Comparing WP_012975150.1 NCBI__GCF_000010725.1:WP_012975150.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
P0A962 L-asparaginase 1; L-asparaginase I; L-ASNase I; L-asparagine amidohydrolase I; EC 3.5.1.1 from Escherichia coli (strain K12) (see paper)
40% identity, 98% coverage: 4:358/362 of query aligns to 6:335/338 of P0A962
6nxcB Ecai(t162a) mutant in complex with citrate at ph 4 (see paper)
40% identity, 98% coverage: 4:358/362 of query aligns to 13:334/336 of 6nxcB
4r8lA Crystal structure of the asp-bound guinea pig l-asparaginase 1 catalytic domain (see paper)
39% identity, 91% coverage: 3:332/362 of query aligns to 3:325/354 of 4r8lA
5dndD Crystal structure of the asn-bound guinea pig l-asparaginase 1 catalytic domain active site mutant t116a (see paper)
39% identity, 91% coverage: 3:332/362 of query aligns to 3:325/357 of 5dndD
2himA Crystal structure and allosteric regulation of the cytoplasmic escherichia coli l-asparaginase i (see paper)
39% identity, 98% coverage: 4:358/362 of query aligns to 4:323/324 of 2himA
7r6bB Crystal structure of mutant r43d/l124d/r125a/c273s of l-asparaginase i from yersinia pestis (see paper)
34% identity, 98% coverage: 4:358/362 of query aligns to 4:300/301 of 7r6bB
5ot0A The thermostable l-asparaginase from thermococcus kodakarensis (see paper)
31% identity, 98% coverage: 3:358/362 of query aligns to 2:326/328 of 5ot0A
1zq1A Structure of gatde tRNA-dependent amidotransferase from pyrococcus abyssi (see paper)
32% identity, 81% coverage: 65:358/362 of query aligns to 145:427/437 of 1zq1A
Sites not aligning to the query:
4q0mA Crystal structure of pyrococcus furiosus l-asparaginase (see paper)
29% identity, 99% coverage: 1:357/362 of query aligns to 1:325/327 of 4q0mA
Q8TZE8 L-asparaginase; EC 3.5.1.1 from Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1) (see 2 papers)
29% identity, 98% coverage: 3:357/362 of query aligns to 2:324/326 of Q8TZE8
4njeA Crystal structure of pyrococcus furiosus l-asparaginase with ligand (see paper)
35% identity, 51% coverage: 3:188/362 of query aligns to 2:174/182 of 4njeA
5b5uA Crystal structure of truncated pyrococcus furiosus l-asparaginase with peptide (see paper)
35% identity, 51% coverage: 3:188/362 of query aligns to 2:174/175 of 5b5uA
Sites not aligning to the query:
P00805 L-asparaginase 2; L-asparaginase II; L-ASNase II; L-asparagine amidohydrolase II; Colaspase; EC 3.5.1.1 from Escherichia coli (strain K12) (see 5 papers)
32% identity, 43% coverage: 32:188/362 of query aligns to 55:204/348 of P00805
Sites not aligning to the query:
1ho3A Crystal structure analysis of e. Coli l-asparaginase ii (y25f mutant) (see paper)
32% identity, 43% coverage: 32:188/362 of query aligns to 33:182/326 of 1ho3A
Sites not aligning to the query:
1jazA Crystal structure of monoclinic form of d90e mutant of escherichia coli asparaginase ii (see paper)
28% identity, 51% coverage: 3:188/362 of query aligns to 3:163/307 of 1jazA
Sites not aligning to the query:
7r5qA Escherichia coli type ii asparaginase n24s mutant in complex with glu (see paper)
29% identity, 51% coverage: 3:188/362 of query aligns to 3:162/306 of 7r5qA
5k45A Wolinella succinogenes l-asparaginase p121 + l-glutamic acid (see paper)
24% identity, 95% coverage: 3:346/362 of query aligns to 3:322/328 of 5k45A
5k3oA Wolinella succinogenes l-asparaginase p121 and l-aspartic acid (see paper)
24% identity, 95% coverage: 3:346/362 of query aligns to 3:322/328 of 5k3oA
6pa3A E. Coli l-asparaginase ii double mutant (t89v,k162t) in complex with l-asn at ph 7.0 (see paper)
30% identity, 43% coverage: 32:188/362 of query aligns to 41:190/334 of 6pa3A
Sites not aligning to the query:
7cbuA Blasnase-t13a with l-asp (see paper)
27% identity, 69% coverage: 87:337/362 of query aligns to 76:306/318 of 7cbuA
Sites not aligning to the query:
>WP_012975150.1 NCBI__GCF_000010725.1:WP_012975150.1
MARVYVLYTGGTIGCVANAEGALAPVPGAEFERLVLAMPGLSDHGVRGYDGLGWTMGWFD
RTLDSSNMTPADWVAIAERLLSIYDQYDGFVVLHGTDSMAYSASALSFLLPGLSKPVVFS
GSQVPLSFTLSDAPANLVGAIVAAGTLPVPEVSVYFNTRLLRGNRSSKIDANRFAGFDSP
NFPPLATIGSVVARNEPYWLPMPGADVSLAEAENRAKRLAALALLPAALAEFSVVMLWLH
PGIRASTVSAMLTGTSPAAKGAVLLAFGEGNGPTDPDFLGALSAGVAAGVVLMDNTQVRR
GAVLPGAYATGLGAIGAIGAYDMTPEASYAKLVCLFADGLDATAVKAAMLVPRAGELTVI
GA
Or try a new SitesBLAST search
SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory