SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing WP_012675324.1 NCBI__GCF_000021565.1:WP_012675324.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

P14193 Ribose-phosphate pyrophosphokinase; RPPK; 5-phospho-D-ribosyl alpha-1-diphosphate synthase; Phosphoribosyl diphosphate synthase; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PPRibP synthase; PRPP synthase; PRPPase; EC 2.7.6.1 from Bacillus subtilis (strain 168) (see 4 papers)
56% identity, 99% coverage: 3:310/311 of query aligns to 8:316/317 of P14193

query
sites
P14193

K

K

H

N

I

L

K

K

L

I

I

F

T

S

G

L

N

N

A

S

N

N

P

P

D

E

F

L

A

A

E

K

K

E

I

I

A

A

D

D

Y

I

L

V

H

G

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V

P

Q

L

L

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G

D

K

T

C

L

S

V

V

T

T

R

R

F

F

S

S

D

D

G

G

E

E

I

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R

Q

V

I

Q

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I

K

E

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E

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S

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R

G

G

A

C

D

D

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C

F

Y

V

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I

I

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L

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T

S

Q

D

P

P

A

V

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N

D

E

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H

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I

M

M

E

E

L

L

L

I

I

M

L

V

D

D

A

A

L

L

K

K

R

R

S

A

S

S

T

A

H

K

R

T

I

I

T

N

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I

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V

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I

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P

Y

Y

F

Y

A

G

Y

Y

A

A

R
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R

Q
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Q

D

D

R

R

K

K

D

A

R

R

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S

R

R

V

E

P

P

I

I

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T

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A

K

K

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F

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A

D

N

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E

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G

A

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Q

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D

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H

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A

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I

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Q

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G

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F

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K

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L

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A

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D

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K

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A

A

I

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Y

D

K
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K

K

R

R
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R

P

P

A
x
R

P

P

N
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N

V

V

V

A

E
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E

T

V

L

M

D

N

V

I

I

V

G

G

D

N

I

I

E

E

G

G

K

K

N

T

A

A

I

I

I

L

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I

D

D

I

I

D
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D

T
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T

A
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A

G
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G

T
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T

I

I

V

T

S

L

A

A

N

N

M

A

L

L

K

V

E

E

K

N

G

G

A

A

K

K

S

E

V

V

I

Y

A

A

A

C

C

C

T

T

H

H

P

P

V

V

F

L

S

S

G

G

P

P

A

A

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V

D

E

R

R

L

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K

N

N

N

S

S

E

T

I

I

E

K

E

E

V

L

I

V

V

V

T

T

D

N

T

S

I

I

P

K

T

L

-

P

T

E

G

E

K

K

E

K

F

I

D

E

K

R

L

F

T

K

V

Q

L

L

S

S

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V

A

G

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P

L

L

V

L

G

A

E

E

A

A

I

I

R

I

R

R

I

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N

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I

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E

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Q

S

S

V

V

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S

S

Y

L

L

F

F

RQ 102:103 (= RQ 97:98) binding ATP
K198 (= K193) mutation to A: Strong decrease of the Vmax value compared to that of the wild-type. The affinity binding for ATP and Rib-5-P are slightly altered compared to the wild-type. The cooperativity of ADP binding is reduced.
R200 (= R195) mutation to A: Strong decrease of the Vmax value compared to that of the wild-type enzyme. The affinity binding for ATP and Rib-5-P are slightly altered compared to the wild-type.
R202 (≠ A197) mutation to A: 3-fold decrease in the affinity binding for ATP. Slight decrease of the Vmax value.
N204 (= N199) mutation to A: 4.5-fold decrease in the affinity binding for ATP. Slight decrease of the Vmax value.
E207 (= E202) mutation to A: 2.5-fold decrease in the affinity binding for ATP. Slight decrease of the Vmax value.
DTAGT 228:232 (= DTAGT 223:227) binding D-ribose 5-phosphate

Sites not aligning to the query:

1 modified: Initiator methionine, Removed

Q63XL8 Ribose-phosphate pyrophosphokinase; RPPK; 5-phospho-D-ribosyl alpha-1-diphosphate synthase; Phosphoribosyl diphosphate synthase; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase; PRPPase; EC 2.7.6.1 from Burkholderia pseudomallei (strain K96243) (see paper)
53% identity, 100% coverage: 1:310/311 of query aligns to 1:315/318 of Q63XL8

query
sites
Q63XL8

M

M

S

S

K

S

H

H

-

D

-

G

I

L

K

M

L

V

I

F

T

T

G

G

N

N

A

A

N

N

P

P

D

A

F

L

A

A

E

Q

K

E

I

V

A

V

D

K

Y

I

L

L

H

G

V

I

P

P

L

L

V

G

D

K

T

A

L

M

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T

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R

R

F

F

S

S

D

D

G

G

E

E

I

I

R

Q

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V

Q

E

I

I

K

Q

E

E

N

N

V

V

R

R

G

G

A

K

D

D

V

V

F

F

V

V

I

L

Q

Q

P

S

L

T

T

C

Q

A

P

P

A

T

N

N

D

D

H

N

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L

M

M

E

E

L

L

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M

L

I

I

M

L

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D

D

A

A

L

L

K

K

R

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T

A

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G

R

R

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I

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T

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A

V

A

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I

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P

Y

Y

F

F

A

G

Y

Y

A

A

R
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R

Q
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Q

D

D

R

R

K

R

D

P

R

R

P

S

-

A

R

R

V

V

P

A

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I

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S

A

A

K

K

L

V

A

A

D

N

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D

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L

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Q

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Q

G

G

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F

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C

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D

N

N

L

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Y

A

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T

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P

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D

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A

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L

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L

L

A

A

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D

K

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K

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R

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P

A

K

P

A

N

N

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V

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A

E

E

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M

D

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V

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I

G

G

D

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M

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V

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T

A

A

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T

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A

A

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K

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A

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Y

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A

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V

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I

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G

A

K

E

E

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F

L

D

A

-

C

-

P

K

K

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A

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S

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S

A

A

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G

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R

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S

D

S

S

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V

S

M

S

S

L

L

F

F

RQ 99:100 (= RQ 97:98) binding ATP

6asvC E. Coli prpp synthetase (see paper)
52% identity, 98% coverage: 5:310/311 of query aligns to 2:311/311 of 6asvC

query
sites
6asvC

I

M

K

K

L

L

I

F

T

A

G

G

N

N

A

A

N

T

P

P

D

E

F

L

A

A

E

Q

K

R

I

I

A

A

D

N

Y

R

L

L

H

Y

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T

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S

L

L

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G

D

D

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A

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A

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V

T

G

R

R

F

F

S

S

D

D

G

G

E

E

I

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R

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V

V

Q

Q

I

I

K

N

E

E

N

N

V

V

R

R

G

G

A

G

D

D

V

I

F

F

V

I

I

I

Q

Q

P

S

L

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T

C

Q

A

P

P

A

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N

N

D

D

H

N

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M

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E

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L

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M

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D

A

A

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A

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Y

F

F

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Y

A

A

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R

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Q

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D

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R

K

R

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-

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A

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G

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F

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P

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V

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D

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N

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A

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Y

D

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L

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L

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N

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L

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D

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N

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D

A

I

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G

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V

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R

A

A

R

R

M

A

L

I

A

A

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R

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L

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G

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-

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A

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A

A

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D

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A

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N

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I

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I

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D

T
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T

A
x
G

G

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T
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T

I
x
L

V

C

S

K

A

A

N

E

M

A

L

L

K

K

E

E

K

R

G

G

A

A

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K

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R

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V

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F

A

A

A

Y

C

A

T

T

H

H

P

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F

F

S

S

G

G

P

N

A

A

V

A

D

N

R

N

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L

K

R

N

N

S

S

E

V

I

I

E

D

E

E

V

V

I

V

V

V

T

C

D

D

T

T

I

I

P

P

T

L

T

S

G

D

-

E

-

I

K

K

E

S

F

L

D

P

K

N

L

V

T

R

V

T

L

L

S

T

V

L

A

S

E

G

L

M

V

L

G

A

E

E

A

A

I

I

R

R

I

I

N

S

I

N

E

E

S

E

S

S

V

I

S

S

S

A

L

M

F

F

binding phosphate ion: D168 (= D170), D218 (= D219), D219 (= D220), D222 (= D223), T223 (= T224), G224 (≠ A225), T226 (= T227), L227 (≠ I228)

P0A717 Ribose-phosphate pyrophosphokinase; RPPK; 5-phospho-D-ribosyl alpha-1-diphosphate synthase; Phosphoribosyl diphosphate synthase; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase; PRPPase; EC 2.7.6.1 from Escherichia coli (strain K12) (see 4 papers)
52% identity, 98% coverage: 5:310/311 of query aligns to 4:313/315 of P0A717

query
sites
P0A717

I

M

K

K

L

L

I

F

T

A

G

G

N

N

A

A

N

T

P

P

D

E

F

L

A

A

E

Q

K

R

I

I

A

A

D

N

Y

R

L

L

H

Y

V

T

P

S

L

L

V

G

D

D

T

A

L

A

V

V

T

G

R

R

F

F

S

S

D

D

G

G

E

E

I

V

R

S

V

V

Q

Q

I

I

K

N

E

E

N

N

V

V

R

R

G

G

A

G

D

D

V

I

F

F

V

I

I

I

Q

Q

P

S

L

T

T

C

Q

A

P

P

A

T

N

N

D

D

H

N

I

L

M

M

E

E

L

L

L

V

I

M

L

V

D

D

A

A

L

L

K

R

R

R

S

A

S

S

T

A

H

G

R

R

I

I

T

T

A

A

V

V

I

I

P

P

Y

Y

F

F

A

G

Y

Y

A

A

R

R

Q

Q

D

D

R

R

K

R

D

V

R

R

P

S

-

A

R

R

V

V

P

P

I

I

S

T

A

A

K

K

L

V

A

A

D

D

I

F

I

L

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S

A

V

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G

A

V

Q

D

R

R

V

V

L

L

T

T

V

V

D
|
D

L

L

H

H

S

A

A

E

Q

Q

I

I

Q

Q

G

G

F

F

D

D

C

V

P

P

V

V

D

D

N

N

L

V

Y

F

A

G

L

S

P

P

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I

I

L

L

L

D

E

Y

D

L

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R

L

N

Q

K

L

N

N

L

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E

D

N

N

M

P

V

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I

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S

S

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P

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D

A

I

G

G

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V

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V

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R

A

A

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A

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A

A

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R

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L

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G

N

-

D

A

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S

D

L

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A

A

I

I

Y

D

K

K

K

R

R

R

P

P

A

R

P

A

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N

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D

H

V

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I

I

G

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D

D

I

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A

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R

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D

A

C

I

V

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D

I

M

I

I

D
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D

T

T

A

G

G

G

T

T

I

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S

K

A

A

N

E

M

A

L

L

K

K

E

E

K

R

G

G

A

A

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K

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V

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F

A

A

A

Y

C

A

T

T

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H

P

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V

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F

F

S

S

G

G

P

N

A

A

V

A

D

N

R

N

L

L

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R

N

N

S

S

E

V

I

I

E

D

E

E

V

V

I

V

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V

T

C

D

D

T

T

I

I

P

P

T

L

T

S

G

D

-

E

-

I

K

K

E

S

F

L

D

P

K

N

L

V

T

R

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T

L

L

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T

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L

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E

G

L

M

V

L

G

A

E

E

A

A

I

I

R

R

I

I

N

S

I

N

E

E

S

E

S

S

V

I

S

S

S

A

L

M

F

F

D129 (= D129) to A: in mutant PRSA1; alters the binding of divalent cations, especially magnesium. Little alteration in the affinity for ribose 5-phosphate and 27-fold decrease of the affinity for ATP. Absence of inhibition by AMP
D220 (= D219) mutation to E: 4-fold decrease in the affinity binding for Rib-5-P in the presence of magnesium ions. In the presence of cobalt ions, it shows a 15-fold decrease in the affinity binding for Rib-5-P.; mutation to F: With magnesium or manganese ions, the affinity binding values for ATP and Rib-5-P are comparable to those of the wild-type.
D221 (= D220) mutation to A: The affinity binding for ATP is comparable to those of the wild-type, apart from a slight decrease in the presence of manganese ions. The affinity binding for Rib-5-P is greatly decreased in the presence of both manganese and cobalt ions but only about 2-fold in the presence of magnesium ions.
D224 (= D223) mutation to A: With magnesium or manganese ions, the affinity binding values for ATP and Rib-5-P are comparable to those of the wild-type.; mutation to S: With magnesium or manganese ions, the affinity binding values for ATP and Rib-5-P are comparable to those of the wild-type.

Sites not aligning to the query:

1 modified: Initiator methionine, Removed

1dkuA Crystal structures of bacillus subtilis phosphoribosylpyrophosphate synthetase: molecular basis of allosteric inhibition and activation. (see paper)
54% identity, 99% coverage: 4:310/311 of query aligns to 1:295/295 of 1dkuA

query
sites
1dkuA

H

N

I

L

K

K

L

I

I

F

T

S

G

L

N

N

A

S

N

N

P

P

D

E

F

L

A

A

E

K

K

E

I

I

A

A

D

D

Y

I

L

V

H

G

V

V

P

Q

L

L

V

G

D

K

T

C

L

S

V

V

T

T

R

R

F

F

S

S

D

D

G

G

E

E

I

V

R

Q

V

I

Q

N

I

I

K

E

E

E

N

S

V

I

R

R

G

G

A

C

D

D

V

C

F

Y

V

I

I

I

Q

Q

P

S

L

T

T

S

Q

D

P

P

A

V

N

N

D

E

H

H

I

I

M

M

E

E

L

L

L

I

I

M

L

V

D

D

A

A

L

L

K

K

R

R

S

A

S

S

T

A

H

K

R

T

I

I

T

N

A

I

V

V

I

I

P

P

Y

Y

F

Y

A

G

Y

Y

A

A

R
|
R

Q

Q

D

D

R

R

K
|
K

D

A

R

R

P
x
S

R
|
R

V

E

P

P

I

I

S

T

A

A

K

K

L

L

L

F

A

A

D

N

I

L

E

E

K

T

A

A

G

G

A

A

Q

T

R

R

V

V

L

I

T

A

V

L

D

D

L

L

H
|
H

S

A

A

P

Q

Q

I

I

Q

Q

G

G

F

F

D

D

C

I

P

P

V

I

D
|
D

N

H

L

L

Y

M

A

G

L

V

P

P

V

I

I

L

L

G

D

E

Y

Y

L

F

R

E

N

G

K

K

N

N

L

L

E

E

N

D

M

I

V

V

I

I

V

V

S

S

P

P

D

D

A

H

G

G

V

V

E

T

R

R

A

A

R

R

M

K

L

L

A

A

N

D

R

R

L

L

G

K

A

A

S

P

L

I

A

A

I

I

Y

D

K

K

K

R

R

-

P

-

A

-

P

-

N

-

V

-

E

-

T

-

L

M

D

N

V

I

I

V

G

G

D

N

I

I

E

E

G

G

K

K

N

T

A

A

I

I

I

L

I

I

D

D

I

I

D

D

T

T

A

A

G

G

T

T

I

I

V

T

S

L

A

A

N

N

M

A

L

L

K

V

E

E

K

N

G

G

A

A

K

K

S

E

V

V

I

Y

A

A

A

C

C

C

T

T

H

H

P

P

V

V

F

L

S

S

G

G

P

P

A

A

V

V

D

E

R

R

L

I

K

N

N

N

S

S

E

T

I

I

E

K

E

E

V

L

I

V

V

V

T

T

D

N

T

S

I

I

P

K

T

L

T

K

G

I

K

E

E

R

F

F

D

K

K

Q

L

-

T

-

V

-

L

L

S

S

V

V

A

G

E

P

L

L

V

L

G

A

E

E

A

A

I

I

R

I

R

R

I

V

N

H

I

E

E

Q

S

Q

S
|
S

V
|
V

S
|
S

S

Y

L

L

F
|
F

binding methyl phosphonic acid adenosine ester: R94 (= R97), H128 (= H131)
binding phosphomethylphosphonic acid adenosyl ester: K98 (= K101), S101 (≠ P104), R102 (= R105), D141 (= D144), S290 (= S305), V291 (= V306), S292 (= S307), F295 (= F310)

1ibsB Phosphoribosyldiphosphate synthetase in complex with cadmium ions (see paper)
53% identity, 99% coverage: 3:310/311 of query aligns to 2:299/299 of 1ibsB

query
sites
1ibsB

K

K

H

N

I

L

K

K

L

I

I

F

T

S

G

L

N

N

A

S

N

N

P

P

D

E

F

L

A

A

E

K

K

E

I

I

A

A

D

D

Y

I

L

V

H

G

V

V

P

Q

L

L

V

G

D

K

T

C

L

S

V

V

T

T

R

R

F

F

S

S

D

D

G

G

E

E

I

V

R

Q

V

I

Q

N

I

I

K

E

E

E

N

S

V

I

R

R

G

G

A

C

D

D

V

C

F

Y

V

I

I

I

Q

Q

P

S

L

T

T

S

Q

D

P

P

A

V

N

N

D

E

H

H

I

I

M

M

E

E

L

L

L

I

I

M

L

V

D

D

A

A

L

L

K

K

R

R

S

A

S

S

T

A

H

K

R

T

I

I

T

N

A

I

V

V

I

I

P

P

Y

Y

F

Y

A

G

Y

Y

A

A

R
|
R

Q
|
Q

D

D

R
|
R

K

K

D

S

R

R

P

E

R

-

V

-

P

P

I

I

S

T

A

A

K

K

L

L

L

F

A

A

D

N

I

L

E

E

K

T

A

A

G

G

A

A

Q

T

R

R

V

V

L

I

T

A

V

L

D

D

L

L

H

H

S

A

A

P

Q

Q

I

I

Q

Q

G

G

F

F

D

D

C

I

P

P

V

I

D

D

N

H

L

L

Y

M

A

G

L

V

P

P

V

I

I

L

L

G

D

E

Y

Y

L

F

R

E

N

G

K

K

N

N

L

L

E

E

N

D

M

I

V

V

I

I

V

V

S

S

P

P

D

D

A

H

G

G

V

V

E

T

R

R

A

A

R

R

M

K

L

L

A

A

N

D

R

R

L

L

G

K

A

A

S

P

L

I

A

A

I

I

Y

D

K

K

K

R

R

-

P

-

A

-

P

-

N

-

V

-

E

-

T

-

L

M

D

N

V

I

I

V

G

G

D

N

I

I

E

E

G

G

K

K

N

T

A

A

I

I

I

L

I

I

D

D

I

I

D

D

T

T

A

A

G

G

T

T

I

I

V

T

S

L

A

A

N

N

M

A

L

L

K

V

E

E

K

N

G

G

A

A

K

K

S

E

V

V

I

Y

A

A

A

C

C

C

T

T

H

H

P

P

V

V

F

L

S

S

G

G

P

P

A

A

V

V

D

E

R

R

L

I

K

N

N

N

S

S

E

T

I

I

E

K

E

E

V

L

I

V

V

V

T

T

D

N

T

S

I

I

P

K

T

L

-

P

T

E

G

E

K

K

E

K

F

I

D

E

K

R

L

F

T

K

V

Q

L

L

S

S

V

V

A

G

E

P

L

L

V

L

G

A

E

E

A

A

I

I

R

I

R

R

I

V

N

H

I

E

E

Q

S

Q

S

S

V

V

S

S

S

Y

L

L

F

F

binding methyl phosphonic acid adenosine ester: R96 (= R97), Q97 (= Q98), R99 (= R100)

4s2uA Crystal structure of the phosphorybosylpyrophosphate synthetase from e. Coli
52% identity, 97% coverage: 5:306/311 of query aligns to 3:308/308 of 4s2uA

query
sites
4s2uA

I

M

K

K

L

L

I

F

T

A

G

G

N

N

A

A

N

T

P

P

D

E

F

L

A

A

E

Q

K

R

I

I

A

A

D

N

Y

R

L

L

H

Y

V

T

P

S

L

L

V

G

D

D

T

A

L

A

V

V

T

G

R

R

F

F

S

S

D

D

G

G

E

E

I

V

R

S

V

V

Q

Q

I

I

K

N

E

E

N

N

V

V

R

R

G

G

A

G

D

D

V

I

F

F

V

I

I

I

Q

Q

P

S

L

T

T

C

Q

A

P

P

A

T

N

N

D

D

H

N

I

L

M

M

E

E

L

L

L

V

I

M

L

V

D

D

A

A

L

L

K

R

R

R

S

A

S

S

T

A

H

G

R

R

I

I

T

T

A

A

V

V

I

I

P

P

Y

Y

F

F

A

G

Y

Y

A

A

R

R

Q

Q

D

D

R

R

K

R

D

V

R

R

P

S

-

A

R

R

V

V

P

P

I

I

S

T

A

A

K

K

L

V

A

A

D

D

I

F

I

L

E

S

K

S

A

V

G

G

A

V

Q

D

R

R

V

V

L

L

T

T

V

V

D

D

L

L

H

H

S

A

A

E

Q

Q

I

I

Q

Q

G

G

F

F

D

D

C

V

P

P

V

V

D

D

N

N

L

V

Y

F

A

G

L

S

P

P

V

I

I

L

L

L

D

E

Y

D

L

M

R

L

N

Q

K

L

N

N

L

L

E

D

N

N

M

P

V

I

I

V

V

V

S

S

P

P

D

D

A

I

G

G

V

V

E

V

R

R

A

A

R

R

M

A

L

I

A

A

N

K

R

L

L

L

G

N

-

D

A

T

S

D

L

M

A

A

I

I

Y

D

K

K

K

R

R

R

P

P

A

R

P

A

N

N

V

V

V

S

E

Q

T

V

L

M

D

H

V

I

I

I

G

G

D

D

I

V

E

A

G

G

K

R

N

D

A

C

I

V

I

L

I

V

D

D

I

M

I

I

D
|
D

T

T

A

G

G

G

T
|
T

I

L

V

C

S

K

A

A

N

E

M

A

L

L

K

K

E

E

K

R

G

G

A

A

K

K

S

R

V

V

I

F

A

A

A

Y

C

A

T

T

H

H

P

P

V

I

F

F

S

S

G

G

P

N

A

A

V

A

D

N

R

N

L

L

K

R

N

N

S

S

E

V

I

I

E

D

E

E

V

V

I

V

V

V

T

C

D

D

T

T

I

I

P

P

T

L

T

S

G

D

-

E

-

I

K

K

E

S

F

L

D

P

K

N

L

V

T

R

V

T

L

L

S

T

V

L

A

S

E

G

L

M

V

L

G

A

E

E

A

A

I

I

R

R

I

I

N

S

I

N

E

E

S

E

S

S

V

I

binding magnesium ion: D223 (= D223), T227 (= T227)

1ibsA Phosphoribosyldiphosphate synthetase in complex with cadmium ions (see paper)
53% identity, 99% coverage: 4:310/311 of query aligns to 1:297/297 of 1ibsA

query
sites
1ibsA

H

N

I

L

K

K

L

I

I

F

T

S

G

L

N

N

A

S

N

N

P

P

D

E

F

L

A

A

E

K

K

E

I

I

A

A

D

D

Y

I

L

V

H

G

V

V

P

Q

L

L

V

G

D

K

T

C

L

S

V

V

T

T

R

R

F

F

S

S

D

D

G

G

E

E

I

V

R

Q

V

I

Q

N

I

I

K

E

E

E

N

S

V

I

R

R

G

G

A

C

D

D

V

C

F

Y

V

I

I

I

Q

Q

P

S

L

T

T

S

Q

D

P

P

A

V

N

N

D

E

H

H

I

I

M

M

E

E

L

L

L

I

I

M

L

V

D

D

A

A

L

L

K

K

R

R

S

A

S

S

T

A

H

K

R

T

I

I

T

N

A

I

V

V

I

I

P

P

Y

Y

F

Y

A

G

Y

Y

A

A

R
|
R

Q
|
Q

D

D

R
|
R

K

K

D

S

R

R

P

E

R

-

V

-

P

P

I

I

S

T

A

A

K

K

L

L

L

F

A

A

D

N

I

L

E

E

K

T

A

A

G

G

A

A

Q

T

R

R

V

V

L

I

T

A

V

L

D

D

L

L

H
|
H

S

A

A

P

Q

Q

I

I

Q

Q

G

G

F

F

D

D

C

I

P

P

V

I

D

D

N

H

L

L

Y

M

A

G

L

V

P

P

V

I

I

L

L

G

D

E

Y

Y

L

F

R

E

N

G

K

K

N

N

L

L

E

E

N

D

M

I

V

V

I

I

V

V

S

S

P

P

D

D

A

H

G

G

V

V

E

T

R

R

A

A

R

R

M

K

L

L

A

A

N

D

R

R

L

L

G

K

A

A

S

P

L

I

A

A

I

I

Y

D

K

K

K

R

R

-

P

-

A

-

P

-

N

-

V

-

E

-

T

-

L

M

D

N

V

I

I

V

G

G

D

N

I

I

E

E

G

G

K

K

N

T

A

A

I

I

I

L

I

I

D

D

I

I

D
|
D

T
|
T

A
|
A

G

G

T
|
T

I

I

V

T

S

L

A

A

N

N

M

A

L

L

K

V

E

E

K

N

G

G

A

A

K

K

S

E

V

V

I

Y

A

A

A

C

C

C

T

T

H

H

P

P

V

V

F

L

S

S

G

G

P

P

A

A

V

V

D

E

R

R

L

I

K

N

N

N

S

S

E

T

I

I

E

K

E

E

V

L

I

V

V

V

T

T

D

N

T

S

I

I

P

K

T

L

-

P

T

E

G

E

K

K

E

K

F

I

D

E

K

R

L

F

T

K

V

Q

L

L

S

S

V

V

A

G

E

P

L

L

V

L

G

A

E

E

A

A

I

I

R

I

R

R

I

V

N

H

I

E

E

Q

S

Q

S

S

V

V

S

S

S

Y

L

L

F

F

binding methyl phosphonic acid adenosine ester: R94 (= R97), Q95 (= Q98), R97 (= R100), H126 (= H131)
binding sulfate ion: D209 (= D223), T210 (= T224), A211 (= A225), T213 (= T227)

7xmvA E.Coli phosphoribosylpyrophosphate (prpp) synthetase type a(amp/adp) filament bound with adp, amp and r5p (see paper)
51% identity, 98% coverage: 5:310/311 of query aligns to 2:305/307 of 7xmvA

query
sites
7xmvA

I

M

K

K

L

L

I

F

T

A

G

G

N

N

A

A

N

T

P

P

D

E

F

L

A

A

E

Q

K

R

I

I

A

A

D

N

Y

R

L

L

H

Y

V

T

P

S

L

L

V

G

D

D

T

A

L

A

V

V

T

G

R

R

F
|
F

S

S

D
|
D

G

G

E
|
E

I

V

R

S

V

V

Q

Q

I

I

K

N

E

E

N

N

V

V

R

R

G

G

A

G

D

D

V

I

F

F

V

I

I

I

Q

Q

P

S

L

T

T

C

Q

A

P

P

A

T

N

N

D

D

H

N

I

L

M

M

E

E

L

L

L

V

I

M

L

V

D

D

A

A

L

L

K

R

R

R

S

A

S

S

T

A

H

G

R

R

I

I

T

T

A

A

V

V

I

I

P

P

Y

Y

F

F

A

G

Y

Y

A

A

R
|
R

Q

Q

D

D

R
|
R

K

R

D
x
V

R
|
R

P

S

-

A

R

R

V

V

P

P

I

I

S

T

A

A

K

K

L

V

A

A

D

D

I

F

I

L

E

S

K

S

A

V

G

G

A

V

Q

D

R

R

V

V

L

L

T

T

V

V

D

D

L

L

H
|
H

S

A

A
x
E

Q

Q

I

I

Q

Q

G

G

F

F

D

D

C

V

P

P

V

V

D

D

N

N

L

V

Y
x
F

A

G

L
x
S

P

P

V

I

I

L

L

L

D

E

Y

D

L

M

R

L

N

Q

K

L

N

N

L

L

E

D

N

N

M

P

V

I

I

V

V

V

S

S

P

P

D

D

A

I

G

G

V

V

E
x
V

R

R

A

A

R

R

M
x
A

L

I

A

A

N

K

R

L

L

L

G

N

-

D

A

T

S

D

L

M

A

A

I

I

Y

D

K

K

K

R

R

R

P

-

A

-

P

-

N

-

V

-

E

Q

T

V

L

M

D

H

V

I

I

I

G

G

D

D

I

V

E

A

G

G

K

R

N

D

A

C

I

V

I

L

I

V

D
|
D

I
x
M

I

I

D
|
D

T
|
T

A

G

G
|
G

T
|
T

I

L

V

C

S

K

A

A

N

E

M

A

L

L

K

K

E

E

K

R

G

G

A

A

K

K

S

R

V

V

I

F

A

A

A

Y

C

A

T

T

H

H

P

P

V

I

F

F

S

S

G

G

P

N

A

A

V

A

D

N

R

N

L

L

K

R

N

N

S

S

E

V

I

I

E

D

E

E

V

V

I

V

V

V

T

C

D

D

T

T

I

I

P

P

T

L

T

S

G

D

-

E

-

I

K

K

E

S

F

L

D

P

K

N

L

V

T

R

V

T

L

L

S

T

V

L

A

S

E

G

L

M

V

L

G

A

E

E

A

A

I

I

R

R

I

I

N

S

I

N

E

E

S

E

S

S

V

I

S

S

S

A

L

M

F

F

binding adenosine-5'-diphosphate: F33 (= F36), D35 (= D38), E37 (= E40), R94 (= R97), R97 (= R100), H129 (= H131)
binding adenosine monophosphate: R97 (= R100), V99 (≠ D102), R100 (= R103), E131 (≠ A133), F145 (≠ Y147), S147 (≠ L149), V173 (≠ E175), A177 (≠ M179)
binding 5-O-phosphono-alpha-D-ribofuranose: D212 (= D219), D213 (= D220), M214 (≠ I221), D216 (= D223), T217 (= T224), G219 (= G226), T220 (= T227)

7xmuA E.Coli phosphoribosylpyrophosphate (prpp) synthetase type a filament bound with adp, pi and r5p (see paper)
51% identity, 98% coverage: 5:310/311 of query aligns to 2:305/307 of 7xmuA

query
sites
7xmuA

I

M

K

K

L

L

I

F

T

A

G

G

N

N

A

A

N

T

P

P

D

E

F

L

A

A

E

Q

K

R

I

I

A

A

D

N

Y

R

L

L

H

Y

V

T

P

S

L

L

V

G

D

D

T

A

L

A

V

V

T

G

R

R

F
|
F

S

S

D
|
D

G

G

E
|
E

I

V

R

S

V

V

Q

Q

I

I

K

N

E

E

N

N

V

V

R

R

G

G

A

G

D

D

V

I

F

F

V

I

I

I

Q

Q

P

S

L

T

T

C

Q

A

P

P

A

T

N

N

D

D

H

N

I

L

M

M

E

E

L

L

L

V

I

M

L

V

D

D

A

A

L

L

K

R

R

R

S

A

S

S

T

A

H

G

R

R

I

I

T

T

A

A

V

V

I

I

P

P

Y

Y

F

F

A

G

Y

Y

A

A

R
|
R

Q
|
Q

D

D

R
|
R

K

R

D

V

R
|
R

P

S

-

A

R

R

V

V

P

P

I

I

S

T

A

A

K

K

L

V

A

A

D

D

I

F

I

L

E

S

K

S

A

V

G

G

A

V

Q

D

R

R

V

V

L

L

T

T

V

V

D

D

L

L

H
|
H

S

A

A
x
E

Q

Q

I

I

Q

Q

G

G

F

F

D

D

C

V

P

P

V

V

D

D

N

N

L

V

Y
x
F

A

G

L
x
S

P

P

V

I

I

L

L

L

D

E

Y

D

L

M

R

L

N

Q

K

L

N

N

L

L

E

D

N

N

M

P

V

I

I

V

V

V

S

S

P

P

D
|
D

A

I

G

G

V

V

E
x
V

R

R

A

A

R

R

M

A

L

I

A

A

N

K

R

L

L

L

G

N

-

D

A

T

S

D

L

M

A

A

I

I

Y

D

K

K

K

R

R

R

P

-

A

-

P

-

N

-

V

-

E

Q

T

V

L

M

D

H

V

I

I

I

G

G

D

D

I

V

E

A

G

G

K

R

N

D

A

C

I

V

I

L

I

V

D
|
D

D

D

I
x
M

I

I

D
|
D

T
|
T

A

G

G

G

T

T

I

L

V

C

S

K

A

A

N

E

M

A

L

L

K

K

E

E

K

R

G

G

A

A

K

K

S

R

V

V

I

F

A

A

A

Y

C

A

T

T

H

H

P

P

V

I

F

F

S

S

G

G

P

N

A

A

V

A

D

N

R

N

L

L

K

R

N

N

S

S

E

V

I

I

E

D

E

E

V

V

I

V

V

V

T

C

D

D

T

T

I

I

P

P

T

L

T

S

G

D

-

E

-

I

K

K

E

S

F

L

D

P

K

N

L

V

T

R

V

T

L

L

S

T

V

L

A

S

E

G

L

M

V

L

G

A

E

E

A

A

I

I

R

R

I

I

N

S

I

N

E

E

S

E

S

S

V

I

S

S

S

A

L

M

F

F

binding adenosine-5'-diphosphate: F33 (= F36), D35 (= D38), E37 (= E40), R94 (= R97), Q95 (= Q98), R97 (= R100), R97 (= R100), R100 (= R103), H129 (= H131), E131 (≠ A133), F145 (≠ Y147), S147 (≠ L149), V173 (≠ E175)
binding 5-O-phosphono-alpha-D-ribofuranose: D168 (= D170), D212 (= D219), M214 (≠ I221), D216 (= D223), T217 (= T224)

3dahC 2.3 a crystal structure of ribose-phosphate pyrophosphokinase from burkholderia pseudomallei (see paper)
52% identity, 97% coverage: 5:306/311 of query aligns to 2:299/300 of 3dahC

query
sites
3dahC

I

L

K

M

L

V

I

F

T

T

G

G

N

N

A

A

N

N

P

P

D

A

F

L

A

A

E

Q

K

E

I

V

A

V

D

K

Y

I

L

L

H

G

V

I

P

P

L

L

V

G

D

K

T

A

L

M

V

V

T

S

R

R

F
|
F

S

S

D
|
D

G

G

E
|
E

I

I

R

Q

V

V

Q

E

I

I

K

Q

E

E

N

N

V

V

R

R

G

G

A

K

D

D

V

V

F

F

V

V

I

L

Q

Q

P

S

L

T

T

C

Q

A

P

P

A

T

N

N

D

D

H

N

I

L

M

M

E

E

L

L

L

M

L

I

I

M

L

V

D

D

A

A

L

L

K

K

R

R

S

A

S

S

T

A

H

G

R

R

I

I

T

T

A

A

V

A

I

I

P

P

Y

Y

F

F

A

G

Y

Y

A

A

R
|
R

Q
|
Q

D

D

R

R

K

R

D

P

R

R

P

S

-

A

R

R

V

V

P

A

I

I

S

S

A

A

K

K

L

V

A

A

D

N

I

M

I

L

E

E

K

I

A

A

G

G

A

V

Q

E

R

R

V

I

L

I

T

T

V

M

D

D

L

L

H

H

S

A

A

D

Q

Q

I

I

Q

Q

G

G

F

F

D

D

C

I

P

P

V

V

D

D

N

N

L

I

Y

Y

A

A

L

T

P

P

V

I

I

L

L

L

D

G

Y

D

L

L

R

R

N

K

K

Q

N

N

L

Y

E

P

N

D

M

L

V

L

I

V

V

V

S

S

P

P

D

D

A

V

G

G

V

V

E

V

R

R

A

A

R

R

M

A

L

L

A

A

N

K

R

Q

L

L

G

N

A

C

S

D

L

L

A

A

I

I

Y

D

K

K

K

R

R

R

P

-

A

-

P

-

N

-

V

-

E

-

T

V

L

M

D

N

V

I

I

I

G

G

D

E

I

V

E

E

G

G

K

R

N

T

A

C

I

V

I

I

I

M

D

D

I

M

I

V

D

D

T

T

A

A

G

G

T

T

I

L

V

C

S

K

A

A

N

Q

M

V

L

L

K

K

E

E

K

R

G

G

A

A

K

K

S

Q

V

V

I

F

A

A

A

Y

C

A

T

T

H

H

P

P

V

V

F

L

S

S

G

G

P

G

A

A

V

A

D

D

R

R

L

I

K

A

N

A

S

S

E

A

I

L

E

D

E

E

V

L

I

V

V

V

T

T

D

D

T

T

I

I

P

P

T

L

T

S

G

A

K

E

E

S

F

L

D

A

-

C

-

P

K

K

L

I

T

R

V

A

L

L

S

S

V

S

A

A

E

G

L

L

V

L

G

A

E

E

A

T

I

F

R

S

R

R

I

I

N

R

I

R

E

G

S

D

S

S

V

V

binding adenosine monophosphate: F33 (= F36), D35 (= D38), E37 (= E40), R94 (= R97), Q95 (= Q98)

6nfeB Crystal structure of ribose-phosphate pyrophosphokinase from legionella pneumophila with bound amp, adp, and ribose-5-phosphate
54% identity, 95% coverage: 7:302/311 of query aligns to 5:299/299 of 6nfeB

query
sites
6nfeB

L

I

I

F

T

T

G

G

N

N

A

A

N

N

P

P

D

E

F

L

A

A

E

L

K

K

I

I

A

S

D

S

Y

H

L

L

H

Q

V

I

P

P

L

I

V

G

D

K

T

A

L

T

V

V

T

G

R

T

F
|
F

S

S

D
|
D

G

G

E
|
E

I

T

R

M

V

V

Q

E

I

I

K

L

E

E

N

N

V

V

R

R

G

G

A

K

D

D

V

V

F

F

V

V

I

L

Q

Q

P

S

L

T

T

C

Q

A

P

P

A

A

N

N

D

N

H

N

I

L

M

M

E

E

L

L

L

I

I

M

L

A

D

D

A

A

L

L

K

R

R

R

S

S

T

A

H

G

R

R

I

I

T

T

A

A

V

V

I

V

P

P

Y

Y

F

F

A

G

Y

Y

A

A

R
|
R

Q
|
Q

D

D

R

R

K

R

D

V

R

R

P

S

-

A

R

R

V

V

P

P

I

I

S

T

A

A

K

K

L

V

A

A

D

D

I

M

E

A

K

S

A

V

G

G

A

I

Q

C

R

R

V

V

L

L

T

T

V

V

D

D

L

L

H
|
H

S

A

A

D

Q

Q

I

I

Q

Q

G

G

F

F

D

Y

C

M

P

P

V

V

D

D

N

N

L

V

Y

Y

A

S

L

T

P

P

V

V

I

L

L

L

D

E

Y

D

L

I

R

T

N

K

K

Q

N

K

L

L

E

N

N

N

M

I

V

M

I

I

V

V

S

S

P

P

D

D

A

V

G

G

V

V

E

V

R

R

A

A

R

R

M

A

L

V

A

A

N

K

R

R

L

L

G

N

-

D

A

A

S

E

L

L

A

S

I

I

Y

D

K

K

K

R

R

R

P

S

A

-

P

-

N

-

V

-

E

E

T

V

L

M

D

H

V

I

I

I

G

G

D

E

I

P

E

A

G

N

K

K

N

N

A

C

I

I

I

V

D
|
D

I
|
I

I

V

D
|
D

T
|
T

A
|
A

G

G

T
|
T

I

L

V

C

S

T

A

A

N

H

M

E

L

L

K

K

E

K

K

N

G

G

A

A

K

K

S

S

V

V

I

R

A

A

A

Y

C

I

T

T

H

H

P

P

V

V

F

L

S

S

G

G

P

P

A

A

V

V

D

N

R

N

L

I

K

K

N

H

S

S

E

G

I

L

E

D

E

E

V

V

I

V

V

V

T

T

D

D

T

T

I

I

P

P

T

L

T

S

-

A

-

E

G

A

K

Q

E

N

F

C

D

E

K

K

L

I

T

R

V

V

L

V

S

S

V

L

A

A

E

D

L

M

V

L

G

A

E

Q

A

A

I

I

R

K

R

R

I

V

N

N

I

V

binding adenosine-5'-diphosphate: F34 (= F36), D36 (= D38), E38 (= E40), R95 (= R97), Q96 (= Q98), H130 (= H131)
binding 5-O-phosphono-alpha-D-ribofuranose: H130 (= H131), D214 (= D219), D215 (= D220), I216 (= I221), D218 (= D223), T219 (= T224), A220 (= A225), T222 (= T227)

6nfeA Crystal structure of ribose-phosphate pyrophosphokinase from legionella pneumophila with bound amp, adp, and ribose-5-phosphate
54% identity, 95% coverage: 7:302/311 of query aligns to 5:298/298 of 6nfeA

query
sites
6nfeA

L

I

I

F

T

T

G

G

N

N

A

A

N

N

P

P

D

E

F

L

A

A

E

L

K

K

I

I

A

S

D

S

Y

H

L

L

H

Q

V

I

P

P

L

I

V

G

D

K

T

A

L

T

V

V

T

G

R

T

F
|
F

S

S

D
|
D

G

G

E
|
E

I

T

R

M

V

V

Q

E

I

I

K

L

E

E

N

N

V

V

R

R

G

G

A

K

D

D

V

V

F

F

V

V

I

L

Q

Q

P

S

L

T

T

C

Q

A

P

P

A

A

N

N

D

N

H

N

I

L

M

M

E

E

L

L

L

I

I

M

L

A

D

D

A

A

L

L

K

R

R

R

S

S

T

A

H

G

R

R

I

I

T

T

A

A

V

V

I

V

P

P

Y

Y

F

F

A

G

Y

Y

A

A

R
|
R

Q
|
Q

D

D

R
|
R

K

R

D
x
V

R

R

P

S

-

A

R

R

V

V

P

P

I

I

S

T

A

A

K

K

L

V

A

A

D

D

I

M

E

A

K

S

A

V

G

G

A

I

Q

C

R

R

V

V

L

L

T

T

V

V

D

D

L

L

H
|
H

S

A

A

D

Q

Q

I

I

Q

Q

G

G

F

F

D

Y

C

M

P

P

V

V

D

D

N

N

L

V

Y
|
Y

A

S

L

T

P

P

V

V

I

L

L

L

D

E

Y

D

L

I

R

T

N

K

K

Q

N

K

L

L

E

N

N

N

M

I

V

M

I

I

V

V

S

S

P

P

D

D

A

V

G

G

V

V

E

V

R
|
R

A

A

R

R

M
x
A

L

V

A

A

N
x
K

R

R

L

L

G

N

-

D

A

A

S

E

L

L

A

S

I

I

Y

D

K

K

K

R

R

R

P

-

A

-

P

-

N

-

V

-

E

E

T

V

L

M

D

H

V

I

I

I

G

G

D

E

I

P

E

A

G

N

K

K

N

N

A

C

I

I

I

V

D
|
D

I
|
I

I

V

D
|
D

T
|
T

A
|
A

G

G

T
|
T

I

L

V

C

S

T

A

A

N

H

M

E

L

L

K

K

E

K

K

N

G

G

A

A

K

K

S

S

V

V

I

R

A

A

A

Y

C

I

T

T

H

H

P

P

V

V

F

L

S

S

G

G

P

P

A

A

V

V

D

N

R

N

L

I

K

K

N

H

S

S

E

G

I

L

E

D

E

E

V

V

I

V

V

V

T

T

D

D

T

T

I

I

P

P

T

L

T

S

-

A

-

E

G

A

K

Q

E

N

F

C

D

E

K

K

L

I

T

R

V

V

L

V

S

S

V

L

A

A

E

D

L

M

V

L

G

A

E

Q

A

A

I

I

R

K

R

R

I

V

N

N

I

V

binding adenosine-5'-diphosphate: F34 (= F36), D36 (= D38), E38 (= E40), R95 (= R97), Q96 (= Q98), H130 (= H131)
binding adenosine monophosphate: R98 (= R100), V100 (≠ D102), Y146 (= Y147), R175 (= R176), A178 (≠ M179), K181 (≠ N182)
binding 5-O-phosphono-alpha-D-ribofuranose: H130 (= H131), D213 (= D219), D214 (= D220), I215 (= I221), D217 (= D223), T218 (= T224), A219 (= A225), T221 (= T227)

5t3oA Crystal structure of the phosphorybosylpyrophosphate synthetase ii from thermus thermophilus (see paper)
49% identity, 98% coverage: 7:310/311 of query aligns to 4:306/307 of 5t3oA

query
sites
5t3oA

L

I

I

F

T

S

G

G

N

Q

A

S

N

N

P

R

D

P

F

L

A

A

E

Q

K

A

I

I

A

A

D

E

Y

A

L

L

H

G

V

L

P

P

L

L

V

G

D

K

T

S

L

T

V

T

T

L

R

R

F

F

S

A

D

N

G

D

E

N

I

L

R

F

V

V

Q

R

I

Y

K

E

E

E

N
x
S

V

L

R
|
R

G

E

A

G

D

D

V

V

F

F

V

I

I

V

Q

Q

P

S

L

F

T

V

Q

P

P

P

A

V

N

Q

D

D

H

H

I

L

M

M

E

E

L

L

L

M

I

M

L

V

D

D

A

A

L

A

K

K

R

G

S

A

S

S

T

A

H

A

R

R

I

V

T

T

A

A

V

V

I

I

P

P

Y

Y

F

F

A

S

Y

Y

A

A

R
|
R

Q
x
S

D

D

R

K

K

K

D
|
D

R

A

P

P

R

R

V

I

P

S

I

I

S

T

A

A

K

R

L

L

L

I

A

A

D

D

I

L

E

Q

K

T

A

A

G

G

A

A

Q

D

R

R

V

V

L

L

T

T

V

M

D

T

L

L

H
|
H

S

S

A

P

Q

Q

I

V

Q

H

G

G

F

F

D

K

C

I

P

P

V

V

D

D

N

H

L

L

Y

S

A

A

L

E

P

P

V

V

I

I

L

A

D

N

Y

Y

L

F

R

A

N

T

K

R

-

V

N

D

L

L

E

E

N

N

M

A

V

V

I

V

V

V

S

A

P

P

D

D

A

A

G

G

G

D

V

L

E

K

R

R

A

A

R

S

M

A

L

L

A

A

N

R

R

R

L

L

G

G

A

L

S

P

L

L

A

A

I

F

I

I

Y

D

K

K

K

E

R
|
R

P

V

A

S

P

D

N

T

V

E

V

V

E

R

T

V

L

R

D

M

V

L

I

V

G

G

D

E

I

V

E

E

G

G

K

K

N

T

A

A

I

L

I

I

I

V

D

D

I

E

I

I

D

S

T

T

A

A

G

G

T

S

I

L

V

V

S

E

A

A

A

V

N

E

M

A

L

L

K

M

E

Q

K

A

G

G

A

A

K

K

S

E

V

V

I

Y

A

A

C

A

T

T

H

H

P

G

V

V

F

Y

S

V

G

G

P

P

A

A

V

L

D

D

R

R

L

I

K

A

N

K

S

S

E

P

I

V

E

K

E

E

V

V

I

A

V

A

T

T

D

D

T

T

I

C

P

P

T

P

T

-

G

-

K

K

E

E

F

G

D

P

K

K

L

L

T

R

V

T

L

L

S

T

V

V

A

A

E

P

L

L

V

F

G

A

E

E

A

A

I

I

R

W

R

R

I

I

N

H

I

R

E

G

S

E

S

S

V

V

S

S

L

L

F

F

binding adenosine-5'-diphosphate: R94 (= R97), S95 (≠ Q98), D99 (= D102), H128 (= H131), R193 (= R195)
binding sulfate ion: S45 (≠ N48), R47 (= R50)

7pn0A Crystal structure of the phosphorybosylpyrophosphate synthetase ii from thermus thermophilus at r32 space group
49% identity, 98% coverage: 7:310/311 of query aligns to 5:307/312 of 7pn0A

query
sites
7pn0A

L

I

I

F

T

S

G

G

N

Q

A

S

N

N

P

R

D

P

F

L

A

A

E

Q

K

A

I

I

A

A

D

E

Y

A

L

L

H

G

V

L

P

P

L

L

V

G

D

K

T

S

L

T

V

T

T

L

R

R

F

F

S

A

D

N

G

D

E

N

I

L

R

F

V

V

Q

R

I

Y

K

E

E

E

N

S

V

L

R

R

G

E

A

G

D

D

V

V

F

F

V

I

I

V

Q

Q

P

S

L

F

T

V

Q

P

P

P

A

V

N

Q

D

D

H

H

I

L

M

M

E

E

L

L

L

M

I

M

L

V

D

D

A

A

L

A

K

K

R

G

S

A

S

S

T

A

H

A

R

R

I

V

T

T

A

A

V

V

I

I

P

P

Y

Y

F

F

A

S

Y

Y

A

A

R
|
R

Q
x
S

D

D

R

K

K

K

D

D

R

A

P

P

R

R

V

I

P

S

I

I

S

T

A

A

K

R

L

L

L

I

A

A

D

D

I

L

E

Q

K

T

A

A

G

G

A

A

Q

D

R

R

V

V

L

L

T

T

V

M

D

T

L

L

H
|
H

S

S

A

P

Q

Q

I

V

Q

H

G

G

F

F

D

K

C

I

P

P

V

V

D

D

N

H

L

L

Y

S

A

A

L

E

P

P

V

V

I

I

L

A

D

N

Y

Y

L

F

R

A

N

T

K

R

-

V

N

D

L

L

E

E

N

N

M

A

V

V

I

V

V

V

S

A

P

P

D

D

A

A

G

G

G

D

V

L

E

K

R

R

A

A

R

S

M

A

L

L

A

A

N

R

R

R

L

L

G

G

A

L

S

P

L

L

A

A

I

F

I

I

Y

D

K

K

K

E

R

R

P

V

A

S

P

D

N

T

V

E

V

V

E

R

T

V

L

R

D

M

V

L

I

V

G

G

D

E

I

V

E

E

G

G

K

K

N

T

A

A

I

L

I

I

I

V

D

D

I

E

I

I

D

S

T

T

A

A

G

G

T

S

I

L

V

V

S

E

A

A

A

V

N

E

M

A

L

L

K

M

E

Q

K

A

G

G

A

A

K

K

S

E

V

V

I

Y

A

A

C

A

T

T

H

H

P

G

V

V

F

Y

S

V

G

G

P

P

A

A

V

L

D

D

R

R

L

I

K

A

N

K

S

S

E

P

I

V

E

K

E

E

V

V

I

A

V

A

T

T

D

D

T

T

I

C

P

P

T

P

T

-

G

-

K

K

E

E

F

G

D

P

K

K

L

L

T

R

V

T

L

L

S

T

V

V

A

A

E

P

L

L

V

F

G

A

E

E

A

A

I

I

R

W

R

R

I

I

N

H

I

R

E

G

S

E

S

S

V

V

S

S

L

L

F

F

binding adenosine-5'-diphosphate: R95 (= R97), S96 (≠ Q98), H129 (= H131)

P60891 Ribose-phosphate pyrophosphokinase 1; PPRibP; Phosphoribosyl pyrophosphate synthase I; PRS-I; EC 2.7.6.1 from Homo sapiens (Human) (see 5 papers)
46% identity, 99% coverage: 4:310/311 of query aligns to 3:313/318 of P60891

query
sites
P60891

H

N

I

I

K

K

L

I

I

F

T

S

G

G

N

S

A

S

N

H

P

Q

D

D

F

L

A
x
S

E

Q

K

K

I

I

A

A

D

D

Y

R

L

L

H

G

V

L

P

E

L

L

V

G

D

K

T

V

L

V

V

T

T

K

R

K

F

F

S

S

D

N

G

Q

E

E

I

T

R

C

V

V

Q

E

I

I

K

G

E

E

N

S

V

V

R

R

G

G

A

E

D
|
D

V

V

F

Y

V

I

I

V

Q

Q

P

S

L

G

T

C

Q

G

P

E

A

I

N

N

D

D

H

N

I

L

M

M

E

E

L

L

L

I

I

M

L

I

D

N

A

A

L

C

K

K

R

I

S

A

S

S

T

A

H

S

R

R

I

V

T

T

A

A

V

V

I

I

P

P

Y

C

F

F

A

P

Y

Y

A

A

R

R

Q

Q

D

D

R

K

K

K

D

D

R

K

P

S

R

R

V

A

P

P

I

I

S

S

A

A

K

K

L

L

L

V

A

A

D
x
N

I

M

I

L

E

S

K

V

A

A

G

G

A

A

Q

D

R

H

V

I

L

I

T

T

V

M

D

D

L
|
L

H

H

S

A

A
x
S

Q

Q

I

I

Q

Q

G

G

F

F

D

D

C

I

P

P

V
|
V

D

D

N
|
N

L

L

Y
|
Y

A

A

L

E

P

P

V

A

I

V

L

L

D

K

Y

W

L

I

R

R

N

E

K

N

-

I

-

S

N

E

L

W

E

R

N

N

M

C

V

T

I

I

V

V

S

S

P

P

D

D

A

A

G

G

V

A

E

K

R

R

A

V

R

T

M

S

L

I

A

A

N
x
D

R

R

L

L

G

N

A

V

S

D

L

F

A
|
A

I

L

I

I

Y
x
H

K

K

K

E

R

R

P

K

A

K

P

A

N

N

V

E

V

V

E
x
D

T

R

L

M

D

V

V

L

I

V

G

G

D

D

I

V

E

K

G

D

K

R

N

V

A

A

I

I

I

L

I
x
V

D

D

I

M

I

A

D

D

T

T

A

C

G

G

T

T

I

I

V

C

S
x
H

A

A

N

D

M

K

L

L

K

L

E

S

K

A

G

G

A

A

K

T

S

R

V

V

I

Y

A

A

A

I

C

L

T

T

H

H

P

G

V

I

F

F

S

S

G

G

P

P

A

A

V

I

D

S

R

R

L

I

K

N

N

N

S

A

E

C

I

F

E

E

E

A

V

V

I

V

V

V

T

T

D

N

T

T

I

I

P

P

T

Q

T

E

G

D

-

K

-

M

K

K

E

H

F

C

D

S

K

K

L

I

T

Q

V

V

L

I

S

D

V

I

A

S

E

M

L

I

V

L

G

A

E

E

A

A

I

I

R

R

I

T

N

H

I

N

E

G

S

E

S

S

V

V

S

S

S

Y

L

L

F

F

S16 (≠ A17) to P: found in patients with phosphoribosyl pyrophosphate synthetase I deficiency; likely pathogenic; dbSNP:rs869025594
D52 (= D53) to H: in PRPS1 superactivity; no effect on Km; resistant to inhibition by ADP and GDP; dbSNP:rs137852542
N114 (≠ D115) to S: in PRPS1 superactivity; no effect on Km; resistant to inhibition by ADP and GDP; dbSNP:rs137852540
L129 (= L130) to I: in PRPS1 superactivity; no effect on Km; resistant to inhibition by ADP and GDP; dbSNP:rs137852543
S132 (≠ A133) mutation to A: Reduces catalytic activity.; mutation to F: No effect on catalytic activity.
V142 (= V143) to L: found in a patient with an intermediate phenotype between ARTS and PRPS1 superactivity; likely pathogenic; normal PRPP synthetase activity in fibroblasts; loss of activity in erythrocytes; dbSNP:rs398122855
N144 (= N145) mutation to H: No effect on catalytic activity.
Y146 (= Y147) mutation to F: No effect on catalytic activity.; mutation to M: Reduces catalytic activity.
D183 (≠ N182) to H: in PRPS1 superactivity; no effect on Km; resistant to inhibition by ADP and GDP; dbSNP:rs137852541
A190 (= A189) to V: in PRPS1 superactivity; no effect on Km; resistant to inhibition by ADP and GDP; dbSNP:rs137852544
H193 (≠ Y192) to Q: in PRPS1 superactivity; no effect on Km; resistant to inhibition by ADP and GDP; dbSNP:rs137852545
D203 (≠ E202) to H: in a breast cancer sample; somatic mutation
V219 (≠ I218) to G: in a breast cancer sample; somatic mutation
H231 (≠ S230) to D: in a colorectal cancer sample; somatic mutation

Sites not aligning to the query:

1 modified: Initiator methionine, Removed

8dbkB Human prps1 with phosphate, atp, and r5p; hexamer with resolved catalytic loops (see paper)
46% identity, 99% coverage: 4:310/311 of query aligns to 2:312/316 of 8dbkB

query
sites
8dbkB

H

N

I

I

K

K

L

I

I

F

T

S

G

G

N

S

A

S

N

H

P

Q

D

D

F

L

A

S

E

Q

K

K

I

I

A

A

D

D

Y

R

L

L

H

G

V

L

P

E

L

L

V

G

D

K

T

V

L

V

V

T

T

K

R

K

F
|
F

S

S

D
x
N

G

Q

E
|
E

I

T

R

C

V

V

Q

E

I

I

K

G

E

E

N
x
S

V

V

R
|
R

G

G

A

E

D

D

V

V

F

Y

V

I

I

V

Q

Q

P

S

L

G

T

C

Q

G

P

E

A

I

N

N

D

D

H

N

I

L

M

M

E

E

L

L

L

I

I

M

L

I

D

N

A

A

L

C

K

K

R

I

S

A

S

S

T

A

H

S

R

R

I

V

T

T

A

A

V

V

I

I

P

P

Y

C

F

F

A

P

Y

Y

A

A

R
|
R

Q
|
Q

D

D

R

K

K

K

D

D

R

K

P

S

R

R

V

A

P

P

I

I

S

S

A

A

K

K

L

L

L

V

A

A

D

N

I

M

I

L

E

S

K

V

A

A

G

G

A

A

Q

D

R

H

V

I

L

I

T

T

V

M

D

D

L

L

H
|
H

S

A

A

S

Q

Q

I

I

Q

Q

G

G

F

F

D

D

C

I

P

P

V

V

D

D

N

N

L

L

Y

Y

A

A

L

E

P

P

V

A

I

V

L

L

D

K

Y

W

L

I

R

R

N

E

K

N

-

I

-

S

N

E

L

W

E

R

N

N

M

C

V

T

I

I

V

V

S

S

P

P

D
|
D

A

A

G
|
G

G

G

V

A

E

K

R

R

A

V

R

T

M

S

L

I

A

A

N

D

R

R

L

L

G

N

A

V

S

D

L

F

A

A

I

L

I

I

Y

H

K
|
K

K

E

R
|
R

P

K

A

K

P

A

N
|
N

V

E

V

V

E

D

T

R

L

M

D

V

V

L

I

V

G

G

D

D

I

V

E

K

G

D

K

R

N

V

A

A

I

I

I

L

I

V

D
|
D

I

M

I

A

D
|
D

T
|
T

A
x
C

G
|
G

T
|
T

I

I

V

C

S

H

A

A

N

D

M

K

L

L

K

L

E

S

K

A

G

G

A

A

K

T

S

R

V

V

I

Y

A

A

A

I

C

L

T

T

H

H

P

G

V

I

F

F

S

S

G

G

P

P

A

A

V

I

D

S

R

R

L

I

K

N

N

N

S

A

E

C

I

F

E

E

E

A

V

V

I

V

V

V

T

T

D

N

T

T

I

I

P

P

T

Q

T

E

G

D

-

K

-

M

K

K

E

H

F

C

D

S

K

K

L

I

T

Q

V

V

L

I

S

D

V

I

A

S

E

M

L

I

V

L

G

A

E

E

A

A

I

I

R

R

I

T

N

H

I

N

E

G

S

E

S

S

V

V

S

S

S

Y

L

L

F

F

binding adenosine monophosphate: R95 (= R97), Q96 (= Q98), N199 (= N199)
binding adenosine-5'-triphosphate: F34 (= F36), N36 (≠ D38), E38 (= E40)
binding phosphate ion: S46 (≠ N48), R48 (= R50)
binding 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose: H129 (= H131), D170 (= D170), G172 (= G172), K193 (= K193), R195 (= R195), D219 (= D219), D220 (= D220), D223 (= D223), T224 (= T224), C225 (≠ A225), G226 (= G226), T227 (= T227)

8dbeA Human prps1 with adp; hexamer (see paper)
46% identity, 99% coverage: 4:310/311 of query aligns to 2:312/316 of 8dbeA

query
sites
8dbeA

H

N

I

I

K

K

L

I

I

F

T

S

G

G

N

S

A

S

N

H

P

Q

D

D

F

L

A

S

E

Q

K

K

I

I

A

A

D

D

Y

R

L

L

H

G

V

L

P

E

L

L

V

G

D

K

T

V

L

V

V

T

T

K

R

K

F
|
F

S

S

D
x
N

G

Q

E
|
E

I

T

R

C

V

V

Q

E

I

I

K

G

E

E

N

S

V

V

R

R

G

G

A

E

D

D

V

V

F

Y

V

I

I

V

Q

Q

P

S

L

G

T

C

Q

G

P

E

A

I

N

N

D

D

H

N

I

L

M

M

E

E

L

L

L

I

I

M

L

I

D

N

A

A

L

C

K

K

R

I

S

A

S

S

T

A

H

S

R

R

I

V

T

T

A

A

V

V

I

I

P

P

Y

C

F

F

A

P

Y

Y

A

A

R
|
R

Q
|
Q

D

D

R
x
K

K
|
K

D
|
D

R

K

P
x
S

R
|
R

V

A

P

P

I

I

S

S

A

A

K

K

L

L

L

V

A

A

D

N

I

M

I

L

E

S

K

V

A

A

G

G

A

A

Q

D

R

H

V

I

L

I

T

T

V

M

D

D

L

L

H
|
H

S

A

A

S

Q

Q

I

I

Q

Q

G

G

F

F

D

D

C

I

P

P

V

V

D
|
D

N

N

L

L

Y
|
Y

A

A

L

E

P

P

V

A

I

V

L

L

D

K

Y

W

L

I

R

R

N

E

K

N

-

I

-

S

N

E

L

W

E

R

N

N

M

C

V

T

I

I

V

V

S

S

P

P

D
|
D

A

A

G

G

V

A

E

K

R

R

A

V

R

T

M

S

L

I

A

A

N

D

R

R

L

L

G

N

A

V

S

D

L

F

A

A

I

L

I

I

Y

H

K

K

K

E

R

R

P

K

A

K

P

A

N

N

V

E

V

V

E

D

T

R

L

M

D

V

V

L

I

V

G

G

D

D

I

V

E

K

G

D

K

R

N

V

A

A

I

I

I

L

I

V

D
|
D

I

M

I

A

D
|
D

T
|
T

A

C

G
|
G

T
|
T

I

I

V

C

S

H

A

A

N

D

M

K

L

L

K

L

E

S

K

A

G

G

A

A

K

T

S

R

V

V

I

Y

A

A

A

I

C

L

T

T

H

H

P

G

V

I

F

F

S

S

G

G

P

P

A

A

V

I

D

S

R

R

L

I

K

N

N

N

S

A

E

C

I

F

E

E

E

A

V

V

I

V

V

V

T

T

D

N

T

T

I

I

P

P

T

Q

T

E

G

D

-

K

-

M

K

K

E

H

F

C

D

S

K

K

L

I

T

Q

V

V

L

I

S

D

V

I

A

S

E

M

L

I

V

L

G

A

E

E

A

A

I

I

R

R

I

T

N

H

I

N

E

G

S

E

S
|
S

V
|
V

S
|
S

S

Y

L

L

F
|
F

binding adenosine-5'-diphosphate: F34 (= F36), N36 (≠ D38), E38 (= E40), R95 (= R97), Q96 (= Q98), K98 (≠ R100), K99 (= K101), D100 (= D102), S102 (≠ P104), R103 (= R105), H129 (= H131), D142 (= D144), Y145 (= Y147), S307 (= S305), V308 (= V306), S309 (= S307), F312 (= F310)
binding 5-O-phosphono-alpha-D-ribofuranose: H129 (= H131), D170 (= D170), D219 (= D219), D220 (= D220), D223 (= D223), T224 (= T224), G226 (= G226), T227 (= T227)

2hcrA Crystal structure of human phosphoribosyl pyrophosphate synthetase 1 in complex with amp(atp), cadmium and sulfate ion (see paper)
45% identity, 99% coverage: 4:310/311 of query aligns to 1:305/305 of 2hcrA

query
sites
2hcrA

H

N

I

I

K

K

L

I

I

F

T

S

G

G

N

S

A

S

N

H

P

Q

D

D

F

L

A

S

E

Q

K

K

I

I

A

A

D

D

Y

R

L

L

H

G

V

L

P

E

L

L

V

G

D

K

T

V

L

V

V

T

T

K

R

K

F

F

S

S

D

N

G

Q

E

E

I

T

R

C

V

V

Q

E

I

I

K

G

E

E

N

S

V

V

R

R

G

G

A

E

D

D

V

V

F

Y

V

I

I

V

Q

Q

P

S

L

G

T

C

Q

G

P

E

A

I

N

N

D

D

H

N

I

L

M

M

E

E

L

L

L

I

I

M

L

I

D

N

A

A

L

C

K

K

R

I

S

A

S

S

T

A

H

S

R

R

I

V

T

T

A

A

V

V

I

I

P

P

Y

C

F

F

A

P

Y

Y

A

A

R
|
R

Q
|
Q

D

D

R
x
K

K

K

D

D

R

K

P

S

R

R

V

A

P

P

I

I

S

S

A

A

K

K

L

L

L

V

A

A

D

N

I

M

I

L

E

S

K

V

A

A

G

G

A

A

Q

D

R

H

V

I

L

I

T

T

V

M

D

D

L

L

H
|
H

S

A

A

S

Q

Q

I

I

Q

Q

G

G

F

F

D

D

C

I

P

P

V

V

D

D

N

N

L

L

Y

Y

A

A

L

E

P

P

V

A

I

V

L

L

D

K

Y

W

L

I

R

R

N

E

K

N

-

I

-

S

N

E

L

W

E

R

N

N

M

C

V

T

I

I

V

V

S

S

P

P

D

D

A

A

G

G

V

A

E

K

R

R

A

V

R

T

M

S

L

I

A

A

N

D

R

R

L

L

G

N

A

V

S

D

L

F

A

A

I

L

I

I

Y

H

K

K

K

E

R

R

P

-

A

-

P

-

N

-

V

-

E

D

T

R

L

M

D

V

V

L

I

V

G

G

D

D

I

V

E

K

G

D

K

R

N

V

A

A

I

I

I

L

I

V

D

D

I

M

I

A

D

D

T

T

A

C

G

G

T

T

I

I

V

C

S

H

A

A

N

D

M

K

L

L

K

L

E

S

K

A

G

G

A

A

K

T

S

R

V

V

I

Y

A

A

A

I

C

L

T

T

H

H

P

G

V

I

F

F

S

S

G

G

P

P

A

A

V

I

D

S

R

R

L

I

K

N

N

N

S

A

E

C

I

F

E

E

E

A

V

V

I

V

V

V

T

T

D

N

T

T

I

I

P

P

T

Q

T

E

G

D

-

K

-

M

K

K

E

H

F

C

D

S

K

K

L

I

T

Q

V

V

L

I

S

D

V

I

A

S

E

M

L

I

V

L

G

A

E

E

A

A

I

I

R

R

I

T

N

H

I

N

E

G

S

E

S

S

V

V

S

S

S

Y

L

L

F

F

binding adenosine monophosphate: R94 (= R97), Q95 (= Q98), K97 (≠ R100), H128 (= H131)

O94413 Ribose-phosphate pyrophosphokinase 2; Phosphoribosyl pyrophosphate synthase 2; EC 2.7.6.1 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
45% identity, 99% coverage: 2:310/311 of query aligns to 3:316/321 of O94413

query
sites
O94413

S

S

K

N

H

S

I

I

K

K

L

I

I

F

T

A

G

G

N

N

A

S

N

H

P

P

D

E

F

L

A

A

E

E

K

K

I

V

A

A

D

R

Y

R

L

I

H

G

V

L

P

S

L

L

V

G

D

K

T

V

L

A

V

V

T

V

R

Q

F

Y

S

S

D

N

G

R

E

E

I

T

R

S

V

V

Q

T

I

I

K

G

E

E

N

S

V

V

R

R

G

D

A

E

D

D

V

V

F

F

V

I

I

L

Q

Q

P

T

L

G

T

C

Q

G

P

S

A

I

N

N

D

D

H

H

I

L

M

M

E

E

L

L

L

I

I

M

L

I

D

N

A

A

L

C

K

R

R

S

S

A

S

S

T

A

H

R

R

R

I

I

T

T

A

A

V

I

I

I

P

P

Y

C

F

F

A

P

Y

Y

A

A

R

R

Q

Q

D

D

R

K

K

K

D

D

R

K

P

S

R

R

V

A

P

P

I

I

S

T

A

A

K

R

L

L

L

V

A

A

D

N

I

M

I

L

E

Q

K

T

A

A

G

G

A

C

Q

N

R

H

V

I

L

I

T

T

V

M

D

D

L

L

H

H

S

A

A

S

Q

Q

I

I

Q

Q

G

G

F

F

D

N

C

V

P

P

V

V

D

D

N

N

L

L

Y

Y

A

A

L

E

P

P

V

S

I

V

L

L

D

R

Y

Y

L

I

R

R

-

E

-

N

-

I

N

D

K

T

N

T

L

V

E

N

N

P

M

T

V

V

I

I

V

V

S
|
S

P

P

D

D

A

A

G

G

V

A

E

K

R

R

A

A

R

T

M

A

L

L

A

A

N

D

R

R

L

L

G

D

A

L

S

D

L

F

A

A

I

L

I

I

Y

H

K

K

K

E

R

R

P

Q

A

K

P

A

N

N

V

E

V

V

E

S

T

R

L

M

D

V

V

L

I

V

G

G

D

D

I

V

E

R

G

D

K

K

N

L

A

A

I

I

I

L

I

V

D

D

I

M

I

A

D

D

T

T

A

C

G

G

T

T

I

L

V

G

S

L

A

A

N

K

M

T

L

L

K

K

E

D

K

N

G

G

A

A

K

K

S

A

V

V

I

Y

A

A

A

I

C

V

T

T

H

H

P

G

V

I

F

L

S

S

G

G

P

K

A

A

V

I

D

K

R

V

L

I

K

N

N

E

S

S

E

A

I

L

E

E

E

K

V

V

I

I

V

V

T

T

D

N

T

T

I

I

P

P

T

H

T

D

G

D

K

K

E

R

-

S

-

L

F

C

D

S

K

K

L

I

T

E

V

T

L

I

S

D

V

I

A

S

E

G

L

V

V

L

G

A

E

E

A

C

I

I

R

R

I

I

N

H

I

H

E

G

S

E

S

S

V

V

S

S

S

V

L

L

F

F

S172 (= S168) modified: Phosphoserine

Query Sequence

>WP_012675324.1 NCBI__GCF_000021565.1:WP_012675324.1
MSKHIKLITGNANPDFAEKIADYLHVPLVDTLVTRFSDGEIRVQIKENVRGADVFVIQPL
TQPANDHIMELLLILDALKRSSTHRITAVIPYFAYARQDRKDRPRVPISAKLLADIIEKA
GAQRVLTVDLHSAQIQGFFDCPVDNLYALPVILDYLRNKNLENMVIVSPDAGGVERARML
ANRLGASLAIIYKKRPAPNVVETLDVIGDIEGKNAIIIDDIIDTAGTIVSAANMLKEKGA
KSVIAACTHPVFSGPAVDRLKNSEIEEVIVTDTIPTTGKEFDKLTVLSVAELVGEAIRRI
NIESSVSSLFV

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory