SitesBLAST
Comparing WP_012850832.1 NCBI__GCF_000024385.1:WP_012850832.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
6lpiB Crystal structure of ahas holo-enzyme (see paper)
31% identity, 98% coverage: 4:524/534 of query aligns to 6:518/539 of 6lpiB
- active site: I27 (= I25), G29 (= G27), G30 (≠ T28), S31 (≠ H29), I32 (≠ N30), E53 (= E50), C76 (≠ T73), F115 (≠ L114), Q116 (≠ H115), E117 (= E116), K165 (≠ L165), M256 (≠ Q254), A283 (≠ W281), V375 (≠ S377), G401 (= G404), M403 (≠ L406), D428 (= D431), N455 (= N458), A457 (≠ G460), L458 (≠ Y461), L460 (≠ E463), V461 (≠ I464), Q464 (≠ E467)
- binding flavin-adenine dinucleotide: R155 (= R155), G212 (= G210), G213 (= G211), G214 (= G212), T236 (= T234), L237 (≠ S235), M238 (≠ N236), L254 (≠ G252), M256 (≠ Q254), H257 (= H255), G276 (= G272), A277 (≠ T273), R278 (≠ E274), D280 (≠ S278), R282 (≠ W280), A283 (≠ W281), D300 (= D295), I301 (≠ V296), D319 (= D314), V320 (≠ A315), M380 (≠ Y382), G398 (≠ T401)
- binding magnesium ion: D428 (= D431), N455 (= N458)
- binding thiamine diphosphate: E53 (= E50), C76 (≠ T73), P79 (= P76), G376 (≠ A378), Q377 (≠ M379), H378 (≠ A380), G401 (= G404), M403 (≠ L406), G427 (= G430), D428 (= D431), G429 (= G432), S430 (≠ G433), M433 (≠ F436), N455 (= N458), A457 (≠ G460), L458 (≠ Y461), G459 (= G462), L460 (≠ E463), V461 (≠ I464)
6bd3A Saccharomyces cerevisiae acetohydroxyacid synthase
27% identity, 98% coverage: 4:528/534 of query aligns to 10:538/538 of 6bd3A
- active site: Y31 (≠ I25), G33 (= G27), G34 (≠ T28), A35 (≠ H29), I36 (≠ N30), E57 (= E50), T80 (= T73), F119 (≠ L114), Q120 (≠ H115), E121 (= E116), K169 (≠ L165), R225 (≠ E219), M261 (≠ Q254), V288 (≠ W281), V404 (≠ S377), L429 (≠ A403), G430 (= G404), M432 (≠ L406), D457 (= D431), N484 (= N458), L498 (= L488), G503 (= G493), L504 (≠ C494), K537 (≠ S527)
- binding flavin-adenine dinucleotide: R159 (= R155), G214 (= G210), A215 (≠ G211), G216 (= G212), N219 (≠ R215), T241 (= T234), L242 (≠ S235), Q243 (≠ N236), L259 (≠ G252), G260 (≠ L253), H262 (= H255), G281 (= G272), A282 (≠ T273), R283 (≠ E274), D285 (≠ S278), R287 (≠ W280), V288 (≠ W281), E314 (≠ D295), V315 (= V296), D333 (= D314), A334 (= A315)
- binding 2-acetyl-thiamine diphosphate: P32 (= P26), E57 (= E50), P83 (= P76)
- binding magnesium ion: D457 (= D431), N484 (= N458)
- binding oxygen molecule: A35 (≠ H29), T80 (= T73), S81 (≠ T74), Q120 (≠ H115)
- binding thiamine diphosphate: V404 (≠ S377), G405 (≠ A378), Q406 (≠ M379), H407 (≠ A380), G430 (= G404), M432 (≠ L406), D457 (= D431), A458 (≠ G432), S459 (≠ G433), M462 (≠ F436), N484 (= N458)
1t9cA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, sulfometuron methyl (see paper)
27% identity, 98% coverage: 4:528/534 of query aligns to 8:557/596 of 1t9cA
- active site: Y29 (≠ I25), G31 (= G27), G32 (≠ T28), A33 (≠ H29), I34 (≠ N30), E55 (= E50), T78 (= T73), F117 (≠ L114), Q118 (≠ H115), E119 (= E116), K167 (≠ L165), R227 (≠ E219), M263 (≠ Q254), V290 (≠ W281), V406 (≠ S377), L431 (≠ A403), G432 (= G404), M434 (≠ L406), D459 (= D431), N486 (= N458), E488 (≠ G460), Q489 (≠ Y461), M491 (≠ E463), V492 (≠ I464), W495 (≠ E467), L517 (= L488), G522 (= G493), L523 (≠ C494), K556 (≠ S527)
- binding methyl 2-[({[(4,6-dimethylpyrimidin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: G32 (≠ T28), V107 (≠ M102), P108 (= P103), F117 (≠ L114), K167 (≠ L165), D288 (= D279), R289 (≠ W280), W495 (≠ E467)
- binding flavin-adenine dinucleotide: R157 (= R155), G216 (= G210), A217 (≠ G211), G218 (= G212), N221 (≠ R215), T243 (= T234), L244 (≠ S235), Q245 (≠ N236), L261 (≠ G252), M263 (≠ Q254), H264 (= H255), G283 (= G272), A284 (≠ T273), R285 (≠ E274), D287 (≠ S278), R289 (≠ W280), V290 (≠ W281), E316 (≠ D295), V317 (= V296), N321 (≠ G300), G334 (= G313), D335 (= D314), A336 (= A315), M411 (≠ Y382), G429 (≠ T401), G430 (= G402)
- binding magnesium ion: D459 (= D431), N486 (= N458), E488 (≠ G460)
1t9bB Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, chlorsulfuron (see paper)
27% identity, 98% coverage: 4:528/534 of query aligns to 8:556/595 of 1t9bB
- active site: Y29 (≠ I25), G31 (= G27), G32 (≠ T28), A33 (≠ H29), I34 (≠ N30), E55 (= E50), T78 (= T73), F117 (≠ L114), Q118 (≠ H115), E119 (= E116), K167 (≠ L165), R226 (≠ E219), M262 (≠ Q254), V289 (≠ W281), V405 (≠ S377), L430 (≠ A403), G431 (= G404), M433 (≠ L406), D458 (= D431), N485 (= N458), E487 (≠ G460), Q488 (≠ Y461), M490 (≠ E463), V491 (≠ I464), W494 (≠ E467), L516 (= L488), G521 (= G493), L522 (≠ C494), K555 (≠ S527)
- binding 1-(2-chlorophenylsulfonyl)-3-(4-methoxy-6-methyl-l,3,5-triazin-2-yl)urea: V107 (≠ M102), P108 (= P103), D287 (= D279), R288 (≠ W280), M490 (≠ E463), W494 (≠ E467)
- binding flavin-adenine dinucleotide: R157 (= R155), G215 (= G210), A216 (≠ G211), G217 (= G212), N220 (≠ R215), T242 (= T234), L243 (≠ S235), Q244 (≠ N236), M259 (≠ A251), L260 (≠ G252), M262 (≠ Q254), H263 (= H255), G282 (= G272), A283 (≠ T273), R284 (≠ E274), D286 (≠ S278), R288 (≠ W280), V289 (≠ W281), E315 (≠ D295), V316 (= V296), N320 (≠ G300), G333 (= G313), D334 (= D314), A335 (= A315), Q409 (≠ C381), M410 (≠ Y382), G428 (≠ T401), G429 (= G402)
- binding magnesium ion: D458 (= D431), N485 (= N458), E487 (≠ G460)
6derA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide metosulam (see paper)
27% identity, 98% coverage: 4:528/534 of query aligns to 14:561/600 of 6derA
- active site: Y35 (≠ I25), G37 (= G27), G38 (≠ T28), A39 (≠ H29), I40 (≠ N30), E61 (= E50), T84 (= T73), F123 (≠ L114), Q124 (≠ H115), E125 (= E116), K173 (≠ L165), K231 (≠ E219), M267 (≠ L253), V294 (vs. gap), V410 (≠ S377), L435 (≠ A403), G436 (= G404), M438 (≠ L406), D463 (= D431), N490 (= N458), E492 (≠ G460), Q493 (≠ Y461), M495 (≠ E463), V496 (≠ I464), W499 (≠ E467), L521 (= L488), N526 (≠ G493), V527 (≠ C494)
- binding flavin-adenine dinucleotide: R163 (= R155), G220 (= G210), A221 (≠ G211), G222 (= G212), N225 (≠ A213), T247 (= T234), L248 (≠ S235), Q249 (≠ N236), L265 (vs. gap), H268 (≠ Q254), G287 (= G272), A288 (vs. gap), R289 (vs. gap), D291 (vs. gap), R293 (vs. gap), V294 (vs. gap), E320 (≠ D295), I321 (≠ V296), N325 (≠ G300), G338 (= G313), D339 (= D314), V340 (≠ A315), Q414 (≠ C381), M415 (≠ Y382), G433 (≠ T401)
- binding Metosulam: R293 (vs. gap), M495 (≠ E463), W499 (≠ E467)
- binding magnesium ion: D463 (= D431), N490 (= N458), E492 (≠ G460)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V410 (≠ S377), G411 (≠ A378), Q412 (≠ M379), H413 (≠ A380), G436 (= G404), M438 (≠ L406), G462 (= G430), D463 (= D431), A464 (≠ G432), S465 (≠ G433), N490 (= N458), E492 (≠ G460), Q493 (≠ Y461), G494 (= G462), M495 (≠ E463), V496 (≠ I464)
- binding 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-2-oxo-2,3-dihydro-1,3-thiazol-5-yl}ethyl trihydrogendiphosphate: V410 (≠ S377), G411 (≠ A378), Q412 (≠ M379), H413 (≠ A380), G436 (= G404), M438 (≠ L406), G462 (= G430), D463 (= D431), A464 (≠ G432), S465 (≠ G433), M468 (≠ F436), N490 (= N458), E492 (≠ G460), Q493 (≠ Y461), G494 (= G462), V496 (≠ I464)
Sites not aligning to the query:
1t9dA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, metsulfuron methyl (see paper)
27% identity, 98% coverage: 4:528/534 of query aligns to 8:557/596 of 1t9dA
- active site: Y29 (≠ I25), G31 (= G27), G32 (≠ T28), A33 (≠ H29), I34 (≠ N30), E55 (= E50), T78 (= T73), F117 (≠ L114), Q118 (≠ H115), E119 (= E116), K167 (≠ L165), R227 (≠ E219), M263 (≠ Q254), V290 (≠ W281), V406 (≠ S377), L431 (≠ A403), G432 (= G404), M434 (≠ L406), D459 (= D431), N486 (= N458), E488 (≠ G460), Q489 (≠ Y461), M491 (≠ E463), V492 (≠ I464), W495 (≠ E467), L517 (= L488), G522 (= G493), L523 (≠ C494), K556 (≠ S527)
- binding methyl 2-[({[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: G32 (≠ T28), A33 (≠ H29), V107 (≠ M102), P108 (= P103), F117 (≠ L114), K167 (≠ L165), M263 (≠ Q254), D288 (= D279), R289 (≠ W280), W495 (≠ E467)
- binding flavin-adenine dinucleotide: R157 (= R155), G216 (= G210), A217 (≠ G211), G218 (= G212), N221 (≠ R215), T243 (= T234), L244 (≠ S235), Q245 (≠ N236), M260 (≠ A251), L261 (≠ G252), H264 (= H255), G283 (= G272), A284 (≠ T273), R285 (≠ E274), D287 (≠ S278), R289 (≠ W280), V290 (≠ W281), E316 (≠ D295), V317 (= V296), N321 (≠ G300), G334 (= G313), D335 (= D314), A336 (= A315), Q410 (≠ C381), M411 (≠ Y382), G429 (≠ T401), G430 (= G402)
- binding magnesium ion: D459 (= D431), N486 (= N458), E488 (≠ G460)
- binding 2,5-dimethyl-pyrimidin-4-ylamine: E55 (= E50), P81 (= P76), Q118 (≠ H115), G432 (= G404), M434 (≠ L406), M464 (≠ F436)
6desA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide propoxycarbazone (see paper)
27% identity, 98% coverage: 4:528/534 of query aligns to 12:559/598 of 6desA
- active site: Y33 (≠ I25), G35 (= G27), G36 (≠ T28), A37 (≠ H29), I38 (≠ N30), E59 (= E50), T82 (= T73), F121 (≠ L114), Q122 (≠ H115), E123 (= E116), K171 (≠ L165), K229 (≠ E219), M265 (≠ L253), V292 (vs. gap), V408 (≠ S377), L433 (≠ A403), G434 (= G404), M436 (≠ L406), D461 (= D431), N488 (= N458), E490 (≠ G460), Q491 (≠ Y461), M493 (≠ E463), V494 (≠ I464), W497 (≠ E467), L519 (= L488), N524 (≠ G493), V525 (≠ C494)
- binding methyl 2-[(4-methyl-5-oxidanylidene-3-propoxy-1,2,4-triazol-1-yl)carbonylsulfamoyl]benzoate: M265 (≠ L253), D290 (vs. gap), R291 (vs. gap), W497 (≠ E467)
- binding flavin-adenine dinucleotide: R161 (= R155), G218 (= G210), A219 (≠ G211), G220 (= G212), N223 (≠ A213), T245 (= T234), L246 (≠ S235), Q247 (≠ N236), L263 (vs. gap), G285 (= G272), A286 (vs. gap), R287 (vs. gap), D289 (vs. gap), R291 (vs. gap), V292 (vs. gap), E318 (≠ D295), I319 (≠ V296), N323 (≠ G300), D337 (= D314), V338 (≠ A315), Q412 (≠ C381), M413 (≠ Y382), G431 (≠ T401)
- binding magnesium ion: D461 (= D431), N488 (= N458), E490 (≠ G460)
- binding 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-2-oxo-2,3-dihydro-1,3-thiazol-5-yl}ethyl trihydrogendiphosphate: V408 (≠ S377), G409 (≠ A378), Q410 (≠ M379), H411 (≠ A380), G434 (= G404), M436 (≠ L406), G460 (= G430), D461 (= D431), A462 (≠ G432), S463 (≠ G433), N488 (= N458), E490 (≠ G460), Q491 (≠ Y461), G492 (= G462), M493 (≠ E463), V494 (≠ I464)
6depA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide sulfometuron methyl (see paper)
27% identity, 98% coverage: 4:528/534 of query aligns to 12:559/598 of 6depA
- active site: Y33 (≠ I25), G35 (= G27), G36 (≠ T28), A37 (≠ H29), I38 (≠ N30), E59 (= E50), T82 (= T73), F121 (≠ L114), Q122 (≠ H115), E123 (= E116), K171 (≠ L165), K229 (≠ E219), M265 (≠ L253), V292 (vs. gap), V408 (≠ S377), L433 (≠ A403), G434 (= G404), M436 (≠ L406), D461 (= D431), N488 (= N458), E490 (≠ G460), Q491 (≠ Y461), M493 (≠ E463), V494 (≠ I464), W497 (≠ E467), L519 (= L488), N524 (≠ G493), V525 (≠ C494)
- binding methyl 2-[({[(4,6-dimethylpyrimidin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: D290 (vs. gap), R291 (vs. gap), M493 (≠ E463), W497 (≠ E467)
- binding flavin-adenine dinucleotide: R161 (= R155), G218 (= G210), A219 (≠ G211), G220 (= G212), N223 (≠ A213), T245 (= T234), L246 (≠ S235), Q247 (≠ N236), L263 (vs. gap), G264 (= G252), G285 (= G272), A286 (vs. gap), R287 (vs. gap), D289 (vs. gap), R291 (vs. gap), V292 (vs. gap), E318 (≠ D295), I319 (≠ V296), N323 (≠ G300), D337 (= D314), V338 (≠ A315), M413 (≠ Y382), G431 (≠ T401)
- binding magnesium ion: D461 (= D431), N488 (= N458), E490 (≠ G460)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V408 (≠ S377), G409 (≠ A378), Q410 (≠ M379), H411 (≠ A380), G434 (= G404), M436 (≠ L406), G460 (= G430), D461 (= D431), A462 (≠ G432), S463 (≠ G433), M466 (≠ F436), N488 (= N458), E490 (≠ G460), Q491 (≠ Y461), G492 (= G462), M493 (≠ E463), V494 (≠ I464)
- binding 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-2-oxo-2,3-dihydro-1,3-thiazol-5-yl}ethyl trihydrogendiphosphate: V408 (≠ S377), G409 (≠ A378), Q410 (≠ M379), H411 (≠ A380), G434 (= G404), M436 (≠ L406), G460 (= G430), D461 (= D431), A462 (≠ G432), S463 (≠ G433), M466 (≠ F436), N488 (= N458), E490 (≠ G460), Q491 (≠ Y461), G492 (= G462), M493 (≠ E463), V494 (≠ I464)
1t9aA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, tribenuron methyl (see paper)
27% identity, 98% coverage: 4:528/534 of query aligns to 9:558/597 of 1t9aA
- active site: Y30 (≠ I25), G32 (= G27), G33 (≠ T28), A34 (≠ H29), I35 (≠ N30), E56 (= E50), T79 (= T73), F118 (≠ L114), Q119 (≠ H115), E120 (= E116), K168 (≠ L165), R228 (≠ E219), M264 (≠ Q254), V291 (≠ W281), V407 (≠ S377), L432 (≠ A403), G433 (= G404), M435 (≠ L406), D460 (= D431), N487 (= N458), E489 (≠ G460), Q490 (≠ Y461), M492 (≠ E463), V493 (≠ I464), W496 (≠ E467), L518 (= L488), G523 (= G493), L524 (≠ C494), K557 (≠ S527)
- binding methyl 2-[4-methoxy-6-methyl-1,3,5-trazin-2-yl(methyl)carbamoylsulfamoyl]benzoate: G33 (≠ T28), V108 (≠ M102), P109 (= P103), F118 (≠ L114), K168 (≠ L165), M264 (≠ Q254), D289 (= D279), R290 (≠ W280), M492 (≠ E463), V493 (≠ I464), W496 (≠ E467)
- binding flavin-adenine dinucleotide: R158 (= R155), G217 (= G210), A218 (≠ G211), G219 (= G212), N222 (≠ R215), T244 (= T234), L245 (≠ S235), Q246 (≠ N236), L262 (≠ G252), M264 (≠ Q254), H265 (= H255), G284 (= G272), A285 (≠ T273), R286 (≠ E274), D288 (≠ S278), R290 (≠ W280), V291 (≠ W281), E317 (≠ D295), V318 (= V296), N322 (≠ G300), G335 (= G313), D336 (= D314), A337 (= A315), Q411 (≠ C381), M412 (≠ Y382), G430 (≠ T401), G431 (= G402)
- binding magnesium ion: D460 (= D431), N487 (= N458), E489 (≠ G460)
- binding propyl trihydrogen diphosphate: V407 (≠ S377), G408 (≠ A378), Q409 (≠ M379), H410 (≠ A380), M435 (≠ L406), G459 (= G430), D460 (= D431), A461 (≠ G432), S462 (≠ G433), N487 (= N458), E489 (≠ G460), Q490 (≠ Y461), G491 (= G462), M492 (≠ E463)
- binding 5-{[ethyl(methyl)amino]methyl}-2-methyl-5,6-dihydropyrimidin-4-amine: G433 (= G404), M435 (≠ L406), M465 (≠ F436)
1n0hA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, chlorimuron ethyl (see paper)
27% identity, 98% coverage: 4:528/534 of query aligns to 10:560/599 of 1n0hA
- active site: Y31 (≠ I25), G33 (= G27), G34 (≠ T28), A35 (≠ H29), I36 (≠ N30), E57 (= E50), T80 (= T73), F119 (≠ L114), Q120 (≠ H115), E121 (= E116), K169 (≠ L165), R230 (≠ E219), M266 (≠ Q254), V293 (≠ W281), V409 (≠ S377), L434 (≠ A403), G435 (= G404), M437 (≠ L406), D462 (= D431), N489 (= N458), E491 (≠ G460), Q492 (≠ Y461), M494 (≠ E463), V495 (≠ I464), W498 (≠ E467), L520 (= L488), G525 (= G493), L526 (≠ C494), K559 (≠ S527)
- binding 4-{[(4'-amino-2'-methylpyrimidin-5'-yl)methyl]amino}pent-3-enyl diphosphate: V409 (≠ S377), G410 (≠ A378), Q411 (≠ M379), H412 (≠ A380), G435 (= G404), M437 (≠ L406), G461 (= G430), D462 (= D431), A463 (≠ G432), S464 (≠ G433), M467 (≠ F436), N489 (= N458), E491 (≠ G460), Q492 (≠ Y461), G493 (= G462), V495 (≠ I464)
- binding 2-[[[[(4-chloro-6-methoxy-2-pyrimidinyl)amino]carbonyl]amino]sulfonyl]benzoic acid ethyl ester: G34 (≠ T28), A35 (≠ H29), V109 (≠ M102), P110 (= P103), F119 (≠ L114), K169 (≠ L165), M266 (≠ Q254), D291 (= D279), R292 (≠ W280), V495 (≠ I464), W498 (≠ E467)
- binding flavin-adenine dinucleotide: R159 (= R155), G219 (= G210), A220 (≠ G211), G221 (= G212), N224 (≠ R215), T246 (= T234), L247 (≠ S235), Q248 (≠ N236), L264 (≠ G252), G265 (≠ L253), M266 (≠ Q254), H267 (= H255), G286 (= G272), A287 (≠ T273), R288 (≠ E274), D290 (≠ S278), R292 (≠ W280), V293 (≠ W281), E319 (≠ D295), V320 (= V296), N324 (≠ G300), G337 (= G313), D338 (= D314), A339 (= A315), M414 (≠ Y382), G432 (≠ T401), G433 (= G402)
- binding magnesium ion: D462 (= D431), N489 (= N458), E491 (≠ G460)
- binding thiamine diphosphate: Y31 (≠ I25), E57 (= E50), P83 (= P76)
1jscA Crystal structure of the catalytic subunit of yeast acetohydroxyacid synthase: a target for herbicidal inhibitors (see paper)
27% identity, 98% coverage: 4:528/534 of query aligns to 10:541/541 of 1jscA
- active site: Y31 (≠ I25), G33 (= G27), G34 (≠ T28), A35 (≠ H29), I36 (≠ N30), E57 (= E50), T80 (= T73), F119 (≠ L114), Q120 (≠ H115), E121 (= E116), K169 (≠ L165), M263 (≠ Q254), V290 (≠ W281), V406 (≠ S377), G432 (= G404), M434 (≠ L406), D459 (= D431), N486 (= N458), E488 (≠ P474), K540 (≠ S527)
- binding dihydrogenphosphate ion: G33 (= G27), G34 (≠ T28), Q120 (≠ H115)
- binding flavin-adenine dinucleotide: R159 (= R155), G216 (= G210), A217 (≠ G211), G218 (= G212), N221 (≠ R215), T243 (= T234), L244 (≠ S235), L261 (≠ G252), G262 (≠ L253), H264 (= H255), G283 (= G272), A284 (≠ T273), R285 (≠ E274), D287 (≠ S278), R289 (≠ W280), V290 (≠ W281), E316 (≠ D295), V317 (= V296), N321 (≠ G300), G334 (= G313), D335 (= D314), A336 (= A315)
- binding magnesium ion: D459 (= D431), N486 (= N458)
- binding thiamine diphosphate: Y31 (≠ I25), P32 (= P26), E57 (= E50), P83 (= P76), V406 (≠ S377), G407 (≠ A378), Q408 (≠ M379), H409 (≠ A380), M434 (≠ L406), D459 (= D431), A460 (≠ G432), S461 (≠ G433), N486 (= N458)
6bd9A Saccharomyces cerevisiae acetohydroxyacid synthase
27% identity, 98% coverage: 4:528/534 of query aligns to 10:542/542 of 6bd9A
- active site: Y31 (≠ I25), G33 (= G27), G34 (≠ T28), A35 (≠ H29), I36 (≠ N30), E57 (= E50), T80 (= T73), F119 (≠ L114), Q120 (≠ H115), E121 (= E116), K169 (≠ L165), R228 (≠ E219), M264 (≠ Q254), V291 (≠ W281), V407 (≠ S377), L432 (≠ A403), G433 (= G404), M435 (≠ L406), D460 (= D431), N487 (= N458), E489 (≠ P474), L502 (= L488), G507 (= G493), L508 (≠ C494), K541 (≠ S527)
- binding flavin-adenine dinucleotide: R159 (= R155), G217 (= G210), A218 (≠ G211), G219 (= G212), N222 (≠ R215), T244 (= T234), L245 (≠ S235), L262 (≠ G252), G263 (≠ L253), H265 (= H255), G284 (= G272), A285 (≠ T273), R286 (≠ E274), D288 (≠ S278), R290 (≠ W280), V291 (≠ W281), E317 (≠ D295), V318 (= V296), N322 (≠ G300), G335 (= G313), D336 (= D314), A337 (= A315)
- binding magnesium ion: D460 (= D431), N487 (= N458)
- binding oxygen molecule: G34 (≠ T28), T80 (= T73), Q120 (≠ H115), A461 (≠ G432), Q494 (≠ A479)
- binding pyruvic acid: G33 (= G27), G34 (≠ T28), G34 (≠ T28), A35 (≠ H29), Q120 (≠ H115)
- binding thiamine diphosphate: P32 (= P26), E57 (= E50), V407 (≠ S377), G408 (≠ A378), Q409 (≠ M379), H410 (≠ A380), G433 (= G404), M435 (≠ L406), G459 (= G430), D460 (= D431), A461 (≠ G432), S462 (≠ G433), M465 (≠ F436), N487 (= N458)
6denA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide iodomuron ethyl (see paper)
27% identity, 98% coverage: 4:528/534 of query aligns to 14:560/599 of 6denA
- active site: Y35 (≠ I25), G37 (= G27), G38 (≠ T28), A39 (≠ H29), I40 (≠ N30), E61 (= E50), T84 (= T73), F123 (≠ L114), Q124 (≠ H115), E125 (= E116), K173 (≠ L165), K230 (≠ E219), M266 (≠ L253), V293 (vs. gap), V409 (≠ S377), L434 (≠ A403), G435 (= G404), M437 (≠ L406), D462 (= D431), N489 (= N458), E491 (≠ G460), Q492 (≠ Y461), M494 (≠ E463), V495 (≠ I464), W498 (≠ E467), L520 (= L488), N525 (≠ G493), V526 (≠ C494)
- binding flavin-adenine dinucleotide: R163 (= R155), G219 (= G210), A220 (≠ G211), G221 (= G212), N224 (≠ A213), T246 (= T234), L247 (≠ S235), Q248 (≠ N236), L264 (vs. gap), G286 (= G272), A287 (vs. gap), R288 (vs. gap), D290 (vs. gap), R292 (vs. gap), V293 (vs. gap), E319 (≠ D295), I320 (≠ V296), N324 (≠ G300), D338 (= D314), V339 (≠ A315), M414 (≠ Y382), G432 (≠ T401)
- binding ethyl 2-{[(4-iodo-6-methoxypyrimidin-2-yl)carbamoyl]sulfamoyl}benzoate: M266 (≠ L253), D291 (vs. gap), R292 (vs. gap), W498 (≠ E467)
- binding magnesium ion: D462 (= D431), N489 (= N458), E491 (≠ G460)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V409 (≠ S377), G410 (≠ A378), Q411 (≠ M379), H412 (≠ A380), G435 (= G404), M437 (≠ L406), G461 (= G430), D462 (= D431), A463 (≠ G432), S464 (≠ G433), N489 (= N458), E491 (≠ G460), Q492 (≠ Y461), G493 (= G462), M494 (≠ E463), V495 (≠ I464)
5wkcA Saccharomyces cerevisiae acetohydroxyacid synthase in complex with the herbicide penoxsulam (see paper)
27% identity, 98% coverage: 4:528/534 of query aligns to 8:552/591 of 5wkcA
- active site: Y29 (≠ I25), G31 (= G27), G32 (≠ T28), A33 (≠ H29), I34 (≠ N30), E55 (= E50), T78 (= T73), F117 (≠ L114), Q118 (≠ H115), E119 (= E116), K167 (≠ L165), R222 (≠ E219), M258 (≠ Q254), V285 (≠ W281), V401 (≠ S377), L426 (≠ A403), G427 (= G404), M429 (≠ L406), D454 (= D431), N481 (= N458), E483 (≠ G460), Q484 (≠ Y461), M486 (≠ E463), V487 (≠ I464), W490 (≠ E467), L512 (= L488), G517 (= G493), L518 (≠ C494), K551 (≠ S527)
- binding 2-[3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-2-[(1~{S})-1-(dioxidanyl)-1-oxidanyl-ethyl]-4-methyl-1,3-thiazol-5-yl]ethyl phosphono hydrogen phosphate: V401 (≠ S377), G402 (≠ A378), Q403 (≠ M379), H404 (≠ A380), G427 (= G404), M429 (≠ L406), G453 (= G430), D454 (= D431), A455 (≠ G432), S456 (≠ G433), M459 (≠ F436), N481 (= N458), E483 (≠ G460), Q484 (≠ Y461), G485 (= G462), M486 (≠ E463), V487 (≠ I464)
- binding ethaneperoxoic acid: G32 (≠ T28), Q118 (≠ H115)
- binding flavin-adenine dinucleotide: R157 (= R155), G211 (= G210), A212 (≠ G211), G213 (= G212), N216 (≠ R215), T238 (= T234), L239 (≠ S235), Q240 (≠ N236), L256 (≠ G252), M258 (≠ Q254), G278 (= G272), A279 (≠ T273), R280 (≠ E274), R284 (≠ W280), V285 (≠ W281), E311 (≠ D295), V312 (= V296), N316 (≠ G300), D330 (= D314), A331 (= A315), M406 (≠ Y382), G424 (≠ T401)
- binding magnesium ion: D454 (= D431), N481 (= N458), E483 (≠ G460)
- binding 2-(2,2-difluoroethoxy)-N-(5,8-dimethoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)-6-(trifluoromethyl)benzenesulfonamide: G32 (≠ T28), A33 (≠ H29), V107 (≠ M102), F117 (≠ L114), K167 (≠ L165), M258 (≠ Q254), R284 (≠ W280), M486 (≠ E463), W490 (≠ E467)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: P30 (= P26), E55 (= E50)
6vz8D Arabidopsis thaliana acetohydroxyacid synthase complex with valine bound (see paper)
29% identity, 97% coverage: 6:523/534 of query aligns to 13:527/531 of 6vz8D
- active site: Y32 (≠ I25), G34 (= G27), G35 (≠ T28), A36 (≠ H29), S37 (≠ N30), E58 (= E50), T81 (= T73), F120 (≠ G112), Q121 (≠ L113), E122 (≠ L114), K170 (≠ L165), M256 (≠ Q254), V283 (≠ S288), V376 (≠ S377), G402 (= G404), M404 (≠ L406), D429 (= D431), N456 (= N458), H458 (≠ G460), L459 (≠ Y461), M461 (vs. gap), V462 (vs. gap), W465 (vs. gap)
- binding flavin-adenine dinucleotide: G214 (= G210), G215 (= G211), G216 (= G212), T236 (= T234), L237 (≠ S235), L254 (≠ G252), H257 (= H255), R278 (≠ E274), R282 (≠ L287), V283 (≠ S288), I291 (≠ V296), G399 (≠ T401)
- binding magnesium ion: H458 (≠ G460), L459 (≠ Y461), G460 (= G462)
- binding thiamine diphosphate: E58 (= E50), P84 (= P76), V376 (≠ S377), G377 (≠ A378), Q378 (≠ M379), H379 (≠ A380), G402 (= G404), M404 (≠ L406), G428 (= G430), D429 (= D431), G430 (= G432), S431 (≠ G433), L459 (≠ Y461), G460 (= G462), M461 (vs. gap), V462 (vs. gap)
6deoA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide iodomuron methyl (see paper)
27% identity, 98% coverage: 4:528/534 of query aligns to 10:554/593 of 6deoA
- active site: Y31 (≠ I25), G33 (= G27), G34 (≠ T28), A35 (≠ H29), I36 (≠ N30), E57 (= E50), T80 (= T73), F119 (≠ L114), Q120 (≠ H115), E121 (= E116), K169 (≠ L165), K224 (≠ E219), M260 (≠ L253), V287 (vs. gap), V403 (≠ S377), L428 (≠ A403), G429 (= G404), M431 (≠ L406), D456 (= D431), N483 (= N458), E485 (≠ G460), Q486 (≠ Y461), M488 (≠ E463), V489 (≠ I464), W492 (≠ E467), L514 (= L488), N519 (≠ G493), V520 (≠ C494)
- binding flavin-adenine dinucleotide: R159 (= R155), G213 (= G210), A214 (≠ G211), G215 (= G212), N218 (≠ A213), T240 (= T234), L241 (≠ S235), Q242 (≠ N236), L258 (vs. gap), G280 (= G272), A281 (vs. gap), R282 (vs. gap), D284 (vs. gap), R286 (vs. gap), V287 (vs. gap), E313 (≠ D295), I314 (≠ V296), N318 (≠ G300), D332 (= D314), V333 (≠ A315), M408 (≠ Y382), G426 (≠ T401)
- binding methyl 2-{[(4-iodo-6-methoxypyrimidin-2-yl)carbamoyl]sulfamoyl}benzoate: M260 (≠ L253), D285 (vs. gap), R286 (vs. gap), M488 (≠ E463), W492 (≠ E467)
- binding magnesium ion: D456 (= D431), N483 (= N458), E485 (≠ G460)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V403 (≠ S377), G404 (≠ A378), Q405 (≠ M379), H406 (≠ A380), G429 (= G404), M431 (≠ L406), G455 (= G430), D456 (= D431), A457 (≠ G432), S458 (≠ G433), M461 (≠ F436), N483 (= N458), E485 (≠ G460), Q486 (≠ Y461), G487 (= G462), M488 (≠ E463), V489 (≠ I464)
6deqA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide penoxsulam (see paper)
27% identity, 98% coverage: 4:528/534 of query aligns to 14:562/601 of 6deqA
- active site: Y35 (≠ I25), G37 (= G27), G38 (≠ T28), A39 (≠ H29), I40 (≠ N30), E61 (= E50), T84 (= T73), F123 (≠ L114), Q124 (≠ H115), E125 (= E116), K173 (≠ L165), K232 (≠ E219), M268 (≠ L253), V295 (vs. gap), V411 (≠ S377), L436 (≠ A403), G437 (= G404), M439 (≠ L406), D464 (= D431), N491 (= N458), E493 (≠ G460), Q494 (≠ Y461), M496 (≠ E463), V497 (≠ I464), W500 (≠ E467), L522 (= L488), N527 (≠ G493), V528 (≠ C494)
- binding flavin-adenine dinucleotide: R163 (= R155), G221 (= G210), A222 (≠ G211), G223 (= G212), N226 (≠ A213), T248 (= T234), L249 (≠ S235), Q250 (≠ N236), L266 (vs. gap), G288 (= G272), A289 (vs. gap), R290 (vs. gap), D292 (vs. gap), R294 (vs. gap), V295 (vs. gap), E321 (≠ D295), I322 (≠ V296), D340 (= D314), V341 (≠ A315), M416 (≠ Y382), G434 (≠ T401)
- binding magnesium ion: D464 (= D431), N491 (= N458), E493 (≠ G460)
- binding 2-(2,2-difluoroethoxy)-N-(5,8-dimethoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)-6-(trifluoromethyl)benzenesulfonamide: M268 (≠ L253), R294 (vs. gap), M496 (≠ E463), V497 (≠ I464), W500 (≠ E467)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V411 (≠ S377), G412 (≠ A378), Q413 (≠ M379), H414 (≠ A380), M439 (≠ L406), G463 (= G430), D464 (= D431), A465 (≠ G432), S466 (≠ G433), N491 (= N458), E493 (≠ G460), Q494 (≠ Y461), G495 (= G462), M496 (≠ E463), V497 (≠ I464)
Sites not aligning to the query:
6demA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide bensulfuron methyl (see paper)
27% identity, 98% coverage: 4:528/534 of query aligns to 12:558/597 of 6demA
- active site: Y33 (≠ I25), G35 (= G27), G36 (≠ T28), A37 (≠ H29), I38 (≠ N30), E59 (= E50), T82 (= T73), F121 (≠ L114), Q122 (≠ H115), E123 (= E116), K171 (≠ L165), K228 (≠ E219), M264 (≠ L253), V291 (vs. gap), V407 (≠ S377), L432 (≠ A403), G433 (= G404), M435 (≠ L406), D460 (= D431), N487 (= N458), E489 (≠ G460), Q490 (≠ Y461), M492 (≠ E463), V493 (≠ I464), W496 (≠ E467), L518 (= L488), N523 (≠ G493), V524 (≠ C494)
- binding methyl 2-[(4,6-dimethoxypyrimidin-2-yl)carbamoylsulfamoylmethyl]benzoate: M264 (≠ L253), D289 (vs. gap), R290 (vs. gap), M492 (≠ E463), W496 (≠ E467)
- binding flavin-adenine dinucleotide: R161 (= R155), G217 (= G210), A218 (≠ G211), G219 (= G212), N222 (≠ A213), T244 (= T234), L245 (≠ S235), Q246 (≠ N236), L262 (vs. gap), G284 (= G272), A285 (vs. gap), R286 (vs. gap), D288 (vs. gap), R290 (vs. gap), V291 (vs. gap), E317 (≠ D295), I318 (≠ V296), N322 (≠ G300), D336 (= D314), V337 (≠ A315), M412 (≠ Y382), G430 (≠ T401)
- binding magnesium ion: D460 (= D431), N487 (= N458), E489 (≠ G460)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V407 (≠ S377), G408 (≠ A378), Q409 (≠ M379), H410 (≠ A380), M435 (≠ L406), G459 (= G430), D460 (= D431), A461 (≠ G432), S462 (≠ G433), M465 (≠ F436), N487 (= N458), E489 (≠ G460), Q490 (≠ Y461), G491 (= G462), M492 (≠ E463), V493 (≠ I464)
Sites not aligning to the query:
6delA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide chlorimuron ethyl (see paper)
27% identity, 98% coverage: 4:528/534 of query aligns to 12:558/597 of 6delA
- active site: Y33 (≠ I25), G35 (= G27), G36 (≠ T28), A37 (≠ H29), I38 (≠ N30), E59 (= E50), T82 (= T73), F121 (≠ L114), Q122 (≠ H115), E123 (= E116), K171 (≠ L165), K228 (≠ E219), M264 (≠ L253), V291 (vs. gap), V407 (≠ S377), L432 (≠ A403), G433 (= G404), M435 (≠ L406), D460 (= D431), N487 (= N458), E489 (≠ G460), Q490 (≠ Y461), M492 (≠ E463), V493 (≠ I464), W496 (≠ E467), L518 (= L488), N523 (≠ G493), V524 (≠ C494)
- binding 2-[[[[(4-chloro-6-methoxy-2-pyrimidinyl)amino]carbonyl]amino]sulfonyl]benzoic acid ethyl ester: D289 (vs. gap), R290 (vs. gap), W496 (≠ E467)
- binding flavin-adenine dinucleotide: R161 (= R155), G217 (= G210), A218 (≠ G211), G219 (= G212), N222 (≠ A213), T244 (= T234), L245 (≠ S235), Q246 (≠ N236), L262 (vs. gap), G284 (= G272), A285 (vs. gap), R286 (vs. gap), D288 (vs. gap), R290 (vs. gap), V291 (vs. gap), E317 (≠ D295), I318 (≠ V296), N322 (≠ G300), D336 (= D314), V337 (≠ A315), M412 (≠ Y382), G430 (≠ T401)
- binding (3Z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl](formyl)amino}-3-sulfanylpent-3-en-1-yl trihydrogen diphosphate: V407 (≠ S377), G408 (≠ A378), Q409 (≠ M379), H410 (≠ A380), G433 (= G404), M435 (≠ L406), G459 (= G430), D460 (= D431), A461 (≠ G432), S462 (≠ G433), M465 (≠ F436), N487 (= N458), E489 (≠ G460), Q490 (≠ Y461), G491 (= G462), M492 (≠ E463), V493 (≠ I464)
- binding magnesium ion: D460 (= D431), N487 (= N458), E489 (≠ G460)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V407 (≠ S377), G408 (≠ A378), Q409 (≠ M379), H410 (≠ A380), G433 (= G404), M435 (≠ L406), G459 (= G430), D460 (= D431), A461 (≠ G432), S462 (≠ G433), M465 (≠ F436), N487 (= N458), E489 (≠ G460), Q490 (≠ Y461), G491 (= G462), M492 (≠ E463), V493 (≠ I464)
6u9dB Saccharomyces cerevisiae acetohydroxyacid synthase (see paper)
27% identity, 98% coverage: 4:528/534 of query aligns to 12:568/607 of 6u9dB
- active site: Y33 (≠ I25), G35 (= G27), G36 (≠ T28), A37 (≠ H29), I38 (≠ N30), E59 (= E50), T82 (= T73), F121 (≠ L114), Q122 (≠ H115), E123 (= E116), K171 (≠ L165), M274 (≠ Q254), V301 (≠ W281), V417 (≠ S377), G443 (= G404), M445 (≠ L406), D470 (= D431), N497 (= N458), E499 (≠ G460), Q500 (≠ Y461), M502 (≠ E463), V503 (≠ I464), W506 (≠ E467)
- binding methyl 2-[(4,6-dimethoxypyrimidin-2-yl)carbamoylsulfamoylmethyl]benzoate: G36 (≠ T28), V111 (≠ M102), P112 (= P103), F121 (≠ L114), K171 (≠ L165), D299 (= D279), R300 (≠ W280), M502 (≠ E463), W506 (≠ E467)
- binding flavin-adenine dinucleotide: R161 (= R155), A228 (≠ G211), G229 (= G212), N232 (≠ R215), T254 (= T234), L255 (≠ S235), Q256 (≠ N236), L272 (≠ G252), M274 (≠ Q254), G294 (= G272), R296 (≠ E274), D298 (≠ S278), R300 (≠ W280), V301 (≠ W281), E327 (≠ D295), V328 (= V296), N332 (≠ G300), D346 (= D314), A347 (= A315), M422 (≠ Y382), G440 (≠ T401), G441 (= G402)
- binding magnesium ion: D470 (= D431), N497 (= N458)
- binding thiamine diphosphate: E59 (= E50), P85 (= P76), V417 (≠ S377), G418 (≠ A378), Q419 (≠ M379), H420 (≠ A380), G443 (= G404), M445 (≠ L406), A471 (≠ G432), S472 (≠ G433), N497 (= N458), E499 (≠ G460), Q500 (≠ Y461), G501 (= G462), M502 (≠ E463), V503 (≠ I464)
Query Sequence
>WP_012850832.1 NCBI__GCF_000024385.1:WP_012850832.1
MATMTGGEALIAALAAHGVDTIFGIPGTHNLSAYAAMKRHGIRHISPRHEQGAGYAADGY
ARSSGRPGVCLTTTGPAILNAASAALQAYSDSVPVLFVSPGMPLRHPGRGNGLLHEVKDQ
SGAMAAILGRSHRVTSVAEIPLAVAQAWTDLTGGRPRPVHLEIPLDLLEERAEVTVVDPV
PATTCTPAPESVTAGAAACAGARRPVLVVGGGARRAGAEVIALAEAVGAPILATSNGKGI
VPEDHPLFVGAGLQHRCVLDLMDDSDLVIAVGTEFAPSDWWIGLPDLSGKVLRIDVDPAG
IVTNVVPAVPVVGDAAVALRALRAELDRPAPAGAAQRAAQWRDRHRQAARAEGEPWLPIV
SAIAEALPRDAIVAADSAMACYYGALSNLPLHRPGAFLYPTGAGTLGFGLPAGIGAKIAD
PDAAVLVLQGDGGTMFTVAELAAAAELGIALPVVVVDNGGYGEIRNEMADRGEPVHAVAL
GRPDFPALARSLGCHGVRAADPAELTGAVKAALEADRPTLIHVREESRAARGMA
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory