Comparing WP_012708868.1 NCBI__GCF_000018545.1:WP_012708868.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
P00898 Anthranilate synthase component 1; AS; ASI; EC 4.1.3.27 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see 2 papers)
31% identity, 62% coverage: 66:514/729 of query aligns to 54:517/520 of P00898
Sites not aligning to the query:
1i1qA Structure of the cooperative allosteric anthranilate synthase from salmonella typhimurium (see paper)
31% identity, 61% coverage: 66:513/729 of query aligns to 50:512/512 of 1i1qA
Sites not aligning to the query:
1i7sA Anthranilate synthase from serratia marcescens in complex with its end product inhibitor l-tryptophan (see paper)
31% identity, 62% coverage: 66:514/729 of query aligns to 45:508/511 of 1i7sA
Sites not aligning to the query:
1i7qA Anthranilate synthase from s. Marcescens (see paper)
31% identity, 62% coverage: 66:514/729 of query aligns to 51:514/517 of 1i7qA
P00897 Anthranilate synthase component 1; AS; ASI; EC 4.1.3.27 from Serratia marcescens (see paper)
30% identity, 62% coverage: 66:514/729 of query aligns to 53:516/519 of P00897
Sites not aligning to the query:
7bvdA Anthranilate synthase component i (trpe)[mycolicibacterium smegmatis]
33% identity, 50% coverage: 142:504/729 of query aligns to 101:487/499 of 7bvdA
Sites not aligning to the query:
A0QX93 Anthranilate synthase component 1; AS; ASI; EC 4.1.3.27 from Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis) (see paper)
33% identity, 50% coverage: 142:504/729 of query aligns to 122:512/524 of A0QX93
P32068 Anthranilate synthase alpha subunit 1, chloroplastic; Anthranilate synthase component 1-1; Anthranilate synthase component I-1; Protein A-METHYL TRYPTOPHAN RESISTANT 1; Protein JASMONATE-INDUCED DEFECTIVE LATERAL ROOT 1; Protein TRYPTOPHAN BIOSYNTHESIS 5; Protein WEAK ETHYLENE INSENSITIVE 2; EC 4.1.3.27 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
32% identity, 49% coverage: 158:513/729 of query aligns to 192:591/595 of P32068
O94582 Probable anthranilate synthase component 1; Anthranilate synthase component I; EC 4.1.3.27 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
37% identity, 36% coverage: 248:511/729 of query aligns to 215:478/489 of O94582
Sites not aligning to the query:
Q94GF1 Anthranilate synthase alpha subunit 1, chloroplastic; OsASA1; EC 4.1.3.27 from Oryza sativa subsp. japonica (Rice) (see paper)
32% identity, 49% coverage: 158:512/729 of query aligns to 174:572/577 of Q94GF1
P28820 Aminodeoxychorismate synthase component 1; ADC synthase; ADCS; 4-amino-4-deoxychorismate synthase component 1; EC 2.6.1.85 from Bacillus subtilis (strain 168) (see paper)
31% identity, 51% coverage: 139:507/729 of query aligns to 84:460/470 of P28820
7pi1DDD Aminodeoxychorismate synthase component 1
31% identity, 51% coverage: 139:507/729 of query aligns to 82:453/459 of 7pi1DDD
Sites not aligning to the query:
5cwaA Structure of anthranilate synthase component i (trpe) from mycobacterium tuberculosis with inhibitor bound (see paper)
31% identity, 53% coverage: 118:504/729 of query aligns to 75:491/505 of 5cwaA
P05041 Aminodeoxychorismate synthase component 1; ADC synthase; ADCS; 4-amino-4-deoxychorismate synthase component 1; EC 2.6.1.85 from Escherichia coli (strain K12) (see 4 papers)
30% identity, 48% coverage: 158:507/729 of query aligns to 105:451/453 of P05041
Sites not aligning to the query:
P00903 Aminodeoxychorismate synthase component 2; ADC synthase; ADCS; 4-amino-4-deoxychorismate synthase component 2; Aminodeoxychorismate synthase, glutamine amidotransferase component; EC 2.6.1.85 from Escherichia coli (strain K12) (see paper)
43% identity, 26% coverage: 531:717/729 of query aligns to 2:185/187 of P00903
1k0eA The crystal structure of aminodeoxychorismate synthase from formate grown crystals (see paper)
28% identity, 48% coverage: 158:507/729 of query aligns to 103:435/437 of 1k0eA
Sites not aligning to the query:
P00900 Anthranilate synthase component 2; AS; ASII; Anthranilate synthase, GATase component; Anthranilate synthase, glutamine amidotransferase component; EC 4.1.3.27 from Serratia marcescens (see 3 papers)
38% identity, 26% coverage: 530:718/729 of query aligns to 3:188/193 of P00900
Sites not aligning to the query:
8hx8A Crystal structure of 4-amino-4-deoxychorismate synthase from streptomyces venezuelae co-crystallized with chorismate (see paper)
28% identity, 48% coverage: 156:507/729 of query aligns to 306:670/673 of 8hx8A
Sites not aligning to the query:
Q42565 Anthranilate synthase beta subunit 1, chloroplastic; Anthranilate synthase component 2-1; Anthranilate synthase, glutamine amidotransferase component 2-1; Protein TRYPTOPHAN BIOSYNTHESIS 4; Protein WEAK ETHYLENE INSENSITIVE 7; EC 4.1.3.27 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
37% identity, 26% coverage: 531:717/729 of query aligns to 75:267/276 of Q42565
1i7qB Anthranilate synthase from s. Marcescens (see paper)
37% identity, 26% coverage: 530:718/729 of query aligns to 2:187/192 of 1i7qB
>WP_012708868.1 NCBI__GCF_000018545.1:WP_012708868.1
MATVILEDGAESYTTNGGIVVTRRRRDASYAEAIASYVDKLDERRGAVFSSNYEYPGRYT
RWDTAVVDPPLAISSFGRSLWIEAYNERGEVLLGLIADHLKTVADITLGASTRRRLDLTI
NEPDRIFTEEERSKMPTVFTVLRAVTNLFHSEEDASLGLYGAFGYDLAFQFDAIDLKLIR
PDDQRDMVLFLPDEILVVDHYAARAWIDRYDFAKDGISTEGKAADIASEPFRTVDSIPPH
GDHRPGEYAELVVKAKESFRRGDLFEVVPGQKFYERCESRPSEISNRLKAINPSPYSFFI
NLGNQEYLVGASPEMFVRVSGRRIETCPISGTIKRGDDPIADSEQILKLLNSKKDESELT
MCSDVDRNDKSRVCVPGSVKVIGRRQIEMYSRLIHTVDHIEGRLRDDMDAFDGFLSHAWA
VTVTGAPKLWAMRFIESHEKSPRAWYGGAIGMVGFNGDMNTGLTLRTIRIKDGIAEVRAG
ATLLYDSNPEEEEAETELKASAMIAAIRDAKSANSAKAARDVAPVGAGVNILLVDHEDSF
VHTLANYFRQTGATVTTVRTPVAEEIFDRVEPDLVVLSPGPGTPKDFDCKATIKKARARN
LPIFGVCLGLQALAEAYGGDLRQLAIPMHGKPSRIRVLEPGIVFSGLGKEVTVGRYHSIF
ADPSSLPRDFMITAESEDGTIMGIEHAKEPVAAVQFHPESIMTLGGDAGMRMIENVVAHL
AKRAKIKAA
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory