SitesBLAST
Comparing WP_012784194.1 NCBI__GCF_000023265.1:WP_012784194.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 11 hits to proteins with known functional sites (download)
3oa4A Crystal structure of hypothetical protein bh1468 from bacillus halodurans c-125
40% identity, 93% coverage: 5:132/137 of query aligns to 4:132/138 of 3oa4A
6wfhA Streptomyces coelicolor methylmalonyl-coa epimerase substrate complex (see paper)
39% identity, 91% coverage: 6:130/137 of query aligns to 5:136/139 of 6wfhA
- active site: H7 (= H8), E43 (= E43), Q60 (= Q54), H84 (= H78), E134 (= E128)
- binding cobalt (ii) ion: H7 (= H8), Q60 (= Q54), H84 (= H78), E134 (= E128)
- binding (3S,5R,9R,19E)-1-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3,5,9,19-tetrahydroxy-8,8,20-trimethyl-10,14-dioxo-2,4,6-trioxa-18-thia-11,15-diaza-3,5-diphosphahenicos-19-en-21-oic acid 3,5-dioxide (non-preferred name): H7 (= H8), Q39 (≠ D39), Q60 (= Q54), A70 (≠ P64), K73 (≠ R67), W74 (≠ F68), H83 (= H77), H84 (= H78), L107 (≠ I101), G114 (= G108), S115 (= S109), F122 (= F116), P125 (= P119), K126 (≠ R120), L132 (= L126), E134 (= E128)
6xbqA Streptomyces coelicolor methylmalonyl-coa epimerase in complex with carboxy-carba(dethia)-coa
39% identity, 91% coverage: 6:130/137 of query aligns to 5:136/144 of 6xbqA
- active site: H7 (= H8), E43 (= E43), Q60 (= Q54), H84 (= H78), E134 (= E128)
- binding carboxymethyldethia coenzyme *a: Q39 (≠ D39), Q60 (= Q54), A70 (≠ P64), K73 (≠ R67), W74 (≠ F68), H83 (= H77), H84 (= H78), L107 (≠ I101), F122 (= F116), P125 (= P119), K126 (≠ R120), L132 (= L126)
- binding cobalt (ii) ion: H7 (= H8), Q60 (= Q54), H84 (= H78), E134 (= E128)
6wfiA Methylmalonyl-coa epimerase in complex with 2-nitronate-propionyl-coa (see paper)
39% identity, 91% coverage: 6:130/137 of query aligns to 5:136/144 of 6wfiA
- active site: H7 (= H8), E43 (= E43), Q60 (= Q54), H84 (= H78), E134 (= E128)
- binding cobalt (ii) ion: H7 (= H8), Q60 (= Q54), H84 (= H78), E134 (= E128)
- binding [1-[2-[3-[[(2~{R})-4-[[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxy-3,3-dimethyl-2-oxidanyl-butanoyl]amino]propanoylamino]ethylsulfanyl]-1-oxidanylidene-propan-2-ylidene]-bis(oxidanidyl)azanium: H7 (= H8), Q39 (≠ D39), Q60 (= Q54), A70 (≠ P64), K73 (≠ R67), W74 (≠ F68), H83 (= H77), H84 (= H78), L107 (≠ I101), G114 (= G108), S115 (= S109), I120 (≠ V114), F122 (= F116), P125 (= P119), L132 (= L126), E134 (= E128)
6wf7A Methylmalonyl-coa epimerase in complex with methylmalonyl-coa and nh4+ (see paper)
39% identity, 91% coverage: 6:130/137 of query aligns to 5:136/144 of 6wf7A
- active site: H7 (= H8), E43 (= E43), Q60 (= Q54), H84 (= H78), E134 (= E128)
- binding (S)-Methylmalonyl-Coenzyme A: Q39 (≠ D39), E43 (= E43), Q60 (= Q54), A70 (≠ P64), W74 (≠ F68), H83 (= H77), H84 (= H78), L107 (≠ I101), G114 (= G108), S115 (= S109), F122 (= F116), P125 (= P119), K126 (≠ R120), L132 (= L126), E134 (= E128)
- binding methylmalonyl-coenzyme a: Q39 (≠ D39), Q60 (= Q54), A70 (≠ P64), W74 (≠ F68), H83 (= H77), H84 (= H78), L107 (≠ I101), G114 (= G108), S115 (= S109), I120 (≠ V114), F122 (= F116), P125 (= P119), K126 (≠ R120), L132 (= L126), E134 (= E128)
6wf6A Streptomyces coelicolor methylmalonyl-coa epimerase (see paper)
39% identity, 91% coverage: 6:130/137 of query aligns to 5:136/141 of 6wf6A
6xbtA Streptomyces coelicolor methylmalonyl-coa epimerase (q60a) in complex with 2-nitronate-propionyl-coa
39% identity, 91% coverage: 6:130/137 of query aligns to 5:136/140 of 6xbtA
- active site: H7 (= H8), E43 (= E43), A60 (≠ Q54), H84 (= H78), E134 (= E128)
- binding cobalt (ii) ion: H7 (= H8), H84 (= H78), E134 (= E128)
- binding coenzyme a: Q39 (≠ D39), A70 (≠ P64), K73 (≠ R67), W74 (≠ F68), K77 (≠ R71), H83 (= H77), L107 (≠ I101), F122 (= F116), P125 (= P119), K126 (≠ R120), L132 (= L126)
- binding [1-[2-[3-[[(2~{R})-4-[[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxy-3,3-dimethyl-2-oxidanyl-butanoyl]amino]propanoylamino]ethylsulfanyl]-1-oxidanylidene-propan-2-ylidene]-bis(oxidanidyl)azanium: H7 (= H8), Q39 (≠ D39), A70 (≠ P64), K73 (≠ R67), W74 (≠ F68), H83 (= H77), H84 (= H78), L107 (≠ I101), G114 (= G108), S115 (= S109), P125 (= P119), K126 (≠ R120), L132 (= L126), E134 (= E128)
Q96PE7 Methylmalonyl-CoA epimerase, mitochondrial; DL-methylmalonyl-CoA racemase; EC 5.1.99.1 from Homo sapiens (Human) (see paper)
32% identity, 91% coverage: 6:129/137 of query aligns to 48:173/176 of Q96PE7
- H50 (= H8) binding Co(2+)
- R104 (≠ E61) to L: in dbSNP:rs6748672
- H122 (= H78) binding Co(2+)
- E172 (= E128) binding Co(2+)
6qh4C Crystal structure of human methylmalonyl-coa epimerase (mcee) p.Arg143cys variant
31% identity, 91% coverage: 6:129/137 of query aligns to 12:135/138 of 6qh4C
2qh0A Crystal structure of a glyoxalase from clostridium acetobutylicum
28% identity, 93% coverage: 5:132/137 of query aligns to 3:129/129 of 2qh0A
7yvvA Acmp1, r-4-hydroxymandelate synthase
29% identity, 99% coverage: 1:135/137 of query aligns to 3:132/335 of 7yvvA
Sites not aligning to the query:
Query Sequence
>WP_012784194.1 NCBI__GCF_000023265.1:WP_012784194.1
MDEPEIDHVGIAVDDLDAAIARWEALGARLAHREHVDSDGIEEVMLAVGPSFIQLVAPTR
EDSPVARFLARRGPGIHHLALRVQSCRDALEEARRQGFDPIDEVPRRGSRGTTVAFVHPR
STGGVLIEFVEEPPATD
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SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory