Comparing WP_012673788.1 NCBI__GCF_000021545.1:WP_012673788.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 13 hits to proteins with known functional sites (download)
Q58667 Methanogen homoaconitase small subunit; HACN; Homoaconitate hydratase; EC 4.2.1.114 from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) (see paper)
56% identity, 97% coverage: 1:160/165 of query aligns to 2:159/170 of Q58667
2pkpA Crystal structure of 3-isopropylmalate dehydratase (leud)from methhanocaldococcus jannaschii dsm2661 (mj1271) (see paper)
56% identity, 97% coverage: 1:160/165 of query aligns to 2:159/167 of 2pkpA
O14289 3-isopropylmalate dehydratase; Alpha-IPM isomerase; IPMI; Isopropylmalate isomerase; EC 4.2.1.33 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
36% identity, 78% coverage: 12:140/165 of query aligns to 554:698/758 of O14289
Sites not aligning to the query:
P9WK95 3-isopropylmalate dehydratase small subunit; Alpha-IPM isomerase; IPMI; Isopropylmalate isomerase; EC 4.2.1.33 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
40% identity, 68% coverage: 10:122/165 of query aligns to 16:138/198 of P9WK95
Sites not aligning to the query:
P09339 Aconitate hydratase A; ACN; Aconitase; Aconitate/2-methylaconitate hydratase; Iron-responsive protein-like; IRP-like; RNA-binding protein; EC 4.2.1.3; EC 4.2.1.- from Bacillus subtilis (strain 168) (see 2 papers)
39% identity, 47% coverage: 49:125/165 of query aligns to 777:857/909 of P09339
Sites not aligning to the query:
D9X0I3 Aconitate hydratase A; ACN; Aconitase; EC 4.2.1.3 from Streptomyces viridochromogenes (strain DSM 40736 / JCM 4977 / BCRC 1201 / Tue 494) (see paper)
41% identity, 40% coverage: 53:118/165 of query aligns to 805:870/931 of D9X0I3
Sites not aligning to the query:
Q9SIB9 Aconitate hydratase 3, mitochondrial; Aconitase 3; mACO1; Citrate hydro-lyase 3; EC 4.2.1.3 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
36% identity, 45% coverage: 50:123/165 of query aligns to 861:930/990 of Q9SIB9
Sites not aligning to the query:
2b3xA Structure of an orthorhombic crystal form of human cytosolic aconitase (irp1) (see paper)
35% identity, 59% coverage: 53:149/165 of query aligns to 766:847/888 of 2b3xA
Sites not aligning to the query:
P21399 Cytoplasmic aconitate hydratase; Aconitase; Citrate hydro-lyase; Ferritin repressor protein; Iron regulatory protein 1; IRP1; Iron-responsive element-binding protein 1; IRE-BP 1; EC 4.2.1.3 from Homo sapiens (Human) (see 2 papers)
35% identity, 59% coverage: 53:149/165 of query aligns to 767:848/889 of P21399
Sites not aligning to the query:
A0QX20 Aconitate hydratase A; ACN; Aconitase; (2R,3S)-2-methylisocitrate dehydratase; (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate dehydratase; Iron-responsive protein-like; IRP-like; Probable 2-methyl-cis-aconitate hydratase; RNA-binding protein; EC 4.2.1.3; EC 4.2.1.99 from Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis) (see paper)
33% identity, 51% coverage: 53:136/165 of query aligns to 811:894/943 of A0QX20
Sites not aligning to the query:
3snpA Crystal structure analysis of iron regulatory protein 1 in complex with ferritin h ire RNA (see paper)
36% identity, 56% coverage: 53:144/165 of query aligns to 728:804/850 of 3snpA
Sites not aligning to the query:
P19414 Aconitate hydratase, mitochondrial; Aconitase; Citrate hydro-lyase; EC 4.2.1.3 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 2 papers)
46% identity, 29% coverage: 53:100/165 of query aligns to 655:702/778 of P19414
Sites not aligning to the query:
P20004 Aconitate hydratase, mitochondrial; Aconitase; Citrate hydro-lyase; EC 4.2.1.3 from Bos taurus (Bovine) (see 2 papers)
44% identity, 29% coverage: 53:100/165 of query aligns to 658:705/780 of P20004
Sites not aligning to the query:
>WP_012673788.1 NCBI__GCF_000021545.1:WP_012673788.1
MIRGRVWKFKDDVDTDQIIPARYLVTTDPKELAKHVMEDADPTFPSKVKEGDILVAGKNF
GCGSSREHAPLAIKGAGISAVVAESFARIFFRNAINLGLLIIESPEAAKEAEEGDTLEID
VNEGIIRNLTKGKEYKIKPLPENLQAILKAGGLMEYAKERLKNAS
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory