Comparing WP_012966499.1 NCBI__GCF_000025505.1:WP_012966499.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 18 hits to proteins with known functional sites (download)
5x6bJ Crystal structure of sepcyse-sepcyss in complex with trnacys from methanocaldococcus jannaschii (see paper)
51% identity, 98% coverage: 1:387/394 of query aligns to 6:375/377 of 5x6bJ
O30207 O-phospho-L-seryl-tRNA:Cys-tRNA synthase 1; Sep-tRNA:Cys-tRNA synthase 1; SepCysS 1; EC 2.5.1.73 from Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16) (see paper)
47% identity, 96% coverage: 11:388/394 of query aligns to 2:370/371 of O30207
2e7iA Crystal structure of sep-trna:cys-tRNA synthase from archaeoglobus fulgidus (see paper)
45% identity, 94% coverage: 19:388/394 of query aligns to 3:343/344 of 2e7iA
5b7uA Apo structure of cysteine desulfurase from thermococcus onnurineus na1 at 1.89a (see paper)
38% identity, 20% coverage: 158:236/394 of query aligns to 162:240/402 of 5b7uA
Sites not aligning to the query:
5b87A Crystal structure of a cysteine desulfurase from thermococcus onnurineus na1 in complex with alanine at 2.3 angstrom resolution (see paper)
38% identity, 20% coverage: 158:236/394 of query aligns to 156:234/397 of 5b87A
Sites not aligning to the query:
Q8KUU5 Cysteine desulfurase; CyD; EC 2.8.1.7 from Synechococcus elongatus (strain ATCC 33912 / PCC 7942 / FACHB-805) (Anacystis nidulans R2) (see paper)
24% identity, 43% coverage: 68:236/394 of query aligns to 291:462/626 of Q8KUU5
Sites not aligning to the query:
7xekA Sufs with d-cysteine for 6 h
28% identity, 22% coverage: 144:228/394 of query aligns to 151:234/413 of 7xekA
Sites not aligning to the query:
7xejA Sufs with d-cysteine for 5 min
28% identity, 22% coverage: 144:228/394 of query aligns to 151:234/413 of 7xejA
Sites not aligning to the query:
7xetA Sufs with beta-cyano-l-alanine
28% identity, 22% coverage: 144:228/394 of query aligns to 151:234/406 of 7xetA
Sites not aligning to the query:
O32164 Cysteine desulfurase SufS; EC 2.8.1.7 from Bacillus subtilis (strain 168) (see 3 papers)
28% identity, 22% coverage: 144:228/394 of query aligns to 151:234/406 of O32164
Sites not aligning to the query:
7cepA Crystal structure of l-cycloserine-bound form of cysteine desulfurase sufs from bacillus subtilis (see paper)
28% identity, 22% coverage: 144:228/394 of query aligns to 153:236/414 of 7cepA
Sites not aligning to the query:
7ceoA Crystal structure of pmp-bound form of cysteine desulfurase sufs from bacillus subtilis (see paper)
28% identity, 22% coverage: 144:228/394 of query aligns to 151:234/412 of 7ceoA
Sites not aligning to the query:
5zsoA Sufs from bacillus subtilis, soaked with l-cysteine for 90 sec (see paper)
28% identity, 22% coverage: 144:228/394 of query aligns to 151:234/405 of 5zsoA
Sites not aligning to the query:
7cerA Crystal structure of d-cycloserine-bound form of cysteine desulfurase sufs h121a from bacillus subtilis (see paper)
28% identity, 22% coverage: 144:228/394 of query aligns to 153:236/414 of 7cerA
Sites not aligning to the query:
5xt6A A sulfur-transferring catalytic intermediate of sufs-sufu complex from bacillus subtilis (see paper)
28% identity, 22% coverage: 144:228/394 of query aligns to 152:235/405 of 5xt6A
Sites not aligning to the query:
7xenA Sufs with l-penicillamine
28% identity, 22% coverage: 144:228/394 of query aligns to 138:221/392 of 7xenA
Sites not aligning to the query:
7xepA Sufs with l-propargylglycine
28% identity, 22% coverage: 144:228/394 of query aligns to 153:236/408 of 7xepA
Sites not aligning to the query:
5j8qA Crystal structure of the cysteine desulfurase sufs of bacillus subtilis (see paper)
28% identity, 22% coverage: 144:228/394 of query aligns to 151:234/413 of 5j8qA
Sites not aligning to the query:
>WP_012966499.1 NCBI__GCF_000025505.1:WP_012966499.1
MNLDRYSPQNLRRPSSGMINVHPIQRGGILTEEARQVILEWADGYSVCDLCLEGRVDLVK
NPPIAEFKRDVAEFLNMDEVRFTAGARHAKFVIMSAFKEKTIVVDSLAHYTSYIAAELND
MKVYEVPNSGYPEFKIEPEKYAETFERVKEETGKYPDLALLTHVDYRYGNLADAKEVGKI
CREYGIPLILNTAYSSGVMEVDGKKLNADFIVASGHKSWAATAPIGILATNYDFVDDVFR
TSKTRGEWSGRAFTKKEVALFGCSPVYGLPIITLMASFPAVVRRIKKWEEEVAKARWFVK
EMEKIEGVQLIGERPKNHTLMQFESPAFHSIAKRHKKRGFFLYHELKKRGIVGVQPGMTK
NFKINVYGLSWEEVEKVAEAFKDIAESYGLEVED
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory