Comparing WP_012675402.1 NCBI__GCF_000021565.1:WP_012675402.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 18 hits to proteins with known functional sites (download)
P44514 Succinyl-diaminopimelate desuccinylase; SDAP desuccinylase; N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase; EC 3.5.1.18 from Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) (see 3 papers)
25% identity, 99% coverage: 1:351/353 of query aligns to 1:371/377 of P44514
5vo3A Crystal structure of dape in complex with the products (succinic acid and diaminopimelic acid) (see paper)
25% identity, 99% coverage: 1:351/353 of query aligns to 5:375/380 of 5vo3A
7uoiA Crystallographic structure of dape from enterococcus faecium (see paper)
27% identity, 94% coverage: 9:339/353 of query aligns to 14:366/383 of 7uoiA
7lgpB Dape enzyme from shigella flexneri
29% identity, 58% coverage: 60:264/353 of query aligns to 61:278/377 of 7lgpB
7t1qA Crystal structure of the succinyl-diaminopimelate desuccinylase (dape) from acinetobacter baumannii in complex with succinic acid
26% identity, 82% coverage: 64:352/353 of query aligns to 64:372/377 of 7t1qA
4pqaA Crystal structure of succinyl-diaminopimelate desuccinylase from neisseria meningitidis mc58 in complex with the inhibitor captopril (see paper)
25% identity, 93% coverage: 11:340/353 of query aligns to 11:360/375 of 4pqaA
4o23A Crystal structure of mono-zinc form of succinyl diaminopimelate desuccinylase from neisseria meningitidis mc58 (see paper)
25% identity, 93% coverage: 11:340/353 of query aligns to 11:360/376 of 4o23A
4h2kA Crystal structure of the catalytic domain of succinyl-diaminopimelate desuccinylase from haemophilus influenzae (see paper)
30% identity, 38% coverage: 1:133/353 of query aligns to 3:143/258 of 4h2kA
Sites not aligning to the query:
5xoyA Crystal structure of lysk from thermus thermophilus in complex with lysine (see paper)
23% identity, 98% coverage: 7:352/353 of query aligns to 5:335/341 of 5xoyA
8uw6B Acetylornithine deacetylase from escherichia coli, di-zinc form. (see paper)
25% identity, 76% coverage: 66:335/353 of query aligns to 77:359/381 of 8uw6B
Sites not aligning to the query:
Q8P8J5 N-acetyl-L-citrulline deacetylase; ACDase; Acetylcitrulline deacetylase; EC 3.5.1.- from Xanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25) (see paper)
23% identity, 93% coverage: 11:340/353 of query aligns to 19:351/366 of Q8P8J5
2f7vA Structure of acetylcitrulline deacetylase complexed with one co (see paper)
23% identity, 93% coverage: 11:340/353 of query aligns to 20:346/360 of 2f7vA
1cg2A Carboxypeptidase g2 (see paper)
25% identity, 71% coverage: 9:257/353 of query aligns to 22:275/389 of 1cg2A
Sites not aligning to the query:
P06621 Carboxypeptidase G2; CPDG2; Folate hydrolase G2; Glutamate carboxypeptidase; Pteroylmonoglutamic acid hydrolase G2; Glucarpidase; EC 3.4.17.11 from Pseudomonas sp. (strain RS-16) (see paper)
25% identity, 71% coverage: 9:257/353 of query aligns to 47:300/415 of P06621
Sites not aligning to the query:
3pfoA Crystal structure of a putative acetylornithine deacetylase (rpa2325) from rhodopseudomonas palustris cga009 at 1.90 a resolution
24% identity, 46% coverage: 41:203/353 of query aligns to 76:244/426 of 3pfoA
Sites not aligning to the query:
4op4B Crystal structure of the catalytic domain of dape protein from v.Cholerea in the zn bound form (see paper)
28% identity, 42% coverage: 11:158/353 of query aligns to 11:167/265 of 4op4B
Sites not aligning to the query:
7m6uB Crystal structure of a circular permutation and computationally designed pro-enzyme of carboxypeptidase g2 (see paper)
25% identity, 56% coverage: 60:257/353 of query aligns to 15:210/392 of 7m6uB
Sites not aligning to the query:
2pokA Crystal structure of a m20 family metallo peptidase from streptococcus pneumoniae
30% identity, 29% coverage: 9:112/353 of query aligns to 27:144/458 of 2pokA
Sites not aligning to the query:
>WP_012675402.1 NCBI__GCF_000021565.1:WP_012675402.1
MREKLKDYLTDLVNIPSVTGNERDIADYVENFLKKLFPEENIIRYNNSIIAFDSINPDKK
TISFIGHLDTVPGENEFTGKIIDNRLYGLGASDMKGGLAVMMALAEYFKDRDKRFNCIYV
FYEREEGPYDENGLEPLLRNFSIIQRSDLAVVLEPTNNNIQVGCLGTMHASVIFKGKRAH
SARPWQGENAIHRSADFLKRLSELKWKEYTFGGLKFVEVMNATMVDYSGGRNIIPDRFVI
NVNYRFAPGKSIEEAKKDVLDLVKGEAEVQFTDLCPSGKVCLDNPVLQELINRFSLKVEA
KQAWTDVARLSLYGVDAVNFGPGDPAQAHQKNEYIPLKNLYENFDILRDFLEG
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory