
8bqgB

F
|
F

L

F

V

V

D

D

L

L

S

S

R

R

C
|
C

M
x
T

G
x
A

C
|
C

M
x
R

A

G

C
|
C

A

Q

V

I

S

A

C
|
C

K

K

A

Q

E

W

N
x
K

D

N

V

L

P

P

L

A

H

E

S

E

W

T

R

R

-

N

-

T

-

G

-

S

-

H

-

Q

-

N

-

P

-

D

-

L

-

S

-

Y

-

V

-

T

-

L

L
x
K

R

T

V

V

K

R

Y

F

I

T

D

E

Q

K

G

S

-

R

E

K

F

G

P

P

E

G

V

I

K

D

R

W

H

L

F

F

V

F

P

P

L

E

R

Q

C
|
C

N
x
R

H

H

C
|
C

E

V

N

E

A

P

P
|
P

C
|
C

E

K

R

G

I

Q

C

A

P

D

V

V

S

D

-

L

-

E

-

G

-

A

-

V

A

V

L

K

H

D

Y

E

L

T

P

T

N

G

G

A

I
x
V

V

L

N

F

V

T

D

E

H

L

N

T

R

A

C

K

I

V

G

D

C

G

A

E

S

S

C

V

M

R

M

S

A

A

C
|
C

P

P

Y

Y

N

D

A
x
I

I
x
P

Y

R

I

I

D

D

P

P

I

V

T

T

N

K

S

R

A

L

D

S

K
|
K

C
|
C

T

D

Y
x
M

C
|
C

A

N

H

D

R

R

I

V

E

Q

V

N

G

G

M

L

P

P

A

A

C
|
C

V

V

V

K

A

T

C
|
C

P
|
P

T
|
T

H

G

A
x
T

N
x
M

I

N

F

F

G

G

D

D

L

E

D

Q

D

E

P

M

E

L

S

A

E

L

I

A

S

E

K

K

Y

R

L

L

K

A

E

E

H

V

K

K

binding iron/sulfur cluster: F4 (= F5), C11 (= C12), T12 (≠ M13), A13 (≠ G14), C14 (= C15), R15 (≠ M16), C17 (= C18), C21 (= C22), K25 (≠ N26), K50 (≠ L35), C73 (= C57), R74 (≠ N58), C76 (= C60), P80 (= P64), C81 (= C65), V102 (≠ I81), C120 (= C99), I124 (≠ A103), P125 (≠ I104), K136 (= K115), C137 (= C116), M139 (≠ Y118), C140 (= C119), C152 (= C131), C156 (= C135), P157 (= P136), T158 (= T137), T160 (≠ A139), M161 (≠ N140)

4v4cB Pyrogallol hydroxytransferase small subunit (see paper)
30% identity, 82% coverage: 5:177/211 of query aligns to 6:188/274 of 4v4cB

query
sites
4v4cB

F

M

L

V

V

I

D

D

L

V

S

A

R

K

C
|
C

M
x
Q

G
x
D

C
|
C

M
x
N

A
x
N

C
|
C

A

F

V

M

S

G

C
|
C

K

M

A

D

E

E

-

H

-

E

-

L

N

N

D

E

V

W

P

P

L

G

-

Y

-

T

-

A

-

S

-

M

-

Q

-

R

-

G

H

H

S

R

W

W

R

-

L

M

R

N

V

I

K

E

Y

R

I

R

D

E

Q

R

G

G

E

T

F

Y

P

P

E

R

V

N

K

D

R
x
I

H
x
N

F

Y

V

R

P

P

L

T

R

P

C
|
C

N
x
M

H
|
H

C
|
C

E

E

N

N

A

A

P

P

C
|
C

E

-

R

V

I

A

C

K

P

G

V

N

S

G

A

A

L

V

H

Y

Y

Q

L

R

P

E

N

D

G

G

I

I

V
|
V

N

L

V

I

D

D

H

P

N

E

R

K

C

A

I

K

G

G

C

K

A

K

S

E

C

L

M

L

M

D

A

T

C
|
C

P

P

Y

Y

N

G

A
x
V

I

M

Y

Y

I

W

D

N

P

E

I

E

T

E

N

N

S

V

A

A

D

Q

K

K

C
|
C

T

T

Y
x
M

C
|
C

A

A

H

H

R

L

I

L

E

D

-

D

-

E

-

S

-

W

V

A

G

P

M

K

M

M

P
|
P

A

R

C
|
C

V

A

V

H

A

N

C
|
C

P

G

T
x
S

H

F

A
x
V

N
x
Y

I

E

F

F

G

L

D

K

L

T

D

-

D

T

P

P

E

E

S

A

E

M

I

A

S

K

K

K

Y

V

L

E

K

E

E

E

H

G

K

L

D

E

V

V

M

I

V

-

R

-

K

K

P

P

E

E

L

L

N

G

T

T

K

K

P

P

K

R

H

V

F

Y

Y

Y

binding calcium ion: I61 (≠ R50), N62 (≠ H51)
binding iron/sulfur cluster: C13 (= C12), Q14 (≠ M13), D15 (≠ G14), C16 (= C15), N17 (≠ M16), N18 (≠ A17), C19 (= C18), C23 (= C22), C68 (= C57), M69 (≠ N58), H70 (= H59), C71 (= C60), C76 (= C65), V92 (= V82), C109 (= C99), V113 (≠ A103), C126 (= C116), M128 (≠ Y118), C129 (= C119), P143 (= P129), C145 (= C131), C149 (= C135), S151 (≠ T137), V153 (≠ A139), Y154 (≠ N140)

Q8GC87 Formate dehydrogenase subunit beta; FDH subunit beta; Formate dehydrogenase small subunit from Megalodesulfovibrio gigas (strain ATCC 19364 / DSM 1382 / NCIMB 9332 / VKM B-1759) (Desulfovibrio gigas) (see paper)
32% identity, 76% coverage: 1:160/211 of query aligns to 1:182/215 of Q8GC87

query
sites
Q8GC87

M

M

R

S

L

K

G

G

F

F

L

F

V

V

D

D

L

T

S

T

R

R

C
|
C

M

T

G

A

C
|
C

M

R

A

G

C
|
C

A

Q

V

V

S

A

C
|
C

K

K

-

Q

-

W

-

H

-

G

-

N

-

P

-

A

-

T

-

P

A

T

E

E

N

N

-

T

-

G

-

F

-

H

-

Q

-

N

-

P

D

D

V

F

P

N

L

F

H

H

S

T

W

Y

R

K

L

L

R

-

V

V

K

R

Y

M

I

H

D

E

Q

Q

G

E

E

I

F

D

P

G

E

R

V

I

K

D

R

W

H

L

F

F

V

F

P

P

L

D

R

Q

C
|
C

N

R

H

H

C
|
C

E

I

N

A

A

P

P

P

C
|
C

E

K

R

-

I

-

C

-

P

-

V

A

S

T

A

A

L

D

H

M

Y

E

L

D

P

E

N

S

G

A

I

I

V

I

N

H

V

D

D

D

H

A

N

T

R

G

C

C

I

V

-

L

-

F

-

T

-

P

-

K

-

T

-

K

-

D

-

L

-

E

G

D

C

Y

A

E

S

S

C

V

M

I

M

S

A

A

C
|
C

P

P

Y

Y

N

D

A

V

I

P

Y

R

I

K

D

V

P

A

I

E

T

S

N

N

S

Q

A

M

D

A

K

K

C
|
C

T

D

Y

M

C
|
C

A

I

H

D

R

R

I

I

E

T

V

N

G

G

M

L

M

R

P

P

A

A

C
|
C

V

V

V

T

A

S

C
|
C

P

P

T

T

H

G

A

A

N

M

I

N

F

F

G

G

D

D

L

L

D

S

D

E

P

M

E

E

S

A

E

M

I

A

S

S

K

A

Y

R

L

L

K

A

E

E

H

I

K

K

C12 (= C12) binding [4Fe-4S] cluster
C15 (= C15) binding [4Fe-4S] cluster
C18 (= C18) binding [4Fe-4S] cluster
C22 (= C22) binding [4Fe-4S] cluster
C73 (= C57) binding [4Fe-4S] cluster
C76 (= C60) binding [4Fe-4S] cluster
C81 (= C65) binding [4Fe-4S] cluster
C121 (= C99) binding [4Fe-4S] cluster
C138 (= C116) binding [4Fe-4S] cluster
C141 (= C119) binding [4Fe-4S] cluster
C153 (= C131) binding [4Fe-4S] cluster
C157 (= C135) binding [4Fe-4S] cluster

7qv7B Cryo-em structure of hydrogen-dependent co2 reductase. (see paper)
34% identity, 62% coverage: 10:139/211 of query aligns to 12:158/183 of 7qv7B

query
sites
7qv7B

S

A

R

K

C
|
C

M

I

G
|
G

C
|
C

M
x
K

A
|
A

C
|
C

A

E

V

V

S

A

C
|
C

K

F

A

A

-

V

-
x
H

-

N

-

R

E

N

N

N

D

H

V

V

P

G

L

A

H

T

S

V

W

G

R

T

L

V

R

S

V

I

K

P

Y

V

I

I

D

P

Q
x
R

G

L

E

H

F

L

P

I

E

K

V

T

K

E

R

H

H

G

F

T

V

M

P

P

L

I

R

Q

C
|
C

N
x
R

H
|
H

C
|
C

E

E

N

D

A
|
A

P

P

C
|
C

E

A

R

N

I

V

C
|
C

P

T

V

V

S

G

A
|
A

L
x
I

H

K

Y

R

L

E

P

G

N

N

G

A

I

I

V

V

N

-

V

V

D

D

H

E

N

K

R

L

C
|
C

I
|
I

G

G

C
|
C

A

K

S

S

C
|
C

M

L

A

A

C
|
C

P

P

Y

F

N

G

A

A

I
|
I

Y

E

I

L

D

L

P

P

I

Q

T

Y

N

E

S

D

-

G

-

R

-

E

-

V

-

F

-

Q

-

I

-

N

-

L

-

K

-

L

-

V

-

Q

-

E

-

P

-

R

-

I

A

A

D

Y

K

K

C
|
C

T

D

Y
x
L

C
|
C

A

N

H

D

R

L

I

G

E

E

V

-

G

-

M

-

P
|
P

A

A

C
|
C

V

V

V

K

A

A

C
|
C

P
|
P

T

E

H

N

A

A

binding iron/sulfur cluster: C14 (= C12), G16 (= G14), C17 (= C15), K18 (≠ M16), A19 (= A17), C20 (= C18), C24 (= C22), H28 (vs. gap), R48 (≠ Q42), C63 (= C57), R64 (≠ N58), H65 (= H59), C66 (= C60), A69 (= A63), C71 (= C65), C75 (= C69), A79 (= A73), I80 (≠ L74), C94 (= C89), I95 (= I90), C97 (= C92), C100 (= C95), C104 (= C99), I109 (= I104), C139 (= C116), L141 (≠ Y118), C142 (= C119), P148 (= P129), C150 (= C131), C154 (= C135), P155 (= P136)

Sites not aligning to the query:

binding iron/sulfur cluster: 159

Query Sequence

>WP_012673645.1 NCBI__GCF_000021545.1:WP_012673645.1
MRLGFLVDLSRCMGCMACAVSCKAENDVPLHSWRLRVKYIDQGEFPEVKRHFVPLRCNHC
ENAPCERICPVSALHYLPNGIVNVDHNRCIGCASCMMACPYNAIYIDPITNSADKCTYCA
HRIEVGMMPACVVACPTHANIFGDLDDPESEISKYLKEHKDVMVRKPELNTKPKHFYVRG
STVALDPLASERPEGYTLFTEVKFLDHIGGH

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory