SitesBLAST
Comparing WP_012966791.1 NCBI__GCF_000025505.1:WP_012966791.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 9 hits to proteins with known functional sites (download)
1aorA Structure of a hyperthermophilic tungstopterin enzyme, aldehyde ferredoxin oxidoreductase (see paper)
38% identity, 97% coverage: 5:645/661 of query aligns to 1:599/605 of 1aorA
- binding fe (iii) ion: E332 (≠ H344), H383 (≠ I394)
- binding tungstopterin cofactor: R76 (= R80), A92 (≠ S96), N93 (= N97), G95 (= G99), R182 (≠ D184), A183 (= A185), G185 (= G187), R186 (= R188), E311 (= E323), E313 (= E325), D338 (≠ N350), D343 (= D355), T344 (≠ A356), R444 (= R458), H448 (= H462), I449 (≠ L463), K450 (≠ R464), D489 (= D512), C494 (= C517), L495 (≠ R518), F496 (= F519)
- binding iron/sulfur cluster: R76 (= R80), C288 (= C297), C291 (= C300), I293 (≠ N302), C295 (= C304), C494 (= C517), F496 (= F519)
8c0zB Cryoem structure of a tungsten-containing aldehyde oxidoreductase from aromatoleum aromaticum (see paper)
37% identity, 96% coverage: 11:647/661 of query aligns to 6:615/616 of 8c0zB
- binding magnesium ion: N92 (= N97), A182 (= A185)
- binding iron/sulfur cluster: R75 (= R80), C295 (= C297), C298 (= C300), C302 (= C304), C509 (= C517)
- binding tungsten cofactor: R75 (= R80), S91 (= S96), N92 (= N97), G94 (= G99), R181 (≠ D184), A182 (= A185), A183 (= A186), G184 (= G187), E329 (= E323), E331 (= E325), N356 (= N350), P362 (≠ A356), L465 (= L463), D504 (= D512), V510 (≠ R518), F511 (= F519)
8c0zA Cryoem structure of a tungsten-containing aldehyde oxidoreductase from aromatoleum aromaticum (see paper)
37% identity, 96% coverage: 11:647/661 of query aligns to 6:615/616 of 8c0zA
- binding iron/sulfur cluster: R181 (≠ D184), C295 (= C297), C298 (= C300), C302 (= C304), C509 (= C517)
- binding tungsten cofactor: R75 (= R80), N92 (= N97), G94 (= G99), R181 (≠ D184), A183 (= A186), G184 (= G187), R185 (= R188), E329 (= E323), E331 (= E325), N356 (= N350), P362 (≠ A356), L465 (= L463), D504 (= D512), V510 (≠ R518), F511 (= F519)
1b4nA Formaldehyde ferredoxin oxidoreductase from pyrococcus furiosus, complexed with glutarate (see paper)
33% identity, 99% coverage: 5:656/661 of query aligns to 1:606/611 of 1b4nA
- binding calcium ion: G179 (≠ W183), E304 (≠ N321), D306 (≠ E323)
- binding glutaric acid: Y307 (≠ F324), E308 (= E325), Y416 (≠ C441), H437 (= H462), R473 (≠ G495), R484 (= R518)
- binding tungstopterin cofactor: K75 (≠ R80), G91 (≠ S96), N92 (= N97), L93 (≠ A98), G94 (= G99), R180 (≠ D184), A181 (= A185), A182 (= A186), G183 (= G187), R184 (= R188), D306 (≠ E323), E308 (= E325), N309 (≠ A326), D333 (≠ N350), M337 (= M354), D338 (= D355), T339 (≠ A356), H436 (≠ D461), H437 (= H462), K438 (≠ L463), F477 (≠ T511), E478 (≠ D512), A482 (≠ S516), C483 (= C517), R484 (= R518), L485 (≠ F519)
- binding iron/sulfur cluster: K75 (≠ R80), G283 (≠ A296), C284 (= C297), C287 (= C300), M289 (≠ N302), C291 (= C304), C483 (= C517), L485 (≠ F519)
1b25A Formaldehyde ferredoxin oxidoreductase from pyrococcus furiosus (see paper)
33% identity, 99% coverage: 5:656/661 of query aligns to 1:606/611 of 1b25A
- binding tungstopterin: K75 (≠ R80), G91 (≠ S96), N92 (= N97), L93 (≠ A98), G94 (= G99), G179 (≠ W183), R180 (≠ D184), A181 (= A185), G183 (= G187), R184 (= R188), T240 (= T246), E304 (≠ N321), D306 (≠ E323), Y307 (≠ F324), E308 (= E325), N309 (≠ A326), D333 (≠ N350), D338 (= D355), T339 (≠ A356), I340 (≠ V357), H436 (≠ D461), H437 (= H462), K438 (≠ L463), E478 (≠ D512), A482 (≠ S516), C483 (= C517), R484 (= R518), L485 (≠ F519)
- binding iron/sulfur cluster: K75 (≠ R80), R180 (≠ D184), C284 (= C297), C287 (= C300), M289 (≠ N302), C291 (= C304), C483 (= C517)
4z3yA Active site complex bambc of benzoyl coenzyme a reductase in complex with benzoyl-coa (see paper)
31% identity, 99% coverage: 6:660/661 of query aligns to 3:650/653 of 4z3yA
- binding benzoyl coenzyme A: P249 (= P234), W259 (≠ G245), F323 (vs. gap), L436 (≠ C441), S439 (≠ R444), M440 (≠ A445), Y445 (≠ G450), T458 (vs. gap), E461 (vs. gap), Q466 (≠ V455), R500 (≠ V489), S504 (≠ K493)
- binding magnesium ion: M94 (≠ N97), S183 (≠ A185)
- binding iron/sulfur cluster: R77 (= R80), R181 (≠ Y182), C299 (= C297), C302 (= C300), M304 (≠ N302), K305 (≠ R303), C306 (= C304), C534 (= C517)
4z3wC Active site complex bambc of benzoyl coenzyme a reductase in complex with 1,5 dienoyl-coa (see paper)
31% identity, 99% coverage: 6:660/661 of query aligns to 3:650/653 of 4z3wC
- binding 1,5 Dienoyl-CoA: P249 (= P234), W259 (≠ G245), H260 (≠ T246), F323 (vs. gap), L436 (≠ C441), L438 (≠ P443), S439 (≠ R444), M440 (≠ A445), Y445 (≠ G450), T458 (vs. gap), E461 (vs. gap), Q466 (≠ V455), P499 (≠ A488), R500 (≠ V489), S504 (≠ K493)
- binding magnesium ion: M94 (≠ N97), S183 (≠ A185)
- binding iron/sulfur cluster: R77 (= R80), R181 (≠ Y182), C299 (= C297), C302 (= C300), M304 (≠ N302), C306 (= C304), C534 (= C517)
4z3zA Active site complex bambc of benzoyl coenzyme a reductase in complex with zinc (see paper)
31% identity, 99% coverage: 6:660/661 of query aligns to 3:650/652 of 4z3zA
- binding magnesium ion: M94 (≠ N97), S183 (≠ A185)
- binding iron/sulfur cluster: R77 (= R80), R181 (≠ Y182), C299 (= C297), C302 (= C300), M304 (≠ N302), C306 (= C304), C534 (= C517)
- binding zinc ion: E251 (≠ K237), H255 (= H241), E257 (≠ V243), H260 (≠ T246)
6x1oC Wor5 from pyrococcus furiosus, as crystallized (see paper)
32% identity, 97% coverage: 5:645/661 of query aligns to 1:606/624 of 6x1oC
- binding magnesium ion: M194 (≠ W183), D323 (≠ N321), D326 (≠ E323)
- binding phosphate ion: R249 (≠ K237), Y296 (≠ S289)
- binding tungstopterin cofactor: K77 (≠ T77), S93 (= S96), V94 (≠ N97), L95 (≠ A98), S96 (≠ G99), H195 (≠ D184), A196 (= A185), A197 (= A186), G198 (= G187), Y199 (≠ R188), D326 (≠ E323), E328 (= E325), D353 (≠ N350), D358 (= D355), G359 (≠ A356), I360 (≠ V357), H469 (= H462), T470 (≠ L463), Y489 (≠ T511), D490 (= D512), I494 (≠ S516), C495 (= C517), N496 (≠ R518), F497 (= F519)
- binding iron/sulfur cluster: S96 (≠ G99), D299 (≠ C297), C302 (= C300), C306 (= C304), C495 (= C517), F497 (= F519), V498 (≠ M520)
- binding (1R)-1-hydroxybutane-1-sulfonic acid: T253 (≠ H241), Y327 (≠ F324), E328 (= E325), H446 (≠ C441), H469 (= H462)
Query Sequence
>WP_012966791.1 NCBI__GCF_000025505.1:WP_012966791.1
MVGKLYAYAGKTLKVDLTREKVVEEPLNKELARKFLGGRGLNAKLLFDLVPPDVHPLSPK
NVLLIATGPINGLLGVTTGRIDVTSLSPLTGIFGNSNAGTDFAAELKYAGYDNIIIFGRA
KKPVYLLIEDGSVEIRDASDLKGAGVFETTHVLKERHGDVKVAAIGPAAENGVLYGSIIF
DYWDAAGRSGMGTVMASKNLKAIAVRGSGSLEVADPERYYEVVREGWLALMNDPGFKTQE
HSVLGTAVCVGWGNAQGWLPTRNFRESYFEEADKISGEVFRDKYSVKDSPIPAGRACMSC
PNRCKRYGVIRSGKYAGTRGNIEFEAIAAFGSKCGVSDFDAVFHANMLANDYGMDAVSTG
NMIATFMELREEGIIDEKFLDGLDLRFGNADAMIEAIHKIAKREGKIGELGALGSYLATK
AIGDKAVYYTSNIKGMDSIACDPRAAKGFGFAFAVASRGSDHLRAHPVFEMLKFPPEVGK
ELFGSPEAVDLRKYGGKPEMVAWHEELAAITDSIGSCRFMHASYYIQYPVPELLHKYLKL
GGKAYSLKYHEWISAATGWEISYEDLLRIGKRIITVERAFNTRRGIRRKDDTLPERFFKE
KIPKGPAKGEVYSKEVFEKMLDRYYEIRGWDKETGLIKRETLESLELHDVLSVLEKEGLV
V
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SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory