SitesBLAST
Comparing WP_012708832.1 NCBI__GCF_000018545.1:WP_012708832.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
P37685 Aldehyde dehydrogenase B; Acetaldehyde dehydrogenase; EC 1.2.1.4 from Escherichia coli (strain K12) (see paper)
74% identity, 98% coverage: 11:502/502 of query aligns to 21:512/512 of P37685
- R197 (≠ E187) mutation to E: Less than 10% of wild-type acetaldehyde dehydrogenase activity.
5l13A Structure of aldh2 in complex with 2p3 (see paper)
45% identity, 96% coverage: 18:497/502 of query aligns to 17:492/494 of 5l13A
- active site: N163 (= N161), K186 (= K184), E262 (= E258), C296 (= C297), E393 (= E398), E470 (= E475)
- binding 2,3,5-trimethyl-6-propyl-7H-furo[3,2-g][1]benzopyran-7-one: F164 (= F162), M168 (= M166), W171 (= W169), F290 (≠ L291), C295 (≠ V296), C296 (= C297), C297 (≠ T298), D451 (≠ H456), F453 (≠ Y458)
4kwgA Crystal structure analysis of aldh2+aldib13 (see paper)
45% identity, 96% coverage: 18:497/502 of query aligns to 17:492/494 of 4kwgA
- active site: N163 (= N161), K186 (= K184), E262 (= E258), C296 (= C297), E393 (= E398), E470 (= E475)
- binding 7-bromo-5-methyl-1H-indole-2,3-dione: F164 (= F162), M168 (= M166), C295 (≠ V296), C296 (= C297), C297 (≠ T298), D451 (≠ H456), F453 (≠ Y458)
4kwfA Crystal structure analysis of aldh2+aldib33 (see paper)
45% identity, 96% coverage: 18:497/502 of query aligns to 17:492/494 of 4kwfA
- active site: N163 (= N161), K186 (= K184), E262 (= E258), C296 (= C297), E393 (= E398), E470 (= E475)
- binding 1-benzyl-1H-indole-2,3-dione: F164 (= F162), M168 (= M166), W171 (= W169), E262 (= E258), C295 (≠ V296), C296 (= C297), C297 (≠ T298), D451 (≠ H456), F453 (≠ Y458), F459 (= F464)
3sz9A Crystal structure of human aldh2 modified with the beta-elimination product of aldi-3; 1-(4-ethylbenzene)prop-2-en-1-one (see paper)
45% identity, 96% coverage: 18:497/502 of query aligns to 17:492/494 of 3sz9A
- active site: N163 (= N161), K186 (= K184), E262 (= E258), C296 (= C297), E393 (= E398), E470 (= E475)
- binding 1-(4-ethylphenyl)propan-1-one: F164 (= F162), C295 (≠ V296), C296 (= C297), D451 (≠ H456), F453 (≠ Y458), F459 (= F464)
3injA Human mitochondrial aldehyde dehydrogenase complexed with agonist alda-1 (see paper)
45% identity, 96% coverage: 18:497/502 of query aligns to 17:492/494 of 3injA
- active site: N163 (= N161), K186 (= K184), E262 (= E258), C296 (= C297), E393 (= E398), E470 (= E475)
- binding N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide: M118 (≠ L116), F164 (= F162), L167 (= L165), F286 (= F286), F290 (≠ L291), D451 (≠ H456), F453 (≠ Y458)
2vleA The structure of daidzin, a naturally occurring anti alcohol- addiction agent, in complex with human mitochondrial aldehyde dehydrogenase (see paper)
45% identity, 96% coverage: 18:497/502 of query aligns to 17:492/494 of 2vleA
- active site: N163 (= N161), K186 (= K184), E262 (= E258), C296 (= C297), E393 (= E398), E470 (= E475)
- binding daidzin: M118 (≠ L116), F164 (= F162), M168 (= M166), W171 (= W169), F286 (= F286), F290 (≠ L291), C295 (≠ V296), C296 (= C297), D451 (≠ H456), V452 (≠ A457), F453 (≠ Y458)
1o01B Human mitochondrial aldehyde dehydrogenase complexed with crotonaldehyde, NAD(h) and mg2+ (see paper)
45% identity, 96% coverage: 18:497/502 of query aligns to 17:492/494 of 1o01B
- active site: N163 (= N161), K186 (= K184), E262 (= E258), C296 (= C297), E393 (= E398), E470 (= E475)
- binding (2e)-but-2-enal: C296 (= C297), C297 (≠ T298), F453 (≠ Y458)
- binding nicotinamide-adenine-dinucleotide: I159 (= I157), I160 (= I158), P161 (= P159), W162 (= W160), K186 (= K184), E189 (= E187), G219 (= G216), G223 (= G220), A224 (≠ K221), F237 (= F234), G239 (= G236), S240 (≠ E237), I243 (≠ T240), L263 (= L259), G264 (= G260), C296 (= C297), Q343 (= Q344), E393 (= E398), F395 (= F400)
1cw3A Human mitochondrial aldehyde dehydrogenase complexed with NAD+ and mn2+ (see paper)
45% identity, 96% coverage: 18:497/502 of query aligns to 17:492/494 of 1cw3A
- active site: N163 (= N161), K186 (= K184), E262 (= E258), C296 (= C297), E393 (= E398), E470 (= E475)
- binding magnesium ion: V34 (≠ T35), D103 (= D101), Q190 (= Q188)
- binding nicotinamide-adenine-dinucleotide: I159 (= I157), I160 (= I158), P161 (= P159), W162 (= W160), K186 (= K184), G219 (= G216), G223 (= G220), A224 (≠ K221), F237 (= F234), G239 (= G236), S240 (≠ E237), I243 (≠ T240), L263 (= L259), G264 (= G260), C296 (= C297), Q343 (= Q344), K346 (= K347), E393 (= E398), F395 (= F400)
P05091 Aldehyde dehydrogenase, mitochondrial; ALDH class 2; ALDH-E2; ALDHI; EC 1.2.1.3 from Homo sapiens (Human) (see 5 papers)
45% identity, 96% coverage: 18:497/502 of query aligns to 40:515/517 of P05091