Comparing WP_012853558.1 NCBI__GCF_000024385.1:WP_012853558.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
P9WQB3 2-isopropylmalate synthase; Alpha-IPM synthase; Alpha-isopropylmalate synthase; EC 2.3.3.13 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
60% identity, 99% coverage: 5:567/569 of query aligns to 36:644/644 of P9WQB3
3figB Crystal structure of leucine-bound leua from mycobacterium tuberculosis (see paper)
62% identity, 99% coverage: 5:567/569 of query aligns to 19:577/577 of 3figB
3hpzB Crystal structure of mycobacterium tuberculosis leua complexed with bromopyruvate
62% identity, 99% coverage: 5:566/569 of query aligns to 19:576/576 of 3hpzB
3hq1A Crystal structure of mycobacterium tuberculosis leua complexed with citrate and mn2+
62% identity, 99% coverage: 5:566/569 of query aligns to 19:573/573 of 3hq1A
1sr9A Crystal structure of leua from mycobacterium tuberculosis (see paper)
62% identity, 99% coverage: 5:566/569 of query aligns to 19:573/573 of 1sr9A
3hpsA Crystal structure of mycobacterium tuberculosis leua complexed with ketoisocaproate (kic)
62% identity, 99% coverage: 5:566/569 of query aligns to 19:575/575 of 3hpsA
4ov4A Isopropylmalate synthase binding with ketoisovalerate (see paper)
27% identity, 64% coverage: 44:407/569 of query aligns to 11:338/379 of 4ov4A
4ov9A Structure of isopropylmalate synthase binding with alpha- isopropylmalate (see paper)
27% identity, 64% coverage: 44:407/569 of query aligns to 11:340/380 of 4ov9A
Q9JZG1 2-isopropylmalate synthase; Alpha-IPM synthase; Alpha-isopropylmalate synthase; EC 2.3.3.13 from Neisseria meningitidis serogroup B (strain MC58) (see 2 papers)
24% identity, 93% coverage: 33:564/569 of query aligns to 1:501/517 of Q9JZG1
Sites not aligning to the query:
Q9FN52 Methylthioalkylmalate synthase 3, chloroplastic; 2-isopropylmalate synthase 2; Methylthioalkylmalate synthase-like; EC 2.3.3.17 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
25% identity, 61% coverage: 11:357/569 of query aligns to 66:404/503 of Q9FN52
6e1jA Crystal structure of methylthioalkylmalate synthase (bjumam1.1) from brassica juncea (see paper)
26% identity, 60% coverage: 14:357/569 of query aligns to 3:337/409 of 6e1jA
Sites not aligning to the query:
Q9FG67 Methylthioalkylmalate synthase 1, chloroplastic; 2-isopropylmalate synthase 3; EC 2.3.3.17 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
25% identity, 60% coverage: 14:357/569 of query aligns to 70:404/506 of Q9FG67
3rmjB Crystal structure of truncated alpha-isopropylmalate synthase from neisseria meningitidis (see paper)
26% identity, 52% coverage: 42:339/569 of query aligns to 9:293/308 of 3rmjB
6ktqA Crystal structure of catalytic domain of homocitrate synthase from sulfolobus acidocaldarius (sahcs(dram)) in complex with alpha- ketoglutarate/zn2+/coa (see paper)
22% identity, 66% coverage: 29:403/569 of query aligns to 14:346/399 of 6ktqA
Q8F3Q1 (R)-citramalate synthase CimA; LiCMS; EC 2.3.3.21 from Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601) (see 2 papers)
21% identity, 89% coverage: 40:547/569 of query aligns to 11:479/516 of Q8F3Q1
Sites not aligning to the query:
2ztjA Crystal structure of homocitrate synthase from thermus thermophilus complexed with alpha-ketoglutarate (see paper)
23% identity, 55% coverage: 38:349/569 of query aligns to 5:288/312 of 2ztjA
2zyfA Crystal structure of homocitrate synthase from thermus thermophilus complexed with magnesuim ion and alpha-ketoglutarate (see paper)
27% identity, 26% coverage: 200:349/569 of query aligns to 143:290/314 of 2zyfA
Sites not aligning to the query:
3a9iA Crystal structure of homocitrate synthase from thermus thermophilus complexed with lys (see paper)
27% identity, 26% coverage: 200:349/569 of query aligns to 142:289/347 of 3a9iA
Sites not aligning to the query:
O87198 Homocitrate synthase; HCS; EC 2.3.3.14 from Thermus thermophilus (strain ATCC BAA-163 / DSM 7039 / HB27) (see paper)
27% identity, 26% coverage: 200:349/569 of query aligns to 149:296/376 of O87198
Sites not aligning to the query:
3ivtB Homocitrate synthase lys4 bound to 2-og (see paper)
23% identity, 54% coverage: 40:349/569 of query aligns to 33:320/400 of 3ivtB
>WP_012853558.1 NCBI__GCF_000024385.1:WP_012853558.1
MKPKQQPSGMPFHRYRPFPPVDLPDRTWPNKTITQAPRWLSTDLRDGNQALIDPMDPARK
LKMFQLLVRMGYKEIEVGFPAASQTDFDFVRLLIEEDHIPDDVQISVLTQAREELIERTV
QSLVGAPRATVHLYNATAPLFRRVVFGIGRDECKALAVEGTRHVMKFAEQYLGDCDFGYE
YSPEIFIDTELDFALEVCEAVMDVWQPGPDREIILNLPSTIERSTPNVYADQVEWMSRNL
SRREHVCLSVHPHNDRGTAVASAELAVMAGADRVEGCLFGNGERTGNVCLVTLGMNLYSQ
GIDPQIDFSDIDEIRRTVEYCNQLPVHERHPYAGDLVYTSFSGSHQDAINKGFAALERDA
AEAGVPVDQYRWQMPYLPIDPKDVGRTYEAVIRVNSQSGKGGVAYIMKTEHALDLPRKLQ
IEFSRVVQQHTDTEGGEVTPEQMWQIFEREYLSSGPRIGLLAHRTSSRVDEKDHLTCDVR
LDGEIREIEGVGNGPISAFVDALGTVGIDVRVLDYAEHALSSGSDAKAAAYIECEIGGRV
LWGVGIDANTVTASLKGVLSAVNRAARTA
Or try a new SitesBLAST search
SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory