SitesBLAST – Find functional sites

 

SitesBLAST

Comparing WP_012973905.1 NCBI__GCF_000010725.1:WP_012973905.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 4 hits to proteins with known functional sites (download)

7bgmA Crystal structure of mthisn2, a bifunctional enzyme from the histidine biosynthetic pathway (see paper)
41% identity, 72% coverage: 11:114/144 of query aligns to 3:106/213 of 7bgmA

query
sites
7bgmA
A
 
A
F
 
V
E
 
D
E
 
S
V
 
L
L
 
L
A
 
D
A
 
S
I
 
V
R
 
K
F
 
W
T
 
D
A
 
N
D
 
K
G
 
G
L
 
L
V
 
A
P
 
V
A
 
A
I
 
I
A
 
A
Q
 
Q
A
 
N
D
 
V
G
 
D
T
 
T
G
 
G
E
 
A
I
 
I
L
 
L
M
 
M
M
 
Q
A
 
G
W
 
F
M
 
A
N
 
N
R
 
R
D
 
E
A
 
A
V
 
V
L
 
A
E
 
T
T
 
T
L
 
I
S
 
S
T
 
S
G
 
R
R
 
K
V
 
A
C
 
T
Y
 
F
W
 
Y
S
 
S
R
 
R
S
 
S
R
 
R
G
 
S
G
 
S
L
 
L
W
 
W
R
 
T
K
 
K
G
 
G
E
 
E
T
 
T
S
 
S
G
 
N
Q
 
N
V
 
F
Q
 
I
R
 
N
L
 
V
K
 
H
D
 
D
F
 
V
R
 
F
V
 
L
D
|
D
C
 
C
D
|
D
G
 
R
D
|
D
T
 
S
L
 
I
L
 
I
L
 
Y
I
 
L
V
 
G
E
 
K
Q
 
P
D
 
D
G
 
G
V
 
P
A
 
T
C
|
C
H
 
H
T
 
T
G
 
G
R
 
A
R
 
E
S
 
T
C
|
C
F
 
Y
Y
 
Y

Sites not aligning to the query:

7bgnA Crystal structure of mthisn2-amp complex, a bifunctional enzyme from the histidine biosynthetic pathway (see paper)
41% identity, 72% coverage: 11:114/144 of query aligns to 1:104/204 of 7bgnA

query
sites
7bgnA
A
 
A
F
 
V
E
 
D
E
 
S
V
 
L
L
 
L
A
 
D
A
 
S
I
 
V
R
 
K
F
 
W
T
 
D
A
 
N
D
 
K
G
 
G
L
 
L
V
 
A
P
 
V
A
 
A
I
 
I
A
 
A
Q
 
Q
A
 
N
D
 
V
G
 
D
T
 
T
G
 
G
E
 
A
I
 
I
L
 
L
M
 
M
M
 
Q
A
 
G
W
 
F
M
 
A
N
 
N
R
 
R
D
 
E
A
 
A
V
 
V
L
 
A
E
 
T
T
 
T
L
 
I
S
 
S
T
 
S
G
 
R
R
 
K
V
 
A
C
 
T
Y
 
F
W
 
Y
S
 
S
R
 
R
S
 
S
R
 
R
G
 
S
G
 
S
L
 
L
W
|
W
R
 
T
K
|
K
G
|
G
E
 
E
T
|
T
S
|
S
G
 
N
Q
 
N
V
 
F
Q
 
I
R
 
N
L
 
V
K
 
H
D
 
D
F
 
V
R
 
F
V
 
L
D
|
D
C
 
C
D
|
D
G
 
R
D
|
D
T
 
S
L
 
I
L
 
I
L
 
Y
I
 
L
V
 
G
E
 
K
Q
 
P
D
 
D
G
 
G
V
 
P
A
x
T
C
|
C
H
|
H
T
 
T
G
 
G
R
 
A
R
 
E
S
 
T
C
|
C
F
 
Y
Y
 
Y

Sites not aligning to the query:

6j2lA Crystal structure of bi-functional enzyme (see paper)
44% identity, 63% coverage: 24:113/144 of query aligns to 15:104/200 of 6j2lA

query
sites
6j2lA
D
 
D
G
 
G
L
 
L
V
 
M
P
 
P
A
 
V
I
 
I
A
 
V
Q
 
Q
A
 
H
D
 
A
G
 
V
T
 
S
G
 
G
E
 
E
I
 
V
L
 
L
M
 
M
M
 
L
A
 
G
W
 
Y
M
 
M
N
 
N
R
 
P
D
 
E
A
 
A
V
 
L
L
 
D
E
 
K
T
 
T
L
 
I
S
 
E
T
 
S
G
 
G
R
 
K
V
 
V
C
 
T
Y
 
F
W
 
F
S
 
S
R
 
R
S
 
T
R
 
K
G
 
Q
G
 
R
L
 
L
W
 
W
R
 
I
K
 
K
G
 
G
E
 
E
T
 
T
S
 
S
G
 
G
Q
 
N
V
 
F
Q
 
L
R
 
N
L
 
V
K
 
V
D
 
S
F
 
I
R
 
A
V
 
P
D
|
D
C
 
C
D
|
D
G
 
N
D
|
D
T
 
T
L
 
L
L
 
L
L
 
V
I
 
L
V
 
A
E
 
N
Q
 
P
D
 
I
G
 
G
V
 
P
A
 
T
C
|
C
H
 
H
T
 
K
G
 
G
R
 
T
R
 
S
S
 
S
C
|
C
F
 
F

Sites not aligning to the query:

6j2lB Crystal structure of bi-functional enzyme (see paper)
42% identity, 63% coverage: 24:113/144 of query aligns to 14:97/185 of 6j2lB

query
sites
6j2lB
D
 
D
G
 
G
L
 
L
V
 
M
P
 
P
A
 
V
I
 
I
A
 
V
Q
 
Q
A
 
H
D
 
A
G
 
V
T
 
S
G
 
G
E
 
E
I
 
V
L
 
L
M
 
M
M
 
L
A
 
G
W
 
Y
M
 
M
N
 
N
R
 
P
D
 
E
A
 
A
V
 
L
L
 
D
E
 
K
T
 
T
L
 
I
S
 
E
T
 
S
G
 
G
R
 
K
V
 
V
C
 
T
Y
 
F
W
 
F
S
 
S
R
 
R
S
 
T
R
 
K
G
 
Q
G
 
R
L
 
L
W
 
W
R
 
I
K
 
K
G
 
G
E
 
E
T
 
T
S
 
S
G
 
G
Q
 
N
V
 
F
Q
 
L
R
 
N
L
 
V
K
 
V
D
 
S
F
 
I
R
 
A
V
 
P
D
|
D
C
 
C
D
|
D
G
 
N
D
|
D
T
 
T
L
 
L
L
 
L
L
 
V
I
 
L
V
 
-
E
 
-
Q
 
-
D
 
-
G
 
-
V
 
-
A
 
A
C
 
N
H
 
P
T
 
I
G
 
G
R
 
P
R
 
S
S
 
S
C
 
C
F
 
F

Sites not aligning to the query:

Query Sequence

>WP_012973905.1 NCBI__GCF_000010725.1:WP_012973905.1
MTDAPSIDAAAFEEVLAAIRFTADGLVPAIAQADGTGEILMMAWMNRDAVLETLSTGRVC
YWSRSRGGLWRKGETSGQVQRLKDFRVDCDGDTLLLIVEQDGVACHTGRRSCFYRAWRNG
TLETIQEVQTDPAILYGGHAHSHG

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory