SitesBLAST
Comparing WP_012709571.1 NCBI__GCF_000018545.1:WP_012709571.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
P04181 Ornithine aminotransferase, mitochondrial; Ornithine delta-aminotransferase; Ornithine--oxo-acid aminotransferase; EC 2.6.1.13 from Homo sapiens (Human) (see 8 papers)
53% identity, 97% coverage: 3:392/401 of query aligns to 39:430/439 of P04181
- G51 (= G15) to D: in HOGA; loss of protein stability; loss of ornithine aminotransferase activity; dbSNP:rs11553554
- Y55 (= Y19) to H: in HOGA; decreased protein abundance; dbSNP:rs121965037
- N89 (= N53) to K: in HOGA; no effect on protein abundance; dbSNP:rs386833602
- Q90 (= Q54) to E: in HOGA; mistargeted, accumulates in cytoplasm; dbSNP:rs121965060
- C93 (= C57) to F: in HOGA; no effect on protein abundance; dbSNP:rs121965038
- Q104 (= Q68) to R: in HOGA; loss of protein stability; loss of ornithine aminotransferase activity; dbSNP:rs386833604
- R154 (= R118) to L: in HOGA; no effect on protein abundance; loss of ornithine aminotransferase activity; dbSNP:rs121965039
- R180 (= R144) to T: in HOGA; no effect on protein abundance; loss of ornithine aminotransferase activity; dbSNP:rs121965040
- A184 (≠ I148) natural variant: Missing (in HOGA; no effect on protein abundance; loss of ornithine aminotransferase activity; dbSNP:rs121965035)
- P199 (= P163) to Q: in HOGA; loss of protein stability; loss of ornithine aminotransferase activity; dbSNP:rs267606925
- A226 (= A189) to V: in HOGA; loss of protein stability; loss of ornithine aminotransferase activity; dbSNP:rs121965059
- P241 (= P204) to L: in HOGA; no effect on protein abundance; dbSNP:rs121965051
- Y245 (= Y208) to C: in HOGA; no effect on protein abundance; dbSNP:rs121965046
- R250 (= R213) to P: in HOGA; no effect on protein abundance; dbSNP:rs121965052
- T267 (= T230) to I: in HOGA; decreased protein abundance; dbSNP:rs386833618
- A270 (≠ G233) to P: decreased protein abundance; dbSNP:rs121965041
- R271 (= R234) to K: in HOGA; no effect on protein abundance; loss of ornithine aminotransferase activity; dbSNP:rs121965042
- K292 (= K255) modified: N6-(pyridoxal phosphate)lysine
- E318 (≠ Q281) to K: in HOGA; loss of protein stability; loss of ornithine aminotransferase activity; dbSNP:rs386833621
- V332 (≠ I295) to M: in HOGA; loss of protein stability; loss of ornithine aminotransferase activity; dbSNP:rs121965047
- G353 (= G316) to D: in HOGA; decreased protein abundance; dbSNP:rs121965053
- G375 (= G338) to A: in HOGA; decreased protein abundance; dbSNP:rs121965045
- C394 (= C356) to R: in HOGA; no effect on protein abundance; dbSNP:rs121965054; to Y: in HOGA; loss of protein stability; loss of ornithine aminotransferase activity; dbSNP:rs386833597
- L402 (≠ I364) to P: in HOGA; may affect protein stability; loss of ornithine aminotransferase activity; dbSNP:rs121965043
- P417 (= P379) to L: in HOGA; loss of protein stability; loss of ornithine aminotransferase activity; dbSNP:rs121965044
Sites not aligning to the query:
- 1:35 modified: transit peptide, Mitochondrion; in renal form
- 436 I → N: in HOGA; loss of protein stability; loss of ornithine aminotransferase activity; dbSNP:rs386833598
- 437 L → F: in HOGA; likely benign; no effect on protein stability; no effect on ornithine aminotransferase activity; dbSNP:rs1800456
7ta0A Human ornithine aminotransferase (hoat) soaked with 5-aminovaleric acid (see paper)
53% identity, 97% coverage: 3:392/401 of query aligns to 3:394/403 of 7ta0A
- binding 5-[({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)amino]pentanoic acid: Y19 (= Y19), Y49 (= Y49), G106 (= G106), V107 (≠ A107), F141 (= F141), W142 (≠ H142), D227 (= D226), I229 (= I228), Q230 (= Q229), K256 (= K255), S285 (= S284), T286 (= T285)
8ez1B Human ornithine aminotransferase (hoat) co-crystallized with its inactivator 3-amino-4-fluorocyclopentenecarboxylic acid (see paper)
53% identity, 97% coverage: 3:392/401 of query aligns to 2:393/402 of 8ez1B
- binding (1R,3S,4Z)-3-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)-4-iminocyclopentane-1-carboxylic acid: Y48 (= Y49), T104 (≠ S105), G105 (= G106), V106 (≠ A107), F140 (= F141), W141 (≠ H142), E198 (= E198), D226 (= D226), I228 (= I228), Q229 (= Q229), K255 (= K255), R376 (= R375)
8ez1A Human ornithine aminotransferase (hoat) co-crystallized with its inactivator 3-amino-4-fluorocyclopentenecarboxylic acid (see paper)
53% identity, 97% coverage: 3:392/401 of query aligns to 2:393/402 of 8ez1A
- binding (3E,4E)-4-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene)-3-iminocyclopent-1-ene-1-carboxylic acid: Y48 (= Y49), G105 (= G106), V106 (≠ A107), F140 (= F141), W141 (≠ H142), E198 (= E198), D226 (= D226), I228 (= I228), Q229 (= Q229), K255 (= K255), R376 (= R375)
7tfpC Human ornithine aminotransferase cocrystallized with its inhibitor, (1s,3s)-3-amino-4-(difluoromethylene)cyclopentane-1-carboxylic acid. (see paper)
53% identity, 97% coverage: 3:392/401 of query aligns to 2:393/402 of 7tfpC
- binding (1S,3S,4S)-3-amino-4-(fluoromethyl)cyclopentane-1-carboxylic acid: Y18 (= Y19), Y48 (= Y49), F140 (= F141), E198 (= E198), K255 (= K255), R376 (= R375)
- binding pyridoxal-5'-phosphate: G105 (= G106), V106 (≠ A107), F140 (= F141), W141 (≠ H142), D226 (= D226), I228 (= I228), Q229 (= Q229), K255 (= K255)
7lk0A Ornithine aminotransferase (oat) cocrystallized with its potent inhibitor - (s)-3-amino-4,4-difluorocyclopent-1-enecarboxylic acid (ss-1-148) (see paper)
53% identity, 97% coverage: 3:392/401 of query aligns to 2:393/402 of 7lk0A
- binding (1R,3S)-3-[(E)-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene)amino]-4-oxocyclopentane-1-carboxylic acid: Y18 (= Y19), Y48 (= Y49), G105 (= G106), V106 (≠ A107), F140 (= F141), W141 (≠ H142), E198 (= E198), D226 (= D226), I228 (= I228), Q229 (= Q229), K255 (= K255)
7jx9A The crystal structure of human ornithine aminotransferase with an intermediate bound during inactivation by (1s,3s)-3-amino-4- (hexafluoropropan-2-ylidenyl)-cyclopentane-1-carboxylic acid. (see paper)
53% identity, 97% coverage: 3:392/401 of query aligns to 2:393/402 of 7jx9A
- active site: F140 (= F141), E193 (= E193), D226 (= D226), Q229 (= Q229), K255 (= K255), T285 (= T285), R376 (= R375)
- binding (1S,3S,4S)-3-[(E)-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene)amino]-4-(1,1,3,3,3-pentafluoroprop-1-en-2-yl)cyclopentane-1-carboxylic acid: Y18 (= Y19), Y48 (= Y49), G105 (= G106), V106 (≠ A107), F140 (= F141), W141 (≠ H142), E198 (= E198), D226 (= D226), I228 (= I228), Q229 (= Q229), K255 (= K255), R376 (= R375)
- binding N-[1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl]glycine: S149 (≠ G150), F163 (= F164), M164 (≠ A165), P165 (= P166), F167 (= F168), R180 (≠ A181), A181 (= A182)
6v8dA Design, synthesis, and mechanism of fluorine-substituted cyclohexene analogues of gama-aminobutyric acid (gaba) as selective ornithine aminotransferase inactivators
53% identity, 97% coverage: 3:392/401 of query aligns to 2:393/402 of 6v8dA
- active site: F140 (= F141), E193 (= E193), D226 (= D226), Q229 (= Q229), K255 (= K255), T285 (= T285), R376 (= R375)
- binding (3Z)-3-iminocyclohex-1-ene-1-carboxylic acid: Y48 (= Y49), K255 (= K255)
- binding pyridoxal-5'-phosphate: T104 (≠ S105), G105 (= G106), V106 (≠ A107), W141 (≠ H142), D226 (= D226), I228 (= I228), Q229 (= Q229), K255 (= K255)
2canA Human ornithine aminotransferase complexed with l-canaline (see paper)
53% identity, 97% coverage: 3:392/401 of query aligns to 2:393/402 of 2canA
- active site: F140 (= F141), E193 (= E193), D226 (= D226), Q229 (= Q229), K255 (= K255), T285 (= T285), R376 (= R375)
- binding canaline: Y18 (= Y19), F140 (= F141), R143 (= R144), G283 (= G283), S284 (= S284)
- binding pyridoxal-5'-phosphate: G105 (= G106), V106 (≠ A107), F140 (= F141), W141 (≠ H142), D226 (= D226), I228 (= I228), Q229 (= Q229), K255 (= K255)
1gbnB Human ornithine aminotransferase complexed with the neurotoxin gabaculine (see paper)
53% identity, 97% coverage: 3:392/401 of query aligns to 2:393/402 of 1gbnB
- active site: F140 (= F141), E193 (= E193), D226 (= D226), Q229 (= Q229), K255 (= K255), T285 (= T285), R376 (= R375)
- binding gabaculine: Y18 (= Y19), Y48 (= Y49), F140 (= F141), E198 (= E198), K255 (= K255)
- binding pyridoxal-5'-phosphate: G105 (= G106), V106 (≠ A107), F140 (= F141), W141 (≠ H142), D226 (= D226), I228 (= I228), K255 (= K255)
1gbnA Human ornithine aminotransferase complexed with the neurotoxin gabaculine (see paper)
53% identity, 97% coverage: 3:392/401 of query aligns to 2:393/402 of 1gbnA
- active site: F140 (= F141), E193 (= E193), D226 (= D226), Q229 (= Q229), K255 (= K255), T285 (= T285), R376 (= R375)
- binding 3-aminobenzoic acid: Y18 (= Y19), Y48 (= Y49), E198 (= E198), K255 (= K255)
- binding pyridoxal-5'-phosphate: G105 (= G106), V106 (≠ A107), F140 (= F141), W141 (≠ H142), D226 (= D226), I228 (= I228), K255 (= K255)
8v9mA Human ornithine aminotransferase cocrystallized with its inhibitor, (r)-3-amino-5,5-difluorocyclohex-1-ene-1-carboxylic acid. (see paper)
53% identity, 97% coverage: 3:392/401 of query aligns to 4:395/404 of 8v9mA