Comparing WP_012974742.1 NCBI__GCF_000010725.1:WP_012974742.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
7qplA Crystal structure of phosphoserine phosphatase (serb) from brucella melitensis in complex with phosphate and magnesium
51% identity, 100% coverage: 1:296/297 of query aligns to 1:294/295 of 7qplA
O53289 Phosphoserine phosphatase SerB2; PSP; PSPase; O-phosphoserine phosphohydrolase; Protein-serine/threonine phosphatase; EC 3.1.3.3; EC 3.1.3.16 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
44% identity, 71% coverage: 79:289/297 of query aligns to 175:385/409 of O53289
Sites not aligning to the query:
5jlpA Crystal structure of mycobacterium avium serb2 in complex with serine at act domain
40% identity, 83% coverage: 44:289/297 of query aligns to 127:383/396 of 5jlpA
Sites not aligning to the query:
A0QJI1 Phosphoserine phosphatase; PSP; PSPase; O-phosphoserine phosphohydrolase; EC 3.1.3.3 from Mycobacterium avium (strain 104) (see paper)
40% identity, 83% coverage: 44:289/297 of query aligns to 131:387/411 of A0QJI1
8a21A Crystal structure of phosphoserine phosphatase serb from mycobacterium avium in complex with phenylimidazole (see paper)
40% identity, 83% coverage: 44:289/297 of query aligns to 127:383/396 of 8a21A
Sites not aligning to the query:
8a1zA Crystal structure of phosphoserine phosphatase serb from mycobacterium avium in complex with 1-(2,4-dichlorophenyl)-3-hydroxyurea (see paper)
40% identity, 83% coverage: 44:289/297 of query aligns to 127:383/396 of 8a1zA
1f5sA Crystal structure of phosphoserine phosphatase from methanococcus jannaschii (see paper)
33% identity, 69% coverage: 81:285/297 of query aligns to 2:206/210 of 1f5sA
Q58989 Phosphoserine phosphatase; PSP; PSPase; O-phosphoserine phosphohydrolase; EC 3.1.3.3 from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) (see 3 papers)
33% identity, 69% coverage: 81:285/297 of query aligns to 3:207/211 of Q58989
1l7nA Transition state analogue of phosphoserine phosphatase (aluminum fluoride complex) (see paper)
33% identity, 69% coverage: 81:285/297 of query aligns to 1:205/209 of 1l7nA
1l7pA Substrate bound phosphoserine phosphatase complex structure (see paper)
33% identity, 69% coverage: 82:285/297 of query aligns to 1:204/208 of 1l7pA
1l7oA Crystal structure of phosphoserine phosphatase in apo form (see paper)
31% identity, 69% coverage: 82:285/297 of query aligns to 1:196/200 of 1l7oA
3m1yC Crystal structure of a phosphoserine phosphatase (serb) from helicobacter pylori
32% identity, 67% coverage: 83:281/297 of query aligns to 3:200/208 of 3m1yC
6hyyA Human phosphoserine phosphatase with serine and phosphate (see paper)
36% identity, 33% coverage: 89:187/297 of query aligns to 16:115/221 of 6hyyA
Sites not aligning to the query:
6hyjB Psph human phosphoserine phosphatase (see paper)
36% identity, 33% coverage: 89:187/297 of query aligns to 20:119/223 of 6hyjB
Sites not aligning to the query:
6q6jB Human phosphoserine phosphatase with substrate analogue homo-cysteic acid (see paper)
36% identity, 33% coverage: 89:187/297 of query aligns to 16:115/217 of 6q6jB
Sites not aligning to the query:
P78330 Phosphoserine phosphatase; PSP; PSPase; L-3-phosphoserine phosphatase; O-phosphoserine phosphohydrolase; EC 3.1.3.3 from Homo sapiens (Human) (see 4 papers)
36% identity, 33% coverage: 89:187/297 of query aligns to 20:119/225 of P78330
Sites not aligning to the query:
1l8oA Molecular basis for the local conformational rearrangement of human phosphoserine phosphatase (see paper)
36% identity, 33% coverage: 89:187/297 of query aligns to 17:116/222 of 1l8oA
Sites not aligning to the query:
1l8lA Molecular basis for the local confomational rearrangement of human phosphoserine phosphatase (see paper)
36% identity, 33% coverage: 89:187/297 of query aligns to 17:116/222 of 1l8lA
Sites not aligning to the query:
4ap9A Crystal structure of phosphoserine phosphatase from t.Onnurineus in complex with ndsb-201 (see paper)
31% identity, 33% coverage: 83:180/297 of query aligns to 9:105/200 of 4ap9A
Sites not aligning to the query:
3r4cA Divergence of structure and function among phosphatases of the haloalkanoate (had) enzyme superfamily: analysis of bt1666 from bacteroides thetaiotaomicron (see paper)
59% identity, 14% coverage: 221:261/297 of query aligns to 194:234/268 of 3r4cA
Sites not aligning to the query:
>WP_012974742.1 NCBI__GCF_000010725.1:WP_012974742.1
MNAVATLIAPRTATLDEAAVQTAKAALVGLGADAGLPDWLAPGGACDLPFGNLAPEQAEA
AIRHALGGATLDIIAQPAATRRKRLLVADMESTIIEQEMLDELGDYVGLKDHIAAITARA
MNGEIDFKDAVRERVALLKGLKETVIDEVWRRATLMPGAAQLVGTMRANGAVCVLVSGGF
RCFTGRVRGWIGFDDDRGNELEVKGGVMTGKVIEPILDKDSKLQALMAYAGEHRVPVAET
MAVGDGANDLPMLLAAGLGVAFHAKAVVAAEARARVDHGDLTALLYAQGYRVTEFVG
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory