SitesBLAST
Comparing WP_012757000.1 NCBI__GCF_000023185.1:WP_012757000.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
1vl8B Crystal structure of gluconate 5-dehydrogenase (tm0441) from thermotoga maritima at 2.07 a resolution
40% identity, 95% coverage: 11:254/256 of query aligns to 2:250/252 of 1vl8B
- active site: G17 (= G26), S143 (= S149), I154 (≠ H159), Y157 (= Y162), K161 (= K166)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G13 (= G22), R16 (≠ S25), G17 (= G26), L18 (≠ I27), S37 (≠ D46), R38 (≠ I47), C63 (= C68), D64 (= D69), V65 (= V70), A91 (≠ S96), A92 (= A97), G93 (= G98), I94 (≠ V99), V114 (≠ I119), I141 (= I147), S143 (= S149), Y157 (= Y162), K161 (= K166), P187 (= P192), G188 (≠ T193), Y190 (≠ V195), T192 (= T197), M194 (≠ L199), T195 (≠ G200)
4wecA Crystal structure of a short chain dehydrogenase from mycobacterium smegmatis
43% identity, 96% coverage: 7:252/256 of query aligns to 2:249/258 of 4wecA
- active site: G21 (= G26), S143 (= S149), Q154 (≠ H159), Y157 (= Y162), K161 (= K166)
- binding nicotinamide-adenine-dinucleotide: G17 (= G22), A19 (= A24), S20 (= S25), G21 (= G26), I22 (= I27), D41 (= D46), I42 (= I47), V61 (≠ C68), D62 (= D69), V63 (= V70), N89 (≠ S96), T141 (≠ I147), Y157 (= Y162), K161 (= K166), P187 (= P192), P189 (≠ V194), V190 (= V195)
4za2D Crystal structure of pectobacterium carotovorum 2-keto-3-deoxy-d- gluconate dehydrogenase complexed with NAD+ (see paper)
37% identity, 95% coverage: 10:253/256 of query aligns to 5:244/247 of 4za2D
- binding nicotinamide-adenine-dinucleotide: G17 (= G22), D19 (≠ A24), L22 (≠ I27), I42 (≠ D46), D65 (= D69), M66 (≠ V70), N92 (≠ S96), A93 (= A97), G94 (= G98), L115 (≠ I119), I143 (= I147), S145 (= S149), Y158 (= Y162), K162 (= K166), G189 (≠ T193), M191 (≠ V195), T193 (= T197), N195 (≠ L199)
3op4A Crystal structure of putative 3-ketoacyl-(acyl-carrier-protein) reductase from vibrio cholerae o1 biovar eltor str. N16961 in complex with NADP+ (see paper)
39% identity, 96% coverage: 11:256/256 of query aligns to 4:247/247 of 3op4A
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G15 (= G22), S17 (≠ A24), R18 (≠ S25), I20 (= I27), T40 (≠ I47), N62 (≠ D69), V63 (= V70), N89 (≠ S96), A90 (= A97), I92 (≠ V99), V139 (≠ I147), S141 (= S149), Y154 (= Y162), K158 (= K166), P184 (= P192), G185 (≠ T193), I187 (≠ V195), T189 (= T197), M191 (≠ L199)
6t77A Crystal structure of klebsiella pneumoniae fabg(NADPH-dependent) NADP- complex at 1.75 a resolution (see paper)
39% identity, 96% coverage: 11:256/256 of query aligns to 1:244/244 of 6t77A
- active site: G16 (= G26), S138 (= S149), Y151 (= Y162)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G12 (= G22), S14 (≠ A24), R15 (≠ S25), T37 (≠ I47), L58 (≠ C68), N59 (≠ D69), V60 (= V70), A87 (= A97), G88 (= G98), I89 (≠ V99)
P0AEK2 3-oxoacyl-[acyl-carrier-protein] reductase FabG; 3-ketoacyl-acyl carrier protein reductase; Beta-Ketoacyl-acyl carrier protein reductase; Beta-ketoacyl-ACP reductase; EC 1.1.1.100 from Escherichia coli (strain K12) (see 2 papers)
40% identity, 97% coverage: 9:256/256 of query aligns to 1:244/244 of P0AEK2
- GASR 12:15 (≠ GGAS 22:25) binding NADP(+)
- T37 (≠ I47) binding NADP(+)
- NV 59:60 (≠ DV 69:70) binding NADP(+)
- N86 (≠ S96) binding NADP(+)
- Y151 (= Y162) mutation to F: Defect in the affinity for NADPH.
- YAAAK 151:155 (≠ YCASK 162:166) binding NADP(+)
- A154 (≠ S165) mutation to T: Decreases in the thermolability of the reductase; when associated with K-233.
- K155 (= K166) mutation to A: Defect in the affinity for NADPH.
- I184 (≠ V195) binding NADP(+)
- E233 (≠ A245) mutation to K: Decreases in the thermolability of the reductase; when associated with T-154.
1q7bA The structure of betaketoacyl-[acp] reductase from e. Coli in complex with NADP+ (see paper)
40% identity, 96% coverage: 10:256/256 of query aligns to 1:243/243 of 1q7bA
- active site: G15 (= G26), E101 (≠ A112), S137 (= S149), Q147 (≠ H159), Y150 (= Y162), K154 (= K166)
- binding calcium ion: E232 (≠ A245), T233 (≠ D246)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G11 (= G22), S13 (≠ A24), R14 (≠ S25), T36 (≠ I47), N58 (≠ D69), V59 (= V70), N85 (≠ S96), A86 (= A97), G87 (= G98), I88 (≠ V99), S137 (= S149), Y150 (= Y162), K154 (= K166), P180 (= P192), G181 (≠ T193), I183 (≠ V195)
4i08A Crystal structure of beta-ketoacyl-acyl carrier protein reductase (fabg) from vibrio cholerae in complex with NADPH (see paper)
39% identity, 96% coverage: 11:256/256 of query aligns to 4:243/243 of 4i08A
- active site: G19 (= G26), N113 (= N120), S141 (= S149), Q151 (≠ H159), Y154 (= Y162), K158 (= K166)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: G15 (= G22), S17 (≠ A24), R18 (≠ S25), I20 (= I27), T40 (≠ I47), N62 (≠ D69), V63 (= V70), N89 (≠ S96), A90 (= A97), G140 (≠ A148), S141 (= S149), Y154 (= Y162), K158 (= K166), P184 (= P192), G185 (≠ T193), T189 (= T197)
P0A2C9 3-oxoacyl-[acyl-carrier-protein] reductase FabG; 3-ketoacyl-acyl carrier protein reductase; Beta-Ketoacyl-acyl carrier protein reductase; Beta-ketoacyl-ACP reductase; EC 1.1.1.100 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see paper)
39% identity, 96% coverage: 11:256/256 of query aligns to 1:244/244 of P0A2C9
- M125 (= M135) mutation to I: Loss of the temperature-sensitive phenotype; when associated with T-223.
- A223 (= A235) mutation to T: Loss of the temperature-sensitive phenotype; when associated with I-125.
- S224 (= S236) mutation to F: Distorts the local conformation and prevent stacking around Phe-221. The S224F mutation would additionally disrupt the hydrogen bond formed between Ser-224 and Glu-226.
1q7cA The structure of betaketoacyl-[acp] reductase y151f mutant in complex with NADPH fragment (see paper)
39% identity, 96% coverage: 10:256/256 of query aligns to 1:243/243 of 1q7cA
- active site: G15 (= G26), S137 (= S149), Q147 (≠ H159), F150 (≠ Y162), K154 (= K166)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: G11 (= G22), S13 (≠ A24), R14 (≠ S25), A35 (≠ D46), T36 (≠ I47), L57 (≠ C68), N58 (≠ D69), V59 (= V70), G87 (= G98), I88 (≠ V99)
3rwbA Crystal structure of complex of 4pal (4-pyridoxolactone) and pldh (tetrameric pyridoxal 4-dehydrogenase) from mesorhizobium loti
42% identity, 94% coverage: 13:252/256 of query aligns to 4:243/247 of 3rwbA
- active site: G17 (= G26), S140 (= S149), Y153 (= Y162), K157 (= K166)
- binding 7-hydroxy-6-methylfuro[3,4-c]pyridin-1(3H)-one: S140 (= S149), N141 (≠ Q150), T142 (≠ A151), M150 (≠ H159), Y153 (= Y162), L185 (≠ V194), H196 (≠ R208)
- binding nicotinamide-adenine-dinucleotide: G13 (= G22), Q16 (≠ S25), G17 (= G26), I18 (= I27), D37 (= D46), I38 (= I47), D60 (= D69), I61 (≠ V70), N87 (≠ S96), A88 (= A97), S89 (≠ G98), I138 (= I147), S140 (= S149), Y153 (= Y162), K157 (= K166), P183 (= P192), L185 (≠ V194), I186 (≠ V195), S188 (≠ T197), G190 (= G200), V191 (≠ R201)
3ndrA Crystal structure of tetrameric pyridoxal 4-dehydrogenase from mesorhizobium loti
42% identity, 94% coverage: 13:252/256 of query aligns to 4:243/247 of 3ndrA
- active site: G17 (= G26), S140 (= S149), Y153 (= Y162), K157 (= K166)
- binding nicotinamide-adenine-dinucleotide: G13 (= G22), Q16 (≠ S25), G17 (= G26), I18 (= I27), D37 (= D46), I38 (= I47), D60 (= D69), I61 (≠ V70), N87 (≠ S96), A88 (= A97), S89 (≠ G98), V110 (≠ I119), I138 (= I147), S140 (= S149), Y153 (= Y162), K157 (= K166), P183 (= P192), L185 (≠ V194), I186 (≠ V195), S188 (≠ T197), G190 (= G200), V191 (≠ R201)
3uf0A Crystal structure of a putative NAD(p) dependent gluconate 5- dehydrogenase from beutenbergia cavernae(efi target efi-502044) with bound NADP (low occupancy)
40% identity, 95% coverage: 11:253/256 of query aligns to 3:246/249 of 3uf0A
- active site: G18 (= G26), S141 (= S149), V151 (≠ H159), Y154 (= Y162), K158 (= K166)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G14 (= G22), S17 (= S25), G18 (= G26), I19 (= I27), R39 (≠ V44), D63 (= D69), L64 (≠ V70), N89 (≠ S96), G91 (= G98), I92 (≠ V99), I139 (= I147), A140 (= A148), S141 (= S149), Y154 (= Y162), K158 (= K166), P184 (= P192), G185 (≠ T193), V187 (= V195), T189 (= T197), N191 (vs. gap), T192 (≠ E198)
6ixmC Crystal structure of the ketone reductase chkred20 from the genome of chryseobacterium sp. Ca49 complexed with NAD (see paper)
39% identity, 95% coverage: 13:256/256 of query aligns to 3:248/248 of 6ixmC
- active site: G16 (= G26), S142 (= S149), Y155 (= Y162), K159 (= K166)
- binding nicotinamide-adenine-dinucleotide: G12 (= G22), S15 (= S25), G16 (= G26), I17 (= I27), D36 (= D46), I37 (= I47), A61 (≠ C68), D62 (= D69), T63 (≠ V70), N89 (≠ S96), A90 (= A97), M140 (≠ I147), S142 (= S149), Y155 (= Y162), K159 (= K166), P185 (= P192), A186 (≠ T193), Y187 (≠ V194), I188 (≠ V195), L192 (= L199)
8y83A Crystal structure of a ketoreductase from sphingobacterium siyangense sy1 with co-enzyme
39% identity, 95% coverage: 13:256/256 of query aligns to 4:249/249 of 8y83A
- binding nicotinamide-adenine-dinucleotide: G13 (= G22), S16 (= S25), G17 (= G26), I18 (= I27), D37 (= D46), I38 (= I47), A62 (≠ C68), D63 (= D69), S64 (≠ V70), N90 (≠ S96), M141 (≠ I147), Y156 (= Y162), K160 (= K166), P186 (= P192), G187 (≠ T193), Y188 (≠ V194), I189 (≠ V195), L193 (= L199)
5itvA Crystal structure of bacillus subtilis bacc dihydroanticapsin 7- dehydrogenase in complex with nadh (see paper)
37% identity, 95% coverage: 11:254/256 of query aligns to 3:253/255 of 5itvA
- active site: G18 (= G26), S141 (= S149), Y154 (= Y162), K158 (= K166)
- binding 1,4-dihydronicotinamide adenine dinucleotide: G14 (= G22), S17 (= S25), G18 (= G26), I19 (= I27), D38 (= D46), I39 (= I47), T61 (≠ C68), I63 (≠ V70), N89 (≠ S96), G91 (= G98), T139 (≠ I147), S141 (= S149), Y154 (= Y162), K158 (= K166), P184 (= P192), G185 (≠ T193), I186 (≠ V194), I187 (≠ V195)
Q48436 Diacetyl reductase [(S)-acetoin forming]; Acetoin(diacetyl) reductase; AR; Meso-2,3-butanediol dehydrogenase; EC 1.1.1.304 from Klebsiella pneumoniae (see paper)
40% identity, 93% coverage: 16:252/256 of query aligns to 3:252/256 of Q48436
- 6:33 (vs. 19:46, 46% identical) binding NAD(+)
- D59 (= D69) binding NAD(+)
- K156 (= K166) binding NAD(+)
5u9pB Crystal structure of a gluconate 5-dehydrogenase from burkholderia cenocepacia j2315 in complex with NADP and tartrate
38% identity, 96% coverage: 10:254/256 of query aligns to 11:258/261 of 5u9pB
- active site: G27 (= G26), S152 (= S149), Y165 (= Y162), K169 (= K166)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G23 (= G22), R26 (≠ S25), G27 (= G26), I28 (= I27), R48 (≠ I47), D73 (= D69), V74 (= V70), N100 (≠ S96), A101 (= A97), I150 (= I147), Y165 (= Y162), K169 (= K166), P195 (= P192), F198 (≠ V195), T200 (= T197), L202 (= L199), N203 (≠ G200)
1gegE Cryatal structure analysis of meso-2,3-butanediol dehydrogenase (see paper)
40% identity, 93% coverage: 16:252/256 of query aligns to 3:252/256 of 1gegE
- active site: G13 (= G26), S139 (= S149), Y152 (= Y162), K156 (= K166), V197 (vs. gap)
- binding alpha-D-glucopyranose: R63 (≠ P73), D64 (≠ Q74), F67 (≠ E77), E123 (≠ R133)
- binding nicotinamide-adenine-dinucleotide: G9 (= G22), Q12 (≠ S25), I14 (= I27), D33 (= D46), Y34 (≠ I47), V58 (≠ C68), D59 (= D69), V60 (= V70), N86 (≠ S96), A87 (= A97), I109 (= I119), S139 (= S149), Y152 (= Y162), K156 (= K166), P182 (= P192), V185 (= V195), T187 (= T197), M189 (vs. gap)
6pejA Structure of sorbitol dehydrogenase from sinorhizobium meliloti 1021 bound to sorbitol
38% identity, 94% coverage: 13:252/256 of query aligns to 4:253/257 of 6pejA
Query Sequence
>WP_012757000.1 NCBI__GCF_000023185.1:WP_012757000.1
MTDSKQIDLNFSLGGKVALVTGGASGIGDAIASAFAAKGAVVGVIDINETVAKSKADALG
NGAKSFVCDVSNPQSVEAVIAAAQAAFAHIDIVVNSAGVAMLAPAEDLTLEAWDRTIDIN
LKGTFLVCQAVGRVMLKAGSGGRIINIASQAGTVAIDQHVAYCASKFGVIGLSKTLAAEW
GKYGITVNTISPTVVLTELGRKAWDNPRGEELKKRIPTGRFAYPEEIAAAAVFLASSGAE
MINGADLLIDGGYTIV
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SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory